Data on the prevalence of celiac disease are scarce in Cameroon; however, it has been demonstrated that the effectiveness of self-reported questionnaires as a tool for identifying individuals at risk of celiac disease has been established. This study was therefore designed to assess the risk of celiac disease among adults in semi-rural and urban areas (Moungo and Wouri) using self-reported questionnaires.

Ultrasound-derived fat fraction (UDFF) is a novel, non-invasive, rapid, and cost-effective technology that assesses liver fat content in various hepatic diseases. Its use in evaluating hepatic steatosis in Wilson’s disease (WD) remains largely unexplored. This study aimed to verify the clinical utility and measurement consistency of UDFF in assessing hepatic steatosis in WD, investigate the relationship between BMI and the severity of hepatic steatosis in WD patients, and determine if UDFF is an effective indicator for this condition.

Stress hyperglycemia ratio (SHR), an index reflecting relative hyperglycemia under stress conditions, has been linked to adverse outcomes in various clinical settings. However, its prognostic significance in individuals with nonalcoholic fatty liver disease (NAFLD) remains poorly understood. This study aimed to examine the association between SHR and mortality risk in adults with NAFLD.

The concept of pre-rehabilitation has been clinically implemented across various surgical fields; however, studies investigating its application in colonoscopy remain limited. This study aimed to evaluate the effectiveness, safety, and patient satisfaction of the pre-rehabilitation concept in bowel preparation for comfort colonoscopy among elderly Chinese patients.

The Allostatic Load Index (ALI), as a comprehensive biomarker for assessing the body’s chronic stress response, has been widely used in quantitative studies of the physiological mechanisms of stress. In this study, we systematically investigated the relationship between ALI and hepatic steatosis and fibrosis through cross-sectional analysis.

Endoscopic transpapillary gallbladder drainage (ETGBD) is used to manage acute cholecystitis (AC) in patients in whom surgery is contraindicated. However, ETGBD is considered challenging, has comparatively lower success rates, and is associated with severe adverse events (AEs). Only a few studies have examined the procedural and anatomical factors that affect the success of technical ETGBD. This study identified predictive factors for ETGBD in AC to improve success rates and minimize AEs.

Recent research has demonstrated the importance of the tumor microenvironment (TME) in the behavior of solid tumors. Numerous discoveries suggest that tumor progression in a variety of malignancies, including those of the gastrointestinal tract, may be predicted by pathological evaluation of the desmoplastic reaction (DR), tumor budding (TB) and tumor-infiltrating lymphocytes (TIL). While some studies have demonstrated the prognostic impact of TIL in patients with squamous cell carcinoma of the esophagus (ESCC), the data have not reached agreement. Furthermore, few studies have investigated the relationship of DR and TB with disease progression. The relationships between DR, TB and TIL in these tumors remain to be investigated. Therefore, this study was undertaken to explore the relationships between DR, TB and TIL and histopathological parameters related to tumor behavior and assess their prognostic role in predicting survival in patients with ESCC.

Early-onset colorectal cancer (EOCRC) and late-onset colorectal cancer (LOCRC) are significant public health concerns. There has been limited research comparing EOCRC and LOCRC, particularly regarding their global burden.

This study aims to compare the therapeutic outcomes of transcystic laparoscopic common bile duct exploration (TC-LCBDE) and transductive laparoscopic common bile duct exploration (TD-LCBDE) for the treatment of common bile duct stones accompanied by gallstones.

This study aimed to elucidate the correlations among dyslipidemia, immune function, and clinical outcomes in patients with acute-on-chronic liver failure (ACLF), with particular emphasis on the clinical significance of lipid metabolism and cellular immune parameters in hepatitis B virus-associated ACLF (HBV-ACLF).

To compare the diagnostic performances of washout (WO) criteria confined to portal venous phase (PVP), extended to transition phase (TP) or hepatobiliary phase (HBP) for subcentimeter hepatocellular carcinoma (HCC) using gadoxetic acid-enhanced MRI.

