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3341. Effects of long-term enalapril therapy on left ventricular diastolic properties in patients with depressed ejection fraction. SOLVD Investigators.
作者: H Pouleur.;M F Rousseau.;C van Eyll.;L Stoleru.;W Hayashida.;J A Udelson.;N Dolan.;D Kinan.;P Gallagher.;S Ahn.
来源: Circulation. 1993年88卷2期481-91页
The aim of the present study was to analyze the changes in left ventricular diastolic function that occur in patients with chronic severe left ventricular systolic dysfunction in the absence or presence of prolonged therapy with an angiotensin converting enzyme inhibitor.
3342. Subsets of ambulatory myocardial ischemia based on heart rate activity. Circadian distribution and response to anti-ischemic medication. The Angina and Silent Ischemia Study Group (ASIS).
作者: T C Andrews.;T Fenton.;N Toyosaki.;S P Glasser.;P M Young.;G MacCallum.;R S Gibson.;T L Shook.;P H Stone.
来源: Circulation. 1993年88卷1期92-100页
Identification of whether episodes of ambulatory ischemia are caused by increases in myocardial oxygen demand or to episodic coronary vasoconstriction in patients with stable coronary disease may be important to guide selection of optimal anti-ischemic therapy and to gain insight into mechanisms responsible for adverse cardiac events.
3343. Beneficial effects of colestipol-niacin therapy on the common carotid artery. Two- and four-year reduction of intima-media thickness measured by ultrasound.
作者: D H Blankenhorn.;R H Selzer.;D W Crawford.;J D Barth.;C R Liu.;C H Liu.;W J Mack.;P Alaupovic.
来源: Circulation. 1993年88卷1期20-8页
Controlled clinical trials have reported treatment effects evaluated with serial imaging in coronary and femoral but not cervical arteries. The Cholesterol Lowering Atherosclerosis Study, a coronary, cervical, and femoral angiographic trial of colestipol plus niacin, included a pilot study of standardized carotid ultrasound imaging.
3344. A prospective randomized repeat-crossover comparison of antitachycardia pacing with low-energy cardioversion.
作者: G H Bardy.;J E Poole.;P J Kudenchuk.;G L Dolack.;D Kelso.;R Mitchell.
来源: Circulation. 1993年87卷6期1889-96页
Multiprogrammable antiarrhythmia devices can treat monomorphic ventricular tachycardia (VT) with autodecremental overdrive pacing and/or with low-energy cardioversion. These two methods provide the opportunity to decrease patient discomfort typically experienced with high-energy pulses. Although both therapies are known to be effective, controversy persists over their relative safety and efficacy.
3345. Dose-dependent effect of aspirin on carotid atherosclerosis.
Antiplatelet treatment with aspirin is well established as secondary prophylaxis after a transient ischemic attack or minor ischemic stroke, but the effect of aspirin treatment on the course of carotid atherosclerosis is unknown. We investigated the effect of aspirin on the initial stages of carotid atherosclerosis.
3346. TIMI perfusion grade 3 but not grade 2 results in improved outcome after thrombolysis for myocardial infarction. Ventriculographic, enzymatic, and electrocardiographic evidence from the TEAM-3 Study.
作者: J L Anderson.;L A Karagounis.;L C Becker.;S G Sorensen.;R L Menlove.
来源: Circulation. 1993年87卷6期1829-39页
Coronary patency has been used as a measure of thrombolysis success after acute myocardial infarction. The Thrombolysis in Myocardial Infarction (TIMI) Study Group perfusion grades have gained wide acceptance, with grades 0 (no distal flow) and 1 perfusion (minimal flow) being designated as thrombolysis failures and grades 2 (partial perfusion) and 3 (complete perfusion) as thrombolysis successes. However, the significance of the individual TIMI grades on clinical outcome has not been adequately assessed.
3347. Incidence of thromboembolic events in congestive heart failure. The V-HeFT VA Cooperative Studies Group.
作者: W B Dunkman.;G R Johnson.;P E Carson.;G Bhat.;L Farrell.;J N Cohn.
来源: Circulation. 1993年87卷6 Suppl期VI94-101页
The incidence of thromboembolism and the benefit of anticoagulation in congestive heart failure are controversial.
3348. Functional capacity in heart failure. Comparison of methods for assessment and their relation to other indexes of heart failure. The V-HeFT VA Cooperative Studies Group.
作者: R F Smith.;G Johnson.;S Ziesche.;G Bhat.;K Blankenship.;J N Cohn.
来源: Circulation. 1993年87卷6 Suppl期VI88-93页
Left ventricular (LV) dysfunction plays a primary role in the pathogenesis of congestive heart failure and correlates with prognosis, but a strong quantitative relation between exercise performance and indexes of LV function has not been demonstrated. We examined the relation between LV ejection fraction at rest, oxygen consumption at peak exercise (VO2), patient and physician assessments of clinical severity, and other clinical attributes in 804 patients with moderate heart failure.
3349. Effect of enalapril, hydralazine plus isosorbide dinitrate, and prazosin on hospitalization in patients with chronic congestive heart failure. The V-HeFT VA Cooperative Studies Group.
作者: H S Loeb.;G Johnson.;A Henrick.;R Smith.;J Wilson.;R Cremo.;J N Cohn.
来源: Circulation. 1993年87卷6 Suppl期VI78-87页
Hospitalization of persons with congestive heart failure for recurrent heart failure or other complications is common.
3350. Evaluation by patients with heart failure of the effects of enalapril compared with hydralazine plus isosorbide dinitrate on quality of life. V-HeFT II. The V-HeFT VA Cooperative Studies Group.
作者: T S Rector.;G Johnson.;W B Dunkman.;G Daniels.;L Farrell.;A Henrick.;B Smith.;J N Cohn.
