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301. Dersimelagon in Erythropoietic Protoporphyrias.
作者: Manisha Balwani.;Herbert L Bonkovsky.;Cynthia Levy.;Karl E Anderson.;D Montgomery Bissell.;Charles Parker.;Fumihiro Takahashi.;Robert J Desnick.;Kirstine Belongie.; .
来源: N Engl J Med. 2023年388卷15期1376-1385页
Erythropoietic protoporphyria and X-linked protoporphyria are inborn errors of heme biosynthesis that cause elevated circulating levels of metal-free protoporphyrin and phototoxicity. Both disorders are characterized by excruciating phototoxic attacks after exposure to visible light. Dersimelagon is a new, orally administered, selective melanocortin 1 receptor agonist that increases levels of skin eumelanin.
302. Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery.
作者: Luis D Pacheco.;Rebecca G Clifton.;George R Saade.;Steven J Weiner.;Samuel Parry.;John M Thorp.;Monica Longo.;Ashley Salazar.;Wendy Dalton.;Alan T N Tita.;Cynthia Gyamfi-Bannerman.;Suneet P Chauhan.;Torri D Metz.;Kara Rood.;Dwight J Rouse.;Jennifer L Bailit.;William A Grobman.;Hyagriv N Simhan.;George A Macones.; .
来源: N Engl J Med. 2023年388卷15期1365-1375页
Prophylactic use of tranexamic acid at the time of cesarean delivery has been shown to decrease the calculated blood loss, but the effect on the need for blood transfusions is unclear.
303. Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections.
作者: Anne F Luetkemeyer.;Deborah Donnell.;Julia C Dombrowski.;Stephanie Cohen.;Cole Grabow.;Clare E Brown.;Cheryl Malinski.;Rodney Perkins.;Melody Nasser.;Carolina Lopez.;Eric Vittinghoff.;Susan P Buchbinder.;Hyman Scott.;Edwin D Charlebois.;Diane V Havlir.;Olusegun O Soge.;Connie Celum.; .
来源: N Engl J Med. 2023年388卷14期1296-1306页
Interventions to reduce sexually transmitted infections (STIs) among men who have sex with men (MSM) are needed.
304. Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants.
作者: Beate Kampmann.;Shabir A Madhi.;Iona Munjal.;Eric A F Simões.;Barbara A Pahud.;Conrado Llapur.;Jeffrey Baker.;Gonzalo Pérez Marc.;David Radley.;Emma Shittu.;Julia Glanternik.;Hasra Snaggs.;James Baber.;Philip Zachariah.;Shaun L Barnabas.;Merlin Fausett.;Tyler Adam.;Nicole Perreras.;Marlies A Van Houten.;Anu Kantele.;Li-Min Huang.;Louis J Bont.;Takeo Otsuki.;Sergio L Vargas.;Joanna Gullam.;Bruce Tapiero.;Renato T Stein.;Fernando P Polack.;Heather J Zar.;Nina B Staerke.;María Duron Padilla.;Peter C Richmond.;Kenneth Koury.;Katherine Schneider.;Elena V Kalinina.;David Cooper.;Kathrin U Jansen.;Annaliesa S Anderson.;Kena A Swanson.;William C Gruber.;Alejandra Gurtman.; .
来源: N Engl J Med. 2023年388卷16期1451-1464页
Whether vaccination during pregnancy could reduce the burden of respiratory syncytial virus (RSV)-associated lower respiratory tract illness in newborns and infants is uncertain.
305. Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults.
作者: Edward E Walsh.;Gonzalo Pérez Marc.;Agnieszka M Zareba.;Ann R Falsey.;Qin Jiang.;Michael Patton.;Fernando P Polack.;Conrado Llapur.;Pablo A Doreski.;Kumar Ilangovan.;Mika Rämet.;Yasushi Fukushima.;Nazreen Hussen.;Louis J Bont.;Jose Cardona.;Elliot DeHaan.;Giselle Castillo Villa.;Marinela Ingilizova.;Daniel Eiras.;Tarek Mikati.;Rupal N Shah.;Katherine Schneider.;David Cooper.;Kenneth Koury.;Maria-Maddalena Lino.;Annaliesa S Anderson.;Kathrin U Jansen.;Kena A Swanson.;Alejandra Gurtman.;William C Gruber.;Beate Schmoele-Thoma.; .
来源: N Engl J Med. 2023年388卷16期1465-1477页
Respiratory syncytial virus (RSV) infection causes considerable illness in older adults. The efficacy and safety of an investigational bivalent RSV prefusion F protein-based (RSVpreF) vaccine in this population are unknown.
