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3321. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients.
作者: Howard J Eisen.;E Murat Tuzcu.;Richard Dorent.;Jon Kobashigawa.;Donna Mancini.;Hannah A Valantine-von Kaeppler.;Randall C Starling.;Keld Sørensen.;Manfred Hummel.;Joan M Lind.;Kamal H Abeywickrama.;Peter Bernhardt.; .
来源: N Engl J Med. 2003年349卷9期847-58页
Everolimus, a novel proliferation inhibitor and immunosuppressive agent, may suppress cardiac-allograft vasculopathy. We conducted a randomized, double-blind, clinical trial comparing everolimus with azathioprine in recipients of a first heart transplant.
3322. Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus.
作者: Jody Lawrence.;Douglas L Mayers.;Katherine Huppler Hullsiek.;Gary Collins.;Donald I Abrams.;Ronald B Reisler.;Lawrence R Crane.;Barry S Schmetter.;Thomas J Dionne.;Jennifer M Saldanha.;Michael C Jones.;John D Baxter.; .
来源: N Engl J Med. 2003年349卷9期837-46页
We compared two strategies for treating patients infected with multidrug-resistant human immunodeficiency virus (HIV).
3323. Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone.
作者: Yunfeng Cheng.;Raymond S M Wong.;Yannie O Y Soo.;Chung Hin Chui.;Fung Yi Lau.;Natalie P H Chan.;Wai Shan Wong.;Gregory Cheng.
来源: N Engl J Med. 2003年349卷9期831-6页
The role of high-dose dexamethasone in the treatment of immune thrombocytopenic purpura in adults is controversial. We assessed the effectiveness of high-dose dexamethasone as initial treatment in a series of consecutive adults with immune thrombocytopenic purpura.
3324. Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia.
作者: Bob Löwenberg.;Wim van Putten.;Matthias Theobald.;Jurg Gmür.;Leo Verdonck.;Pieter Sonneveld.;Martin Fey.;Harry Schouten.;Georgine de Greef.;Augustin Ferrant.;Tibor Kovacsovics.;Alois Gratwohl.;Simon Daenen.;Peter Huijgens.;Marc Boogaerts.; .; .
来源: N Engl J Med. 2003年349卷8期743-52页
Sensitization of leukemic cells with hematopoietic growth factors may enhance the cytotoxicity of chemotherapy in acute myeloid leukemia (AML).
3325. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction.
作者: Henning R Andersen.;Torsten T Nielsen.;Klaus Rasmussen.;Leif Thuesen.;Henning Kelbaek.;Per Thayssen.;Ulrik Abildgaard.;Flemming Pedersen.;Jan K Madsen.;Peer Grande.;Anton B Villadsen.;Lars R Krusell.;Torben Haghfelt.;Preben Lomholt.;Steen E Husted.;Else Vigholt.;Henrik K Kjaergard.;Leif Spange Mortensen.; .
来源: N Engl J Med. 2003年349卷8期733-42页
For the treatment of myocardial infarction with ST-segment elevation, primary angioplasty is considered superior to fibrinolysis for patients who are admitted to hospitals with angioplasty facilities. Whether this benefit is maintained for patients who require transportation from a community hospital to a center where invasive treatment is available is uncertain.
3326. Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis.
作者: Vera M R Heydendael.;Phyllis I Spuls.;Brent C Opmeer.;Corianne A J M de Borgie.;Johannes B Reitsma.;Wouter F M Goldschmidt.;Patrick M M Bossuyt.;Jan D Bos.;Menno A de Rie.
来源: N Engl J Med. 2003年349卷7期658-65页
Methotrexate and cyclosporine are well-known systemic therapies for moderate-to-severe chronic plaque psoriasis. We conducted a randomized, controlled trial comparing methotrexate and cyclosporine in terms of effectiveness, side effects, and the quality of life.
3327. Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism.
作者: Clive Kearon.;Jeffrey S Ginsberg.;Michael J Kovacs.;David R Anderson.;Philip Wells.;Jim A Julian.;Betsy MacKinnon.;Jeffrey I Weitz.;Mark A Crowther.;Sean Dolan.;Alexander G Turpie.;William Geerts.;Susan Solymoss.;Paul van Nguyen.;Christine Demers.;Susan R Kahn.;Jeannine Kassis.;Marc Rodger.;Julie Hambleton.;Michael Gent.; .
来源: N Engl J Med. 2003年349卷7期631-9页
Warfarin is very effective in preventing recurrent venous thromboembolism but is also associated with a substantial risk of bleeding. After three months of conventional warfarin therapy, a lower dose of anticoagulant medication may result in less bleeding and still prevent recurrent venous thromboembolism.
