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242. Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors.
作者: Mrinal Gounder.;Ravin Ratan.;Thierry Alcindor.;Patrick Schöffski.;Winette T van der Graaf.;Breelyn A Wilky.;Richard F Riedel.;Allison Lim.;L Mary Smith.;Stephanie Moody.;Steven Attia.;Sant Chawla.;Gina D'Amato.;Noah Federman.;Priscilla Merriam.;Brian A Van Tine.;Bruno Vincenzi.;Charlotte Benson.;Nam Quoc Bui.;Rashmi Chugh.;Gabriel Tinoco.;John Charlson.;Palma Dileo.;Lee Hartner.;Lore Lapeire.;Filomena Mazzeo.;Emanuela Palmerini.;Peter Reichardt.;Silvia Stacchiotti.;Howard H Bailey.;Melissa A Burgess.;Gregory M Cote.;Lara E Davis.;Hari Deshpande.;Hans Gelderblom.;Giovanni Grignani.;Elizabeth Loggers.;Tony Philip.;Joseph G Pressey.;Shivaani Kummar.;Bernd Kasper.
来源: N Engl J Med. 2023年388卷10期898-912页
Desmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors without approved treatments.
243. An Mpox-Related Death in the United States.
作者: Jemma Alarcón.;Moon Kim.;Dawn Terashita.;Kusha Davar.;Jacob M Garrigues.;Jack P Guccione.;Mark G Evans.;Peera Hemarajata.;Noah Wald-Dickler.;Paul Holtom.;Rodrigo Garcia Tome.;Lovelyn Anyanwu.;Naman K Shah.;Matthew Miller.;Todd Smith.;Audrey Matheny.;Whitni Davidson.;Christina L Hutson.;Jonathan Lucas.;Odey C Ukpo.;Nicole M Green.;Sharon E Balter.
来源: N Engl J Med. 2023年388卷13期1246-1247页 245. Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression.
作者: Eric J Lenze.;Benoit H Mulsant.;Steven P Roose.;Helen Lavretsky.;Charles F Reynolds.;Daniel M Blumberger.;Patrick J Brown.;Pilar Cristancho.;Alastair J Flint.;Marie A Gebara.;Torie R Gettinger.;Emily Lenard.;J Philip Miller.;Ginger E Nicol.;Hanadi A Oughli.;Vy T Pham.;Bruce L Rollman.;Lei Yang.;Jordan F Karp.
来源: N Engl J Med. 2023年388卷12期1067-1079页
The benefits and risks of augmenting or switching antidepressants in older adults with treatment-resistant depression have not been extensively studied.
247. Cancer Screening after the Adoption of Paid-Sick-Leave Mandates.
作者: Kevin Callison.;Michael F Pesko.;Serena Phillips.;Julie A Sosa.
来源: N Engl J Med. 2023年388卷9期824-832页
By the end of 2022, nearly 20 million workers in the United States have gained paid-sick-leave coverage from mandates that require employers to provide benefits to qualified workers, including paid time off for the use of preventive services. Although the lack of paid-sick-leave coverage may hinder access to preventive care, current evidence is insufficient to draw meaningful conclusions about its relationship to cancer screening.
248. Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma.
作者: Sapna P Patel.;Megan Othus.;Yuanbin Chen.;G Paul Wright.;Kathleen J Yost.;John R Hyngstrom.;Siwen Hu-Lieskovan.;Christopher D Lao.;Leslie A Fecher.;Thach-Giao Truong.;Jennifer L Eisenstein.;Sunandana Chandra.;Jeffrey A Sosman.;Kari L Kendra.;Richard C Wu.;Craig E Devoe.;Gary B Deutsch.;Aparna Hegde.;Maya Khalil.;Ankit Mangla.;Amy M Reese.;Merrick I Ross.;Andrew S Poklepovic.;Giao Q Phan.;Adedayo A Onitilo.;Demet G Yasar.;Benjamin C Powers.;Gary C Doolittle.;Gino K In.;Niels Kokot.;Geoffrey T Gibney.;Michael B Atkins.;Montaser Shaheen.;James A Warneke.;Alexandra Ikeguchi.;Jose E Najera.;Bartosz Chmielowski.;Joseph G Crompton.;Justin D Floyd.;Eddy Hsueh.;Kim A Margolin.;Warren A Chow.;Kenneth F Grossmann.;Eliana Dietrich.;Victor G Prieto.;Michael C Lowe.;Elizabeth I Buchbinder.;John M Kirkwood.;Larissa Korde.;James Moon.;Elad Sharon.;Vernon K Sondak.;Antoni Ribas.