306. Vedolizumab for the Treatment of Chronic Pouchitis.
作者: Simon Travis.;Mark S Silverberg.;Silvio Danese.;Paolo Gionchetti.;Mark Löwenberg.;Vipul Jairath.;Brian G Feagan.;Brian Bressler.;Marc Ferrante.;Ailsa Hart.;Dirk Lindner.;Armella Escher.;Stephen Jones.;Bo Shen.; .
来源: N Engl J Med. 2023年388卷13期1191-1200页
Approximately half the patients with ulcerative colitis who undergo restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) will subsequently have pouchitis, and among those patients, one fifth will have chronic pouchitis.
307. Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer.
作者: Mansoor R Mirza.;Dana M Chase.;Brian M Slomovitz.;René dePont Christensen.;Zoltán Novák.;Destin Black.;Lucy Gilbert.;Sudarshan Sharma.;Giorgio Valabrega.;Lisa M Landrum.;Lars C Hanker.;Ashley Stuckey.;Ingrid Boere.;Michael A Gold.;Annika Auranen.;Bhavana Pothuri.;David Cibula.;Carolyn McCourt.;Francesco Raspagliesi.;Mark S Shahin.;Sarah E Gill.;Bradley J Monk.;Joseph Buscema.;Thomas J Herzog.;Larry J Copeland.;Min Tian.;Zangdong He.;Shadi Stevens.;Eleftherios Zografos.;Robert L Coleman.;Matthew A Powell.; .
来源: N Engl J Med. 2023年388卷23期2145-2158页
Dostarlimab is an immune-checkpoint inhibitor that targets the programmed cell death 1 receptor. The combination of chemotherapy and immunotherapy may have synergistic effects in the treatment of endometrial cancer.
308. Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer.
作者: Ramez N Eskander.;Michael W Sill.;Lindsey Beffa.;Richard G Moore.;Joanie M Hope.;Fernanda B Musa.;Robert Mannel.;Mark S Shahin.;Guilherme H Cantuaria.;Eugenia Girda.;Cara Mathews.;Juraj Kavecansky.;Charles A Leath.;Lilian T Gien.;Emily M Hinchcliff.;Shashikant B Lele.;Lisa M Landrum.;Floor Backes.;Roisin E O'Cearbhaill.;Tareq Al Baghdadi.;Emily K Hill.;Premal H Thaker.;Veena S John.;Stephen Welch.;Amanda N Fader.;Matthew A Powell.;Carol Aghajanian.
来源: N Engl J Med. 2023年388卷23期2159-2170页
Standard first-line chemotherapy for endometrial cancer is paclitaxel plus carboplatin. The benefit of adding pembrolizumab to chemotherapy remains unclear.
309. Acute Effects of Coffee Consumption on Health among Ambulatory Adults.
作者: Gregory M Marcus.;David G Rosenthal.;Gregory Nah.;Eric Vittinghoff.;Christina Fang.;Kelsey Ogomori.;Sean Joyce.;Defne Yilmaz.;Vivian Yang.;Tara Kessedjian.;Emily Wilson.;Michelle Yang.;Kathleen Chang.;Grace Wall.;Jeffrey E Olgin.
来源: N Engl J Med. 2023年388卷12期1092-1100页
Coffee is one of the most commonly consumed beverages in the world, but the acute health effects of coffee consumption remain uncertain.
310. Hydrocortisone in Severe Community-Acquired Pneumonia.
作者: Pierre-François Dequin.;Ferhat Meziani.;Jean-Pierre Quenot.;Toufik Kamel.;Jean-Damien Ricard.;Julio Badie.;Jean Reignier.;Nicholas Heming.;Gaëtan Plantefève.;Bertrand Souweine.;Guillaume Voiriot.;Gwenhaël Colin.;Jean-Pierre Frat.;Jean-Paul Mira.;Nicolas Barbarot.;Bruno François.;Guillaume Louis.;Sébastien Gibot.;Christophe Guitton.;Christophe Giacardi.;Sami Hraiech.;Sylvie Vimeux.;Erwan L'Her.;Henri Faure.;Jean-Etienne Herbrecht.;Camille Bouisse.;Aurélie Joret.;Nicolas Terzi.;Arnaud Gacouin.;Charlotte Quentin.;Mercé Jourdain.;Marie Leclerc.;Carine Coffre.;Hélène Bourgoin.;Céline Lengellé.;Caroline Caille-Fénérol.;Bruno Giraudeau.;Amélie Le Gouge.; .
来源: N Engl J Med. 2023年388卷21期1931-1941页
Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is unclear.
311. Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis.
