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3241. Folate therapy and in-stent restenosis after coronary stenting.
作者: Helmut Lange.;Harry Suryapranata.;Giuseppe De Luca.;Caspar Börner.;Joep Dille.;Klaus Kallmayer.;M Noor Pasalary.;Eberhard Scherer.;Jan-Henk E Dambrink.
来源: N Engl J Med. 2004年350卷26期2673-81页
Vitamin therapy to lower homocysteine levels has recently been recommended for the prevention of restenosis after coronary angioplasty. We tested the effect of a combination of folic acid, vitamin B6, and vitamin B12 (referred to as folate therapy) on the risk of angiographic restenosis after coronary-stent placement in a double-blind, multicenter trial.
3242. Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid.
作者: Lotta Gustafsson.;Irene Leijonhufvud.;Annika Aronsson.;Ann-Kristin Mossberg.;Catharina Svanborg.
来源: N Engl J Med. 2004年350卷26期2663-72页
We studied the effect on skin papillomas of topical application of a complex of alpha-lactalbumin and oleic acid (often referred to as human alpha-lactalbumin made lethal to tumor cells [HAMLET]) to establish proof of the principle that alpha-lactalbumin-oleic acid kills transformed cells but not healthy, differentiated cells.
3243. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.
作者: Jonathan C W Edwards.;Leszek Szczepanski.;Jacek Szechinski.;Anna Filipowicz-Sosnowska.;Paul Emery.;David R Close.;Randall M Stevens.;Tim Shaw.
来源: N Engl J Med. 2004年350卷25期2572-81页
An open-label study indicated that selective depletion of B cells with the use of rituximab led to sustained clinical improvements for patients with rheumatoid arthritis. To confirm these observations, we conducted a randomized, double-blind, controlled study.
3244. A trial of three antiretroviral regimens in HIV-1-infected children.
作者: Katherine Luzuriaga.;Margaret McManus.;Lynne Mofenson.;Paula Britto.;Bobbie Graham.;John L Sullivan.; .
来源: N Engl J Med. 2004年350卷24期2471-80页
Depletion of CD4 T-cell counts or progression of human immunodeficiency virus (HIV) disease occurs rapidly in children, but few data address the efficacy of aggressive therapy for HIV-infected children.
3245. Noninvasive positive-pressure ventilation for respiratory failure after extubation.
作者: Andrés Esteban.;Fernando Frutos-Vivar.;Niall D Ferguson.;Yaseen Arabi.;Carlos Apezteguía.;Marco González.;Scott K Epstein.;Nicholas S Hill.;Stefano Nava.;Marco-Antonio Soares.;Gabriel D'Empaire.;Inmaculada Alía.;Antonio Anzueto.
来源: N Engl J Med. 2004年350卷24期2452-60页
The need for reintubation after extubation and discontinuation of mechanical ventilation is not uncommon and is associated with increased mortality. Noninvasive positive-pressure ventilation has been suggested as a promising therapy for patients with respiratory failure after extubation, but a single-center, randomized trial recently found no benefit. We conducted a multicenter, randomized trial to evaluate the effect of noninvasive positive-pressure ventilation on mortality in this clinical setting.
3246. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting.
作者: Christian C Apfel.;Kari Korttila.;Mona Abdalla.;Heinz Kerger.;Alparslan Turan.;Ina Vedder.;Carmen Zernak.;Klaus Danner.;Ritva Jokela.;Stuart J Pocock.;Stefan Trenkler.;Markus Kredel.;Andreas Biedler.;Daniel I Sessler.;Norbert Roewer.; .
来源: N Engl J Med. 2004年350卷24期2441-51页
Untreated, one third of patients who undergo surgery will have postoperative nausea and vomiting. Although many trials have been conducted, the relative benefits of prophylactic antiemetic interventions given alone or in combination remain unknown.
3247. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer.
