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281. Oxygen Saturation Targets and Neurologic Outcomes Following Cardiac Arrest: A Secondary Analysis of the Pragmatic Investigation of Optimal Oxygen Targets Trial.
作者: Stephanie C DeMasi.;Alexander T Clark.;Amelia L Muhs.;Jin H Han.;Kipp Shipley.;Jared J McKinney.;Li Wang.;Todd W Rice.;Ari Moskowitz.;Matthew E Prekker.;Nicholas J Johnson.;Wesley H Self.;Jonathan D Casey.;Matthew W Semler.;Kevin P Seitz.; .
来源: Chest. 2025年
More than 600,000 adults in the United States experience an out-of-hospital or in-hospital cardiac arrest each year. Following resuscitation from cardiac arrest, most patients receive mechanical ventilation. The oxygenation target that optimizes neurologic outcomes following cardiac arrest is uncertain.
282. The Frequency and Predictors of Pulmonary Rehabilitation Referrals Among Patients With Pulmonary Arterial Hypertension: An Analysis of the Pulmonary Hypertension Association Registry.
作者: Morgan Bailey.;Robert Frantz.;Jasleen Minhas.;Thomas Cascino.;Charles Burger.;Oksana Shlobin.;Jeffrey Sager.;Abhijit Raval.;Matthew Lammi.;James Runo.;Thenappan Thenappan.;Teresa De Marco.;Ashwin Ravichandran.;Zeenat Safdar.;Daniel Lachant.;David Badesch.;Delphine Yung.;Hilary DuBrock.; .
来源: Chest. 2025年168卷4期996-1006页
Pulmonary arterial hypertension (PAH) is a complex cardiopulmonary disease associated with exertional dyspnea and impaired health-related quality of life (HRQOL) despite medical therapy. Pulmonary rehabilitation (PR), a supervised exercise program for patients with chronic lung disease, improves symptoms, HRQOL, and exercise capacity. Despite these benefits, there is a paucity of data regarding PR in PAH.
283. A Prospective, Multicenter Evaluation of Safety and Diagnostic Outcomes With Robotic-Assisted Bronchoscopy: Results of the Transbronchial Biopsy Assisted by Robot Guidance in the Evaluation of Tumors of the Lung (TARGET) Trial.
作者: Septimiu Murgu.;Alexander C Chen.;Christopher R Gilbert.;Daniel H Sterman.;Damaris Pederson.;Samaan Rafeq.;Balaji Laxmanan.;Michael L Schwiers.;Jaime Connelly.;Heather L Benz.;Kazuhiro Yasufuku.;Gerard A Silvestri.; .
来源: Chest. 2025年168卷2期539-555页
It remains challenging to safely and reliably biopsy peripheral pulmonary lesions (PPLs). Robotic-assisted bronchoscopy (RAB) is gaining adoption for navigation to PPLs. However, evidence from large studies remains limited.
284. Postoperative Lung Transplant Considerations in the Older Recipient.
作者: Sandrine Hanna.;Kristi Beermann.;Deborah J Levine.;Gabriel Loor.;Jonathan P Singer.;Patrick J Smith.;Hakim Azfar Ali.
来源: Chest. 2025年168卷2期435-448页
Lung transplantation (LTx) remains the ultimate treatment for many patients with advanced lung disease. Although the age cutoffs for LTx have been debated due to variable outcomes, the number of LTx procedures performed on patients aged ≥ 65 years has significantly increased in recent decades, reflecting the realities of an aging demographic. This trend underscores the unique management challenges faced by this cohort and highlights the importance of addressing evidence gaps in their perioperative and postoperative care.
285. Impact of COVID-19 on Pulmonary Critical Care Fellows In-Training Exam Performance: A National Study.
作者: Mahmoud Alwakeel.;Paru Patrawalla.;Brian Carlin.;Doreen Addrizzo-Harris.;John Mastronarde.;Joyce Reitzner.;Hiram L Rivas Perez.;Xiaofeng Wang.;Neal Chaisson.
来源: Chest. 2025年168卷3期710-718页
Between 2020 and 2022, the COVID-19 pandemic disrupted health and education. Many training institutions modified trainees' rotations, decreasing outpatient clinics while increasing inpatient and ICU time. Understanding the pandemic's impact on medical trainees' cognitive performance is essential for informing strategies and supporting trainee well-being during crises.
