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302. Small bowel lymphoma presenting with frequent perforation: a single center experience focusing on the monomorphic epitheliotropic intestinal T-cell lymphoma.
作者: Wan-Chih Yeh.;Ming-Lun Han.;Chia-Hung Tu.;Chien-Chuan Chen.;Tsu-Yao Cheng.
来源: BMC Gastroenterol. 2026年26卷1期132页
Small bowel malignancies are rare and initial symptoms are generally vague and non-specific. Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a primary lymphoma of the gastrointestinal tract typically localizing to the small bowel. We attempted to analyze small bowel lymphoma patients in a tertiary care center focusing on the current diagnostic and treatment strategies of MEITL.
304. Downregulation of MUC6 improves esophageal epithelial barrier dysfunction and inhibits epithelial-mesenchymal transition in reflux esophagitis.
作者: Xue Jia.;Ying Zhao.;Hongrui Li.;Shuaishuai Fan.;Haiqing Hu.
来源: BMC Gastroenterol. 2026年26卷1期53页
Reflux esophagitis (RE) is a chronic inflammatory condition resulting from the reflux of gastric contents. Mucin 6 (MUC6), a member of the mucin family, has been found to have dysregulated expression in various esophageal diseases. However, the specific role of MUC6 in RE remains largely unclear.
305. Diagnostic delay in children with coeliac disease: a national multicentre study in Turkey.
作者: Yasin Sahin.;Eylem Sevinc.;Fatma Ilknur Varol.;Ulas Emre Akbulut.;Nevzat Aykut Bayrak.;Aysegul Bukulmez.
来源: BMC Gastroenterol. 2026年26卷1期131页
There are few studies conducted investigating diagnostic delay in children with coeliac disease (CD). A better understanding of the factors associated with diagnostic delay and the development of strategies to reduce it are important in preventing long-term complications related to the disease. This study aimed to determine the median diagnostic delay in children with CD and to investigate possible underlying factors associated with diagnostic delay.
306. Influences of transcutaneous neuromodulation on fecal microbiota and short chain fatty acids in patients with functional constipation.
作者: Shengai Zhang.;Honggang Shi.;Bojia Liu.;Zhenyang Ge.;Nina Zhang.;Qigui Liu.;Zhijun Duan.;Qingyong Chang.
来源: BMC Gastroenterol. 2026年26卷1期51页
Transcutaneous neuromodulation (TN) has been reported effective for functional constipation (FC). The underlying mechanism remains unclear. In this study, we aimed to investigate the gut microbiota (GM) and short chain fatty acids (SCFAs) metabolism changed in FC patients due to TN treatment. The correlation between GM and 5-HT was evaluated.
307. Non-invasive staging of hepatic steatosis by Quantification Attenuation Index (QAI).
作者: Giovanni Galletti.;Elena Formisano.;Andrea Ghezzi.;Matteo Tozzi.;Sharmila Fagoonee.;Enzo Andorno.;Paolo Borro.
来源: Minerva Gastroenterol (Torino). 2026年72卷1期4-12页
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition that can progress to cirrhosis and hepatocellular carcinoma. Non-invasive techniques are increasingly used to assess hepatic steatosis. This study aimed to evaluate the accuracy of the Quantification Attenuation Index (QAI) and define diagnostic cut-offs by comparing QAI to liver biopsy and controlled attenuation parameter (CAP).
308. Melanoma antigen genes A1 and A3 as predictors of treatment response and survival in HCV-associated hepatocellular carcinoma: a prospective study.
作者: Hoda Elgamal.;Dina Elhammady.;Salwa M Abo El-Khair.;Adel El-Badrawy.;Amr Samir.;Khaled Farid.;Hatem El Alfy.
来源: BMC Gastroenterol. 2026年26卷1期68页
Hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancers resulting in approximately 830,000 deaths in 2020, making HCC the sixth most common cancer globally. Several members of the Melanoma Antigen Gene (MAGE) family, such as MAGE-A1 and A3 genes of the MAGE I-A subfamily, are abnormally expressed in a variety of cancers including melanomas, colorectal cancer, non-small cell lung cancer, gliomas, HCC, prostate, and breast cancers. In addition, they have been linked to tumor stemness and, therefore, may predict therapeutic response and prognosis.
309. Outcomes of bile duct-guided right hepatic inflow occlusion and extended procedures in laparoscopic liver surgery.
作者: Mingming Fan.;Zhishi Yang.;Zhiying Xu.;Zhuangzhi Cong.;Hu Liu.;Lianwei Peng.;Weifeng Tan.;Qifei Zou.
来源: BMC Gastroenterol. 2026年26卷1期130页
This study aimed to assess the safety and feasibility of bile duct-guided right hepatic inflow occlusion and associated extended procedures in laparoscopic liver surgery (LLS).
310. Multidisciplinary artificial intelligence systems versus single-model approaches for the diagnosis and management of ileus and volvulus.
