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281. Diagnostic and clinical relevance of targeted metabolomic analysis of serum bile acid profiles in acute pancreatitis.
This study aims to identify specific bile acids with potential early diagnostic value for acute pancreatitis (AP) and to provide a foundation for improved early diagnosis and the development of future therapeutic targets.
282. A cost-effective measure to prevent hemorrhage in ultrasound-guided percutaneous liver biopsy.
Liver biopsy is a procedure whereby a biopsy needle is used to extract tissue from the liver parenchyma or focal lesions of the liver for pathological or microbiological examination. Percutaneous liver biopsy(PC-LB) is the most commonly employed and least expensive modality. However, it is associated with a significant risk of bleeding complications, which may potentially result in patient mortality. The objective of this study was to investigate the efficacy of Absorbable Gelatin Sponge sheet filler agent (AGS-SFA) in preventing bleeding complications during liver tissue biopsy and to validate a cost-effective surgical technique.
283. THSD7A as a novel prognostic factor for colorectal carcinoma.
作者: Oktay Halit Aktepe.;Olcay Kurtulan.;Pinar Ezgi Dama.;Ahmet Melih Arslan.;Elif Atag.;Meral Uner.;Berfu Korucu.;Aziz Karaoglu.;Suayib Yalcin.
来源: BMC Gastroenterol. 2025年25卷1期179页
Thrombospondin type 1 domain-containing 7 A (THSD7A) expression, an angiogenesis-related protein, has been implicated in various aspects of cancer progression, reflecting its potential as a prognostic marker for various cancers. Therefore, we investigated the prognostic value of THSD7A expression in colorectal cancer (CRC).
284. Association between vitamin C, D, and K intake and inflammatory bowel disease risk: findings from 2009 to 2010 NHANES.
Micronutrient deficiency is commonly observed in patients with inflammatory bowel disease (IBD), yet the role of certain dietary trace elements in the risk of IBD development remains unclear.
285. Using a nomogram based on the controlling nutritional status score to predict prognosis after surgery in patients with resectable gastric cancer.
作者: Xinghao Ma.;Xiaoyang Jiang.;Hao Guo.;Jiajia Wang.;Tingting Wang.;Jiahu Yao.;Song Liang.;Xiuming Lu.;Chuanxia Wang.;Chuansi Wang.
来源: BMC Gastroenterol. 2025年25卷1期180页
Various studies have shown that the controlling nutritional status (CONUT) score contributes to assessing the prognosis of cancer patients. This study aimed to establish a nomogram based on the CONUT score and several other important parameters based on patient age and tumor characteristics to accurately forecast the overall survival (OS) of patients with resectable gastric cancer (GC).
286. Evolution of Esophageal Adenocarcinoma From Precursor Lesion Stem Cells.
作者: Wa Xian.;Shan Wang.;Jingzhong Xie.;Yusuke Yamamoto.;Melina Khorrami.;Yanting Zhang.;Raul Caballero Montes.;Caycel Desales.;Melika Khorrami.;Zaal Mory.;Ashley Hoffman.;Amber Su.;Crystal Nguyen.;Peter J A Davies.;Clifford Stephan.;Shuang Pan.;Wengen Wu.;Yuxin Liu.;Jeremy Siegelman.;Rebecca E Waters.;William A Ross.;Shumei Song.;Mark Metersky.;David G Beer.;Christopher P Crum.;Alexander J Stewart.;Matthew Vincent.;Richard Russell.;Robert A Izard.;Khek Yu Ho.;Jack Hung-Sen Lai.;William W Bachovchin.;Jaffer A Ajani.;Frank D McKeon.
来源: Gastroenterology. 2025年
Metastatic cancers arise from a decades-long succession of increasingly virulent precursor lesions, each of which represents prospective targets for therapeutic intervention. This evolutionary process has been particularly vivid in esophageal adenocarcinoma (EAC), as this cancer and associated precursor lesions, including Barrett's esophagus (BE), low-grade dysplasia (LGD), and high-grade dysplasia (HGD), coexist in an accessible, 2-dimensional pattern in esophageal mucosa. Given the durability of these precursor lesions, it is likely that they, like EAC, rely on stem cells for their regenerative growth. To assess the role of stem cells in the evolution of EAC, we apply technology that selectively clones stem cells from the gastrointestinal tract to patient-matched endoscopic biopsies from each of the precursor lesions implicated in EAC.
287. Endoscopic treatment for gastroesophageal varices in patients with cirrhosis: a survey comparing between developed and developing countries.
