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281. Association of Echocardiographic Parameters and Health Status in Patients With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM.
作者: Suzanne V Arnold.;Kensey L Gosch.;Chantal Dolan.;Jennifer T Fine.;Ahmad Masri.;Sara Saberi.;Andrew Wang.;Perry M Elliott.;Sheila M Hegde.;Jenny Lam.;Amy J Sehnert.;Sharon Cresci.;Richard G Bach.;John A Spertus.
来源: Circulation. 2024年150卷19期1560-1562页 282. Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol-Mediated Cardiovascular Risk: A Participant-Level Meta-Analysis.
作者: Harpreet S Bhatia.;Simon Wandel.;Peter Willeit.;Anastasia Lesogor.;Keith Bailey.;Paul M Ridker.;Paul Nestel.;John Simes.;Andrew Tonkin.;Gregory G Schwartz.;Helen Colhoun.;Christoph Wanner.;Sotirios Tsimikas.
来源: Circulation. 2025年151卷4期312-321页
Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) levels are independently associated with atherosclerotic cardiovascular disease (ASCVD). However, the relationship between Lp(a) level, LDL-C level, and ASCVD risk at different thresholds is not well defined.
283. Validation of the Valve Academic Research Consortium High Bleeding Risk Definition in Patients Undergoing TAVR.
作者: Marisa Avvedimento.;Pedro Cepas-Guillén.;Julien Ternacle.;Marina Urena.;Alberto Alperi.;Asim Cheema.;Gabriela Veiga-Fernandez.;Luis Nombela-Franco.;Victoria Vilalta.;Giovanni Esposito.;Francisco Campelo-Parada.;Ciro Indolfi.;Maria Del Trigo.;Antonio Muñoz-Garcia.;Nicolás Maneiro.;Lluís Asmarats.;Ander Regueiro.;David Del Val.;Vicenç Serra.;Vincent Auffret.;Thomas Modine.;Guillaume Bonnet.;Jules Mesnier.;Gaspard Suc.;Pablo Avanzas.;Effat Rezaei.;Victor Fradejas-Sastre.;Gabriela Tirado-Conte.;Eduard Fernández-Nofrerias.;Anna Franzone.;Thibaut Guitteny.;Sabato Sorrentino.;Juan Francisco Oteo.;Jorge Nuche.;Lola Gutiérrez-Alonso.;Eduardo Flores-Umanzor.;Fernando Alfonso.;Andrea Monastyrski.;Maxime Nolf.;Mélanie Côté.;Roxana Mehran.;Marie-Claude Morice.;Davide Capodanno.;Philippe Garot.;Josep Rodés-Cabau.
来源: Circ Cardiovasc Interv. 2025年18卷1期e014800页
The Valve Academic Research Consortium for High Bleeding Risk (VARC-HBR) has recently introduced a consensus document that outlines risk factors to identify high bleeding risk in patients undergoing transcatheter aortic valve replacement. The objective of the present study was to evaluate the prevalence and predictive value of the VARC-HBR definition in a contemporary, large-scale transcatheter aortic valve replacement population.
284. Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial.
作者: Wissam A Jaber.;Carin F Gonsalves.;Stefan Stortecky.;Samuel Horr.;Orestis Pappas.;Ripal T Gandhi.;Keith Pereira.;Jay Giri.;Sameer J Khandhar.;Khawaja Afzal Ammar.;David M Lasorda.;Brian Stegman.;Lucas Busch.;David J Dexter.;Ezana M Azene.;Nikhil Daga.;Fakhir Elmasri.;Chandra R Kunavarapu.;Mark E Rea.;Joseph S Rossi.;Joseph Campbell.;Jonathan Lindquist.;Adam Raskin.;Jason C Smith.;Thomas M Tamlyn.;Gabriel A Hernandez.;Parth Rali.;Torrey R Schmidt.;Jeffrey T Bruckel.;Juan C Camacho.;Jun Li.;Samy Selim.;Catalin Toma.;Sukhdeep Singh Basra.;Brian A Bergmark.;Bhavraj Khalsa.;David M Zlotnick.;Jordan Castle.;David J O'Connor.;C Michael Gibson.; .
来源: Circulation. 2025年151卷5期260-273页
There are a lack of randomized controlled trial data comparing outcomes of different catheter-based interventions for intermediate-risk pulmonary embolism.
285. Impacts of Hospital Volume and Patient-Hospital Distances on Outcomes of Older Adults Receiving Percutaneous Microaxial Ventricular Assist Devices for Cardiogenic Shock.
