当前位置: 首页 >> 检索结果
3121. Fibrin D-dimer and beta-thromboglobulin as markers of thrombogenesis and platelet activation in atrial fibrillation. Effects of introducing ultra-low-dose warfarin and aspirin.
作者: G Y Lip.;P L Lip.;J Zarifis.;R D Watson.;D Bareford.;G D Lowe.;D G Beevers.
来源: Circulation. 1996年94卷3期425-31页
Previous studies have demonstrated increased markers of thrombogenesis in patients with atrial fibrillation (AF), suggesting the presence of a hypercoagulable or prothrombotic state. The objective of this study was to determine the effects of introducing ultra-low-dose warfarin (1 mg), conventional warfarin, and aspirin. (300 mg) therapy on thrombogenesis and platelet activation in AF.
3122. Diltiazem improves cardiac function and exercise capacity in patients with idiopathic dilated cardiomyopathy. Results of the Diltiazem in Dilated Cardiomyopathy Trial.
作者: H R Figulla.;F Gietzen.;U Zeymer.;M Raiber.;J Hegselmann.;R Soballa.;R Hilgers.
来源: Circulation. 1996年94卷3期346-52页
Evidence is arising that calcium antagonists in idiopathic dilated cardiomyopathy (IDC) may have beneficial effects on virus-induced cardiopathology, alcohol toxicity, micro-circulatory disorders, and impaired calcium cycling, all possibly involved in the pathogenesis of the disease. Thus, the effect of adjunct diltiazem (60 to 90 mg TID) on standard treatment was investigated.
3123. Beneficial effects of RheothRx injection in patients receiving thrombolytic therapy for acute myocardial infarction. Results of a randomized, double-blind, placebo-controlled trial.
作者: G L Schaer.;L J Spaccavento.;K F Browne.;K A Krueger.;D Krichbaum.;J M Phelan.;W O Fletcher.;C L Grines.;S Edwards.;M K Jolly.;R J Gibbons.
来源: Circulation. 1996年94卷3期298-307页
RheothRx (poloxamer 188) is a surfactant with hemorheological and antithrombotic properties that reduces myocardial reperfusion injury in animal models of myocardial infarction. The purpose of the present study was to evaluate the safety and efficacy of adjunctive therapy with poloxamer 188 in patients receiving thrombolytic therapy for acute myocardial infarction.
3124. Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Québec cardiovascular study.
作者: B Lamarche.;S Moorjani.;P J Lupien.;B Cantin.;P M Bernard.;G R Dagenais.;J P Després.
来源: Circulation. 1996年94卷3期273-8页
Results obtained largely from case-control studies have suggested that an elevated plasma concentration of apolipoprotein (apo) B may be considered an important risk factor for ischemic heart disease (IHD). Prospective data on the relevance of measuring apo A-I and apo B levels in the assessment of IHD risk, however, remain sparse as well as controversial.
3125. Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing ENdothelial Dysfunction) Study.
作者: G B Mancini.;G C Henry.;C Macaya.;B J O'Neill.;A L Pucillo.;R G Carere.;T J Wargovich.;H Mudra.;T F Lüscher.;M I Klibaner.;H E Haber.;A C Uprichard.;C J Pepine.;B Pitt.
来源: Circulation. 1996年94卷3期258-65页
Angiotensin-converting enzyme (ACE) inhibitors may exert some of their benefits in the therapy of hypertension, congestive heart failure, and acute myocardial infarction by their improvement of endothelial dysfunction. TREND (Trial on Reversing ENdothelial Dysfunction) investigated whether quinapril might improve endothelial dysfunction in normotensive patients with coronary artery disease and no heart failure, cardiomyopathy, or major lipid abnormalities so that confounding variables that affect endothelial dysfunction could be minimized.
3126. Quality of life, employment status, and anginal symptoms after coronary angioplasty or bypass surgery. 3-year follow-up in the Randomized Intervention Treatment of Angina (RITA) Trial.
The Randomized Intervention Treatment of Angina (RITA) trial compares initial policies of percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass graft surgery (CABG) in 1011 patients with angina. This report assesses the impact of these revascularization procedures on angina, quality of life (according to the Nottingham Health Profile), and employment over 3 years of follow-up.