作者: Wenhui Zhang.;Ning Kang.;Yanling Wang.;Fulong Zhang.;Jianbo Xue.;Enqiang Linghu.
来源: BMC Gastroenterol. 2025年25卷1期176页
In this survey, we compared endoscopists' approach to treatment of gastroesophageal varices (GOV) in patients with cirrhosis between developed and developing countries. The objective of this study was to undertake a comparative analysis of the approaches employed by endoscopists in developed and developing countries with regard to the treatment of GOV in patients with cirrhosis.
288. Factors associated with lymph node metastasis and survival in T2 colon cancer.
This study aimed to explore the clinical factors associated with lymph node metastasis (LNM) and survival in T2 colon cancer.
289. A prospective randomized study of the efficacy of continuous active warming in patients undergoing laparoscopic gastrectomy.
作者: Mengjia Luo.;Yanran Dai.;Xiangying Feng.;Yujie Wang.;Xin Guo.;Juan Du.;Gang Ji.;Hongjuan Lang.
来源: BMC Gastroenterol. 2025年25卷1期174页
The RCT study on the efficacy of continuous active warming (CAW) in patients undergoing laparoscopic gastrectomy is scarce. The purpose of this research was to determine if a significant difference between continuous active warming (CAW) and active warming when body temperature is below 36 °C (BAW) in terms of incidence of intraoperative hypothermia and clinical rehabilitation in patients undergoing laparoscopic gastrectomy surgery.
290. Efficacy and safety of pembrolizumab in advanced gastric and gastroesophageal junction cancer: a systematic review and meta-analysis.
作者: Xiaoying Ji.;Guoping Wang.;Dandan Pan.;Shanxia Xu.;Xinming Lei.
来源: BMC Gastroenterol. 2025年25卷1期173页
Pembrolizumab, a PD-1 inhibitor, has shown potential for treating advanced gastric and gastroesophageal junction (GEJ) cancer. This meta-analysis evaluates its efficacy and safety, alone or combined with chemotherapy, in this population.
291. Mucosal Macrophages Govern Intestinal Regeneration in Response to Injury.
作者: Ilias Moraitis.;Jasin Taelman.;Borja Arozamena.;Loris Mularoni.;Olga Wienskowska.;Xavier Sanjuan Garriga.;Laura Arregui.;Milica Stefanovic.;Ignasi Modolell Farré.;Ferran Guedea.;Mònica Diaz.;Jordi Guiu.
来源: Gastroenterology. 2025年169卷1期119-135.e26页
Radiation-induced enteritis develops in cancer patients treated with radiotherapy in the abdominal and pelvic cavity, a condition that impairs their quality of life. Radiation injury depletes proliferative intestinal stem cells; in response to this, the epithelium activates a regenerative program that facilitates the healing of the intestine. However, the mechanisms that induce the activation of the intestinal regenerative program are poorly characterized.
292. Estimated sdLDL-C as a biomarker of hepatic steatosis severity in MASLD: a retrospective study.
作者: Shuo Jiang.;Fan Zhang.;Hui Yang.;Xue Han.;Jieru Mao.;Guojun Zheng.;Yan Fan.
来源: BMC Gastroenterol. 2025年25卷1期168页
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide. However, there is a lack of cost-effective and accurate biomarkers to assess the degree of hepatic steatosis. Estimated small dense low-density lipoprotein cholesterol (EsdLDL-C), a calculated value derived from triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) levels, has emerged as a potential indicator. This study aimed to explore the relationship between EsdLDL-C and the severity of hepatic steatosis.
293. Biological age prediction and NAFLD risk assessment: a machine learning model based on a multicenter population in Nanchang, Jiangxi, China.
作者: Lianrui Deng.;Jing Huang.;Hang Yuan.;Qiangdong Liu.;Weiming Lou.;Pengfei Yu.;Xiaohong Xie.;Xuyu Chen.;Yang Yang.;Li Song.;Libin Deng.
来源: BMC Gastroenterol. 2025年25卷1期172页
The objective was to develop a biological age prediction model (NC-BA) for the Chinese population to enrich the relevant studies in this population. And to investigate the association between accelerated age and NAFLD.
294. Colitis can reduce the cingulate cortex neuronal density in rats.
作者: Fazel Isapanah Amlashi.;Sima Besharat.;Mehrdad Jahanshahi.;Hesamaddin Shirzad-Aski.;Fatemeh Nassaj Torshizi.
