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281. Controlling asthma by training of Capnometry-Assisted Hypoventilation (CATCH) vs slow breathing: a randomized controlled trial.
作者: Thomas Ritz.;David Rosenfield.;Ashton M Steele.;Mark W Millard.;Alicia E Meuret.
来源: Chest. 2014年146卷5期1237-1247页
Hyperventilation has been associated with adverse effects on lung function, symptoms, and well-being in asthma. We examined whether raising end-tidal CO2 levels (ie, Pco2) compared with slow breathing is associated with improvements in asthma control, including peak flow variability.
282. Sex differences in response to tadalafil in pulmonary arterial hypertension.
作者: Stephen C Mathai.;Paul M Hassoun.;Milo A Puhan.;Yi Zhou.;Robert A Wise.
来源: Chest. 2015年147卷1期188-197页
Pulmonary arterial hypertension (PAH) is a progressive disease with high rates of morbidity and mortality. Current therapies improve symptoms, functional capacity, and, in select cases, survival. Little is known about patient factors that may predict the likelihood of patient-important, clinically relevant responses to therapy such as the 6-min walk distance (6MWD) and health-related quality of life (HRQoL).
283. Long-acting bronchodilators and arterial stiffness in patients with COPD: a comparison of fluticasone furoate/vilanterol with tiotropium.
作者: Jean-Louis Pepin.;John R Cockcroft.;Dawn Midwinter.;Sanjay Sharma.;David B Rubin.;Stefan Andreas.
来源: Chest. 2014年146卷6期1521-1530页
Increased arterial stiffness as measured by aortic pulse wave velocity (aPWV) predicts cardiovascular events and mortality and is elevated in patients with COPD. Prior investigation suggests that a long-acting β-agonist (LABA)/inhaled corticosteroid (ICS) lowers aPWV in patients with baseline aPWV ≥ 11 m/s. This study compared the effect of the ICS/LABA fluticasone furoate/vilanterol (FF/VI), 100/25 μg, delivered via the ELLIPTA dry powder inhaler, with tiotropium bromide (TIO), 18 μg, on aPWV.
284. The anticoagulation of calf thrombosis (ACT) project: results from the randomized controlled external pilot trial.
作者: Daniel Horner.;Kerstin Hogg.;Richard Body.;Michael J Nash.;Trevor Baglin.;Kevin Mackway-Jones.
来源: Chest. 2014年146卷6期1468-1477页
There is currently little evidence defining the clinical importance of detecting and treating isolated distal DVT (IDDVT). International guidelines vary regarding diagnostic and therapeutic advice. The potential benefits of anticoagulation are unquantified. We sought to evaluate the feasibility of a randomized controlled study within a modern framework and provide a primary outcome point estimate.
285. Novel use of pleural ultrasound can identify malignant entrapped lung prior to effusion drainage.
作者: Matthew R Salamonsen.;Ada K C Lo.;Arnold C T Ng.;Farzad Bashirzadeh.;William Y S Wang.;David I K Fielding.
来源: Chest. 2014年146卷5期1286-1293页
The presence of entrapped lung changes the appropriate management of malignant pleural effusion from pleurodesis to insertion of an indwelling pleural catheter. No methods currently exist to identify entrapped lung prior to effusion drainage. Our objectives were to develop a method to identify entrapped lung using tissue movement and deformation (strain) analysis with ultrasonography and compare it to the existing technique of pleural elastance (PEL).
286. Effect of oxygen and acetazolamide on nocturnal cardiac conduction, repolarization, and arrhythmias in precapillary pulmonary hypertension and sleep-disturbed breathing.
作者: Deborah S Schumacher.;Séverine Müller-Mottet.;Elisabeth D Hasler.;Florian F Hildenbrand.;Stephan Keusch.;Rudolf Speich.;Konrad E Bloch.;Silvia Ulrich.
来源: Chest. 2014年146卷5期1226-1236页
Sleep-disturbed breathing (SDB) is common in patients with precapillary pulmonary hypertension (PH). Nocturnal oxygen therapy (NOT) and acetazolamide improve SDB in patients with PH, and NOT improves exercise capacity. We investigated the effect of NOT and acetazolamide on nocturnal cardiac conduction, repolarization, and arrhythmias in patients with PH and SDB.
287. Acute hemodynamic effects of riociguat in patients with pulmonary hypertension associated with diastolic heart failure (DILATE-1): a randomized, double-blind, placebo-controlled, single-dose study.
