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247. Transfusion of Fresh Frozen Plasma and Platelets in Critically Ill Adults: An American College of Chest Physicians Clinical Practice Guideline.
作者: Angel Coz Yataco.;Israa Soghier.;Paul C Hébert.;Emilie Belley-Cote.;Margaret Disselkamp.;David Flynn.;Karin Halvorson.;Jonathan M Iaccarino.;Wendy Lim.;Christina C Lindenmeyer.;Peter J Miller.;Kevin O'Neil.;Kathryn M Pendleton.;Lisa Vande Vusse.;Daniel R Ouellette.
来源: Chest. 2025年
Platelets and fresh frozen plasma (FFP) are frequently administered to critically ill patients. Considering the variability in indications and thresholds guiding these transfusions, a comprehensive review of current evidence was conducted to provide guidance to critical care practitioners. This American College of Chest Physicians guideline examined the literature on platelet transfusions in critically ill patients with thrombocytopenia, with and without active bleeding, as well as data on prophylactic platelet and FFP transfusions for common procedures in the critical care setting.
249. Association Between Preserved Ratio Impaired Spirometry and COPD With Coronary Artery Calcification Measured by Coronary CT Scan.
作者: Purnadeo N Persaud.;Lauren S Munoz Tremblay.;Yanjun Wu.;Peter Oro.;Daniel A Culver.;James K Stoller.;Xiaofeng Wang.;Raul Seballos.;Richard H Cartabuke.;Trishul Siddharthan.;Vickram Tejwani.
来源: Chest. 2025年168卷2期410-414页 250. Importance of Preserved Ratio Impaired Spirometry as a Risk Factor for Development of COPD, Also in Those Who Do Not Smoke.
作者: Helena Backman.;Tomi Myrberg.;Linnea Hedman.;Caroline Stridsman.;Eva Rönmark.;Anne Lindberg.
来源: Chest. 2025年168卷1期83-94页
COPD is largely underdiagnosed. Active identification of cases is crucial to establish preventive measures before manifestation of clinical disease. The significance of different spirometric patterns preceding COPD, especially preserved ratio impaired spirometry (PRISm), has been highlighted but remains unclear.
251. Diagnostic Evaluation and Clinical Findings in Children With Persistent Tachypnea of Infancy/Neuroendocrine Cell Hyperplasia of Infancy: A European Multicenter Retrospective Study.
作者: Honorata Marczak.;Katarzyna Krenke.;Matthias Griese.;Joanna Peradzyńska.;Joanna Lange.;Marek Kulus.;Magdalena Grochowska.;Elias Seidl.;Jean-Christophe Dubus.;Julia Rodler.;Nicolaus Schwerk.;Julia Carlens.;Oded Breuer.;Avigdor Hevroni.;Silvia Castillo-Corullón.;Malena Aldeco.;Frederik Fouirnaies Buchvald.;Kim G Nielsen.;Sarah Mayell.;Alba Torrent.;Maynor Bravo-López.;Nicolas Regamey.;Florian Stehling.;Philipp Latzin.;Anna Zschocke.;Elpis Hatziagorou.;Roser Ayats.;Tuğba Şişmanlar Eyüboğlu.;Ela Erdem.;Marijke Proesmans.;Steve Cunningham.;Dafni Moriki.;Sevgi Pekcan.;Nazan Cobanoglu.;Lutz Naehrlich.;Christiane Lex.;Nicola Ullmann.;Winfried Baden.;Dora Krikovszky.;Mirella Gaboli.;Nuria Diez Monge.;David Naranjo Vivas.;Sune Leisgaard Mørck Rubak.;Brigitte Willemse.;Laura Petrarca.;Anna Wiemers.;Dirk Schramm.;Christoph Mueller.;Freerk Prenzel.;Vaclav Koucky.;Juan A López-Andreu.;Nadia Nathan.
来源: Chest. 2025年168卷1期171-182页
Persistent tachypnea of infancy (PTI) or neuroendocrine cell hyperplasia of infancy (NEHI) is a form of childhood interstitial lung disease (chILD) that predominantly affects young children. Although it is one of the most common chILDs, no unified diagnostic approach specific to this condition exists.
252. Prevalence of Airflow Limitation and Emphysema in Lung Cancer Screening Populations: A Systematic Review and Meta-Analysis.
作者: Hyewon Choi.;Il-Youp Kwak.;Chung Ryul Oh.;Jin Mo Goo.;Soon Ho Yoon.
来源: Chest. 2025年168卷1期67-82页
Early detection and treatment of COPD are becoming important for improving the prognosis of individuals who have a history of heavy tobacco use. Despite the higher risk of COPD among individuals participating in lung cancer screening, many of these patients continue to show rates of underdiagnosis of lung cancer.
253. Changes in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis.
作者: Justin M Oldham.;Megan L Neely.;Daniel M Wojdyla.;Mridu Gulati.;Peide Li.;Divya C Patel.;Scott M Palmer.;Jamie L Todd.; .
来源: Chest. 2025年168卷2期415-422页
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease associated with lung function decline and high mortality.
254. Role of Characteristic Pulmonary Impedance With Exercise for Detection of Abnormal Pulmonary Vascular Response and Uncoupling in Pulmonary Hypertension Resulting From Heart Failure With Preserved Ejection Fraction.