来源: BMC Gastroenterol. 2025年25卷1期171页
Hyperalgesia and hypersensitivity in patients with Inflammatory Bowel Disease (IBD) can be related to central nervous system (CNS) changes, particularly in the pain pathways. The objective of this study was to examine the neuronal density of the cingulate cortex area (CC) and amygdala in an animal model of colitis.
295. One in three adenomas could be missed by white-light colonoscopy - findings from a systematic review and meta-analysis.
作者: Beate Jahn.;Marvin Bundo.;Marjan Arvandi.;Monika Schaffner.;Jovan Todorovic.;Gaby Sroczynski.;Amy Knudsen.;Timo Fischer.;Irmgard Schiller-Fruehwirth.;Dietmar Öfner.;Friedrich Renner.;Michael Jonas.;Igor Kuchin.;Julia Kruse.;Júlia Santamaria.;Monika Ferlitsch.;Uwe Siebert.
来源: BMC Gastroenterol. 2025年25卷1期170页
White light (conventional) colonoscopy (WLC) is widely used for colorectal cancer screening, diagnosis and surveillance but endoscopists may fail to detect adenomas. Our goal was to assess and synthesize overall and subgroup-specific adenoma miss rates (AMR) of WLC in daily practice.
296. Clinical value of systemic immunoinflammatory index in predicting recurrence and metastasis in patients with primary liver cancer.
作者: Yang Deng.;Zhili Chen.;Qiufeng He.;Bei Wu.;Ting Su.;Chuangjie Mao.;Rong Hu.
来源: BMC Gastroenterol. 2025年25卷1期169页
Primary liver cancer is a highly aggressive neoplasm with high incidence and mortality. Due to the high ability to metastasis, the 5-year survival rate of patients with primary liver cancer is poor.
297. The association between the dietary index for gut microbiota and non-alcoholic fatty liver disease and liver fibrosis: evidence from NHANES 2017-2020.
作者: Ce Zheng.;Zeming Qi.;Rui Chen.;Zhixiong Liao.;Lanfeng Xie.;Fumang Zhang.
来源: BMC Gastroenterol. 2025年25卷1期163页
Imbalance in the gut microbiota is a key factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis. The Dietary Index for Gut Microbiota (DI-GM) integrates the potential relationship between diet and gut microbiota diversity. This study aims to investigate the association between DI-GM and the risk of NAFLD and liver fibrosis, providing theoretical support for dietary intervention strategies.
298. Comparing the bowel cleansing efficacy between sodium picosulfate vs. 2L polyethylene glycol electrolyte lavage solution for colonoscopy: a prospective observational study.
作者: Jing Shan.;Yang Su.;Dan Luo.;Lin Jiang.;Chen Zhang.;Yifeng Liu.;Xiaobin Sun.
来源: BMC Gastroenterol. 2025年25卷1期164页
This study aimed to compare the bowel cleansing efficacy, adverse reactions, and patient compliance of two low-volume bowel preparation regimens, sodium picosulfate (PICO) and 2 L polyethylene glycol electrolyte lavage solution (2 L PEG-ELS).
299. Readmission of patients with hypertriglyceridemia-induced acute pancreatitis: a prospective cohort study.
作者: Yuxiang Liu.;Ling Ding.;Xin Xu.;Langyi Guan.;Wenhua He.;Liang Xia.;Nonghua Lu.;Yin Zhu.
来源: BMC Gastroenterol. 2025年25卷1期167页
Acute pancreatitis (AP) is a common cause of acute hospital admissions in digestive system diseases. In East Asia, hypertriglyceridemia is gradually emerged as the second most common cause of pancreatitis. Vigilance for recurrence and unplanned readmissions due to other causes is still necessary after discharge. studies on hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are scarce and mainly consists of retrospective studies.
300. Low-residue diet with oral nutritional supplements prior to colonoscopy improves the quality of bowel preparation: an endoscopist-blinded, randomized controlled trial.
作者: Huilin Shen.;Yijie Sun.;Jin Qian.;Jiaqi Wu.;Xueqing Zhong.;Guodong Li.;Weimin Li.
来源: BMC Gastroenterol. 2025年25卷1期166页
Poor bowel preparation has been a great problem of endoscopists for a long time. Low-residue diet (LRD) is often recommended on the day before colonoscopy. However, the quality of bowel preparation with LRD alone is suboptimal. The aim of our study was to examine whether patients who consumed LRD with oral nutritional supplements (ONSs) had higher quality of bowel preparation than patients who consumed LRD alone before colonoscopy.
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