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3301. Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography. The Canadian Coronary Atherosclerosis Intervention Trial.
作者: D Waters.;L Higginson.;P Gladstone.;B Kimball.;M Le May.;S J Boccuzzi.;J Lespérance.
来源: Circulation. 1994年89卷3期959-68页
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors are widely prescribed for hyperlipidemia, yet their effect on the evolution of coronary atherosclerosis has not been defined.
3302. Diagnostic and prognostic value of dipyridamole echocardiography in patients with suspected coronary artery disease. Comparison with exercise electrocardiography.
作者: S Severi.;E Picano.;C Michelassi.;F Lattanzi.;P Landi.;A Distante.;A L'Abbate.
来源: Circulation. 1994年89卷3期1160-73页
Before any new diagnostic test is accepted in clinical practice, such a test should be compared with established diagnostic tools in an appropriately large series of patients encompassing the complete spectrum of challenges to which the test is exposed. The aim of the present study was to assess the relative diagnostic and prognostic accuracies of high-dose dipyridamole echocardiography (two-dimensional echocardiographic monitoring during dipyridamole infusion up to 0.84 mg/kg over 10 hours) versus maximal symptom-limited bicycle exercise ECG test in patients with angina.
3303. Long-term graft patency (3 years) after coronary artery surgery. Effects of aspirin: results of a VA Cooperative study.
作者: S Goldman.;J Copeland.;T Moritz.;W Henderson.;K Zadina.;T Ovitt.;K B Kern.;G Sethi.;G V Sharma.;S Khuri.
来源: Circulation. 1994年89卷3期1138-43页
The long-term success of coronary bypass surgery is dependent on graft patency after surgery. This trial was designed to determine if aspirin improved saphenous vein graft or internal mammary artery (IMA) graft patency between 1 and 3 years after coronary artery bypass grafting (CABG).
3304. A randomized comparison of the effects of gradual prolonged versus standard primary balloon inflation on early and late outcome. Results of a multicenter clinical trial. Perfusion Balloon Catheter Study Group.
作者: E M Ohman.;J F Marquis.;D R Ricci.;R I Brown.;M L Knudtson.;D J Kereiakes.;J K Samaha.;J R Margolis.;A L Niederman.;L S Dean.
来源: Circulation. 1994年89卷3期1118-25页
Observational studies have suggested that prolonged balloon inflation during coronary angioplasty is associated with a high clinical success rate. This randomized clinical trial sought to evaluate the impact of primary gradual and prolonged inflations versus standard short dilatations in patients undergoing elective angioplasty.
3305. Prospective, randomized comparison in humans of a unipolar defibrillation system with that using an additional superior vena cava electrode.
作者: G H Bardy.;G L Dolack.;P J Kudenchuk.;J E Poole.;R Mehra.;G Johnson.
来源: Circulation. 1994年89卷3期1090-3页
A unipolar defibrillation system using a single right ventricular (RV) electrode and the active shell or "CAN" of the implantable cardioverter-defibrillator itself situated in a left infraclavicular pocket has been shown to be as efficient in defibrillation as an epicardial lead system. The purpose of this study was to determine whether defibrillation efficacy can be improved further by adding a superior vena cava (SVC) electrode to this already efficient defibrillation system.
3306. Significance of arrhythmias during the first 24 hours of acute myocardial infarction treated with alteplase and effect of early administration of a beta-blocker or a bradycardiac agent on their incidence.
作者: H Heidbüchel.;J Tack.;L Vanneste.;A Ballet.;H Ector.;F Van de Werf.
来源: Circulation. 1994年89卷3期1051-9页
Although early intravenous beta-blocker therapy during acute myocardial infarction (AMI) reduces the incidence of fatal arrhythmias in patients not treated with thrombolytic agents, its antiarrhythmic effect in thrombolysed patients remains controversial. We investigated prospectively the arrhythmia incidence in 244 patients with AMI receiving alteplase and a double-blind randomized adjunctive therapy with intravenous atenolol, alinidine, or placebo. Moreover, the characteristics and prognostic significance of early arrhythmias and their relation with infarct size and coronary patency were evaluated.