作者: Atsuyuki Watanabe.;Yoshihisa Miyamoto.;Hiroki A Ueyama.;Hiroshi Gotanda.;Jacob C Jentzer.;Navin K Kapur.;Ulrich P Jorde.;Yusuke Tsugawa.;Toshiki Kuno.
来源: Circ Cardiovasc Interv. 2024年17卷12期e014738页
Percutaneous microaxial ventricular assist devices (pVADs) have the potential to reduce mortality of patients with cardiogenic shock (CS). However, the association between the distribution of pVAD-performing centers and outcomes of CS has not been explored.
286. Cardiovascular Disease Pathogenicity Predictor (CVD-PP): A Tissue-Specific In Silico Tool for Discriminating Pathogenicity of Variants of Unknown Significance in Cardiovascular Disease Genes.
作者: Megan E Ramaker.;Jawan W Abdulrahim.;Kristin M Corey.;Ryne C Ramaker.;Lydia Coulter Kwee.;William E Kraus.;Svati H Shah.
来源: Circ Genom Precis Med. 2024年17卷6期e004464页
Interpretation of variants of uncertain significance (VUSs) remains a challenge in the care of patients with inherited cardiovascular diseases (CVDs); 56% of variants within CVD risk genes are VUS, and machine learning algorithms trained upon large data resources can stratify VUS into higher versus lower probability of contributing to a CVD phenotype.
288. Effect of Acoramidis on Myocardial Structure and Function in Transthyretin Amyloid Cardiomyopathy: Insights From the ATTRibute-CM Cardiac Magnetic Resonance (CMR) Substudy.
作者: Yousuf Razvi.;Daniel P Judge.;Ana Martinez-Naharro.;Adam Ioannou.;Lucia Venneri.;Rishi Patel.;Julian D Gillmore.;Peter Kellman.;Laura Edwards.;Jorg Taubel.;Jing Du.;Jean-François Tamby.;Adam Castaño.;Suresh Siddhanti.;Leonid Katz.;Jonathan C Fox.;Marianna Fontana.
来源: Circ Heart Fail. 2024年17卷12期e012135页 289. Association Between Delay to First Shock and Successful First-Shock Ventricular Fibrillation Termination in Patients With Witnessed Out-of-Hospital Cardiac Arrest.
作者: Remy Stieglis.;Bas J Verkaik.;Hanno L Tan.;Rudolph W Koster.;Hans van Schuppen.;Christian van der Werf.
来源: Circulation. 2025年151卷3期235-244页
In patients with out-of-hospital cardiac arrest who present with an initial shockable rhythm, a longer delay to the first shock decreases the probability of survival, often attributed to cerebral damage. The mechanisms of this decreased survival have not yet been elucidated. Estimating the probability of successful defibrillation and other factors in relation to the time to first shock may guide prehospital care systems to implement policies that improve patient survival by decreasing time to first shock.
290. Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Coronary Artery Disease.
作者: Michael J Foley.;Christopher A Rajkumar.;Fiyyaz Ahmed-Jushuf.;Florentina Simader.;Shayna Chotai.;Henry Seligman.;Krzysztof Macierzanka.;John R Davies.;Thomas R Keeble.;Peter O'Kane.;Peter Haworth.;Helen Routledge.;Tushar Kotecha.;Gerald Clesham.;Rupert Williams.;Jehangir Din.;Sukhjinder S Nijjer.;Nick Curzen.;Manas Sinha.;Ricardo Petraco.;James Spratt.;Sayan Sen.;Graham D Cole.;Frank E Harrell.;James P Howard.;Darrel P Francis.;Matthew J Shun-Shin.;Rasha Al-Lamee.; .
来源: Circulation. 2025年151卷3期202-214页
ORBITA-2 (the Placebo-Controlled Trial of Percutaneous Coronary Intervention for the Relief of Stable Angina) provided evidence for the role of percutaneous coronary intervention (PCI) for angina relief in stable coronary artery disease. Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are often used to guide PCI; however, their ability to predict placebo-controlled angina improvement is unknown.
293. Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial.
作者: Elric Zweck.;Christian Hassager.;Rasmus P Beske.;Lisette O Jensen.;Hans Eiskjær.;Norman Mangner.;Amin Polzin.;P Christian Schulze.;Carsten Skurk.;Peter Nordbeck.;Peter Clemmensen.;Vasileios Panoulas.;Sebastian Zimmer.;Andreas Schäfer.;Malte Kelm.;Thomas Engstrøm.;Lene Holmvang.;Anders Junker.;Henrik Schmidt.;Christian J Terkelsen.;Axel Linke.;Ralf Westenfeld.;Jacob E Møller.; .
