Gastroesophageal reflux disease (GERD) is a common chronic digestive disorder with a growing epidemiological footprint worldwide. However, the specific characteristics and burden of GERD in East Asia, particularly in China, remain insufficiently documented.

Irritable bowel syndrome (IBS) is one of the most common brain-gut interaction disorders, characterized by chronic abdominal pain, altered bowel habits, and heightened stress responses that significantly affect patients' psychological functioning and quality of life. Given that chronic stress plays a central role in the onset and maintenance of IBS symptoms, identifying psychological resources that promote adaptation and well-being is crucial. The present study aimed to examine the mediating role of resilience in the relationship between cognitive flexibility and psychological well-being among patients with IBS.

Clinical outcomes and histologic characteristics of biopsy-proven steatotic liver disease (SLD) subtypes remain understudied. We investigated clinical outcomes and fibrosis patterns in metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-related liver disease (MetALD), and alcohol-associated liver disease (ALD).

Treatment of Helicobacter pylori infection after previous eradication failure remains challenging. This study evaluated the efficacy and safety of a vonoprazan-tetracycline (VT) dual regimen as a potential rescue therapy.

For the local excision of early rectal tumors (ERTs), the relative effectiveness of endoscopic submucosal dissection (ESD) vs transanal endoscopic microsurgery (TEM) is subject to debate. The comparisons are limited to retrospective, single-center studies lacking a health economic assessment.

Severe acute pancreatitis (SAP) is characterized by persistent organ failure and a high mortality rate, early diagnosis and disease assessment are crucial for improving patient prognosis.

Transjugular liver biopsy (TJLB) enables histopathological diagnosis of liver disease and simultaneous assessment of the hepatic venous pressure gradient (HVPG).

Gastric cancer (GC) is one of the most common causes of cancer-related deaths worldwide. Gastrectomy with lymph node dissection is the standard treatment for GC worldwide. Due to advancements in surgical techniques, the use of laparoscopic gastrectomy (LG) has broadened. However, the incidence of post-operative pancreatic fistula (POPF) after LG is higher than that after open surgery, and the definition and measurement of POPF in gastrectomy have not yet been established. We introduced polyglycolic acid (PGA) sheet to prevent POPF after LG and retrospectively evaluated its effectiveness.

Coeliac disease (CD) is a chronic, immune-mediated enteropathy triggered by gluten ingestion in genetically predisposed individuals carrying HLA-DQ2 and/or -DQ8 alleles. Its diagnosis traditionally combines serology and confirmatory duodenal biopsy. IgA anti-tissue transglutaminase is the first-line test, supported by endomysial antibody. Duodenal histology remains the gold standard, though limitations include patchy involvement and variability in interpretation. Recent advances have proposed biopsy-sparing approaches, whereas applicability in adults remains debated. Moreover, CD is increasingly recognized in association with autoimmune conditions, including type 1 diabetes mellitus and autoimmune thyroid disease, underscoring the importance of proactive screening. However, distinguishing true CD from potential CD or false-positive serology requires careful clinical integration and, often, biopsy confirmation. Mass screening appears to demonstrate high yield and potential cost-effectiveness compared with case-finding. However, evidence is emerging and not yet definitive, and its implementation remains limited. For patients already on a gluten-free diet, gluten challenge protocols combined with HLA genotyping enhance diagnostic accuracy. Overall, while duodenal biopsy is still pivotal in most guidelines, evolving evidence supports a tailored, less invasive approach that integrates serology, genetics, histology, and novel diagnostics to improve early detection and management of CD.

Colorectal cancer (CRC) is one of the most prevalent malignant diseases worldwide and displays significant heterogeneity. The aim of this study was to investigate the application of machine learning algorithms to incorporate preoperative laboratory tests for predicting the 5-year recurrence risk in patients with stage III colon cancer (CC) postsurgery.

Laryngopharyngeal reflux (LPR) is reflux of gastric contents proximal to the upper esophageal sphincter and leading to a variety of symptoms including cough, dysphonia, globus, and sore throat. There is currently no diagnostic gold standard for LPR which often leads to over or under diagnosis and complicates therapeutic approach to this group of patients. This uncertainty has led to a high economic burden of the disease. The goal of this review was to present current recommendations in the diagnosis and treatment of LPR to aid in clinical decision making. There has been emerging research regarding the role of laryngeal hypersensitivity, mediated through neuronal hyperresponsiveness, autonomic dysfunction and symptom hypervigilance. Diagnosis remains a challenge, but novel biomarkers show promise. Therapeutics involve the consideration of acid suppression with an increasing emphasis on neuromodulators and external compression devices. There remains a great need for further research on both diagnostic and therapeutics to develop a gold standard for this disease.