287. A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis.
作者: Daniel Blockmans.;Sara K Penn.;Arathi R Setty.;Wolfgang A Schmidt.;Andrea Rubbert-Roth.;Ellen M Hauge.;Helen I Keen.;Tomonori Ishii.;Nader Khalidi.;Christian Dejaco.;Maria C Cid.;Bernhard Hellmich.;Meng Liu.;Weihan Zhao.;Ivan Lagunes.;Ana B Romero.;Peter K Wung.;Peter A Merkel.; .
来源: N Engl J Med. 2025年392卷20期2013-2024页
Giant-cell arteritis is a systemic vasculitis with limited treatment options. The efficacy and safety of upadacitinib - a selective Janus kinase (JAK) inhibitor that blocks the signaling of several cytokines, including interleukin-6 and interferon-γ - are unknown in patients with giant-cell arteritis.
294. Modest Blood Pressure Increase with Age in Adults with Down's Syndrome.
作者: Andrea Kelly.;Meghan Shirley Bezerra.;Kate Fitzpatrick.;Kat Adams.;Ahtish Arputhan.;Rachel Walega.;Patricia Y Chu.;John Cockcroft.;Raymond R Townsend.
来源: N Engl J Med. 2025年392卷13期1346-1348页 299. Association between Wealth and Mortality in the United States and Europe.
作者: Sara Machado.;Ilias Kyriopoulos.;E John Orav.;Irene Papanicolas.
来源: N Engl J Med. 2025年392卷13期1310-1319页
Amid growing wealth disparity, we have little information on how health among older Americans compares with that among older Europeans across the distribution of wealth.
300. The Genetic Architecture of Congenital Diarrhea and Enteropathy.
作者: Zeenat Gaibee.;Neil Warner.;Katlynn Bugda Gwilt.;Wenjuan Li.;Rei Guan.;Michael Yourshaw.;Ryder Whittaker Hawkins.;Christiane Zorbas.;Jonathan St-Germain.;Mahdi Tabatabaie.;Suli Mao.;Vered Pinsk.;Baruch Yerushalmi.;Lee-Kai Wang.;Stanley F Nelson.;Laura Wozniak.;Dror S Shouval.;Manar Matar.;Amit Assa.;Nathaniel Frost.;Lissette Jimenez.;Sari Acra.;Thomas Walters.;Stephen Mouat.;Michael Li.;Denis L J Lafontaine.;Matthew Tyska.;Brian Raught.;Yaron Avitzur.;Wayne I Lencer.;James R Goldenring.;Martín G Martín.;Jay R Thiagarajah.;Aleixo M Muise.
来源: N Engl J Med. 2025年392卷13期1297-1309页
Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated with high morbidity and mortality. Although treatment of these disorders is largely supportive, emerging targeted therapies based on genetic diagnoses include specific diets, pharmacologic treatments, and surgical interventions.
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