3127. Modulation of oxidant stress in vivo in chronic cigarette smokers.
Free radical-induced oxidative damage is thought to be involved in the pathogenesis of diseases associated with cigarette smoking. We examined the production of 8-epi-prostaglandin (PG) F2 alpha, a stable product of lipid peroxidation in vivo, and its modulation by aspirin and antioxidant vitamins in chronic cigarette smokers.
3128. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure.
作者: T S Rector.;A J Bank.;K A Mullen.;L K Tschumperlin.;R Sih.;K Pillai.;S H Kubo.
来源: Circulation. 1996年93卷12期2135-41页
Patients with heart failure have reduced peripheral blood flow at rest, during exercise, and in response to endothelium-dependent vasodilators. Nitric oxide formed from L-arginine metabolism in endothelial cells contributes to regulation of blood flow under these conditions. A randomized, double-blind crossover study design was used to determine whether supplemental oral L-arginine can augment peripheral blood flow and improve functional status in patients with moderate to severe heart failure.
3129. Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators.
作者: B M Massie.;S G Fisher.;M Radford.;P C Deedwania.;B N Singh.;R D Fletcher.;S N Singh.
来源: Circulation. 1996年93卷12期2128-34页
Although trials of amiodarone therapy in patients with congestive heart failure have produced discordant results with regard to effects on survival, most studies have reported a significant rise in left ventricular ejection fraction during long-term therapy. In the present study, we determined whether this increase in ejection fraction is associated with an improvement in the symptoms and/or physical findings of heart failure or a reduction in the number of hospitalizations for heart failure.
3130. Diabetics with coronary disease have a prevalence of asymptomatic ischemia during exercise treadmill testing and ambulatory ischemia monitoring similar to that of nondiabetic patients. An ACIP database study. ACIP Investigators. Asymptomatic Cardiac Ischemia Pilot Investigators.
作者: E A Caracciolo.;B R Chaitman.;S A Forman.;P H Stone.;M G Bourassa.;G Sopko.;N L Geller.;C R Conti.
来源: Circulation. 1996年93卷12期2097-105页
There are conflicting data as to whether diabetics have a higher prevalence of asymptomatic ST-segment depression during exercise treadmill testing (ETT) and ambulatory ECG (AECG) monitoring. This study was conducted to determine whether diabetic patients with coronary disease enrolled in the Asymptomatic Cardiac Ischemia Pilot (ACIP) have more episodes of asymptomatic ischemia during ETT and 48-hour AECG monitoring than nondiabetic patients and to compare differences in angiographic variables and the magnitude of ischemia as measured by standard ETT and AECG criteria.
3131. Effects of brain natriuretic peptide on exercise hemodynamics and neurohormones in isolated diastolic heart failure.
作者: P B Clarkson.;N M Wheeldon.;R J MacFadyen.;S D Pringle.;T M MacDonald.
来源: Circulation. 1996年93卷11期2037-42页
Experimental models suggest that brain natriuretic peptide (BNP) can modify left ventricular diastolic performance. The aim of this study was to evaluate the effects of BNP on resting and exercise hemodynamics and neurohormones in patients with isolated diastolic heart failure.
3132. Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction. Comparison with plasma atrial natriuretic peptide and N-terminal proatrial natriuretic peptide.
作者: T Omland.;A Aakvaag.;V V Bonarjee.;K Caidahl.;R T Lie.;D W Nilsen.;J A Sundsfjord.;K Dickstein.
来源: Circulation. 1996年93卷11期1963-9页
Elevated plasma levels of atrial natriuretic peptide (ANP) and the N-terminal fragment of the ANP prohormone (N-ANP) are associated with decreased left ventricular function and decreased long-term survival after acute myocardial infarction (AMI). Previous data suggest that plasma brain natriuretic peptide (BNP) may increase proportionally more than plasma ANP after AMI and in chronic heart failure. The diagnostic and prognostic value of plasma BNP as an indicator of left ventricular dysfunction and long-term survival after AMI, relative to that of ANP and N-ANP, remain to be established.
3133. Effectiveness of revascularization in the Emory angioplasty versus surgery trial. A randomized comparison of coronary angioplasty with bypass surgery.
作者: X Q Zhao.;B G Brown.;D K Stewart.;L A Hillger.;H X Barnhart.;A S Kosinski.;W S Weintraub.;S B King.
来源: Circulation. 1996年93卷11期1954-62页
The Emory Angioplasty Versus Surgery Trial (EAST) was designed to determine whether percutaneous transluminal coronary angioplasty (PTCA) is as effective as coronary artery bypass graft surgery (CABG) in restoring arterial perfusion capacity in eligible patients with multivessel disease.