作者: Christopher G Lechuga.;Farhan Raza.;Mitchel J Colebank.;Claudia E Korcarz.;Aimee T Broman.;Jens C Eickhoff.;Naomi C Chesler.
来源: Chest. 2025年168卷2期488-501页
Pulmonary hypertension (PH) resulting from heart failure with preserved ejection fraction (PH-HFpEF) can lead to right ventricular-pulmonary arterial (RV-PA) uncoupling despite normal steady hemodynamics (eg, pulmonary vascular resistance). Unsteady hemodynamics, quantified by characteristic pulmonary impedance (ZC), may be useful in differentiating those patients with PH-HFpEF who have sufficient coupling from those who have insufficient coupling. We hypothesized that abnormal pulsatile hemodynamics with exercise, quantified by ZC, could precisely detect abnormal cardiopulmonary function in PH-HFpEF.
255. Deciphering the Role of Fluorodeoxyglucose-Positron Emission Tomography/CT Imaging in the Management of Sarcoidosis.
作者: Ryan Donnelly.;Alessandro N Franciosi.;Sarah H Forde.;Michael McDermott.;Michael P Keane.;David J Murphy.;Emmet E McGrath.;Cormac McCarthy.
来源: Chest. 2025年168卷1期146-155页
2-Deoxy-2-[18F]fluoro-d-glucose (FDG)-PET/CT imaging has utility in identifying sites of active sarcoidosis. However, the role of FDG-PET/CT imaging in predicting treatment response and guiding therapy outside of cardiac disease is yet to be completely understood.
256. Diagnostic Yield and Synergistic Impact of Needle Aspiration and Forceps Biopsy With Electromagnetic Navigation Bronchoscopy for Peripheral Pulmonary Lesions: A Randomized Controlled Trial.
作者: Yeon Wook Kim.;Hyung-Jun Kim.;Byoung Soo Kwon.;Ye Jin Lee.;Myung Jin Song.;Sung Hyun Yoon.;Sung Yoon Lim.;Yeon Joo Lee.;Jong Sun Park.;Young-Jae Cho.;Kyung Hee Lee.;Jin-Haeng Chung.;Yeon Bi Han.;Fabien Maldonado.;So Yeon Ahn.;Youngmi Park.;Dong-Hyun Joo.;Jae Ho Lee.;Choon-Taek Lee.
来源: Chest. 2025年168卷1期236-247页
Electromagnetic navigation bronchoscopy (ENB) is an advanced imaging-guided technique used to diagnose peripheral pulmonary lesions. However, the optimal strategy for selecting biopsy devices remains unclear.
257. Estimating the Causal Effect of Double-Blind Peer Review for a Pulmonary, Critical Care, and Sleep Medicine Journal.
作者: Hayley B Gershengorn.;Kelly C Vranas.;Colin R Cooke.;Christopher G Slatore.;Stephanie M Levine.
来源: Chest. 2025年168卷1期160-170页
Double-blind peer review (DBPR; reviewers masked to author identities and vice versa) aims to reduce biases. The effectiveness of DBPR has not been studied in pulmonary, critical care, and sleep journals.
258. Prognostic Value of Main Pulmonary Artery Diameter in Pulmonary Arterial Hypertension.
作者: Jacob Y Cao.;Rita-Maria Abdo.;Nelson Wang.;Nick Olsen.;Kate Kearney.;Kirby Wong.;Edmund Lau.;David Celermajer.;Eugene Kotlyar.;Rachael Cordina.
来源: Chest. 2025年168卷2期476-487页
Accurate risk stratification is critical aspect of pulmonary arterial hypertension (PAH) management. It is unclear whether main pulmonary artery (MPA) enlargement offers additional prognostic value to validated risk scores.
259. Growing Up With Developmental Lung Diseases: A Review for the Adult Pulmonologist.
作者: Yadira Rivera-Sanchez.;Zachary W Blair.;Tyler J Wall.;Kara N Goss.
来源: Chest. 2025年168卷1期95-105页
Improved childhood management strategies have decreased the early life morbidity and mortality of severe developmental lung disorders, such that an increasing number of individuals ultimately transition care to adult pulmonologists for management. Alternatively, individuals with milder malformations may present in adulthood or may have an increased risk for the development of more common adult pulmonary comorbidities (eg, COPD, pulmonary hypertension). As such, there is a critical need for adult pulmonologists to understand how developmental lung disorders may impact respiratory morbidity over the lifespan.
260. Impact of Noninvasive Ventilation Before and After Cardiac Surgery for Preventing Cardiac and Pulmonary Complications: A Clinical Randomized Trial.
作者: Marion Goret.;Kevin Pluchon.;Raphaël Le Mao.;Ali Badra.;Jean-Ferréol Oilleau.;Yohann Morvan.;Marc Beaumont.;Gwenaëlle Desanglois.;Marie Guegan.;Aude Barnier.;Christophe Gut-Gobert.;Cécile Tromeur.;Christophe Leroyer.;Jean-Noël Choplain.;Ahmed Khalifa.;Eric Bezon.;Francis Couturaud.
来源: Chest. 2025年167卷6期1727-1736页
The immediate postoperative period after heart surgery poses a substantial risk of life-threatening complications, notably acute pulmonary and cardiac failure. Use of noninvasive ventilation (NIV) may reduce the incidence of pulmonary or heart failure, or both.
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