作者: Thierry André.;Corrado Boni.;Lamia Mounedji-Boudiaf.;Matilde Navarro.;Josep Tabernero.;Tamas Hickish.;Clare Topham.;Marta Zaninelli.;Philip Clingan.;John Bridgewater.;Isabelle Tabah-Fisch.;Aimery de Gramont.; .
来源: N Engl J Med. 2004年350卷23期2343-51页
The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin (FL). Oxaliplatin improves the efficacy of this combination in patients with metastatic colorectal cancer. We evaluated the efficacy of treatment with FL plus oxaliplatin in the postoperative adjuvant setting.
3248. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.
作者: Herbert Hurwitz.;Louis Fehrenbacher.;William Novotny.;Thomas Cartwright.;John Hainsworth.;William Heim.;Jordan Berlin.;Ari Baron.;Susan Griffing.;Eric Holmgren.;Napoleone Ferrara.;Gwen Fyfe.;Beth Rogers.;Robert Ross.;Fairooz Kabbinavar.
来源: N Engl J Med. 2004年350卷23期2335-42页
Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and clinical activity against metastatic colorectal cancer, particularly in combination with chemotherapy.
3249. Peginterferon alfa-2b and ribavirin for the treatment of chronic hepatitis C in blacks and non-Hispanic whites.
作者: Andrew J Muir.;Jeffrey D Bornstein.;Paul G Killenberg.; .
来源: N Engl J Med. 2004年350卷22期2265-71页
Several small studies have reported a lower response rate to interferon alfa among black patients with chronic hepatitis C infection than among white patients. The increased prevalence of infection with hepatitis C virus (HCV) genotype 1, which has a lower response rate than other genotypes, has been suggested as the cause.
3250. A comparison of albumin and saline for fluid resuscitation in the intensive care unit.
作者: Simon Finfer.;Rinaldo Bellomo.;Neil Boyce.;Julie French.;John Myburgh.;Robyn Norton.; .
来源: N Engl J Med. 2004年350卷22期2247-56页
It remains uncertain whether the choice of resuscitation fluid for patients in intensive care units (ICUs) affects survival. We conducted a multicenter, randomized, double-blind trial to compare the effect of fluid resuscitation with albumin or saline on mortality in a heterogeneous population of patients in the ICU.
3251. Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliter.
作者: Ian M Thompson.;Donna K Pauler.;Phyllis J Goodman.;Catherine M Tangen.;M Scott Lucia.;Howard L Parnes.;Lori M Minasian.;Leslie G Ford.;Scott M Lippman.;E David Crawford.;John J Crowley.;Charles A Coltman.
来源: N Engl J Med. 2004年350卷22期2239-46页
The optimal upper limit of the normal range for prostate-specific antigen (PSA) is unknown. We investigated the prevalence of prostate cancer among men in the Prostate Cancer Prevention Trial who had a PSA level of 4.0 ng per milliliter or less.
3253. Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy.
作者: Alan Kadish.;Alan Dyer.;James P Daubert.;Rebecca Quigg.;N A Mark Estes.;Kelley P Anderson.;Hugh Calkins.;David Hoch.;Jeffrey Goldberger.;Alaa Shalaby.;William E Sanders.;Andi Schaechter.;Joseph H Levine.; .
来源: N Engl J Med. 2004年350卷21期2151-8页
Patients with nonischemic dilated cardiomyopathy are at substantial risk for sudden death from cardiac causes. However, the value of prophylactic implantation of an implantable cardioverter-defibrillator (ICD) to prevent sudden death in such patients is unknown.
3254. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure.
作者: Michael R Bristow.;Leslie A Saxon.;John Boehmer.;Steven Krueger.;David A Kass.;Teresa De Marco.;Peter Carson.;Lorenzo DiCarlo.;David DeMets.;Bill G White.;Dale W DeVries.;Arthur M Feldman.; .
