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3241. Value of physical signs in the diagnosis of ventricular tachycardia.
作者: C J Garratt.;M J Griffith.;G Young.;N Curzen.;S Brecker.;A F Rickards.;A J Camm.
来源: Circulation. 1994年90卷6期3103-7页
Although the use of physical signs for the diagnosis of ventricular tachycardia (VT) was described in the early 1900s, their value in this role has never been systematically assessed.
3242. Interaction of baseline characteristics with the hazard of encainide, flecainide, and moricizine therapy in patients with myocardial infarction. A possible explanation for increased mortality in the Cardiac Arrhythmia Suppression Trial (CAST).
作者: J L Anderson.;E V Platia.;A Hallstrom.;R W Henthorn.;T A Buckingham.;M D Carlson.;P E Carson.
来源: Circulation. 1994年90卷6期2843-52页
The Cardiac Arrhythmia Suppression Trial (CAST) was designed to test the hypothesis that suppression of ventricular ectopy with antiarrhythmic drugs after a myocardial infarction reduces the incidence of sudden arrhythmic death. Patients in whom ventricular ectopy could be suppressed with encainide, flecainide, or moricizine were randomly assigned to receive either active drug or placebo. The encainide and flecainide arms of the study were discontinued in 1989 (CAST-I) and the moricizine arm in 1991 (CAST-II) because of excess mortality. To explore the mechanisms of these adverse outcomes, we examined the interaction of baseline characteristics with the hazard of therapy with encainide, flecainide, or moricizine compared with their respective placebos.
3243. Results and efficiency of programmed ventricular stimulation with four extrastimuli compared with one, two, and three extrastimuli.
作者: J D Hummel.;S A Strickberger.;E Daoud.;M Niebauer.;O Bakr.;K C Man.;B D Williamson.;F Morady.
来源: Circulation. 1994年90卷6期2827-32页
Conventional programmed ventricular stimulation protocols are inefficient compared with more recently proposed protocols. The purpose of the present study was to determine if additional efficiency could be derived from a 6-step programmed ventricular stimulation protocol that exclusively uses four extrastimuli.
3244. Cardiac hypertrophy, aortic compliance, peripheral resistance, and wave reflection in end-stage renal disease. Comparative effects of ACE inhibition and calcium channel blockade.
作者: G M London.;B Pannier.;A P Guerin.;S J Marchais.;M E Safar.;J L Cuche.
来源: Circulation. 1994年90卷6期2786-96页
We wished to assess the respective roles of the antihypertensive and blood pressure (BP)-independent effects of antihypertensive drugs on arterial hemodynamics and left ventricular hypertrophy (LVH) in end-stage renal disease (ESRD) patients.
3245. Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition.
作者: W Kiowski.;J Beermann.;P Rickenbacher.;R Haemmerli.;M Thomas.;F Burkart.;T Meinertz.
来源: Circulation. 1994年90卷6期2748-56页
The contribution of nonangiotensinergic effects of converting enzyme inhibitors to their hemodynamic effects in patients with chronic heart failure is not clear. A comparison of the effects of renin and converting enzyme inhibition should help to clarify this issue.
3246. Trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study. Studio Trapidil versus Aspirin nella Restenosi Coronarica.
作者: A Maresta.;M Balducelli.;L Cantini.;A Casari.;R Chioin.;M Fabbri.;A Fontanelli.;P A Monici Preti.;S Repetto.;S De Servi.
来源: Circulation. 1994年90卷6期2710-5页
Trapidil is an antiplatelet drug with specific platelet-derived growth factor antagonism and antiproliferative effects in the rat and rabbit models after balloon angioplasty.
3247. Mortality within 24 hours of thrombolysis for myocardial infarction. The importance of early reperfusion. The GUSTO Investigators, Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.
作者: N S Kleiman.;H D White.;E M Ohman.;A M Ross.;L H Woodlief.;R M Califf.;D R Holmes.;E Bates.;M Pfisterer.;A Vahanian.
