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261. Remimazolam alleviates hepatic ischemia-reperfusion injury by activating FOXO1/3 signaling : Remimazolam alleviates hepatic ischemia reperfusion injury.
Hepatic ischemia reperfusion injury (HIRI) frequently gives rise to aggravated liver damage. Currently, there exists a diverse range of anesthetic drugs that possess protective capabilities against ischemia-reperfusion injury (IRI). Nevertheless, the specific functions and underlying mechanisms of remimazolam (RMZL) in HIRI have not been fully elucidated.
262. Comparison of the predictive value of TyG index and METS-IR for OSA combined with NAFLD: a retrospective observational study based on a physical examination population.
Obstructive sleep apnoea (OSA), Non-alcoholic fatty liver disease (NAFLD) and insulin resistance (IR) are interlinked. The aim of our study was to investigate the predictive value of metabolic score for insulin resistance (METS-IR) and triglyceride-glucose(TyG) index in relation to OSA combined with NAFLD in physical examination population.
263. The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation study.
作者: Yanjun Lu.;Xinxuan Zhao.;Haiyi Liu.;Yixun Zhang.;Linghong Guo.;Lichun Wang.
来源: BMC Gastroenterol. 2025年25卷1期280页
The correlation between tumor-specific growth factor (TSGF) and the prognosis of colorectal cancer (CRC)has not been extensively studied. Research was designed to evaluate the potential of TSGF as a predictive marker for the prognosis of patients with CRC.
264. The relationship between the eradication of Helicobacter pylori and the occurrence of stomach cancer: an updated meta-analysis and systemic review.
作者: Zhouhan Wu.;Yi Tang.;Meiwen Tang.;Zhoutong Wu.;Yonghui Xu.
来源: BMC Gastroenterol. 2025年25卷1期278页
Helicobacter pylori (H. pylori) are classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC), highlighting its well-established role in gastric carcinogenesis. While previous studies and systematic reviews suggest that H. pylori eradication may lower the incidence and mortality of gastric cancer, the evolving body of evidence necessitates continual reassessment. In light of newly available data, we conducted a comprehensive meta-analysis to evaluate the association between H. pylori eradication therapy and gastric cancer risk, aiming to strengthen the evidence base and inform clinical decision-making.
265. Oncologic outcomes of surgically treated colorectal cancer in octogenarians: a comparative study using inverse probability of treatment weighting (IPTW).
作者: Soo Young Oh.;Jung Yun Park.;Kwan Mo Yang.;Seong-A Jeong.;Yong Jae Kwon.;Yun Tae Jung.;Chung Hyeun Ma.;Keong Won Yun.;Kwang Hyun Yoon.;Jae Young Kwak.;Chang Sik Yu.
来源: BMC Gastroenterol. 2025年25卷1期276页
Octogenarians constitute a growing number of diagnoses for colorectal cancer. However, the optimal treatment for these increasingly vulnerable octogenarians with colorectal cancer remains a challenging issue. The aim of this study was to evaluate the oncologic outcomes of colorectal cancer, comparing octogenarians (> 80 years) and younger age (60-79 years).
266. Immunohistochemical expression of PD-L1 in colorectal carcinoma among black patients and the clinicopathological correlates: a cross-sectional study.
作者: Felix Emeka Menkiti.;Chukwudi Onyeaghana Okani.;Igwebuike Victor Onyiaorah.;Cornelius Ozobia Ukah.;Ifeoma Oluchukwu Menkiti.;Eric Chukwudi Ihekwoaba.;Odili Aloysius Okoye.;Ogochukwu Chioma Ofiaeli.;Frank Chinedu Akpuaka.
来源: BMC Gastroenterol. 2025年25卷1期277页
Colorectal cancer (CRC) incidence is rising in Nigeria, with majority of patients presenting with advanced disease. Despite promising results of PD-L1 antibody therapy in clinical trials, efficacy data exclusively derives from Caucasian populations, leaving a critical knowledge gap for African populations. This study investigated PD-L1 expression in CRC among blacks, correlating it with clinicopathologic parameters.