3307. Effects on left ventricular hypertrophy of long-term nonpharmacological treatment with sodium restriction in mild-to-moderate essential hypertension.
Cross-sectional studies on human hypertension have suggested an association between sodium intake and left ventricular hypertrophy (LVH).
3308. Morning increase in ambulatory ischemia in patients with stable coronary artery disease. Importance of physical activity and increased cardiac demand.
作者: J D Parker.;M A Testa.;A H Jimenez.;G H Tofler.;J E Muller.;J O Parker.;P H Stone.
来源: Circulation. 1994年89卷2期604-14页
The morning increase in asymptomatic ambulatory ischemia may be due to heightened coronary tone, increased physical activity, or both. If ambulatory ischemia is primarily due to physical activity, then alterations in the schedule of physical activity should be reflected in a corresponding alteration in the occurrence of ischemia. This study was designed to examine the relation between activity patterns and the frequency of ambulatory ischemic episodes and the effect of nadolol on these relations.
3309. Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus Aspirin Patency Trial (RAPT).
来源: Circulation. 1994年89卷2期588-95页
Aspirin, by nonselectively blocking cyclooxygenase both in platelets and in endothelial cells, not only inhibits the thromboxane A2 pathway of platelet activation but at the same time also the generation of vasodilating and platelet-inhibitory prostanoids, such as prostacyclin, by the endothelial cells. Ridogrel, by inhibiting thromboxane A2 synthase and blocking the thromboxane A2/prostaglandin endoperoxide receptors, is a more potent antiplatelet agent than aspirin and might offer an advantage over aspirin as an adjunct to thrombolysis. This study was performed to compare the efficacy and safety of ridogrel with that of aspirin as conjunctive therapy for thrombolysis in patients with acute myocardial infarction.
3310. Effects of beta-adrenergic blockade on immunologic and cardiovascular changes induced by mental stress.
作者: R J Benschop.;E E Nieuwenhuis.;E A Tromp.;G L Godaert.;R E Ballieux.;L J van Doornen.
来源: Circulation. 1994年89卷2期762-9页
Acute mental stress evokes responses in the cardiovascular and the immune systems. In particular, the subset of natural killer (NK) cells is found to be responsive to mental stress. The role of beta-adrenergic mechanisms in these processes in the subject of this investigation.
3311. Effect of acute magnesium administration on the frequency of ventricular arrhythmia in patients with heart failure.
作者: C A Sueta.;S W Clarke.;S H Dunlap.;L Jensen.;M B Blauwet.;G Koch.;J H Patterson.;K F Adams.
来源: Circulation. 1994年89卷2期660-6页
There is a high incidence of ventricular arrhythmia and sudden death in patients with heart failure. Unfortunately, currently available antiarrhythmic agents have only limited efficacy and may result in proarrhythmia and hemodynamic deterioration in these patients.
3312. Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina. European Cooperative Study Group.
作者: M L Simoons.;M J de Boer.;M J van den Brand.;A J van Miltenburg.;J C Hoorntje.;G R Heyndrickx.;L R van der Wieken.;D de Bono.;W Rutsch.;T F Schaible.
来源: Circulation. 1994年89卷2期596-603页
Patients with unstable angina despite intensive medical therapy, ie, refractory angina, are at high risk for developing thrombotic complications: myocardial infarction or coronary occlusion during percutaneous transluminal coronary angioplasty (PTCA). Chimeric 7E3 (c7E3) Fab is an antibody fragment that blocks the platelet glycoprotein (GP) IIb/IIIa receptor and potently inhibits platelet aggregation.
3313. Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users. Primary end points analysis from the ATACS trial. Antithrombotic Therapy in Acute Coronary Syndromes Research Group.