作者: Diana Bonderman.;Ingrid Pretsch.;Regina Steringer-Mascherbauer.;Pavel Jansa.;Stephan Rosenkranz.;Caroline Tufaro.;Andja Bojic.;Carolyn S P Lam.;Reiner Frey.;Michael Ochan Kilama.;Sigrun Unger.;Lothar Roessig.;Irene M Lang.
来源: Chest. 2014年146卷5期1274-1285页
Deficient nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate signaling results from endothelial dysfunction and may underlie impaired cardiac relaxation in patients with heart failure with preserved left ventricular ejection fraction (HFpEF) and pulmonary hypertension (PH). The acute hemodynamic effects of riociguat, a novel soluble guanylate cyclase stimulator, were characterized in patients with PH and HFpEF.
288. Decreased cough sensitivity and aspiration in Parkinson disease.
作者: Michelle S Troche.;Alexandra E Brandimore.;Michael S Okun.;Paul W Davenport.;Karen W Hegland.
来源: Chest. 2014年146卷5期1294-1299页
Aspiration pneumonia is a leading cause of death in people with Parkinson disease (PD). The pathogenesis of these infections is largely attributed to the presence of dysphagia with silent aspiration or aspiration without an appropriate cough response. The goal of this study was to test reflex cough thresholds and associated urge-to-cough (UTC) ratings in participants with PD with and without dysphagia.
289. A randomized, investigator-masked, double-blind, placebo-controlled trial on thalidomide in severe cutaneous sarcoidosis.
作者: Catherine Droitcourt.;Michel Rybojad.;Raphaël Porcher.;Caroline Juillard.;Anne Cosnes.;Pascal Joly.;Jean-Philippe Lacour.;Michel D'Incan.;Nicolas Dupin.;Bruno Sassolas.;Laurent Misery.;Jacqueline Chevrant-Breton.;Bénédicte Lebrun-Vignes.;Kristell Desseaux.;Dominique Valeyre.;Jean Revuz.;Abdellatif Tazi.;Olivier Chosidow.;Alain Dupuy.
来源: Chest. 2014年146卷4期1046-1054页
Thalidomide use in cutaneous sarcoidosis is based on data from small case series or case reports. The objective of this study was to evaluate the efficacy and safety of thalidomide in severe cutaneous sarcoidosis.
290. Benefits of high-dose N-acetylcysteine to exacerbation-prone patients with COPD.
作者: Hoi Nam Tse.;Luca Raiteri.;King Ying Wong.;Lai Yun Ng.;Kwok Sang Yee.;Cee Zhung Steven Tseng.
来源: Chest. 2014年146卷3期611-623页
Although high-dose N-acetylcysteine (NAC) has been suggested to reduce COPD exacerbations, it is unclear which category of patients with COPD would benefit most from NAC treatment. The objective of this study was to compare the effect of high-dose NAC (600 mg bid) between high-risk and low-risk Chinese patients with COPD.
291. Comparing cost of indwelling pleural catheter vs talc pleurodesis for malignant pleural effusion.
作者: Erika D Penz.;Eleanor K Mishra.;Helen E Davies.;Braden J Manns.;Robert F Miller.;Najib M Rahman.
来源: Chest. 2014年146卷4期991-1000页
Malignant pleural effusion is associated with short life expectancy and significant morbidity. A randomized controlled trial comparing indwelling pleural catheters (IPCs) with talc pleurodesis found that IPCs reduced in-hospital time and the need for additional procedures but were associated with excess adverse events.
292. Cerebral oxygenation in patients with OSA: effects of hypoxia at altitude and impact of acetazolamide.
作者: Silvia Ulrich.;Yvonne Nussbaumer-Ochsner.;Irena Vasic.;Elisabeth Hasler.;Tsogyal D Latshang.;Malcolm Kohler.;Thomas Muehlemann.;Martin Wolf.;Konrad E Bloch.
来源: Chest. 2014年146卷2期299-308页
Sleep-disordered breathing may impair cerebral oxygenation in patients with OSA syndrome, in particular during altitude travel. We studied cerebral tissue oxygenation (CTO) at low and moderate altitude in patients with OSA and evaluated whether acetazolamide improved CTO.
293. The efficacy of a brief motivational enhancement education program on CPAP adherence in OSA: a randomized controlled trial.
作者: Agnes Y K Lai.;Daniel Y T Fong.;Jamie C M Lam.;Terri E Weaver.;Mary S M Ip.
来源: Chest. 2014年146卷3期600-610页
Poor adherence to CPAP treatment in OSA adversely affects the effectiveness of this therapy. This randomized controlled trial (RCT) examined the efficacy of a brief motivational enhancement education program in improving adherence to CPAP treatment in subjects with OSA.
