321. Cerebral oxygenation in patients with OSA: effects of hypoxia at altitude and impact of acetazolamide.
作者: Silvia Ulrich.;Yvonne Nussbaumer-Ochsner.;Irena Vasic.;Elisabeth Hasler.;Tsogyal D Latshang.;Malcolm Kohler.;Thomas Muehlemann.;Martin Wolf.;Konrad E Bloch.
来源: Chest. 2014年146卷2期299-308页
Sleep-disordered breathing may impair cerebral oxygenation in patients with OSA syndrome, in particular during altitude travel. We studied cerebral tissue oxygenation (CTO) at low and moderate altitude in patients with OSA and evaluated whether acetazolamide improved CTO.
322. The efficacy of a brief motivational enhancement education program on CPAP adherence in OSA: a randomized controlled trial.
作者: Agnes Y K Lai.;Daniel Y T Fong.;Jamie C M Lam.;Terri E Weaver.;Mary S M Ip.
来源: Chest. 2014年146卷3期600-610页
Poor adherence to CPAP treatment in OSA adversely affects the effectiveness of this therapy. This randomized controlled trial (RCT) examined the efficacy of a brief motivational enhancement education program in improving adherence to CPAP treatment in subjects with OSA.
323. Detection of fibroproliferation by chest high-resolution CT scan in resolving ARDS.
作者: Ellen L Burnham.;Robert C Hyzy.;Robert Paine.;Aine M Kelly.;Leslie E Quint.;David Lynch.;Douglas Curran-Everett.;Marc Moss.;Theodore J Standiford.
来源: Chest. 2014年146卷5期1196-1204页
In ARDS, the extent of fibroproliferative activity on chest high-resolution CT (HRCT) scan has been reported to correlate with poorer short-term outcomes and pulmonary-associated quality of life. However, clinical factors associated with HRCT scan fibroproliferation are incompletely characterized. We questioned if lung compliance assessed at the bedside would be associated with fibroproliferation on HRCT scans obtained during the resolution phase of ARDS.
324. Adenovirus-specific IgG maturation as a surrogate marker in acute exacerbations of COPD.
作者: Lucas Boeck.;Mikael Gencay.;Michael Roth.;Hans H Hirsch.;Mirjam Christ-Crain.;Beat Mueller.;Michael Tamm.;Daiana Stolz.
来源: Chest. 2014年146卷2期339-347页
B cells in airways and lung parenchyma may be involved in COPD evolution; however, whether their pathogenic role is beneficial or harmful remains controversial. The objective of this study was to investigate the maturation of adenovirus-specific immunoglobulins in patients with COPD with respect to clinical outcome.
325. Ventilator-associated pneumonia during weaning from mechanical ventilation: role of fluid management.
作者: Armand Mekontso Dessap.;Sandrine Katsahian.;Ferran Roche-Campo.;Hugo Varet.;Achille Kouatchet.;Vinko Tomicic.;Gaetan Beduneau.;Romain Sonneville.;Samir Jaber.;Michael Darmon.;Diego Castanares-Zapatero.;Laurent Brochard.;Christian Brun-Buisson.
来源: Chest. 2014年146卷1期58-65页
Pulmonary edema may alter alveolar bacterial clearance and infectivity. Manipulation of fluid balance aimed at reducing fluid overload may, therefore, influence ventilator-associated pneumonia (VAP) occurrence in intubated patients. The objective of the present study was to assess the impact of a depletive fluid-management strategy on ventilator-associated complication (VAC) and VAP occurrence during weaning from mechanical ventilation.
326. Omega-3 fatty acid supplementation during pregnancy and respiratory symptoms in children.
作者: María Consuelo Escamilla-Nuñez.;Albino Barraza-Villarreal.;Leticia Hernández-Cadena.;Efraín Navarro-Olivos.;Peter D Sly.;Isabelle Romieu.
来源: Chest. 2014年146卷2期373-382页
Prenatal consumption of omega-3 fatty acids can act as an adjuvant in the development of the immune system and affect the inflammatory response of neonates.
327. Endosonographic mediastinal lymph node staging of lung cancer.
作者: Moishe Liberman.;John Sampalis.;André Duranceau.;Vicky Thiffault.;Rachid Hadjeres.;Pasquale Ferraro.
来源: Chest. 2014年146卷2期389-397页
It is unclear whether endoscopic mediastinal lymph node (LN) staging techniques are equivalent to surgical mediastinal staging (SMS) techniques in patients with potentially operable non-small cell lung cancer (NSCLC).
328. Standardizing the analysis of physical activity in patients with COPD following a pulmonary rehabilitation program.
作者: Heleen Demeyer.;Chris Burtin.;Hans Van Remoortel.;Miek Hornikx.;Daniel Langer.;Marc Decramer.;Rik Gosselink.;Wim Janssens.;Thierry Troosters.