3134. Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans.
作者: W G Haynes.;C J Ferro.;K P O'Kane.;D Somerville.;C C Lomax.;D J Webb.
来源: Circulation. 1996年93卷10期1860-70页
Although local inhibition of the generation or actions of endothelin-1 has been shown to cause forearm vasodilatation, the systemic effects of endothelin receptor blockade in healthy humans are unknown. We therefore investigated the cardiovascular effects of a potent peptide endothelin ETA/B receptor antagonist, TAK-044, in healthy men.
3135. LDL-Apheresis Atherosclerosis Regression Study (LAARS). Effect of aggressive versus conventional lipid lowering treatment on coronary atherosclerosis.
作者: A A Kroon.;W R Aengevaeren.;T van der Werf.;G J Uijen.;J H Reiber.;A V Bruschke.;A F Stalenhoef.
来源: Circulation. 1996年93卷10期1826-35页
Intensive lipid lowering may retard the progression of coronary atherosclerosis. LDL-apheresis has the potential to decrease LDL cholesterol to very low levels. To assess the effect of more aggressive lipid lowering with LDL-apheresis, we set up a randomized study in men with hypercholesterolemia and severe coronary atherosclerosis.
3136. Cholesterol lowering and the use of healthcare resources. Results of the Scandinavian Simvastatin Survival Study.
作者: T R Pedersen.;J Kjekshus.;K Berg.;A G Olsson.;L Wilhelmsen.;H Wedel.;K Pyörälä.;T Miettinen.;T Haghfelt.;O Faergeman.;G Thorgeirsson.;B Jönsson.;J S Schwartz.
来源: Circulation. 1996年93卷10期1796-802页
Advances in the treatment of cardiovascular disease have increased costs; annual cardiovascular healthcare expenditure in the United States currently exceeds $100 billion. Physicians and third-party payers need to assess the economic impact of treatments that reduce cardiovascular morbidity and mortality.
3137. Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy.
作者: G Brevetti.;F di Lisa.;S Perna.;R Menabó.;R Barbato.;V D Martone.;N Siliprandi.
来源: Circulation. 1996年93卷9期1685-9页
Carnitine metabolism is altered in peripheral arterial disease. L-carnitine supplementation may correct these alterations and improve walking performance.
3138. Relation between troponin T and the risk of subsequent cardiac events in unstable coronary artery disease. The FRISC study group.
Early risk assessment is important in patients with unstable coronary artery disease, ie, unstable angina or non-Q-wave myocardial infarction. Some previous small studies have indicated that patients with unstable angina and elevation of troponin T (tn-T) have worse short-term and long-term prognoses. In this study, the prognostic value of tn-T was evaluated and compared with other early available risk indicators.
3139. Leukocyte depletion attenuates reperfusion injury in patients with left ventricular hypertrophy.
作者: Y Sawa.;K Taniguchi.;K Kadoba.;M Nishimura.;H Ichikawa.;A Amemiya.;T Kuratani.;H Matsuda.
来源: Circulation. 1996年93卷9期1640-6页
Reperfusion injury can occur after a long period of aortic cross-clamping in patients with left ventricular hypertrophy during open-heart surgery, even with the most up-to-date techniques of myocardial protection. In the present study, we examined whether leukocyte depletion as an adjunct to terminal blood cardioplegia (LDTC) attenuates reperfusion injury in patients with left ventricular hypertrophy (LV mass, >300 g; left ventricular end-systolic volume index, >100 mL/m2) in a group of 30 patients undergoing aortic valve replacement.
3140. Prediction of successful ablation site of concealed posteroseptal accessory pathways by a novel algorithm using baseline electrophysiological parameters: implication for an abbreviated ablation procedure.
作者: C E Chiang.;S A Chen.;C T Tai.;T J Wu.;S H Lee.;C C Cheng.;C W Chiou.;K C Ueng.;Z C Wen.;M S Chang.
来源: Circulation. 1996年93卷5期982-91页
Radiofrequency catheter ablation of concealed posteroseptal accessory pathways (APS) has been a relatively difficult task for electrophysiologists. Without a detailed mapping procedure, the left versus the right posteroseptal AP could not be distinguished. We investigated the electrophysiological characteristics of concealed posteroseptal APs and defined criteria from baseline parameters to predict the successful ablation site. Validity of the criteria was prospectively verified.
|