3328. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer.
作者: Umberto Veronesi.;Giovanni Paganelli.;Giuseppe Viale.;Alberto Luini.;Stefano Zurrida.;Viviana Galimberti.;Mattia Intra.;Paolo Veronesi.;Chris Robertson.;Patrick Maisonneuve.;Giuseppe Renne.;Concetta De Cicco.;Francesca De Lucia.;Roberto Gennari.
来源: N Engl J Med. 2003年349卷6期546-53页
Although numerous studies have shown that the status of the sentinel node is an accurate predictor of the status of the axillary nodes in breast cancer, the efficacy and safety of sentinel-node biopsy require validation.
3329. Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women.
作者: Howard N Hodis.;Wendy J Mack.;Stanley P Azen.;Roger A Lobo.;Donna Shoupe.;Peter R Mahrer.;David P Faxon.;Linda Cashin-Hemphill.;Miguel E Sanmarco.;William J French.;Thomas L Shook.;Thomas D Gaarder.;Anilkumar O Mehra.;Ramin Rabbani.;Alex Sevanian.;Asit B Shil.;Mina Torres.;K Heiner Vogelbach.;Robert H Selzer.; .
来源: N Engl J Med. 2003年349卷6期535-45页
In postmenopausal women with coronary artery disease, conjugated equine estrogen with or without continuous administration of medroxyprogesterone acetate has failed to slow the progression of atherosclerosis. Whether 17beta-estradiol (the endogenous estrogen molecule) alone or administered sequentially with medroxyprogesterone acetate can slow the progression of atherosclerosis is unknown.
3330. Estrogen plus progestin and the risk of coronary heart disease.
作者: JoAnn E Manson.;Judith Hsia.;Karen C Johnson.;Jacques E Rossouw.;Annlouise R Assaf.;Norman L Lasser.;Maurizio Trevisan.;Henry R Black.;Susan R Heckbert.;Robert Detrano.;Ora L Strickland.;Nathan D Wong.;John R Crouse.;Evan Stein.;Mary Cushman.; .
来源: N Engl J Med. 2003年349卷6期523-34页
Recent randomized clinical trials have suggested that estrogen plus progestin does not confer cardiac protection and may increase the risk of coronary heart disease (CHD). In this report, we provide the final results with regard to estrogen plus progestin and CHD from the Women's Health Initiative (WHI).
3331. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer.
作者: James C Yang.;Leah Haworth.;Richard M Sherry.;Patrick Hwu.;Douglas J Schwartzentruber.;Suzanne L Topalian.;Seth M Steinberg.;Helen X Chen.;Steven A Rosenberg.
来源: N Engl J Med. 2003年349卷5期427-34页
Mutations in the tumor-suppressor gene VHL cause oversecretion of vascular endothelial growth factor by clear-cell renal carcinomas. We conducted a clinical trial to evaluate bevacizumab, a neutralizing antibody against vascular endothelial growth factor, in patients with metastatic renal-cell carcinoma.
3332. Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis.
作者: Atul Sinha.;Jeremy Nightingale.;Kevin P West.;Jorge Berlanga-Acosta.;Raymond J Playford.
来源: N Engl J Med. 2003年349卷4期350-7页
Epidermal growth factor (EGF) is a potent mitogenic peptide produced by salivary glands. We examined whether EGF enemas are an effective treatment for active left-sided ulcerative colitis and ulceration limited to the rectum (proctitis).
3333. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.
作者: Christine M Ribic.;Daniel J Sargent.;Malcolm J Moore.;Stephen N Thibodeau.;Amy J French.;Richard M Goldberg.;Stanley R Hamilton.;Pierre Laurent-Puig.;Robert Gryfe.;Lois E Shepherd.;Dongsheng Tu.;Mark Redston.;Steven Gallinger.
来源: N Engl J Med. 2003年349卷3期247-57页
Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II and stage III colon cancer.
3334. Evaluation of impermeable covers for bedding in patients with allergic rhinitis.
作者: Ingrid Terreehorst.;Eelko Hak.;Albert J Oosting.;Zana Tempels-Pavlica.;Jan G R de Monchy.;Carla A F M Bruijnzeel-Koomen.;Rob C Aalberse.;Roy Gerth van Wijk.