来源: Chest. 2014年146卷2期318-327页
There is a wide variability in measurement methodology of physical activity. This study investigated the effect of different analysis techniques on the statistical power of physical activity outcomes after pulmonary rehabilitation.
329. Do field walking tests produce similar cardiopulmonary demands to an incremental treadmill test in obese individuals with treated OSA?
作者: Rachael A Evans.;Thomas E Dolmage.;Priscila G Robles.;Roger S Goldstein.;Dina Brooks.
来源: Chest. 2014年146卷1期81-87页
Cardiorespiratory fitness, assessed during cardiopulmonary exercise tests by peak oxygen uptake (Vo2pk), is an independent predictor of mortality in obesity. We investigated whether Vo2pk and systemic responses measured during field walking tests were similar to those measured during an incremental treadmill test (ITMT) in obese individuals with treated OSA.
330. Laterality defects other than situs inversus totalis in primary ciliary dyskinesia: insights into situs ambiguus and heterotaxy.
作者: Adam J Shapiro.;Stephanie D Davis.;Thomas Ferkol.;Sharon D Dell.;Margaret Rosenfeld.;Kenneth N Olivier.;Scott D Sagel.;Carlos Milla.;Maimoona A Zariwala.;Whitney Wolf.;Johnny L Carson.;Milan J Hazucha.;Kimberlie Burns.;Blair Robinson.;Michael R Knowles.;Margaret W Leigh.; .
来源: Chest. 2014年146卷5期1176-1186页
Motile cilia dysfunction causes primary ciliary dyskinesia (PCD), situs inversus totalis (SI), and a spectrum of laterality defects, yet the prevalence of laterality defects other than SI in PCD has not been prospectively studied.
331. Efficacy and safety of early dexmedetomidine during noninvasive ventilation for patients with acute respiratory failure: a randomized, double-blind, placebo-controlled pilot study.
作者: John W Devlin.;Nada S Al-Qadheeb.;Amy Chi.;Russel J Roberts.;Imrana Qawi.;Erik Garpestad.;Nicholas S Hill.
来源: Chest. 2014年145卷6期1204-1212页
Successful application of noninvasive ventilation (NIV) for acute respiratory failure (ARF) requires patient cooperation and comfort. The efficacy and safety of early IV dexmedetomidine when added to protocolized, as-needed IV midazolam and fentanyl remain unclear.
332. Chinese water-pipe smoking and the risk of COPD.
作者: Jun She.;Ping Yang.;Yuqi Wang.;Xinyu Qin.;Jia Fan.;Yi Wang.;Guangsuo Gao.;Guangxiong Luo.;Kaixiang Ma.;Baoyan Li.;Caihua Li.;Xiangdong Wang.;Yuanlin Song.;Chunxue Bai.
来源: Chest. 2014年146卷4期924-931页
Studies show that the incidence of COPD has remained high in southwest China despite the 1976 National Stove Improvement Program for indoor air quality. Chinese water-pipe tobacco smoking (commonly referred to as water-pipe smoking), which is thought to be less harmful under the assumption that no charcoal is used and water filters tobacco smoke, is popular in China. We investigated whether Chinese water-pipe use and exposure are associated with the risk of COPD.
333. A randomized controlled trial of angiotensin-converting enzyme inhibition for skeletal muscle dysfunction in COPD.
作者: Dinesh Shrikrishna.;Rebecca J Tanner.;Jen Y Lee.;Amanda Natanek.;Amy Lewis.;Patrick B Murphy.;Nicholas Hart.;John Moxham.;Hugh E Montgomery.;Paul R Kemp.;Michael I Polkey.;Nicholas S Hopkinson.
来源: Chest. 2014年146卷4期932-940页
Skeletal muscle impairment is a recognized complication of COPD, predicting mortality in severe disease. Increasing evidence implicates the renin-angiotensin system in control of muscle phenotype. We hypothesized that angiotensin-converting enzyme (ACE) inhibition would improve quadriceps function and exercise performance in COPD.
334. Attentional modulation of reflex cough.
作者: Thomas Janssens.;Mitchell Silva.;Paul W Davenport.;Ilse Van Diest.;Lieven J Dupont.;Omer Van den Bergh.
来源: Chest. 2014年146卷1期135-141页
Reflex cough is a defensive response generated in the brainstem in response to chemical and mechanical stimulation of the airways. However, converging evidence shows that reflex cough is also influenced by central neural control processes. In this study, we investigate whether reflex cough can be modulated by attentional focus on either external stimuli or internal cough-related stimuli.