The accurate and timely diagnosis of ileus versus volvulus is essential in emergency care, as treatment choices directly influence patient outcomes. In this study, the diagnostic accuracy and adherence to guidelines of multidisciplinary AI systems were compared with those of single-model approaches and actual clinical decisions in managing these acute gastrointestinal conditions.
311. Long-term clinical course, treatment patterns, and prognosis in pediatric-onset vs. adult-onset IBD: a multicenter retrospective cohort study in Korea.
作者: Yong Eun Park.;Su Bum Park.;Sang-Bum Kang.;Yehyun Park.;Dae Sung Kim.;Soo-Young Na.;Won Moon.; .
来源: BMC Gastroenterol. 2026年26卷1期125页
This study aimed to compare the long-term clinical characteristics, treatment patterns, and prognosis of inflammatory bowel disease (IBD) in patients diagnosed before and after 18 years of age.
314. Identifying patients at high risk of decompensated liver disease through unscheduled care attendance data: a retrospective cohort study.
作者: R Swann.;J Lewsey.;D Jamieson.;S Padmanabhan.;J P Pell.;D Mackay.;R Dundas.;J M Friday.;T Q B Tran.;D Brown.;F K Ho.;C Hastie.;M Fleming.;C Geue.;A Stevenson.;C du Toit.;A Fraser.;E H Forrest.
来源: BMC Gastroenterol. 2026年26卷1期126页
Liver cirrhosis is one of the leading causes of mortality and morbidity in those of working age. Mortality from liver disease in the UK has continued to rise over the past decade. A significant proportion of patients presenting with decompensated liver disease have no prior diagnosis of liver disease despite multiple acute healthcare interactions providing opportunities for detection. We aimed to characterise patients presenting to unscheduled care with no known liver disease who subsequently had a liver related admission (DLD), and determine if a simple predictive score could identify those at high risk.
315. mNGS improves the efficiency of infection diagnosis and treatment in acute-on-chronic liver failure.
作者: Yushan Liu.;Qiao Zhang.;Juan Li.;Xiaonan Wu.;Qijuan Zang.;Qiannan Wang.;Pan Huang.;Yamin Wang.;Shuting Zhang.;Siyi Liu.;Chengbin Zhu.;Yingren Zhao.;Taotao Yan.;Yingli He.
来源: BMC Gastroenterol. 2026年26卷1期129页
The early diagnosis of infections in acute-on-chronic liver failure (ACLF) is still difficult. mNGS(metagenomic next-generation sequencing) is a no-bias, sensitive pathogen diagnosis method, and further research on mNGS in ACLF is needed.
316. Interpretable model for early prediction of 28-day mortality in patients with cirrhosis and sepsis: a multi-cohort ICU study.
Cirrhosis complicated by sepsis is a common reason for intensive care unit (ICU) admission and is associated with a markedly increased risk of short-term mortality. However, early assessment of 28-day mortality risk at ICU admission remains uncertain in this population. Existing scoring systems often rely on subjective assessments or clinical variables that may not be readily available at the time of admission, highlighting the need for a simple and objective model based on routinely obtainable data for early risk stratification.
317. Conceptual and operational consistency in defining intestinal failure across randomized controlled trials: a systematic review and meta-research analysis.
作者: Kevin Fernando Montoya-Quintero.;Sandra Valencia.;María Cristina Florián Pérez.;Fabriccio J Visconti-Lopez.;Yadira Marín-Hamburguer.;Ivan David Lozada-Martinez.
来源: BMC Gastroenterol. 2026年26卷1期128页
Intestinal failure (IF) is a rare but serious condition associated with high morbidity, mortality, and healthcare resource use. Although consensus-based definitions for IF exist, their adoption in randomized controlled trials (RCTs) remains uncertain. This variability compromises the comparability of evidence and hinders the development of robust clinical guidelines. The aim of this study was to examine the conceptual and operational consistency of IF definitions in RCTs, assess methodological and reporting quality, and explore implications for research synthesis and clinical decision-making.
318. Inflammatory indices as independent predictors of in-hospital mortality in acute upper gastrointestinal bleeding.
作者: Mustafa Oguz Cumaoglu.;Abdussamed Vural.;Mustafa Alpaslan.;Turgut Dolanbay.;Abdul Ridvan Kulu.;Ercan Sezgin.;Seyyid Rasim Yanmaz.
来源: BMC Gastroenterol. 2026年26卷1期127页
Acute upper gastrointestinal bleeding (UGIB) remains a high-risk emergency with non-negligible in-hospital mortality. Inflammatory indices derived from routine admission tests may provide additional bedside information reflecting inflammatory burden and physiologic reserve, but their prognostic value in UGIB is not well defined.
319. Soil properties and spatial distribution of chronic gastritis in Yanshan County, China: a spatial epidemiological study.
Chronic gastritis is a common gastrointestinal disorder and a potential precursor to gastric cancer. Although environmental factors have been associated with its occurrence, the combined relationships of soil characteristics and demographic variables with its spatial distribution remain unclear. This study aims to quantify associations between soil properties and the spatial distribution of chronic gastritis after accounting for population structure and spatial dependence.
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