Hemorrhoids, a common anorectal condition, can be managed through surgical or conservative treatments. The aim of this meta-analysis is to compare the efficacy and safety of surgical and conservative treatments for hemorrhoids.

The objective of this study was to identify prognostic clinicopathological factors in patients with Crohn's disease (CD) receiving infliximab (IFX) treatment and to develop a new nomogram for predicting outcomes in this population.

Crohn's disease (CD) is a chronic non-specific inflammatory bowel disease with an increasing incidence worldwide. Patients with CD are facing elevated risk for mental disorders (MD) than healthy people, and chronic psychological stress is considered to trigger deterioration and relapse of CD. The microbiome-gut-brain axis (MGBA) is recognized as a crucial factor in unraveling this connection. Whereas, so far, few studies have revealed the relationship of the microbiota communities and tryptophan catabolites of the terminal ileum mucosa on gut-brain communication.

To investigate the diagnosis and treatment methods for hemothorax resulting from local ablation in patients with primary liver cancer.

The association between dietary flavonoids and fatty liver disease is still controversial. This study investigated the link between dietary flavonoids intake and metabolic-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD).

Hepatocellular carcinoma (HCC) represents the most prevalent histological subtype of primary liver cancer. This study aimed to establish a miRNA-related prognostic genes signature, providing a theoretical framework for prognosis and therapy in patients with HCC. The miRNA-correlated (MIRcor) genes were identified through correlation analysis of miRNA-mRNA relationships from three databases. Consensus clustering was then applied to HCC samples based on these MIRcor genes. Differentially expressed genes (DEGs) between HCC and normal samples, as well as between subtypes with the most significant survival differences, were extracted. Subtype-and-tumor common DEGs were identified by intersecting these DEGs. Prognostic genes were derived using univariate Cox and least absolute shrinkage and selection operator (LASSO) regression analyses. A risk model was developed with the The Cancer Genome Atlas-Hepatocellular Carcinoma (TCGA-HCC) dataset and validated in the International Cancer Genome Consortium-Hepatocellular Carcinoma (ICGC-HCC) dataset, while independent prognostic predictors were confirmed through Cox analysis. Additionally, an immune microenvironment analysis was conducted to compare high- and low-risk groups. From the subtype-and-tumor common DEGs, five prognostic genes were identified and used to construct a prognostic gene signature. Expression of these genes was further validated at both protein and mRNA levels via Western blotting and Reverse Transcription Polymerase Chain Reaction (RT-PCR). The risk score and T stage emerged as reliable independent prognostic predictors. We observed significant differences in the abundance of 11 types of immune cells between the high-risk and low-risk groups. All five prognostic genes were expressed at significantly higher levels in normal liver tissues than in HCC tumor tissues. A risk model based on these genes offers a theoretical basis and valuable reference for HCC management.

To evaluate the diagnostic efficacy of magnetic resonance imaging proton density fat fraction (MRI-PDFF) in assessing hepatic steatosis among patients with metabolic dysfunction-associated steatotic liver disease (MASLD) through systematic review and meta-analysis approaches.

Helicobacter pylori infection is an important risk factor for gastric cancer. In Japan, national health insurance has covered eradication therapy for H. pylori infection-associated gastritis from 2013. However, gastric cancer was the fourth leading cause of cancer death in 2023. We aimed to investigate differences in gastric cancer risk among patients with gastritis, gastric ulcer, duodenal ulcer, and gastric ulcer and duodenal ulcer after H. pylori eradication.

Chronic hepatitis B (CHB) is a major health problem worldwide and is a major contributor to the progression of cirrhosis and hepatocellular carcinoma (HCC). Accurate monitoring of the immune response and liver inflammation in CHB patients is critical for effective disease management. N6-methyladenosine (m6A) plays a pivotal role in viral replication and immune modulation. However, the clinical significance of m6A regulators in the host immune system during CHB is still unclear. This study investigated the expression of key m6A regulators (METTL3, METTL14, IGF2BP3, and ALKBH5) in peripheral blood mononuclear cells (PBMCs) from CHB patients to explore their potential as noninvasive biomarkers for CHB diagnosis.