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241. Cost-Effectiveness of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular Disease.
作者: Louise B Russell.;Kevin G M Volpp.;Mitesh S Patel.;Neel P Chokshi.;Samantha Coratti.;David Farraday.;Laurie Norton.;Charles Rareshide.;Jingsan Zhu.;Tamar Klaiman.;Julia E Szymczak.;Dylan S Small.;Alexander C Fanaroff.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e011839页
The BE ACTIVE trial (Behavioral Economic Approaches to Increase Physical Activity Among Patients with Elevated Risk for Cardiovascular Disease) documented the effectiveness, compared with an attention control arm that received daily text messages, of gamification, financial incentives, or gamification+financial incentives to increase steps/day. Increases in daily step count are associated with longer life expectancy, but understanding the cost-effectiveness of these interventions is essential for payers and other stakeholders seeking to implement findings.
244. Family Screening in Relatives at Risk for Plakophilin-2-Associated Arrhythmogenic Right Ventricular Cardiomyopathy.
作者: Steven A Muller.;Babken Asatryan.;Alessio Gasperetti.;Maarten J Cramer.;Ahmad S Amin.;Peter Loh.;Richard T Carrick.;Moniek G P J Cox.;Pim van der Harst.;Marish I F J Oerlemans.;Crystal Tichnell.;Sing-Chien Yap.;Brittney Murray.;Stefan L Zimmerman.;J Peter van Tintelen.;Hugh Calkins.;Anneline S J M Te Riele.;Cynthia A James.
来源: Circulation. 2025年152卷5期313-326页
Penetrance and risk of ventricular arrhythmias (VAs) in arrhythmogenic right ventricular cardiomyopathy (ARVC) are increasingly recognized as being genotype specific. Therefore, genotype-informed family screening protocols may lead to safer and more personalized recommendations than the current one-size-fits-all screening recommendations. We aimed to develop a safe, evidence-based plakophilin-2 (PKP2)-specific longitudinal screening algorithm.
247. Response by Vukadinović et al to Letter Regarding Article, "Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis".249. Influence of Resuscitated Cardiac Arrest on Efficacy and Safety of Extracorporeal Life Support in Infarct-Related Cardiogenic Shock: A Substudy of the ECLS-SHOCK Trial.
作者: Uwe Zeymer.;Anne Freund.;Marko Noc.;Ibrahim Akin.;Kurt Huber.;Janine Pöss.;Steffen Schneider.;Tienush Rassaf.;Christian Jung.;Eike Tigges.;Taoufik Ouarrak.;Steffen Desch.;Holger Thiele.
来源: Circulation. 2025年151卷24期1752-1754页 250. Impact of the Volume-Based Procurement Policy on the Use of Coronary Stents in China: Cross-Sectional Study.
作者: Zhao Yang.;Wei Zhao.;Liangyu Ni.;Linlin Da.;Yongyi Wu.;Yuxi Li.;Qiyun Zhu.;Jianping Li.;Dennis Ross-Degnan.;Bin Jiang.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e011374页 251. Response by Doust et al to Letter Regarding Article "Assessing the Accuracy of Cardiovascular Disease Prediction Using Female-Specific Risk Factors in Women Aged 45 to 69 Years in the UK Biobank Study".
作者: Jenny Doust.;Mohammad Reza Baneshi.;Hsin-Fang Chung.;Louise Forsyth Wilson.;Gita Devi Mishra.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e012021页 252. Letter by Rich-Edwards et al Regarding Article, "Assessing the Accuracy of Cardiovascular Disease Prediction Using Female-Specific Risk Factors in Women Aged 45 to 69 Years in the UK Biobank Study".
作者: Janet W Rich-Edwards.;Kathryn M Rexrode.;Tiange Liu.;Chuan Hong.;Johanna Quist-Nelson.;Marie-Louise Meng.;Hanne Dahl Vonen.;Michael J Pencina.;Ricardo Henao.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e011970页 254. Identifying a Heterogeneous Effect of Atrial Fibrillation Screening in Older Adults: A Secondary Analysis of the VITAL-AF Trial.
作者: Sachin J Shah.;Jay M Iyer.;Leila Agha.;Yuchiao Chang.;Jeffrey M Ashburner.;Steven J Atlas.;David D McManus.;Patrick T Ellinor.;Steven A Lubitz.;Daniel E Singer.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e011482页
One-time atrial fibrillation (AF) screening trials in older adults have produced mixed results. In a secondary analysis of the VITAL-AF trial, we aimed to identify a subset of people in whom such screening is effective, using effect-based and risk-based approaches.
255. Association Between Automated Coronary Artery Calcium From Routine Chest Computed Tomography Scans and Cardiovascular Risk in Patients With Colorectal or Gastric Cancer.
作者: Subin Kim.;Seonji Kim.;Min Jae Cha.;Hyo Song Kim.;Han Sang Kim.;Woo Jin Hyung.;Iksung Cho.;Seng Chan You.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e011656页
As cardiovascular disease (CVD) is the leading cause of noncancer mortality in colorectal or gastric cancer patients, it is essential to identify patients at increased CVD risk. Coronary artery calcium (CAC) is an established predictor of atherosclerotic CVD; however, its application is limited in this population. This study evaluates the association between automated CAC scoring using chest computed tomography and atherosclerotic CVD risk in colorectal or gastric cancer patients.