335. Multidisciplinary Approach to Management of Maternal Asthma (MAMMA): a randomized controlled trial.
作者: Angelina S Lim.;Kay Stewart.;Michael J Abramson.;Susan P Walker.;Catherine L Smith.;Johnson George.
来源: Chest. 2014年145卷5期1046-1054页
Uncontrolled asthma during pregnancy is associated with maternal and perinatal hazards. A pharmacist-led intervention directed at improving maternal asthma control, involving multidisciplinary care, education, and regular monitoring to help reduce these risks, was developed and evaluated.
336. Clinical application of the COPD assessment test: longitudinal data from the COPD History Assessment in Spain (CHAIN) cohort.
作者: Juan P de Torres.;Jose M Marin.;Cristina Martinez-Gonzalez.;Pilar de Lucas-Ramos.;Isabel Mir-Viladrich.;Borja Cosio.;German Peces-Barba.;Miryam Calle-Rubio.;Ingrid Solanes-García.;Ramón Agüero Balbin.;Alfredo de Diego-Damia.;Nuria Feu-Collado.;Inmaculada Alfageme Michavila.;Rosa Irigaray.;Eva Balcells.;Antònia Llunell Casanovas.;Juan Bautista Galdiz Iturri.;Margarita Marín Royo.;Juan J Soler-Cataluña.;Jose Luis Lopez-Campos.;Joan B Soriano.;Ciro Casanova.; .
来源: Chest. 2014年146卷1期111-122页
The COPD Assessment Test (CAT) has been proposed for assessing health status in COPD, but little is known about its longitudinal changes. The objective of this study was to evaluate 1-year CAT variability in patients with stable COPD and to relate its variations to changes in other disease markers.
337. Cross-sectional survey on lobectomy approach (X-SOLA).
作者: Christopher Cao.;David H Tian.;Kevin Wolak.;Jonathan Oparka.;Jianxing He.;Joel Dunning.;William S Walker.;Tristan D Yan.
来源: Chest. 2014年146卷2期292-298页
Lobectomy for non-small cell lung cancer (NSCLC) can be performed either through open thoracotomy or video-assisted thoracoscopic surgery (VATS). To improve the understanding of current attitudes of the thoracic community toward VATS lobectomy, the Collaborative Research Group conducted the Cross-sectional Survey on Lobectomy Approach (X-SOLA) study. We surveyed a large cohort of lobectomy-performing thoracic surgeons to examine their adoption of VATS lobectomy and their opinions of this technique vs conventional open thoracotomy.
338. Endobronchial ultrasound-guided transbronchial needle aspiration vs conventional transbronchial needle aspiration in the diagnosis of sarcoidosis.
作者: Dheeraj Gupta.;Devendra S Dadhwal.;Ritesh Agarwal.;Nalini Gupta.;Amanjit Bal.;Ashutosh N Aggarwal.
来源: Chest. 2014年146卷3期547-556页
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is superior to conventional transbronchial needle aspiration (cTBNA) in the staging of lung cancer. However, its efficiency in diagnosis of sarcoidosis when combined with endobronchial biopsy (EBB) and transbronchial lung biopsy (TBLB) has not been studied. This randomized controlled trial compares diagnostic yield of EBUS-TBNA vs cTBNA in combination with EBB and TBLB.
339. Use and outcomes of noninvasive positive pressure ventilation in acute care hospitals in Massachusetts.
作者: Aylin Ozsancak Ugurlu.;Samy S Sidhom.;Ali Khodabandeh.;Michael Ieong.;Chester Mohr.;Denis Y Lin.;Irwin Buchwald.;Imad Bahhady.;John Wengryn.;Vinay Maheshwari.;Nicholas S Hill.
来源: Chest. 2014年145卷5期964-971页
This study determined actual utilization rates and outcomes of noninvasive positive pressure ventilation (NIV) at selected hospitals that had participated in a prior survey on NIV use.
340. Airway inflammation and illness severity in response to experimental rhinovirus infection in asthma.
作者: Jie Zhu.;Simon D Message.;Yusheng Qiu.;Patrick Mallia.;Tatiana Kebadze.;Marco Contoli.;Christine K Ward.;Elliot S Barnathan.;Mary Ann Mascelli.;Onn M Kon.;Alberto Papi.;Luminita A Stanciu.;Peter K Jeffery.;Sebastian L Johnston.
来源: Chest. 2014年145卷6期1219-1229页
The nature of bronchial mucosal inflammation and its physiologic and clinical significance in rhinovirus-induced asthma exacerbations is unclear. We investigated bronchial mucosal inflammatory response and its association with physiologic and clinical outcomes in an experimental model of rhinovirus-induced asthma exacerbations.
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