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281. Low-Dose Aspirin Use Does Not Increase Survival in 2 Independent Population-Based Cohorts of Patients With Esophageal or Gastric Cancer.
作者: Andrew D Spence.;John Busby.;Brian T Johnston.;John A Baron.;Carmel M Hughes.;Helen G Coleman.;Chris R Cardwell.
来源: Gastroenterology. 2018年154卷4期849-860.e1页
Preclinical studies have shown aspirin to have anticancer properties and epidemiologic studies have associated aspirin use with longer survival times of patients with cancer. We studied 2 large cohorts to determine the association between aspirin use and cancer-specific mortality in patients with esophageal or gastric cancer.
282. p53 expression in patients with ulcerative colitis - associated with dysplasia and carcinoma: a systematic meta-analysis.
Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was to investigate the association between p53 expression and different pathological types of UC.
283. Prokinetics for the treatment of functional dyspepsia: Bayesian network meta-analysis.
作者: Young Joo Yang.;Chang Seok Bang.;Gwang Ho Baik.;Tae Young Park.;Suk Pyo Shin.;Ki Tae Suk.;Dong Joon Kim.
来源: BMC Gastroenterol. 2017年17卷1期83页
Controversies persist regarding the effect of prokinetics for the treatment of functional dyspepsia (FD). This study aimed to assess the comparative efficacy of prokinetic agents for the treatment of FD.
284. Tests for Serum Transglutaminase and Endomysial Antibodies Do Not Detect Most Patients With Celiac Disease and Persistent Villous Atrophy on Gluten-free Diets: a Meta-analysis.
作者: Jocelyn A Silvester.;Satya Kurada.;Andrea Szwajcer.;Ciarán P Kelly.;Daniel A Leffler.;Donald R Duerksen.
来源: Gastroenterology. 2017年153卷3期689-701.e1页
Tests to measure serum endomysial antibodies (EMA) and antibodies to tissue transglutaminase (tTG) were developed to screen for celiac disease in patients consuming gluten. However, they are commonly used to monitor patients on a gluten-free diet (GFD). We conducted a meta-analysis to assess the sensitivity and specificity of tTG IgA and EMA IgA assays in identifying patients with celiac disease who have persistent villous atrophy despite a GFD.
285. Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice.
作者: Pankaj Yadav.;David Ellinghaus.;Gaëlle Rémy.;Sandra Freitag-Wolf.;Anabelle Cesaro.;Frauke Degenhardt.;Gabrielle Boucher.;Myriam Delacre.; .;Laurent Peyrin-Biroulet.;Muriel Pichavant.;John D Rioux.;Philippe Gosset.;Andre Franke.;L Philip Schumm.;Michael Krawczak.;Mathias Chamaillard.;Astrid Dempfle.;Vibeke Andersen.
来源: Gastroenterology. 2017年153卷2期550-565页
The role of tobacco smoke in the etiology of inflammatory bowel disease (IBD) is unclear. We investigated interactions between genes and smoking (gene-smoking interactions) that affect risk for Crohn's disease (CD) and ulcerative colitis (UC) in a case-only study of patients and in mouse models of IBD.
286. Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis: A Systematic Review and Meta-analysis.
作者: Lorenzo Loffredo.;Daniele Pastori.;Alessio Farcomeni.;Francesco Violi.
来源: Gastroenterology. 2017年153卷2期480-487.e1页
Liver cirrhosis is complicated by bleeding from portal hypertension but also by portal vein thrombosis (PVT). PVT occurs in approximately 20% to 50% of patients with cirrhosis, and is a warning sign for poor outcome. It is a challenge to treat patients with cirrhosis using anticoagulants, because of the perception that the coexistent coagulopathy could promote bleeding. We performed a systematic review and meta-analysis to determine the effects of anticoagulant therapy in patients with cirrhosis and PVT.
287. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis.
作者: James K Y Hooi.;Wan Ying Lai.;Wee Khoon Ng.;Michael M Y Suen.;Fox E Underwood.;Divine Tanyingoh.;Peter Malfertheiner.;David Y Graham.;Vincent W S Wong.;Justin C Y Wu.;Francis K L Chan.;Joseph J Y Sung.;Gilaad G Kaplan.;Siew C Ng.
来源: Gastroenterology. 2017年153卷2期420-429页
The epidemiology of Helicobacter pylori infection has changed with improvements in sanitation and methods of eradication. We performed a systematic review and meta-analysis to evaluate changes in the global prevalence of H pylori infection.
288. Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies.
作者: María Inés Pinto-Sánchez.;Natalia Causada-Calo.;Premysl Bercik.;Alexander C Ford.;Joseph A Murray.;David Armstrong.;Carol Semrad.;Sonia S Kupfer.;Armin Alaedini.;Paul Moayyedi.;Daniel A Leffler.;Elena F Verdú.;Peter Green.
来源: Gastroenterology. 2017年153卷2期395-409.e3页
Patients with celiac disease should maintain a gluten-free diet (GFD), excluding wheat, rye, and barley. Oats might increase the nutritional value of a GFD, but their inclusion is controversial. We performed a systematic review and meta-analysis to evaluate the safety of oats as part of a GFD in patients with celiac disease.
289. Systematic review with network meta-analysis: dual therapy for high-risk bleeding peptic ulcers.
作者: Keda Shi.;Zeren Shen.;Guiqi Zhu.;Fansheng Meng.;Mengli Gu.;Feng Ji.
来源: BMC Gastroenterol. 2017年17卷1期55页
Adding a second endoscopic therapy to epinephrine injection might improve hemostatic efficacy in patients with high-risk bleeding ulcers but the optimum modality remains unknown. We aimed to estimate the comparative efficacy of different dual endoscopic therapies for the management of bleeding peptic ulcers through random-effects Bayesian network meta-analysis.
290. Inflammatory Bowel Disease (IBD) pharmacotherapy and the risk of serious infection: a systematic review and network meta-analysis.
作者: Chelle L Wheat.;Cynthia W Ko.;Kindra Clark-Snustad.;David Grembowski.;Timothy A Thornton.;Beth Devine.
来源: BMC Gastroenterol. 2017年17卷1期52页
The magnitude of risk of serious infections due to available medical therapies of inflammatory bowel disease (IBD) remains controversial. We conducted a systematic review and network meta-analysis of the existing IBD literature to estimate the risk of serious infection in adult IBD patients associated with available medical therapies.
291. Impact of antiviral therapy on hepatocellular carcinoma and mortality in patients with chronic hepatitis C: systematic review and meta-analysis.
The long-term clinical outcomes of antiviral therapy for patients with chronic hepatitis C are uncertain in terms of hepatitis C virus (HCV)-related morbidity and mortality according to the response to antiviral therapy. This study aimed to assess the impact of antiviral treatment on the development of HCC and mortality in patients with chronic HCV infection.
292. How to select patients and timing for rectal indomethacin to prevent post-ERCP pancreatitis: a systematic review and meta-analysis.
作者: Jianhua Wan.;Yuping Ren.;Zhenhua Zhu.;Liang Xia.;Nonghua Lu.
来源: BMC Gastroenterol. 2017年17卷1期43页
Acute pancreatitis is a severe complication of endoscopic retrograde cholangiopancreatography (ERCP). Previous meta-analyses have shown that indomethacin effectively prevents this complication; however, the data are limited. We performed a systematic review and meta-analysis to clarify the applications for rectal indomethacin.
293. Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis.
作者: Nicole T Shen.;Anna Maw.;Lyubov L Tmanova.;Alejandro Pino.;Kayley Ancy.;Carl V Crawford.;Matthew S Simon.;Arthur T Evans.
来源: Gastroenterology. 2017年152卷8期1889-1900.e9页
Systematic reviews have provided evidence for the efficacy of probiotics in preventing Clostridium difficile infection (CDI), but guidelines do not recommend probiotic use for prevention of CDI. We performed an updated systematic review to help guide clinical practice.
294. Endoscopic imaging modalities for diagnosing invasion depth of superficial esophageal squamous cell carcinoma: a systematic review and meta-analysis.
作者: Ryu Ishihara.;Noriko Matsuura.;Noboru Hanaoka.;Sachiko Yamamoto.;Tomofumi Akasaka.;Yoji Takeuchi.;Koji Higashino.;Noriya Uedo.;Hiroyasu Iishi.
来源: BMC Gastroenterol. 2017年17卷1期24页
Diagnosis of cancer invasion depth is crucial for selecting the optimal treatment strategy in patients with gastrointestinal cancers. We conducted a meta-analysis to determine the utilities of different endoscopic modalities for diagnosing invasion depth of esophageal squamous cell carcinoma (SCC).
295. Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis.
作者: Fabiane Klem.;Akhilesh Wadhwa.;Larry J Prokop.;Wendy J Sundt.;Gianrico Farrugia.;Michael Camilleri.;Siddharth Singh.;Madhusudan Grover.