来源: N Engl J Med. 2004年350卷21期2140-50页
We tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation with a pacemaker with or without a defibrillator would reduce the risk of death and hospitalization among patients with advanced chronic heart failure and intraventricular conduction delays.
3255. A comparison of laparoscopically assisted and open colectomy for colon cancer.
作者: .;Heidi Nelson.;Daniel J Sargent.;H Sam Wieand.;James Fleshman.;Mehran Anvari.;Steven J Stryker.;Robert W Beart.;Michael Hellinger.;Richard Flanagan.;Walter Peters.;David Ota.
来源: N Engl J Med. 2004年350卷20期2050-9页
Minimally invasive, laparoscopically assisted surgery was first considered in 1990 for patients undergoing colectomy for cancer. Concern that this approach would compromise survival by failing to achieve a proper oncologic resection or adequate staging or by altering patterns of recurrence (based on frequent reports of tumor recurrences within surgical wounds) prompted a controlled trial evaluation.
3256. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer.
作者: Jacques Bernier.;Christian Domenge.;Mahmut Ozsahin.;Katarzyna Matuszewska.;Jean-Louis Lefèbvre.;Richard H Greiner.;Jordi Giralt.;Philippe Maingon.;Frédéric Rolland.;Michel Bolla.;Francesco Cognetti.;Jean Bourhis.;Anne Kirkpatrick.;Martine van Glabbeke.; .
来源: N Engl J Med. 2004年350卷19期1945-52页
We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer.
3257. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck.
作者: Jay S Cooper.;Thomas F Pajak.;Arlene A Forastiere.;John Jacobs.;Bruce H Campbell.;Scott B Saxman.;Julie A Kish.;Harold E Kim.;Anthony J Cmelak.;Marvin Rotman.;Mitchell Machtay.;John F Ensley.;K S Clifford Chao.;Christopher J Schultz.;Nancy Lee.;Karen K Fu.; .
来源: N Engl J Med. 2004年350卷19期1937-44页
Despite the use of resection and postoperative radiotherapy, high-risk squamous-cell carcinoma of the head and neck frequently recurs in the original tumor bed. We tested the hypothesis that concurrent postoperative administration of cisplatin and radiotherapy would improve the rate of local and regional control.
3258. Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection.
作者: Roy M Gulick.;Heather J Ribaudo.;Cecilia M Shikuma.;Stephanie Lustgarten.;Kathleen E Squires.;William A Meyer.;Edward P Acosta.;Bruce R Schackman.;Christopher D Pilcher.;Robert L Murphy.;William E Maher.;Mallory D Witt.;Richard C Reichman.;Sally Snyder.;Karin L Klingman.;Daniel R Kuritzkes.; .
来源: N Engl J Med. 2004年350卷18期1850-61页
Regimens containing three nucleoside reverse-transcriptase inhibitors offer an alternative to regimens containing nonnucleoside reverse-transcriptase inhibitors or protease inhibitors for the initial treatment of human immunodeficiency virus type 1 (HIV-1) infection, but data from direct comparisons are limited.
3259. Open mesh versus laparoscopic mesh repair of inguinal hernia.
作者: Leigh Neumayer.;Anita Giobbie-Hurder.;Olga Jonasson.;Robert Fitzgibbons.;Dorothy Dunlop.;James Gibbs.;Domenic Reda.;William Henderson.; .
来源: N Engl J Med. 2004年350卷18期1819-27页
Repair of inguinal hernias in men is a common surgical procedure, but the most effective surgical technique is unknown.
3260. A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest.
作者: Maria Beatriz M Perondi.;Amelia G Reis.;Edison F Paiva.;Vinay M Nadkarni.;Robert A Berg.
来源: N Engl J Med. 2004年350卷17期1722-30页
When efforts to resuscitate a child after cardiac arrest are unsuccessful despite the administration of an initial dose of epinephrine, it is unclear whether the next dose of epinephrine (i.e., the rescue dose) should be the same (standard) dose or a higher dose.
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