来源: N Engl J Med. 2003年349卷3期237-46页
Encasing bedding in impermeable covers reduces exposure to house-dust mites, but the clinical benefit of this intervention as part of mite-avoidance measures for patients with allergic rhinitis is not known. We performed a multicenter, randomized, placebo-controlled trial of one year of use of impermeable bedding covers in the bedrooms of patients with rhinitis who were sensitized to house-dust mites to determine the effects on the signs and symptoms of disease.
3335. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma.
作者: Ashley Woodcock.;Louise Forster.;Edward Matthews.;Jeannett Martin.;Louise Letley.;Madge Vickers.;John Britton.;David Strachan.;Peter Howarth.;Daniel Altmann.;Christopher Frost.;Adnan Custovic.; .
来源: N Engl J Med. 2003年349卷3期225-36页
The effectiveness of avoidance of house-dust-mite allergen (Dermatophagoides pteronyssinus 1 [Der p1]) in the management of asthma is uncertain.
3336. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer.
作者: Agnes Y Y Lee.;Mark N Levine.;Ross I Baker.;Chris Bowden.;Ajay K Kakkar.;Martin Prins.;Frederick R Rickles.;Jim A Julian.;Susan Haley.;Michael J Kovacs.;Michael Gent.; .
来源: N Engl J Med. 2003年349卷2期146-53页
Patients with cancer have a substantial risk of recurrent thrombosis despite the use of oral anticoagulant therapy. We compared the efficacy of a low-molecular-weight heparin with that of an oral anticoagulant agent in preventing recurrent thrombosis in patients with cancer.
3337. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies.
作者: David Jayne.;Niels Rasmussen.;Konrad Andrassy.;Paul Bacon.;Jan Willem Cohen Tervaert.;Jolanta Dadoniené.;Agneta Ekstrand.;Gill Gaskin.;Gina Gregorini.;Kirsten de Groot.;Wolfgang Gross.;E Christiaan Hagen.;Eduardo Mirapeix.;Erna Pettersson.;Carl Siegert.;Alberto Sinico.;Vladimir Tesar.;Kerstin Westman.;Charles Pusey.; .
来源: N Engl J Med. 2003年349卷1期36-44页
The primary systemic vasculitides usually associated with autoantibodies to neutrophil cytoplasmic antigens include Wegener's granulomatosis and microscopic polyangiitis. We investigated whether exposure to cyclophosphamide in patients with generalized vasculitis could be reduced by substitution of azathioprine at remission.
3338. A multicenter, randomized, double-blind, controlled trial of nebulized epinephrine in infants with acute bronchiolitis.
作者: Claire Wainwright.;Luis Altamirano.;Marise Cheney.;Joyce Cheney.;Scott Barber.;Darrell Price.;Sue Moloney.;Ann Kimberley.;Nick Woolfield.;Susan Cadzow.;Frank Fiumara.;Peter Wilson.;Steve Mego.;Dianne VandeVelde.;Sharon Sanders.;Peter O'Rourke.;Paul Francis.
来源: N Engl J Med. 2003年349卷1期27-35页
The treatment of infants with bronchiolitis is largely supportive. The role of bronchodilators is controversial. Most studies of the use of bronchodilators have enrolled small numbers of subjects and have examined only short-term outcomes, such as clinical scores.
3339. Conventional adjuvant chemotherapy with or without high-dose chemotherapy and autologous stem-cell transplantation in high-risk breast cancer.
作者: Martin S Tallman.;Robert Gray.;Nicholas J Robert.;Charles F LeMaistre.;C Kent Osborne.;William P Vaughan.;William J Gradishar.;Thomas M Pisansky.;John Fetting.;Elisabeth Paietta.;Hillard M Lazarus.
来源: N Engl J Med. 2003年349卷1期17-26页
The prognosis for women with primary breast cancer and 10 or more involved axillary lymph nodes is poor. High-dose chemotherapy with autologous hematopoietic stem-cell transplantation has been reported to be effective in the adjuvant setting for patients at high risk for relapse.
3340. High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer.
作者: Sjoerd Rodenhuis.;Marijke Bontenbal.;Louk V A M Beex.;John Wagstaff.;Dick J Richel.;Marianne A Nooij.;Emile E Voest.;Pierre Hupperets.;Harm van Tinteren.;Hans L Peterse.;Elisabeth M TenVergert.;Elisabeth G E de Vries.; .
来源: N Engl J Med. 2003年349卷1期7-16页
The use of high-dose adjuvant chemotherapy for high-risk primary breast cancer is controversial. We studied its efficacy in patients with 4 to 9 or 10 or more tumor-positive axillary lymph nodes.
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