作者: Jonathan I Silverberg.;Emma Guttman-Yassky.;Diamant Thaçi.;Alan D Irvine.;Linda Stein Gold.;Andrew Blauvelt.;Eric L Simpson.;Chia-Yu Chu.;Zhuqing Liu.;Renata Gontijo Lima.;Sreekumar G Pillai.;Julien Seneschal.; .
来源: N Engl J Med. 2023年388卷12期1080-1091页
Lebrikizumab, a high-affinity IgG4 monoclonal antibody targeting interleukin-13, prevents the formation of the interleukin-4Rα-interleukin-13Rα1 heterodimer receptor signaling complex.
312. Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes.
作者: R Paul Wadwa.;Zachariah W Reed.;Bruce A Buckingham.;Mark D DeBoer.;Laya Ekhlaspour.;Gregory P Forlenza.;Melissa Schoelwer.;John Lum.;Craig Kollman.;Roy W Beck.;Marc D Breton.; .
来源: N Engl J Med. 2023年388卷11期991-1001页
Closed-loop control systems of insulin delivery may improve glycemic outcomes in young children with type 1 diabetes. The efficacy and safety of initiating a closed-loop system virtually are unclear.
313. Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer.
作者: Freddie C Hamdy.;Jenny L Donovan.;J Athene Lane.;Chris Metcalfe.;Michael Davis.;Emma L Turner.;Richard M Martin.;Grace J Young.;Eleanor I Walsh.;Richard J Bryant.;Prasad Bollina.;Andrew Doble.;Alan Doherty.;David Gillatt.;Vincent Gnanapragasam.;Owen Hughes.;Roger Kockelbergh.;Howard Kynaston.;Alan Paul.;Edgar Paez.;Philip Powell.;Derek J Rosario.;Edward Rowe.;Malcolm Mason.;James W F Catto.;Tim J Peters.;Jon Oxley.;Naomi J Williams.;John Staffurth.;David E Neal.; .
来源: N Engl J Med. 2023年388卷17期1547-1558页
Between 1999 and 2009 in the United Kingdom, 82,429 men between 50 and 69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer was diagnosed in 2664 men. Of these men, 1643 were enrolled in a trial to evaluate the effectiveness of treatments, with 545 randomly assigned to receive active monitoring, 553 to undergo prostatectomy, and 545 to undergo radiotherapy.
314. Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors.
作者: Mrinal Gounder.;Ravin Ratan.;Thierry Alcindor.;Patrick Schöffski.;Winette T van der Graaf.;Breelyn A Wilky.;Richard F Riedel.;Allison Lim.;L Mary Smith.;Stephanie Moody.;Steven Attia.;Sant Chawla.;Gina D'Amato.;Noah Federman.;Priscilla Merriam.;Brian A Van Tine.;Bruno Vincenzi.;Charlotte Benson.;Nam Quoc Bui.;Rashmi Chugh.;Gabriel Tinoco.;John Charlson.;Palma Dileo.;Lee Hartner.;Lore Lapeire.;Filomena Mazzeo.;Emanuela Palmerini.;Peter Reichardt.;Silvia Stacchiotti.;Howard H Bailey.;Melissa A Burgess.;Gregory M Cote.;Lara E Davis.;Hari Deshpande.;Hans Gelderblom.;Giovanni Grignani.;Elizabeth Loggers.;Tony Philip.;Joseph G Pressey.;Shivaani Kummar.;Bernd Kasper.
来源: N Engl J Med. 2023年388卷10期898-912页
Desmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors without approved treatments.
315. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension.
作者: Marius M Hoeper.;David B Badesch.;H Ardeschir Ghofrani.;J Simon R Gibbs.;Mardi Gomberg-Maitland.;Vallerie V McLaughlin.;Ioana R Preston.;Rogerio Souza.;Aaron B Waxman.;Ekkehard Grünig.;Grzegorz Kopeć.;Gisela Meyer.;Karen M Olsson.;Stephan Rosenkranz.;Yayun Xu.;Barry Miller.;Marcie Fowler.;John Butler.;Joerg Koglin.;Janethe de Oliveira Pena.;Marc Humbert.; .
来源: N Engl J Med. 2023年388卷16期1478-1490页
Pulmonary arterial hypertension is a progressive disease involving proliferative remodeling of the pulmonary vessels. Despite therapeutic advances, the disease-associated morbidity and mortality remain high. Sotatercept is a fusion protein that traps activins and growth differentiation factors involved in pulmonary arterial hypertension.
316. Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation.