267. Assessment of the impact of power business intelligence on adenoma detection rate: a prospective observational trial.
作者: Ya-Hui Hsu.;Chia-Hsin Cheng.;Ping-Hung Ko.;Chia-Pei Tang.;Chih-Wei Huang.;Chih-Wei Tseng.
来源: BMC Gastroenterol. 2025年25卷1期275页
Adenoma detection rate (ADR) is a key quality indicator in colonoscopy, with low ADRs linked to higher risks of post-colonoscopy colorectal cancers. Feedback to endoscopists has been shown to improve ADRs; however, many feedback systems lack automation and real-time interactivity. This study evaluates the effectiveness of Power Business Intelligence (Power BI) on ADR enhancement.
268. Associations between non-insulin-based insulin resistance surrogate markers and liver-related outcomes in metabolic dysfunction-associated steatotic liver disease: a nationwide cohort study in South Korea.
作者: Sang Yi Moon.;Minkook Son.;Yeo Wool Kang.;Myeongseok Koh.;Jong Yoon Lee.;Yang Hyun Baek.
来源: BMC Gastroenterol. 2025年25卷1期274页
Insulin resistance (IR) is a crucial mechanism in the pathogenesis and clinical progression of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to examine the relationship between non-insulin-based IR surrogate markers and the incidence of liver-related outcomes in individuals with MASLD in a nationwide Korean cohort.
269. Optimizing prediction of metastasis among colorectal cancer patients using machine learning technology.
Colorectal cancer is among the most prevalent and deadliest cancers. Early prediction of metastasis in patients with colorectal cancer is crucial in preventing it from the advanced stages and enhancing the prognosis among these patients. So far, previous studies have been conducted to predict metastasis in colorectal cancer patients using clinical data. The current research attempts to leverage a combination of demographic, lifestyle, nutritional, and clinical factors, such as diagnostic and therapeutical factors, to construct an ML model with more predictive insights and generalizability than previous ones.
270. Meta-analysis of the efficacy of applying reduced surgery for the treatment of asymptomatic unresectable advanced gastric cancer.
作者: Xiong Li.;Ting Lei.;Liangyin Fu.;Ruiyu Gao.;Ning Cao.;Yuanhui Gu.;He Su.;Tiankang Guo.;Yang Che.
来源: BMC Gastroenterol. 2025年25卷1期271页
Systematic evaluation of the efficacy and safety of reduction surgery in asymptomatic unresectable advanced gastric cancer.
271. Effect of Saccharomyces boulardii supplementation to bismuth quadruple therapy on Helicobacter pylori eradication.
作者: Yi-Zhou Jiang.;Kai Ma.;Cheng Cui.;Zhuo-Ya Li.;Xiao-Yong Wang.
来源: BMC Gastroenterol. 2025年25卷1期273页
Helicobacter pylori (H. pylori) infection is a common chronic infection, and there are over half of the global population infected with H. pylori. It is still controversial whether the supplementation of Saccharomyces boulardii (S. boulardii) to bismuth quadruple therapy is beneficial for H. pylori eradication.
272. Effect of biliopancreatic tree anatomy on development of acute gallstone pancreatitis.
作者: Ahmet Sukru Alparslan.;Serkan Ocal.;Osman Cagin Buldukoglu.;Galip Egemen Atar.;Lutfullah Zahit Koc.;Merve Eren Durmus.;Serdar Akca.;Ferda Akbay Harmandar.;Ayhan Hilmi Cekin.
来源: BMC Gastroenterol. 2025年25卷1期269页
Acute pancreatitis (AP) is a complex disorder with gallstones being the most common underlying cause. Anatomical variations of gallbladder, cystic duct (CD), common bile duct and main pancreatic duct and their courses and interactions with each other have been studied and shown to be related to development of AP in various studies. With this study, we aimed to investigate the relationship between biliopancreatic tree anatomy and acute gallstone pancreatitis.