294. Detection of fibroproliferation by chest high-resolution CT scan in resolving ARDS.
作者: Ellen L Burnham.;Robert C Hyzy.;Robert Paine.;Aine M Kelly.;Leslie E Quint.;David Lynch.;Douglas Curran-Everett.;Marc Moss.;Theodore J Standiford.
来源: Chest. 2014年146卷5期1196-1204页
In ARDS, the extent of fibroproliferative activity on chest high-resolution CT (HRCT) scan has been reported to correlate with poorer short-term outcomes and pulmonary-associated quality of life. However, clinical factors associated with HRCT scan fibroproliferation are incompletely characterized. We questioned if lung compliance assessed at the bedside would be associated with fibroproliferation on HRCT scans obtained during the resolution phase of ARDS.
295. Ventilator-associated pneumonia during weaning from mechanical ventilation: role of fluid management.
作者: Armand Mekontso Dessap.;Sandrine Katsahian.;Ferran Roche-Campo.;Hugo Varet.;Achille Kouatchet.;Vinko Tomicic.;Gaetan Beduneau.;Romain Sonneville.;Samir Jaber.;Michael Darmon.;Diego Castanares-Zapatero.;Laurent Brochard.;Christian Brun-Buisson.
来源: Chest. 2014年146卷1期58-65页
Pulmonary edema may alter alveolar bacterial clearance and infectivity. Manipulation of fluid balance aimed at reducing fluid overload may, therefore, influence ventilator-associated pneumonia (VAP) occurrence in intubated patients. The objective of the present study was to assess the impact of a depletive fluid-management strategy on ventilator-associated complication (VAC) and VAP occurrence during weaning from mechanical ventilation.
296. Omega-3 fatty acid supplementation during pregnancy and respiratory symptoms in children.
作者: María Consuelo Escamilla-Nuñez.;Albino Barraza-Villarreal.;Leticia Hernández-Cadena.;Efraín Navarro-Olivos.;Peter D Sly.;Isabelle Romieu.
来源: Chest. 2014年146卷2期373-382页
Prenatal consumption of omega-3 fatty acids can act as an adjuvant in the development of the immune system and affect the inflammatory response of neonates.
297. Endosonographic mediastinal lymph node staging of lung cancer.
作者: Moishe Liberman.;John Sampalis.;André Duranceau.;Vicky Thiffault.;Rachid Hadjeres.;Pasquale Ferraro.
来源: Chest. 2014年146卷2期389-397页
It is unclear whether endoscopic mediastinal lymph node (LN) staging techniques are equivalent to surgical mediastinal staging (SMS) techniques in patients with potentially operable non-small cell lung cancer (NSCLC).
298. Standardizing the analysis of physical activity in patients with COPD following a pulmonary rehabilitation program.
作者: Heleen Demeyer.;Chris Burtin.;Hans Van Remoortel.;Miek Hornikx.;Daniel Langer.;Marc Decramer.;Rik Gosselink.;Wim Janssens.;Thierry Troosters.
来源: Chest. 2014年146卷2期318-327页
There is a wide variability in measurement methodology of physical activity. This study investigated the effect of different analysis techniques on the statistical power of physical activity outcomes after pulmonary rehabilitation.
299. Do field walking tests produce similar cardiopulmonary demands to an incremental treadmill test in obese individuals with treated OSA?
作者: Rachael A Evans.;Thomas E Dolmage.;Priscila G Robles.;Roger S Goldstein.;Dina Brooks.
来源: Chest. 2014年146卷1期81-87页
Cardiorespiratory fitness, assessed during cardiopulmonary exercise tests by peak oxygen uptake (Vo2pk), is an independent predictor of mortality in obesity. We investigated whether Vo2pk and systemic responses measured during field walking tests were similar to those measured during an incremental treadmill test (ITMT) in obese individuals with treated OSA.
300. Efficacy and safety of early dexmedetomidine during noninvasive ventilation for patients with acute respiratory failure: a randomized, double-blind, placebo-controlled pilot study.
作者: John W Devlin.;Nada S Al-Qadheeb.;Amy Chi.;Russel J Roberts.;Imrana Qawi.;Erik Garpestad.;Nicholas S Hill.
来源: Chest. 2014年145卷6期1204-1212页
Successful application of noninvasive ventilation (NIV) for acute respiratory failure (ARF) requires patient cooperation and comfort. The efficacy and safety of early IV dexmedetomidine when added to protocolized, as-needed IV midazolam and fentanyl remain unclear.
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