来源: Gastroenterology. 2017年152卷5期1042-1054.e1页
Foodborne illness affects 15% of the US population each year, and is a risk factor for irritable bowel syndrome (IBS). We evaluated risk of, risk factors for, and outcomes of IBS after infectious enteritis.
296. Smoking influences the need for surgery in patients with the inflammatory bowel diseases: a systematic review and meta-analysis incorporating disease duration.
作者: M Ellen Kuenzig.;Sang Min Lee.;Bertus Eksteen.;Cynthia H Seow.;Cheryl Barnabe.;Remo Panaccione.;Gilaad G Kaplan.
来源: BMC Gastroenterol. 2016年16卷1期143页
Studies examining the association between smoking and the need for surgery in patients with Crohn's disease and ulcerative colitis have reached inconsistent conclusions. These studies often do not differentiate between patients undergoing early surgery and patients having surgery later in their disease course. Our study examined the association between smoking status and time to first bowel resection in patients with Crohn's disease and ulcerative colitis.
297. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.
作者: Steven R Brant.;David T Okou.;Claire L Simpson.;David J Cutler.;Talin Haritunians.;Jonathan P Bradfield.;Pankaj Chopra.;Jarod Prince.;Ferdouse Begum.;Archana Kumar.;Chengrui Huang.;Suresh Venkateswaran.;Lisa W Datta.;Zhi Wei.;Kelly Thomas.;Lisa J Herrinton.;Jan-Micheal A Klapproth.;Antonio J Quiros.;Jenifer Seminerio.;Zhenqiu Liu.;Jonathan S Alexander.;Robert N Baldassano.;Sharon Dudley-Brown.;Raymond K Cross.;Themistocles Dassopoulos.;Lee A Denson.;Tanvi A Dhere.;Gerald W Dryden.;John S Hanson.;Jason K Hou.;Sunny Z Hussain.;Jeffrey S Hyams.;Kim L Isaacs.;Howard Kader.;Michael D Kappelman.;Jeffry Katz.;Richard Kellermayer.;Barbara S Kirschner.;John F Kuemmerle.;John H Kwon.;Mark Lazarev.;Ellen Li.;David Mack.;Peter Mannon.;Dedrick E Moulton.;Rodney D Newberry.;Bankole O Osuntokun.;Ashish S Patel.;Shehzad A Saeed.;Stephan R Targan.;John F Valentine.;Ming-Hsi Wang.;Martin Zonca.;John D Rioux.;Richard H Duerr.;Mark S Silverberg.;Judy H Cho.;Hakon Hakonarson.;Michael E Zwick.;Dermot P B McGovern.;Subra Kugathasan.
来源: Gastroenterology. 2017年152卷1期206-217.e2页
The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD) cause significant morbidity and are increasing in prevalence among all populations, including African Americans. More than 200 susceptibility loci have been identified in populations of predominantly European ancestry, but few loci have been associated with IBD in other ethnicities.
298. Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis.
Certain subsets of colorectal serrated polyps (SP) have malignant potential. We performed a systematic review and meta-analysis to investigate the association between modifiable lifestyle factors and risk for SPs.
299. Diagnostic performance of confocal laser endomicroscopy for optical diagnosis of gastric intestinal metaplasia: a meta-analysis.
Gastric intestinal metaplasia (IM) is generally considered as a precancerous condition, a related risk factor for intestinal-type gastric cancer. However, an accurate endoscopic diagnosis of IM is a clinical challenge. Confocal Laser Endomicroscopy (CLE) is a newly technique that can provide real-time magnified images and visualize tissues at cellular or subcellular levels. The aim of this study is to clarify the diagnostic value of CLE in detection of IM in patients at high risk of gastric cancer.
300. Endoscopic ultrasonography with fine-needle aspiration for histological diagnosis of solid pancreatic masses: a meta-analysis of diagnostic accuracy studies.
作者: Omar Banafea.;Fabian Pius Mghanga.;Jinfang Zhao.;Ruifeng Zhao.;Liangru Zhu.
来源: BMC Gastroenterol. 2016年16卷1期108页
Previous studies have demonstrated that endoscopic ultrasound-fine needle aspiration (EUS-FNA) is a reliable tool for diagnosing pancreatic lesions; however, the reported sensitivity and specificity vary greatly across studies. The aim of this study was to pool the existing literature and assess the overall performance of EUS-FNA in the diagnosis of solid pancreatic lesions.
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