来源: Circulation. 1994年90卷6期2658-65页
A paradoxical increased risk of death has been reported during the first 24 hours after thrombolysis for myocardial infarction. The mechanism of this phenomenon is not known, nor is its relation to the success or failure of reperfusion. The present study was a prospectively designed analysis of deaths occurring within the first 24 hours in the GUSTO trial.
3248. Treatment of postoperative hypertension after coronary artery bypass surgery. Double-blind comparison of intravenous isradipine and sodium nitroprusside.
作者: J Leslie.;N Brister.;J H Levy.;J P Yared.;A Marty.;H Martin.;R Hines.;J Savino.;M Cohen.
来源: Circulation. 1994年90卷5 Pt 2期II256-61页
Hypertension commonly occurs after cardiac surgery and requires therapy to prevent the potentially deleterious effects.
3249. Cardiopulmonary bypass, temperature, and central nervous system dysfunction.
作者: R F McLean.;B I Wong.;C D Naylor.;W G Snow.;E M Harrington.;M Gawel.;S E Fremes.
来源: Circulation. 1994年90卷5 Pt 2期II250-5页
Neurological injury is an important cause of morbidity and mortality after cardiac surgery. With the advent of warm heart surgery, the neuroprotective role of hypothermic cardiopulmonary bypass (CPB) has come under increasing scrutiny. Preliminary work by us in the area found no increased risk of neurological morbidity with normothermic CPB in a small group of patients and suggested a possible benefit. The purpose of the present study is to compare the incidence of neurological and neuropsychological dysfunction in a larger number of patients randomized to warm or cold aortocoronary bypass surgery.
3250. Late hemodynamic effects of the preserved papillary muscles during mitral valve replacement.
作者: M Komeda.;T E David.;V Rao.;Z Sun.;R D Weisel.;R J Burns.
来源: Circulation. 1994年90卷5 Pt 2期II190-4页
The late hemodynamic effects of preserving the papillary muscles during mitral valve replacement have not been evaluated.
3251. VA Study of Unstable Angina. 10-year results show duration of surgical advantage for patients with impaired ejection fraction.
In a randomized study of unstable angina, medically treated patients with impaired left ventricular (LV) ejection fractions (EF = 0.3 to 0.58) were at significantly higher risk of mortality than patients treated by coronary artery bypass graft surgery (CABG). Because the duration of this surgical advantage is unknown, 10-year cumulative mortality rates of patients with impaired LVEF were determined and compared with the previously observed rates at 2, 5, and 8 years.
3252. A comparison of internal mammary artery and saphenous vein grafts after coronary artery bypass surgery. No difference in 1-year occlusion rates and clinical outcome. CABADAS Research Group of the Interuniversity Cardiology Institute of The Netherlands.
作者: J van der Meer.;H L Hillege.;W H van Gilst.;A Brutel de la Rivière.;P H Dunselman.;V Fidler.;G J Kootstra.;B J Mulder.;M Pfisterer.;K I Lie.
来源: Circulation. 1994年90卷5期2367-74页
Superior patency rates for internal mammary artery (IMA) grafts compared with vein coronary bypass grafts have been demonstrated by retrospective studies. This difference may have been affected by selection bias of patients and coronary arteries for IMA grafting.
3253. Upper limit of vulnerability reliably predicts the defibrillation threshold in humans.
作者: C Hwang.;C D Swerdlow.;R M Kass.;E S Gang.;W J Mandel.;C T Peter.;P S Chen.
来源: Circulation. 1994年90卷5期2308-14页
The upper limit of vulnerability is the stimulus strength above which electrical stimulation cannot induce ventricular fibrillation even when the stimulus occurs during the vulnerable period of the cardiac cycle. The purpose of this study was to test the hypothesis that the upper limit of vulnerability can accurately predict the defibrillation threshold in patients undergoing implantable cardioverter-defibrillator (ICD) implantation using nonthoracotomy lead systems.