256. Inactivation of RhoA for Hypertension Treatment Through the TRPV4-RhoA-RhoGDI1 Axis.
作者: Jiawen Wang.;Zhen Yuan.;Na Yu.;Qian Jiao.;Honglei Zhou.;Wenjie Liao.;Jiwei Shan.;Shanshan Ruan.;Yi Zhao.;Ya Mo.;Luyao Qi.;Tiejun Li.;Jianjun Fu.;Bowen Ke.;Yufang Xu.;Xuhong Qian.;Jian Zhang.;Zhenjiang Zhao.;Shiliang Li.;Rui Wang.;Honglin Li.
来源: Circulation. 2025年152卷8期519-536页
The RhoA (Ras homolog family member A) signaling pathway is pivotal in regulating vascular smooth muscle cells (VSMCs) function and blood pressure homeostasis. Current inhibitors of the RhoA signaling pathway are limited in hypertension treatment, suffering from poor efficacy, insufficient specificity, and developmental challenges.
258. Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: the PRINCE Randomized Clinical Trial.
作者: Massimiliano Greco.;Gaetano Lombardi.;Claudia Brusasco.;Marina Pieri.;Agostino Roasio.;Fabrizio Monaco.;Levan Berikashvili.;Alessandro Belletti.;Francesco Meroi.;Stefano Fresilli.;Aituar Kabibulatov.;Giuseppe Giardina.;Andrea Russo.;Federico Mattia Oliva.;Sergey Efremov.;Rosalba Lembo.;Lini Wang.;Simone Vietri.;Elena Momesso.;Filippo D'Amico.;Kristina Kadantseva.;Rosa Labanca.;Pavel Ryzhkov.;Marilena Marmiere.;Valery Subbotin.;Alessandro Pruna.;Nerlep Rana.;Francesca Livi.;Hugo Mantilla-Gutierrez.;Fabio Guarracino.;Lorenzo Schiavoni.;Ivan Šitum.;Marco Micali.;Stefano Bosso.;Anastasia Smirnova.;Giuseppe Fresta.;Andrey Cherednichenko.;Luigi Beretta.;Giacomo Monti.;Lian Kah Ti.;Pasquale Sansone.;Francesco Corradi.;Maurizio Cecconi.;Andrey Yavorovskiy.;Chong Lei.;Aidos Konkayev.;Tiziana Bove.;Valery Likhvantsev.;Alberto Zangrillo.;Giovanni Landoni.;Rinaldo Bellomo.;Remo Daniel Covello.;Stefano Turi.; .
来源: Circulation. 2025年
Major noncardiac surgery carries high rates of postoperative myocardial injury and other complications. Remote ischemic preconditioning (RIPC) was reported to decrease these complications. However, such supportive evidence lacks robustness.
259. How a Topological Mindset May Offer Extra Control During Mapping and Ablation of Left-Sided Reentrant Atrial Tachycardia.
作者: Mattias Duytschaever.;Maarten De Smet.;Jordi Martens.;Milad El Haddad.;Benjamin De Becker.;Clara Francois.;Rene Tavernier.;Robin Van den Abeele.;Sander Hendrickx.;Nele Vandersickel.;Jean-Benoit Le Polain de Waroux.;Sebastien Knecht.
来源: Circ Arrhythm Electrophysiol. 2025年18卷7期e013780页
Reentry (macro or localized) is historically described as multiple pathways that are separated by barriers (either anatomic or functional) and involve active and passive loops (identified by electro-anatomic and entrainment mapping, EAM/ETM). Some reentrant atrial tachycardia (AT) cases are characterized by challenging activation patterns and unexpected ablation responses. A recent translational study, focusing on topology (TOP) and the role of boundaries, suggests that thinking topology within EAM/ETM might offer extra control during mapping and ablation of reentrant AT. We aimed to propose and prospectively validate a workflow (EAM/ETM+TOP) in which we integrate topological thinking within an EAM/ETM workflow for mapping and ablation of left-sided (left atrium) AT.
260. Feasibility of Machine Learned Intracardiac Electrograms to Predict Postinfarction Ventricular Scar Topography.
作者: Kasun De Silva.;Timothy G Campbell.;Richard G Bennett.;Samual Turnbull.;Ashwin Bhaskaran.;Robert D Anderson.;Christopher Davey.;Alexandra K O'Donohue.;Aaron Schindeler.;Dinesh Selvakumar.;Yasuhito Kotake.;Chi-Jen Hsu.;James J H Chong.;Eddy Kizana.;Saurabh Kumar.
来源: Circ Arrhythm Electrophysiol. 2025年18卷7期e013611页
Accurate delineation of scar patterns is valuable for guiding catheter ablation of ventricular tachycardia. We hypothesized that scar and its pattern of distribution can be determined from intracardiac electrograms using computational signal processing and that further improvements in classification can be achieved with a convolutional neural network.
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