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2721. Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade.
Coronary stenting with use of heparin, aspirin, and ticlopidine for thromboprophylaxis is performed in more than 500,000 patients per year worldwide. We did a randomised controlled trial to assess the role of platelet glycoprotein-IIb/IIIa blockade for use in elective stenting.
2722. Randomised investigation of effects of pentoxifylline on left-ventricular performance in idiopathic dilated cardiomyopathy.
There is accumulating evidence that inflammatory cytokines have an important role in the pathogenesis of heart failure. Plasma concentrations of tumour necrosis factor alpha (TNF-alpha) are high in heart failure and have been correlated with the severity of symptoms. Pentoxifylline suppresses the production of TNF-alpha. This study aimed to assess the effects of pentoxifylline on left-ventricular function and functional class in patients with idiopathic dilated cardiomyopathy.
2724. Randomised trial of interferon alpha-2a as adjuvant therapy in resected primary melanoma thicker than 1.5 mm without clinically detectable node metastases. French Cooperative Group on Melanoma.
作者: J J Grob.;B Dreno.;P de la Salmonière.;M Delaunay.;D Cupissol.;B Guillot.;P Souteyrand.;B Sassolas.;J P Cesarini.;S Lionnet.;C Lok.;C Chastang.;J J Bonerandi.
来源: Lancet. 1998年351卷9120期1905-10页
Owing to the limited efficacy of therapy on melanoma at the stage of distant metastases, a well-tolerated adjuvant therapy is needed for patients with high-risk primary melanoma. Our hypothesis was that an adjuvant treatment with low doses of interferon alpha could be effective in patients with localised melanoma.
2725. Randomised placebo-controlled crossover trial on effect of inactivated influenza vaccine on pulmonary function in asthma.
作者: K G Nicholson.;J S Nguyen-Van-Tam.;A H Ahmed.;M J Wiselka.;J Leese.;J Ayres.;J H Campbell.;P Ebden.;N M Eiser.;B J Hutchcroft.;J C Pearson.;R F Willey.;R J Wolstenholme.;M A Woodhead.
来源: Lancet. 1998年351卷9099期326-31页
Despite current recommendations, many people with asthma do not receive annual vaccination against influenza, partly because of concern that vaccine may trigger exacerbations. Colds can trigger exacerbations, which may be mistaken for vaccine-related adverse events. We undertook a double-blind placebo-controlled multicentre crossover study to assess the safety of influenza vaccine in patients with asthma, with allowance for the occurrence of colds.
2726. Randomised trial of laparoscopic versus open cholecystectomy for acute and gangrenous cholecystitis.
Laparoscopic cholecystectomy (LC) has become the treatment of choice for elective cholecystectomy, but controversy persists over use of this approach in the treatment of acute cholecystitis. We undertook a randomised comparison of the safety and outcome of LC and open cholecystectomy (OC) in patients with acute cholecystitis.
2728. Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome.
作者: H R Andersen.;J C Nielsen.;P E Thomsen.;L Thuesen.;P T Mortensen.;T Vesterlund.;A K Pedersen.
来源: Lancet. 1997年350卷9086期1210-6页
In a previous study of 225 patients with sick-sinus syndrome randomised to either single-chamber atrial pacing (n=110) or single-chamber ventricular pacing (n=115), we found that after a mean follow-up of 3.3 years, atrial pacing was associated with significantly less atrial fibrillation and thromboembolism whereas there was no significant difference in mortality and heart failure between the two groups. We aimed to find out whether this beneficial effect of atrial pacing is maintained during extended follow-up of up to 8 years.
2729. Randomised placebo-controlled trial of rhesus-human reassortant rotavirus vaccine for prevention of severe rotavirus gastroenteritis.
Rotavirus is the most common cause of acute childhood gastroenteritis. Vaccination with live oral heterologous rotavirus vaccines may prevent rotavirus gastroenteritis. We assessed the efficacy of rhesus-human reassortant rotavirus tetravalent vaccine (RRV-TV) against severe rotavirus gastroenteritis in Finnish children in a randomised placebo-controlled double-blind trial.
2730. Randomised placebo-controlled trial of human recombinant insulin-like growth factor I plus intensive insulin therapy in adolescents with insulin-dependent diabetes mellitus.
作者: C L Acerini.;C M Patton.;M O Savage.;A Kernell.;O Westphal.;D B Dunger.
来源: Lancet. 1997年350卷9086期1199-204页
Good glycaemic control in insulin-dependent diabetes mellitus (IDDM) to prevent complications may be difficult to achieve during adolescence, because abnormalities in production of growth hormone or insulin-like growth-factor-I (IGF-I) can lead to lower insulin sensitivity. Recombinant human IGF-I (rhIGF-I) given as an adjunct to insulin therapy in IDDM, might improve glycaemic control in adolescents; we investigated the effects of the addition of IGF-I in a randomised, double-blind, placebo-controlled trial.
2731. Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients. CHIB 201 International Study Group.
作者: B Nashan.;R Moore.;P Amlot.;A G Schmidt.;K Abeywickrama.;J P Soulillou.
来源: Lancet. 1997年350卷9086期1193-8页
Currently available immunosuppressive regimens for cadaver-kidney recipients are far from ideal because acute-rejection episodes occur in about 30% to 50% of these patients. In the phase III study described here we assessed the ability of basiliximab, a chimeric interleukin (IL)-2 receptor monoclonal antibody, to prevent acute-rejection episodes in renal allograft recipients.
2732. Effect of breathing rate on oxygen saturation and exercise performance in chronic heart failure.
作者: L Bernardi.;G Spadacini.;J Bellwon.;R Hajric.;H Roskamm.;A W Frey.
来源: Lancet. 1998年351卷9112期1308-11页
In chronic heart failure (CHF), impaired pulmonary function can independently contribute to oxygen desaturation and reduced physical activity. We investigated the effect of breathing rate on oxygen saturation and other respiratory indices.
2735. Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy.
作者: K J Osterziel.;O Strohm.;J Schuler.;M Friedrich.;D Hänlein.;R Willenbrock.;S D Anker.;P A Poole-Wilson.;M B Ranke.;R Dietz.
来源: Lancet. 1998年351卷9111期1233-7页
Some studies have suggested that treatment with recombinant human growth hormone (rhGH) increases left-ventricular mass and improves haemodynamic and functional status in patients with heart failure due to dilated cardiomyopathy. We did a double-blind, randomised, placebo-controlled study of rhGH in patients with chronic heart failure due to dilated cardiomyopathy.
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