作者: M Cohen.;P C Adams.;G Parry.;J Xiong.;D Chamberlain.;I Wieczorek.;K A Fox.;J H Chesebro.;J Strain.;C Keller.
来源: Circulation. 1994年89卷1期81-8页
The purpose of this study was to compare combination antithrombotic therapy with aspirin plus anticoagulation versus aspirin alone, when added to conventional antianginal therapy in patients with unstable rest angina or non-Q-wave myocardial infarction who were nonprior aspirin users.
3314. Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction. The protective effects of captopril.
作者: M St John Sutton.;M A Pfeffer.;T Plappert.;J L Rouleau.;L A Moyé.;G R Dagenais.;G A Lamas.;M Klein.;B Sussex.;S Goldman.
来源: Circulation. 1994年89卷1期68-75页
Left ventricular enlargement after myocardial infarction increases the likelihood of an adverse outcome. In an echocardiographic substudy of the Survival and Ventricular Enlargement (SAVE) Trial, we assessed whether captopril would attenuate progressive left ventricular enlargement in patients with left ventricular dysfunction after acute myocardial infarction and, if so, whether this would be associated with improved clinical outcome.
3315. Long-term prognostic importance of patency of the infarct-related coronary artery after thrombolytic therapy for acute myocardial infarction.
After thrombolytic therapy, long-term patency of the infarct-related artery may reduce arrhythmias, limit ventricular dilatation, and provide collaterals to another infarct zone if further infarction occurs. However, independent long-term prognostic value of infarct artery patency has not been shown.
3316. Angiotensin-converting enzyme inhibition with fosinopril sodium in the prevention of restenosis after coronary angioplasty.
作者: W Desmet.;M Vrolix.;I De Scheerder.;J Van Lierde.;J L Willems.;J Piessens.
来源: Circulation. 1994年89卷1期385-92页
Several angiotensin-converting enzyme inhibitors have antiproliferative effects in a rat model after carotid artery balloon injury.
3317. A comparison of low- with high-osmolality contrast agents in cardiac angiography. Identification of criteria for selective use.
作者: W H Matthai.;W G Kussmaul.;J Krol.;J E Goin.;J S Schwartz.;J W Hirshfeld.
来源: Circulation. 1994年89卷1期291-301页
Controversy exists as to whether low-osmolality radiographic contrast agents, which have less detrimental pharmacological effects but are considerably more expensive than high-osmolality agents, should be used universally or only for selected high-risk patients.
3318. Effect of combined supplementation with alpha-tocopherol, ascorbate, and beta carotene on low-density lipoprotein oxidation.
Data continue to accumulate supporting a proatherogenic role for oxidized low-density lipoprotein (Ox-LDL). Antioxidant micronutrients such as ascorbate, alpha-tocopherol, and beta carotene, levels of which can be favorably manipulated by dietary measures without side effects, could be a safe approach in inhibiting LDL oxidation. In fact, in vitro studies have shown that all three antioxidants can inhibit LDL oxidation. The present study was undertaken to ascertain both the safety and antioxidant effect of combined supplementation with alpha-tocopherol, ascorbate, and beta carotene on LDL oxidation.
3319. Effects of intensive lipid-lowering therapy on the coronary arteries of asymptomatic subjects with elevated apolipoprotein B.
作者: X Q Zhao.;B G Brown.;L Hillger.;D Sacco.;B Bisson.;L Fisher.;J J Albers.
来源: Circulation. 1993年88卷6期2744-53页
Do the benefits of intensive lipid-lowering therapy seen in symptomatic patients extend to high-risk subjects who have never had symptoms?
3320. Platelet activation during coronary angioplasty in humans.
Previous studies have indicated that balloon angioplasty is associated with local platelet activation. In addition, different contrast media have different effects on thrombus formation during angioplasty in humans. We hypothesized that coronary angioplasty in humans is associated with activation of platelets to specific platelet agonists and that this activation may be differently modified by different angiographic contrast agents.
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