273. Association between non-skimmed milk consumption and metabolic dysfunction-associated fatty liver disease in US adults: insights from NHANES data.
作者: Futao Wu.;Fuying Zheng.;Xue Li.;Danzhu Wu.;Honghao Li.;Yingyi Zeng.;Yan Tang.;Side Liu.;Aimin Li.
来源: BMC Gastroenterol. 2025年25卷1期270页
Previous studies on the association between non-skimmed milk consumption and non-alcoholic fatty liver disease (NAFLD) have reported inconsistent findings, with some suggesting an increased risk and others indicating a protective effect. Moreover, as the research focus has shifted globally from NAFLD to metabolic dysfunction-associated fatty liver disease (MAFLD), there remains limited evidence on the relationship between non-skimmed milk consumption and MAFLD. The objective of this cross-sectional study was to investigate this association using data from the National Health and Nutrition Examination Survey (NHANES).
274. Structural Variations in Ulcerative Colitis-associated Escherichia coli Reduce Fructose Utilization and Aggravate Inflammation Under High-Fructose Diet.
作者: Xia Wu.;Yuejuan Li.;Pan Li.;Gaochen Lu.;Jianyu Wu.;Zheyu Wang.;Quan Wen.;Bota Cui.;Jun Wang.;Faming Zhang.
来源: Gastroenterology. 2025年
Structural variations (SVs) have significant effects on microbial phenotypes. The underlying mechanism of functional changes caused by gut microbial SVs in the development of ulcerative colitis (UC) need further investigation.
276. The association between modified cardiometabolic index with non-alcoholic fatty liver disease and liver fibrosis: a cross-sectional study.
Cardiometabolic index (CMI) was proposed ten years ago as an indicator combining obesity and dyslipidemia. This study aimed to investigate the relationships between newly modified CMI (MCMI) with non-alcoholic fatty liver disease (NAFLD) and liver fibrosis.
277. Cost-effectiveness of NALIRIFOX versus Nab-paclitaxel and gemcitabine in previously untreated metastatic pancreatic ductal adenocarcinoma.
作者: Wenjie Liu.;Yuting Fang.;Chao Zhang.;Midan Xiang.;Lijuan Qi.;Aijiang Su.;Yongkun Sun.
来源: BMC Gastroenterol. 2025年25卷1期266页
The NAPOLI 3 trial demonstrated that compared to the nab-paclitaxel and gemcitabine (GemNab) regimen, the NALIRIFOX (5-fluorouracil, leucovorin, liposomal irinotecan, oxaliplatin) regimen can significantly improve patients' overall survival (OS) and progression-free survival (PFS), and the safety of this regimen is generally controllable. To ensure the appropriateness of the chosen treatment, economic evaluation is essential. Thus, from the perspective of American healthcare systems, we explored the cost-effectiveness comparison between NALIRIFOX or GemNab in treating patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) who had not previously received treatment.
278. MAFLD mediates the association between CHR and gallstones in the U.S. adults: evidence from NHANES 2021-2023.
作者: Xin Feng.;Xiangyu Song.;Xi'an Yang.;Fuxiang Luan.;Yufei Gu.;Fengyu Zheng.;Huahu Guo.;Shishi Qiao.
来源: BMC Gastroenterol. 2025年25卷1期268页
Gallstones, a global hepatobiliary disorder, are linked to systemic inflammation, lipid disturbances, and metabolic-associated fatty liver disease (MAFLD). This population-based study aims to investigate the association of the novel inflammation-lipid composite biomarker high-sensitivity C-reactive protein-to-HDL cholesterol ratio (CHR) with gallstones and evaluate whether MAFLD mediates this relationship.
279. A nomogram to predict pulmonary complications after gastrointestinal surgery: a retrospective study.
We aimed at developing a nomogram able to predict postoperative pulmonary complications (PPC) after gastrointestinal surgery.
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