作者: Gregg W Stone.;William T Abraham.;JoAnn Lindenfeld.;Saibal Kar.;Paul A Grayburn.;D Scott Lim.;Jacob M Mishell.;Brian Whisenant.;Michael Rinaldi.;Samir R Kapadia.;Vivek Rajagopal.;Ian J Sarembock.;Andreas Brieke.;Steven O Marx.;David J Cohen.;Federico M Asch.;Michael J Mack.; .
来源: N Engl J Med. 2023年388卷22期2037-2048页
Data from a 5-year follow-up of outcomes after transcatheter edge-to-edge repair of severe mitral regurgitation, as compared with outcomes after maximal doses of guideline-directed medical therapy alone, in patients with heart failure are now available.
317. Transcatheter Repair for Patients with Tricuspid Regurgitation.
作者: Paul Sorajja.;Brian Whisenant.;Nadira Hamid.;Hursh Naik.;Raj Makkar.;Peter Tadros.;Matthew J Price.;Gagan Singh.;Neil Fam.;Saibal Kar.;Jonathan G Schwartz.;Shamir Mehta.;Richard Bae.;Nishant Sekaran.;Travis Warner.;Moody Makar.;George Zorn.;Erin M Spinner.;Phillip M Trusty.;Raymond Benza.;Ulrich Jorde.;Patrick McCarthy.;Vinod Thourani.;Gilbert H L Tang.;Rebecca T Hahn.;David H Adams.; .
来源: N Engl J Med. 2023年388卷20期1833-1842页
Severe tricuspid regurgitation is a debilitating condition that is associated with substantial morbidity and often with poor quality of life. Decreasing tricuspid regurgitation may reduce symptoms and improve clinical outcomes in patients with this disease.
318. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients.
作者: Steven E Nissen.;A Michael Lincoff.;Danielle Brennan.;Kausik K Ray.;Denise Mason.;John J P Kastelein.;Paul D Thompson.;Peter Libby.;Leslie Cho.;Jorge Plutzky.;Harold E Bays.;Patrick M Moriarty.;Venu Menon.;Diederick E Grobbee.;Michael J Louie.;Chien-Feng Chen.;Na Li.;LeAnne Bloedon.;Paula Robinson.;Maggie Horner.;William J Sasiela.;Jackie McCluskey.;Deborah Davey.;Pedro Fajardo-Campos.;Predrag Petrovic.;Jan Fedacko.;Witold Zmuda.;Yury Lukyanov.;Stephen J Nicholls.; .
来源: N Engl J Med. 2023年388卷15期1353-1364页
Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events; its effects on cardiovascular outcomes remain uncertain.
319. Intravascular Imaging-Guided or Angiography-Guided Complex PCI.
作者: Joo Myung Lee.;Ki Hong Choi.;Young Bin Song.;Jong-Young Lee.;Seung-Jae Lee.;Sang Yeub Lee.;Sang Min Kim.;Kyeong Ho Yun.;Jae Young Cho.;Chan Joon Kim.;Hyo-Suk Ahn.;Chang-Wook Nam.;Hyuck-Jun Yoon.;Yong Hwan Park.;Wang Soo Lee.;Jin-Ok Jeong.;Pil Sang Song.;Joon-Hyung Doh.;Sang-Ho Jo.;Chang-Hwan Yoon.;Min Gyu Kang.;Jin-Sin Koh.;Kwan Yong Lee.;Young-Hyo Lim.;Yun-Hyeong Cho.;Jin-Man Cho.;Woo Jin Jang.;Kook-Jin Chun.;David Hong.;Taek Kyu Park.;Jeong Hoon Yang.;Seung-Hyuk Choi.;Hyeon-Cheol Gwon.;Joo-Yong Hahn.; .
来源: N Engl J Med. 2023年388卷18期1668-1679页
Data regarding clinical outcomes after intravascular imaging-guided percutaneous coronary intervention (PCI) for complex coronary-artery lesions, as compared with outcomes after angiography-guided PCI, are limited.
320. Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression.
作者: Eric J Lenze.;Benoit H Mulsant.;Steven P Roose.;Helen Lavretsky.;Charles F Reynolds.;Daniel M Blumberger.;Patrick J Brown.;Pilar Cristancho.;Alastair J Flint.;Marie A Gebara.;Torie R Gettinger.;Emily Lenard.;J Philip Miller.;Ginger E Nicol.;Hanadi A Oughli.;Vy T Pham.;Bruce L Rollman.;Lei Yang.;Jordan F Karp.
来源: N Engl J Med. 2023年388卷12期1067-1079页
The benefits and risks of augmenting or switching antidepressants in older adults with treatment-resistant depression have not been extensively studied.
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