The association between red blood cell distribution width (RDW) and short- and long-term all-cause mortality in patients with acute pancreatitis (AP) and sepsis remains unclear.

Emerging epidemiological studies have identified associations between perianal abscess (PA) and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), though the pathophysiological mechanisms underlying their comorbidity remain incompletely understood. To elucidate potential causal relationships between these clinical entities, we conducted a comprehensive investigation employing bidirectional two-sample Mendelian randomization (MR) analysis complemented by multivariable Mendelian randomization (MVMR) methodology. This analytical approach enables systematic evaluation of causal directionality while accounting for potential confounding factors inherent in observational studies.

Cardiometabolic Index (CMI) is positively correlated with liver fibrosis in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), but its association with mortality risk in MASLD patients remains unclear.

Although systemic inflammatory response syndrome (SIRS) is associated with the progression of cirrhosis, its clinical significance in patients with cirrhosis and hepatic encephalopathy (HE) remains unclear.

Obstructive jaundice from pancreatobiliary diseases represents a significant global health challenge, particularly in resource-limited settings like Rwanda. While endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic biliary drainage (PTBD) are now available at tertiary centers in Kigali, there is limited local clinical data on the management and outcomes of these conditions. This study aims to assess the patterns, therapeutic approaches, and outcomes of obstructive jaundice in the Rwandan healthcare context.

To analyze the influencing factors and nursing strategies for enteral nutrition patients complicated with refeeding syndrome (RS) in the ICU.

Colon cancer is a highly heterogeneous and most common malignant tumor of the gastrointestinal tract, which is prone to metastasis in advanced stages, leading to a poor prognosis for patients.

Limited data exist regarding the efficacy and safety of vedolizumab (VDZ) in China's elderly adult population with ulcerative colitis (UC) in China. In this investigation, a comparative analysis of its efficacy and safety was performed between elderly and younger adult UC cohorts.

The global prevalence of non-alcoholic fatty liver disease (NAFLD) has reached an alarming 25%, based on recent population-based studies. NAFLD diagnosis primarily relies on imaging methods, which may be invasive, costly, or limited. Existing prediction models, such as the Fatty Liver Index (FLI) and NAFLD Liver Fat Score (NLFS), mainly incorporate metabolic parameters from Western populations and neglect non-metabolic factors, limiting their generalizability. To address these limitations, this study developed a screening model integrating both metabolic and non-metabolic indicators, tailored specifically to diverse populations undergoing routine physical examinations.

Anthropometric measurements and lipid profiles are associated with the onset of gallstone disease, with these associations exhibiting sex-specific variations. This study investigated the association between the prevalence of gallstones and two anthropometric-lipid markers, namely Lipid Accumulation Products (LAP) and Cardiometabolic Index (CMI), while also assessing the presence of sex disparities.

Esophageal diseases (ED) are a common category of upper gastrointestinal disorders, mainly including gastroesophageal reflux disease (GERD), esophagitis, Barrett's esophagus, achalasia, and esophageal cancer (EC). In recent years, the high recurrence rate of GERD and poor prognosis of EC are paid more attention, collectively contributing to the global burden of ED.

This study developed and validated prognostic nomograms incorporating inflammatory and nutritional biomarkers to predict disease-free survival (DFS) and overall survival (OS) in patients with non-metastatic right-sided colon adenocarcinoma (NRCA).

Contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) has promising potential in the diagnosis of pancreatic tumors, assessment of fibrosis, and prediction of chemotherapy efficacy. We hypothesize that radiation therapy might reduce variations in chemotherapeutic efficacy caused by fibrosis-induced blood flow disparities, as we explored the relationship between CH-EUS patterns and the efficacy of neoadjuvant chemoradiotherapy (NACRT) in resectable pancreatic cancer (PC).

To investigate the effectiveness of combining ursodeoxycholic acid (UDCA) and vitamin D (VitD) in treating patients with primary biliary cholangitis (PBC) and its impact on hepatic fibrosis.

Circulating platelet-derived growth factor receptor-β (PDGFRβ) has recently been found to correlate with severity of liver disease in multiple etiologies, including liver steatosis. In diabetic patients with metabolic-associated fatty liver disease (MAFLD), widely used non-invasive scoring systems, particularly the fibrosis-4 (FIB-4) score, showed unsatisfactory performance in predicting liver fibrosis severity. The aim of this study was to evaluate the productivity of serum PDGFRβ as a non-invasive biomarker of liver fibrosis in diabetic MAFLD patients.

Pegylated interferon alfa (pegIFN-α) is one of the main therapeutic strategies for chronic hepatitis B (CHB) infection. Although interferon-based treatment strategies have great potential in combating CHB, they have significant side effects, and many patients do not respond. In this study, nontargeted metabolomics was performed to investigate the effects of interferon therapy on metabolites and their correlations with clinical indicators. Each group of 20 patients received PEG-IFN alfa-2b for 0, 1, 3, or 6 months. At the end of the IFN-α treatment, patient serum samples were processed for clinical, biological, and metabolomic analyses. The results revealed that in all four groups, the most affected metabolic pathways were ABC transporter, caffeine metabolism, and protein digestion and absorption. Notably, among the top 8 differentially abundant metabolites with high ROC AUC values (≥ 0.95), three were related to pyrimidine nucleoside metabolites (cytidine, 3-methyluridine and ribothymidine), indicating the pivotal role of altered nucleoside metabolism in HBV infection and suggesting that IFN-α treatment might partially correct this dysregulation. The top 20 metabolites were strongly associated with clinical indicators, with significant differences after IFN-α treatment, and may serve as promising biomarkers for monitoring HBV progression and the therapeutic effect of IFN-α treatment for chronic HBV infection.

Cirrhosis is a major global health burden, often requiring ICU admission due to complications. Acetaminophen (APAP) is frequently used for pain and fever management in critically ill patients, but its safety in cirrhotic patients remains uncertain.