来源: Circulation. 1993年87卷6 Suppl期VI71-7页
Two new questionnaires concerning the quality of life of patients with heart failure were used in a randomized, controlled trial to determine if the patients' perceptions of the effects of enalapril on their daily activities and sense of well-being were different from those of a group treated with hydralazine and isosorbide dinitrate.
3351. Echocardiographic variables as prognostic indicators and therapeutic monitors in chronic congestive heart failure. Veterans Affairs cooperative studies V-HeFT I and II. V-HeFT VA Cooperative Studies Group.
作者: M Wong.;G Johnson.;R Shabetai.;V Hughes.;G Bhat.;B Lopez.;J N Cohn.
来源: Circulation. 1993年87卷6 Suppl期VI65-70页
Echocardiographic indexes of ventricular function have become indispensable in clinical cardiology but have not been tested as prognostic markers or therapeutic monitors in clinical trials. In two Veterans Administration trials on heart failure (Vasodilator-Heart Failure Trials I and II, V-HeFT I and II), echocardiographic variables were analyzed as predictors and monitors and were compared with other indicators of cardiac performance.
3352. Hydralazine and isosorbide dinitrate combination improves exercise tolerance in heart failure. Results from V-HeFT I and V-HeFT II. The V-HeFT VA Cooperative Studies Group.
To better define the effects of long-term vasodilator therapy on exercise performance in chronic congestive heart failure, we compared placebo with prazosin and with the combination of hydralazine and isosorbide dinitrate (Hyd-Iso) in 642 men over a 5-year period in V-HeFT I.
3353. Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. The V-HeFT VA Cooperative Studies Group.
作者: J N Cohn.;G R Johnson.;R Shabetai.;H Loeb.;F Tristani.;T Rector.;R Smith.;R Fletcher.
来源: Circulation. 1993年87卷6 Suppl期VI5-16页
Recognition of the complex pathophysiology of heart failure and its high mortality has emphasized the need for prognostic markers that can be used in clinical assessment as well as in the design of mortality trials. Data from the Department of Veterans Affairs Cooperative Vasodilator-Heart Failure Trials (V-HeFT I, 642 patients; V-HeFT II, 804 patients) were therefore examined to determine the influence of prerandomization measurements on subsequent mortality.
3354. Enalapril decreases prevalence of ventricular tachycardia in patients with chronic congestive heart failure. The V-HeFT II VA Cooperative Studies Group.
作者: R D Fletcher.;G B Cintron.;G Johnson.;J Orndorff.;P Carson.;J N Cohn.
来源: Circulation. 1993年87卷6 Suppl期VI49-55页
Patients with heart failure have a high prevalence of serious arrhythmias and sudden cardiac-death.
3355. Plasma norepinephrine, plasma renin activity, and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA Cooperative Studies Group.
作者: G S Francis.;J N Cohn.;G Johnson.;T S Rector.;S Goldman.;A Simon.
来源: Circulation. 1993年87卷6 Suppl期VI40-8页
Congestive heart failure is a clinical syndrome characterized by neuroendocrine activation. Measurements of plasma norepinephrine and plasma renin activity were performed in the Vasodilator-Heart Failure Trial II (V-HeFT II) to characterize the effect of therapy on neuroendocrine activation and to examine the responses to therapy among patients with different degrees of activation.
3356. Influence of prerandomization (baseline) variables on mortality and on the reduction of mortality by enalapril. Veterans Affairs Cooperative Study on Vasodilator Therapy of Heart Failure (V-HeFT II). V-HeFT VA Cooperative Studies Group.
The effects of hydralazine plus isosorbide dinitrate were compared with those of enalapril in 804 men receiving digoxin and diuretic therapy for chronic congestive heart failure (CHF) in the Department of Veterans Affairs Cooperative Vasodilator-Heart Failure Trial (V-HeFT II).
3357. Mechanism of death in heart failure. The Vasodilator-Heart Failure Trials. The V-HeFT VA Cooperative Studies Group.
作者: S Goldman.;G Johnson.;J N Cohn.;G Cintron.;R Smith.;G Francis.
来源: Circulation. 1993年87卷6 Suppl期VI24-31页
The Vasodilator-Heart Failure Trial (V-HeFT) data base provides information on the mechanism of death of male veterans entered into two trials that evaluated the effect of vasodilator therapy on survival in heart failure.
3358. Prognostic significance of serial changes in left ventricular ejection fraction in patients with congestive heart failure. The V-HeFT VA Cooperative Studies Group.
In congestive heart failure patients, a single measurement of left ventricular ejection fraction (LVEF) provides important prognostic information. The importance, if any, of improvement or worsening in serial LVEF has not been defined. The Department of Veterans Affairs Cooperative Vasodilator-Heart Failure Trials (V-HeFT) data base was analyzed to determine the prognostic importance of LVEF changes.
3359. Influence of age on mechanisms and prognosis of heart failure. The V-HeFT VA Cooperative Studies Group.
Advanced age is commonly thought to carry a poor prognosis in congestive heart failure, but the case has not been established. The Department of Veterans Affairs Cooperative Vasodilator-Heart Failure Trials (V-HeFT I and II) provided a large data base to assess the effect of age on hemodynamic profiles and survival in the failing heart.
3360. The influence of atrial fibrillation on prognosis in mild to moderate heart failure. The V-HeFT Studies. The V-HeFT VA Cooperative Studies Group.
作者: P E Carson.;G R Johnson.;W B Dunkman.;R D Fletcher.;L Farrell.;J N Cohn.
来源: Circulation. 1993年87卷6 Suppl期VI102-10页
Atrial fibrillation occurs commonly in heart failure; however, its importance in terms of prognosis is controversial.
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