This systematic review evaluates the oncologic and reproductive outcomes of fertility-sparing surgery (FSS) in women diagnosed with stage I ovarian cancer, as classified by the International Federation of Gynecology and Obstetrics (FIGO). This study aimed to assess the safety and effectiveness of FSS in preserving fertility without compromising survival outcomes.

As machine learning (ML) continuously develops in cancer diagnosis and treatment, some researchers have attempted to predict the expression of programmed death ligand-1 (PD-L1) in non-small cell lung cancer (NSCLC) by ML. However, there is a lack of systematic evidence on the effectiveness of ML.

Bladder cancer is uncommon in individuals under the age of 45, and its clinical and molecular characteristics in this population differ significantly from those observed in older patients. This systematic review aims to evaluate recurrence, progression, survival outcomes, and molecular profiles of bladder cancer in young adults.

Blockage of PD-1 with drugs such as nivolumab (Nivo) and pembrolizumab (Pembro) has been successfully implemented in the treatment of Hodgkin lymphoma among other types of tumors. Exorbitant costs hinder access for many patients living in low- and middle-income countries (LMICs). Dose reductions on the basis of pharmacodynamic studies have been used to allow access to these drugs to patients with no further options because of economic constraints. In this study, we aimed to systematically review and assess evidence regarding the efficacy and safety of this adapted intervention.

Non-melanoma skin cancers (NMSCs), including basal (BCC) and squamous cell carcinoma (SCC), are the most prevalent malignancies affecting the skin, with the head and neck region being the most common site of involvement. Surgical excision remains the primary treatment modality. The role of surgical margins in the treatment of skin SCC and BCC of the head and neck remains a subject of ongoing debate. Clear definitions and guidelines regarding adequate surgical margins, as well as their impact on recurrence rates and overall outcomes, are critical for improving clinical management. This systematic review aims to evaluate the current literature on the definitions of surgical margins for SCC and BCC of the head and neck, as well as their impact on local recurrence, disease free survival, and other patient-centred outcomes.

Major salivary gland malignancies (MSGM) are a rare and heterogeneous group of tumours accounting for 1-5% of all head and neck cancers. When feasible, surgical removal with negative margins is the preferred treatment, reserving adjuvant radiotherapy for adverse clinicopathological features such as high-grade, advanced-stage, extranodal extension, lympho-vascular invasion, perineural invasion, and positive margins. This systematic review aims to evaluate the current literature on the definition of negative and close margins for MSGM, their impact on loco-regional recurrence (LRR), disease-free (DFS), and overall survival (OS), and their implications in the choice of multimodal therapies.

Hypopharyngeal squamous cell carcinoma is an aggressive malignancy with poor prognosis due to frequently late-stage presentation and intrinsic anatomical complexity. Surgery remains a key treatment, and resection margins are crucial for local control and survival. However, achieving adequate margins is challenging due to submucosal tumour spread and common "skip lesions". This systematic review examines the impact of positive and close margins on oncological outcomes and their role in treatment planning.

Over the past two decades there has been a strategic shift in treating laryngeal cancer, with an increasing emphasis on preserving the anatomical structure and function of the larynx, even in cases of intermediate or advanced stages of disease. Open partial horizontal laryngectomies (OPHL) are widely adopted to spare the physiological functions of the larynx while achieving good oncological control. Positive, close or narrow surgical margins remain a critical prognostic factor, with their impact varying by tumour location and laryngeal subsite. This review examines the influence of positive margins on survival and the potential need for adjuvant treatments to optimise functional and oncological outcomes.

To evaluate the prognostic significance of surgical margins in patients undergoing transoral laser microsurgery (TLM) for laryngeal squamous cell carcinoma (LSCC).

Nasopharyngeal malignancies are rare heterogenous histologies (nasopharyngeal carcinoma [NPC], minor salivary glands carcinomas, and low-grade papillary nasopharyngeal adenocarcinoma) and a significant proportion of patients experience loco-regional recurrence after primary treatment. Resection margin status is a key prognostic factor that influences recurrence and survival, although definitions and criteria for negative, close, and positive margins remain inconsistent. This systematic review with meta-analysis aimed to summarise the existing definitions of resection margins in the literature and evaluate their impact on clinical outcomes in patients undergoing nasopharyngectomy with a specific focus on NPC.

Surgery remains a cornerstone in treatment of sinonasal malignancies, but the prognostic role of margin status is controversial. This systematic review and meta-analysis evaluated the prognostic significance of surgical margins in sinonasal cancer and their impact on survival, alongside key challenges in its evaluation.