3254. Randomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial infarction.
作者: S G Ellis.;E R da Silva.;G Heyndrickx.;J D Talley.;C Cernigliaro.;G Steg.;C Spaulding.;M Nobuyoshi.;R Erbel.;C Vassanelli.
来源: Circulation. 1994年90卷5期2280-4页
When used in the setting of acute myocardial infarction, intravenous thrombolytic agents fail to achieve early infarct artery patency in 15% to 50% of patients. We tested the hypothesis that immediate balloon angioplasty applied to patients with failed early reperfusion would improve left ventricular function and clinical outcome at 30 days compared with conservative management alone.
3255. Adjunctive intracoronary infusion of antithrombin III during percutaneous transluminal coronary angioplasty. Results of a prospective, randomized trial.
作者: V Schächinger.;M Allert.;W Kasper.;H Just.;W Vach.;A M Zeiher.
来源: Circulation. 1994年90卷5期2258-66页
Heparin needs the plasma protein antithrombin III to function as an inhibitor of thrombin, and local antithrombin III deficiency might therefore limit the antithrombotic effectiveness of heparin during percutaneous transluminal coronary angioplasty.
3256. Do fish oils prevent restenosis after coronary angioplasty?
作者: A Leaf.;M B Jorgensen.;A K Jacobs.;G Cote.;D A Schoenfeld.;J Scheer.;B H Weiner.;J D Slack.;M A Kellett.;A E Raizner.
来源: Circulation. 1994年90卷5期2248-57页
The omega-3 polyunsaturated fatty acids derived from fish oils have been shown to modulate many factors believed to affect the pathogenesis of atherosclerosis. Because certain features of restenosis following angioplasty mimic some of the early changes of atherogenesis, some researchers have suggested that fish oil might prevent restenosis following angioplasty. We report the effects of omega-3 fatty acids on the rate of restenosis following percutaneous intraluminal coronary angioplasty (PTCA).
3257. Superiority of treadmill walking exercise versus strength training for patients with peripheral arterial disease. Implications for the mechanism of the training response.
In patients with intermittent claudication, a supervised walking exercise program increases peak exercise performance and community-based functional status. Patients with peripheral arterial disease also have muscle weakness in the affected extremity that may contribute to the walking impairment. However, the potential benefits of training modalities other than walking exercise, such as strength training, have not been critically evaluated in this patient population. The present study tested the hypothesis that a strength training program would be as effective as treadmill walking exercise and that combinations of strengthening and walking exercise would be more effective than either alone in improving exercise performance.
3258. Effect of capacitor size and pathway resistance on defibrillation threshold for implantable defibrillators.
The time constant of truncated exponential pulses used with implantable defibrillators is determined by the output capacitor size and defibrillation pathway resistance. The optimal capacitor size is unknown.
3259. A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees.
来源: Circulation. 1994年90卷4期1765-73页
Functional benefit in heart failure due to idiopathic dilated cardiomyopathy has been observed after beta-blockade, but improvement in survival has not been established in a large-scale randomized trial. This was the main objective of the Cardiac Insufficiency Bisoprolol Study (CIBIS).
3260. Effects of captopril on ischemic events after myocardial infarction. Results of the Survival and Ventricular Enlargement trial. SAVE Investigators.
作者: J D Rutherford.;M A Pfeffer.;L A Moyé.;B R Davis.;G C Flaker.;P R Kowey.;G A Lamas.;H S Miller.;M Packer.;J L Rouleau.
来源: Circulation. 1994年90卷4期1731-8页
In the Survival and Ventricular Enlargement (SAVE) trial, recurrent myocardial infarction (MI) was the most important predictor of a poor outcome and conferred a sevenfold increase in risk of death. The purpose of this study was to determine the predictors of recurrent MI in study participants and to examine the influence of the angiotensin-converting enzyme inhibitor captopril on this and other myocardial ischemic events.
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