286. Exercise Hemodynamics and the Evolving Definition of Precapillary Pulmonary Hypertension.
作者: Louisa A Mounsey.;Ceanna J Kalaria.;Alyssa Kowal.;Casey Hoenstine.;Shania McGinnis.;Isabela Landsteiner.;Rajeev Malhotra.;Greg D Lewis.;Alexandra K Wong.;Alison S Witkin.;Josanna Rodriguez-Lopez.;C Corey Hardin.
来源: Chest. 2025年168卷3期780-784页 287. Association of Lung Quantitative CT Scan Textures With Systemic Inflammation and Mortality in COPD.
作者: Hira A Awan.;Muhammad F A Chaudhary.;Anthony D El-Sokkary.;Eric A Hoffman.;Alejandro P Comellas.;Junfeng Guo.;Igor Z Barjaktarevic.;R Graham Barr.;Surya P Bhatt.;Sandeep Bodduluri.;Russell P Bowler.;Luis G Vargas Buonfiglio.;Christopher B Cooper.;Ashraf Fawzy.;Annette T Hastie.;Wassim W Labaki.;Fernando J Martinez.;Martha G Menchaca.;Wanda O'Neal.;Robert Paine.;Joyce D Schroeder.;Prescott G Woodruff.;Jeffrey L Curtis.;Joseph M Reinhardt.
来源: Chest. 2025年
COPD is characterized by persistent inflammation that is responsible for remodeling the bronchovascular bundles (BVBs), which may lead to poor quality of life. Quantitative CT (QCT) scan textures of the lung can capture local disease patterns of inflammation and related respiratory morbidity.
288. Association of Physical Frailty With Incidence and Life Expectancy of COPD: A Population-Based Cohort Study.
作者: Chao Liu.;Hui Xiong.;Xia Han.;Yanling Lv.;Decai Wang.;Jiannan Hu.;Ziling Li.;Xinyue Ma.;Yunfei Zhu.;Shuyun Xu.;Liangkai Chen.
来源: Chest. 2025年168卷4期890-900页
The bidirectional relationship between frailty and COPD is documented. However, longitudinal studies examining the combined effects of genetic predisposition and preserved ratio impaired spirometry (PRISm) on frailty in COPD development are lacking.
289. XALOC-1: Clinical Remission Over 2 Years With Benralizumab in Severe Eosinophilic Asthma.
作者: Girolamo Pelaia.;David J Jackson.;Parameswaran Nair.;Benjamin Emmanuel.;Trung N Tran.;Andrew Menzies-Gow.;Michael Watt.;Sheena Kayaniyil.;Silvia Boarino.;Javier Nuevo.;Marisa Pardal.;Anat Shavit.;Vivian H Shih.;David Cohen.;Claudia Loureiro.;Alicia Padilla-Galo.
来源: Chest. 2025年168卷1期19-32页
Long-term real-world data on clinical remission in patients with severe eosinophilic asthma (SEA) receiving biologics are lacking. We describe clinical remission over 2 years in patients with SEA receiving benralizumab.
290. Forecasting the Global Economic and Health Burden of COPD From 2025 Through 2050.
作者: Elroy Boers.;Angier Allen.;Meredith Barrett.;Adam V Benjafield.;Mary B Rice.;Jadwiga A Wedzicha.;Leanne Kaye.;Heather J Zar.;Sanjeev Sinha.;Obianuju Ozoh.;Laura E Crotty Alexander.;Atul Malhotra.
来源: Chest. 2025年168卷4期880-889页
Studies have reported estimates of the economic and health burden of COPD. They have been limited largely to current-day estimates or relatively short-term future projections.
291. Local Anesthetic Use in Pleural Procedures: Time to Reconsider the Guidelines?
作者: Craig A Mounsey.;Imogen R Mechie.;Dinesh N Addala.;Rhea Suribhatla.;Zara O Small.;Ella M Smith.;Robyn A E Gould.;Grace A Annetts.;Daniela Krouzkova.;Nikolaos I Kanellakis.;Najib M Rahman.
来源: Chest. 2025年168卷3期839-842页 292. Clinical Impact of Tirzepatide on Patients With OSA and Obesity.
作者: Jheng-Yan Wu.;Chia-Chen Chen.;Wan Ling Tu.;Wan-Hsuan Hsu.;Ting-Hui Liu.;Ya-Wen Tsai.;Po-Yu Huang.;Min-Hsiang Chuang.;Kuo-Chuan Hung.;Tsung Yu.;Chih-Cheng Lai.
来源: Chest. 2025年168卷3期785-796页
OSA is a prevalent chronic condition linked to obesity that is associated with increased risks of cardiovascular and kidney disease. Although weight loss can improve OSA outcomes, additional effective therapeutic options are needed. Tirzepatide, a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, has shown promise in promoting significant weight loss and reducing OSA severity.