In oropharyngeal squamous cell carcinoma (OPSCC), proper definition of surgical margins may have substantial impact on oncologic outcomes. Minimally-invasive techniques prioritise reduced morbidity, yet open approaches remain significant due to limited large-scale evidence comparing their outcomes with transoral methods. The purpose of the present systematic review was to assess the incidence of positive margins in OPSCC management based on surgical approach (open vs transoral) and the subsequent risk of additional treatments.

The aim of this study is to analyse the impact of surgical margins on survival outcomes for patients with oral cavity squamous cell carcinoma (OCSCC).

Microplastic exposure can contaminate multiple organs through nasal, dermal, and respiratory routes. The effect of microplastic exposure on colorectal adenocarcinoma development has gained attention. This systematic review aimed to summarize studies of microplastic exposure in humans with colorectal cancer. The relevant studies were collected through a computer-assisted search in PubMed, ISI Web of Science, Embase, Scopus, and Google Scholar databases. A total of 747 documents were evaluated for eligibility by two independent authors. The quality assessment of eligible studies was evaluated by the JBI checklist, and required data were collected and extracted from the included studies. After analysis, four studies were found eligible. The microplastic infiltration in colorectal tissue biopsies was relatively high; polyamide, polycarbonate, and polypropylene polymers were among the most common polymers in colorectal tissue samples of patients with colorectal adenocarcinoma. The average particle size was 0.1 µm to 1.6 mm. Microplastics shape in colorectal cancerous tissue, including fibers, fragments, and films. Microplastic abundance in colorectal tumor tissue was 25.9-32.2 particles/g tissue. In the case-control study, the microplastic accumulation in colorectal cancer tissue samples was significantly higher than in controls. The etiology of colorectal cancer remains unclear; however, environmental factors are actively contributing to colorectal cancer development. While there are few studies on microplastics in patients with colorectal adenocarcinoma, existing evidence indicates microplastic accumulation in the colorectal tissue of these patients. Further research is needed to determine if microplastic exposure initiates or leads to the development of colorectal cancer events.

The effectiveness of radioiodine therapy (RAI) in reducing recurrence and improving overall survival in differentiated thyroid carcinoma (DTC) remains debated. This systematic review evaluates the impact of RAI on DTC recurrence and survival.

Pelvic exenteration is a curative option for select patients with locally invasive or recurrent colorectal cancer. Achieving clear margins (R0 resection) is critical for optimal oncological outcomes and quality of life. Minimally invasive surgery (MIS), including laparoscopic and robotic approaches, offers advantages in visualisation and precision, but its feasibility is debated given data limitations. This meta-analysis compares outcomes of MIS with open pelvic exenteration for colorectal cancer.

The use of prophylactic cranial irradiation (PCI) in early stage small cell lung cancer (SCLC) patients post-surgery remains controversial. This meta-analysis aimed to evaluate the efficacy of PCI in resected early stage SCLC patients.

To evaluate the diagnostic value of magnetic resonance imaging (MRI) radiomics in distinguishing high-grade meningiomas (HGM) from low-grade meningiomas (LGM). A systematic search was conducted in PubMed, EMbase, Web of Science, and The Cochrane Library databases up to December 31, 2023. Two researchers independently screened studies, extracted data, and assessed risk of bias and quality of included studies as well. Meta-analysis was performed using Stata 14 software to calculate pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC). A total of 21 studies with 2253 patients were included (607 HGM, 1646 LGM). Meta-analysis showed an overall SEN of 0.82 (95% CI 0.74-0.88) and SPE of 0.85 (95% CI 0.81-0.89). The PLR and NLR were 5.64 (95% CI 4.17-7.64) and 0.21 (95% CI 0.14-0.31), respectively, with a pooled DOR of 26.66 (95% CI 14.42-49.27) and an AUC of 0.91 (95% CI 0.88-0.93), indicating high diagnostic accuracy. Although additional research is required to validate suitable techniques, MRI radiomics shows strong potential as an accurate tool for meningioma grading. Standardizing radiomics application could enhance diagnostic precision and clinical decision-making for meningioma grading in the future.Trial Registration: CRD42024500086.

Positron emission tomography (PET) with prostate-specific membrane antigen (PSMA) radioligands has an established role in the assessment of recurrence of prostate cancer (PC) after primary treatment. However, an updated understanding of its diagnostic utility is warranted, particularly in the context of emerging targeted and systemic treatment options for recurrent PC. Our aim was to evaluate the diagnostic performance of PSMA PET for staging and detection of local or metastatic disease in patients with biochemical recurrence (BCR) following definitive treatment for PC.

Active surveillance (AS) is the preferred management for most patients with stage 1 testicular germ cell tumors (GCT) after orchidectomy as it avoids chemotherapy in up to 85% of patients. International guidelines recommend a combination of imaging, serum tumor markers and physical examination. The aim of this review was to analyze the diagnostic yield of physical examination for detecting relapse in these patients.