来源: Circulation. 2024年150卷25期1990-2003页
In DanGer Shock (the Danish-German Cardiogenic Shock trial), use of a microaxial flow pump (mAFP) in patients with ST-segment-elevation myocardial infarction-related cardiogenic shock led to lower all-cause mortality but higher rates of renal replacement therapy (RRT). In this prespecified analysis, rates and predictors of acute kidney injury (AKI) and RRT were assessed.
294. Using Atrial Fibrillation Burden Trends and Machine Learning to Predict Near-Term Risk of Cardiovascular Hospitalization.
作者: James Peacock.;Evan J Stanelle.;Lawrence C Johnson.;Elaine M Hylek.;Rahul Kanwar.;Dhanunjaya R Lakkireddy.;Suneet Mittal.;Rod S Passman.;Andrea M Russo.;Dana Soderlund.;Mellanie True Hills.;Jonathan P Piccini.
来源: Circ Arrhythm Electrophysiol. 2024年17卷11期e012991页
Atrial fibrillation is associated with an increased risk of cardiovascular hospitalization (CVH), which may be triggered by changes in daily burden. Machine learning of dynamic trends in atrial fibrillation burden, as measured by insertable cardiac monitors (ICMs), may be useful in predicting near-term CVH.
295. Performance of Atrial Fibrillation Burden Trends for Stroke Risk Stratification.
作者: Jonathan P Piccini.;Evan J Stanelle.;Cody C Johnson.;Elaine M Hylek.;Rahul Kanwar.;Dhanunjaya R Lakkireddy.;Suneet Mittal.;James Peacock.;Andrea M Russo.;Dana Soderlund.;Mellanie True Hills.;Rod S Passman.
来源: Circ Arrhythm Electrophysiol. 2024年17卷11期e012394页
Atrial fibrillation (AF) is associated with an increased risk of stroke, yet the limitations of conventional monitoring have restricted our understanding of AF burden risk thresholds. Predictive algorithms incorporating continuous AF burden measures may be useful for predicting stroke. This study evaluated the performance of temporal AF burden trends as predictors of stroke from a large cohort with insertable cardiac monitors.
296. Multicenter Hemodynamic Assessment of the LOT-CRT Strategy: When Does Combining Left Bundle Branch Pacing and Coronary Venous Pacing Enhance Resynchronization?: Primary Results of the CSPOT Study.
作者: Marek Jastrzębski.;Paul Foley.;Badrinathan Chandrasekaran.;Zachary Whinnett.;Pugazhendhi Vijayaraman.;Gaurav A Upadhyay.;Robert D Schaller.;Rafał Gardas.;Travis Richardson.;D'Anne Kudlik.;Robert W Stadler.;Patrick Zimmerman.;James Burrell.;Robert Waxman.;Richard N Cornelussen.;Jonathan Lyne.;Bengt Herweg.
来源: Circ Arrhythm Electrophysiol. 2024年17卷11期e013059页
Left bundle branch area pacing (LBBAP) may be an alternative to biventricular pacing (BVP) for cardiac resynchronization therapy (CRT). We sought to compare the acute hemodynamic and ECG effects of LBBAP, BVP, and left bundle-optimized therapy CRT (LOT-CRT) in CRT candidates with advanced conduction disease.
297. Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis.
作者: Johan O Wedin.;Viktor Näslund.;Sergey Rodin.;Oscar E Simonson.;Frank A Flachskampf.;Stefan K James.;Elisabeth Ståhle.;Karl-Henrik Grinnemo.
来源: Circulation. 2025年151卷5期288-298页
This study aimed to compare the incidence and prognostic implications of new-onset conduction disturbances after surgical aortic valve replacement (SAVR) in patients with bicuspid aortic valve (BAV) aortic stenosis (AS) versus patients with tricuspid aortic valve (TAV) AS (ie, BAV-AS and TAV-AS, respectively). Additionally, the study included stratification of BAV patients according to subtype.
300. Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations.
作者: Yang Yang.;Xiuju Wu.;Yan Zhao.;Daoqin Zhang.;Li Zhang.;Xinjiang Cai.;Jaden Ji.;Zheng Jing.;Kristina I Boström.;Yucheng Yao.
来源: Circulation. 2025年151卷5期299-317页
Arteriovenous malformations (AVMs) are characteristic of hereditary hemorrhagic telangiectasia. Loss-of-function mutations in the activin receptor-like kinase 1 (Alk1) are linked to hemorrhagic telangiectasia type 2.
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