293. Coronary Artery Calcification Identified on Lung Cancer Screening CT Scans: A Scoping Review.
作者: Nada Al-Antary.;Kelly A Hirko.;Andrea E Cassidy-Bushrow.;Katie R Zarins.;Mike J Simoff.;Thomas Song.;Avi Cohen.;Christine Neslund-Dudas.
来源: Chest. 2025年168卷3期719-736页
Coronary artery calcification (CAC) can be a significant incidental finding on low-dose CT scans performed for lung cancer screening (LCS). CAC presence and grade hold important diagnostic and preventive value, particularly in patients without previously recognized coronary artery disease.
294. Characteristics, Prognosis, and European Society of Cardiology and European Respiratory Society Risk Stratification in Patients With Obesity and Pulmonary Arterial Hypertension.
作者: Giulio Savonitto.;Davide Barbisan.;Pietro Ameri.;Carlo Maria Lombardi.;Mauro Driussi.;Piero Gentile.;Luke Howard.;Matteo Toma.;Matteo Pagnesi.;Valentino Collini.;Carolina Bauleo.;Matteo Rugolotto.;Giovanni Santi.;Francesca Coppi.;Gianluca Pagnoni.;Pier Paolo Bocchino.;Claudia Raineri.;Alberto Giannoni.;Massimo Imazio.;Edoardo Airo.;Marco Metra.;Andrea Garascia.;Gianfranco Sinagra.;Francesco Lo Giudice.;Davide Stolfo.
来源: Chest. 2025年168卷3期749-762页
The impact of obesity on pulmonary arterial hypertension (PAH) remains largely underexplored, with excess weight potentially masking symptoms and affecting the reliability of current risk stratification tools.
295. Echocardiographic Parameters and Risk Prediction in Pulmonary Arterial Hypertension: Insights From the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Network.
作者: Monica Mukherjee.;Vivek P Jani.;Ryan Osgueritchian.;Hoda Mombeini.;Aiden Abidov.;Gerald Beck.;Serpil Erzurum.;Robert P Frantz.;Paul M Hassoun.;Anna R Hemnes.;Nicholas S Hill.;Evelyn M Horn.;Jiwon Kim.;Deborah Kwon.;A Brett Larive.;Peter J Leary.;Jane A Leopold.;Stephen C Mathai.;Reena Mehra.;Margaret M Park.;Erika B Rosenzweig.;W H Wilson Tang.;Christine L Jellis.;Franz P Rischard.;Roberto Badagliacca.; .
来源: Chest. 2025年168卷2期502-519页
Echocardiographic metrics of right ventricular (RV) chamber size and function enhance prognostication, risk stratification, and measurement of therapeutic response in patients with pulmonary arterial hypertension (PAH), though the most effective metrics remain unclear.
296. Machine Listening for OSA Diagnosis: A Bayesian Meta-Analysis.
作者: Benjamin Kye Jyn Tan.;Esther Yanxin Gao.;Nicole Kye Wen Tan.;Brian Sheng Yep Yeo.;Claire Jing-Wen Tan.;Adele Chin Wei Ng.;Zhou Hao Leong.;Chu Qin Phua.;Maythad Uataya.;Liang Chye Goh.;Thun How Ong.;Leong Chai Leow.;Guang-Bin Huang.;Song Tar Toh.
来源: Chest. 2025年168卷2期520-530页
Among 1 billion patients worldwide with OSA, 90% remain undiagnosed. The main barrier to diagnosis is the overnight polysomnogram, which requires specialized equipment, skilled technicians, and inpatient beds available only in tertiary sleep centers. Recent advances in artificial intelligence (AI) have enabled OSA detection using breathing sound recordings.
297. Characterizing Patients With Sarcoidosis With Obstructive Respiratory Physiology.
作者: Daniel VanDerhoef.;Nicholas Marka.;Benjamin Langworthy.;Nikhil Kapur.;Bharat Thayagarajan.;David M Perlman.;Maneesh Bhargava.
来源: Chest. 2025年168卷3期688-696页
Lung involvement occurs in > 95% of sarcoidosis cases. The World Association of Sarcoidosis and Other Granulomatous Disorders Organ Assessment Instrument does not assign the likelihood of lung involvement based on pulmonary function test (PFT) results. Clinical characteristics linked to normal and abnormal physiologic pattern on PFTs in sarcoidosis are incompletely understood.
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