来源: N Engl J Med. 2023年388卷9期813-823页
Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would increase event-free survival among patients with resectable stage III or IV melanoma is unknown.
249. Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus.
作者: George M Varghese.;Divya Dayanand.;Karthik Gunasekaran.;Debasree Kundu.;Mukta Wyawahare.;Navneet Sharma.;Dhruva Chaudhry.;Sanjay K Mahajan.;Kavitha Saravu.;Blessed W Aruldhas.;Binu S Mathew.;Roshini G Nair.;Nalini Newbigging.;Aswathy Mathew.;Kundavaram P P Abhilash.;Manisha Biswal.;Ann H Prasad.;Anand Zachariah.;Ramya Iyadurai.;Samuel G Hansdak.;Sowmya Sathyendra.;Thambu D Sudarsanam.;John A J Prakash.;Abi Manesh.;Alladi Mohan.;Joel Tarning.;Stuart D Blacksell.;Pimnara Peerawaranun.;Naomi Waithira.;Mavuto Mukaka.;Phaik Yeong Cheah.;John V Peter.;Ooriapadickal C Abraham.;Nicholas P J Day.; .
来源: N Engl J Med. 2023年388卷9期792-803页
The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear.
250. Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence.
作者: Nasser A Dhayat.;Olivier Bonny.;Beat Roth.;Andreas Christe.;Alexander Ritter.;Nilufar Mohebbi.;Nicolas Faller.;Lisa Pellegrini.;Giulia Bedino.;Reto M Venzin.;Philipp Grosse.;Carina Hüsler.;Irene Koneth.;Christian Bucher.;Rosaria Del Giorno.;Luca Gabutti.;Michael Mayr.;Urs Odermatt.;Florian Buchkremer.;Thomas Ernandez.;Catherine Stoermann-Chopard.;Daniel Teta.;Bruno Vogt.;Marie Roumet.;Luca Tamò.;Grazia M Cereghetti.;Sven Trelle.;Daniel G Fuster.
来源: N Engl J Med. 2023年388卷9期781-791页
Nephrolithiasis is one of the most common conditions affecting the kidney and is characterized by a high risk of recurrence. Thiazide diuretic agents are widely used for prevention of the recurrence of kidney stones, but data regarding the efficacy of such agents as compared with placebo are limited. Furthermore, dose-response data are also limited.
252. Viral Lineages in the 2022 RSV Surge in the United States.
作者: Gordon Adams.;Gage K Moreno.;Brittany A Petros.;Rockib Uddin.;Zoe Levine.;Ben Kotzen.;Katelyn S Messer.;Sabrina T Dobbins.;Katherine C DeRuff.;Christine M Loreth.;Taylor Brock-Fisher.;Stephen F Schaffner.;Sushma Chaluvadi.;Sanjat Kanjilal.;Jeremy Luban.;Al Ozonoff.;Daniel J Park.;Sarah E Turbett.;Katherine J Siddle.;Bronwyn L MacInnis.;Pardis C Sabeti.;Jacob E Lemieux.
来源: N Engl J Med. 2023年388卷14期1335-1337页 253. Safety and Efficacy of Denosumab for Fibrous Dysplasia of Bone.
作者: Luis F de Castro.;Zachary Michel.;Kristen Pan.;Jocelyn Taylor.;Vivian Szymczuk.;Sriram Paravastu.;Babak Saboury.;Georgios Z Papadakis.;Xiaobai Li.;Kelly Milligan.;Brendan Boyce.;Scott M Paul.;Michael T Collins.;Alison M Boyce.
来源: N Engl J Med. 2023年388卷8期766-768页 254. Treatment Strategy for Rifampin-Susceptible Tuberculosis.
作者: Nicholas I Paton.;Christopher Cousins.;Celina Suresh.;Erlina Burhan.;Ka Lip Chew.;Victoria B Dalay.;Qingshu Lu.;Tutik Kusmiati.;Vincent M Balanag.;Shu Ling Lee.;Rovina Ruslami.;Yogesh Pokharkar.;Irawaty Djaharuddin.;Jani J R Sugiri.;Rholine S Veto.;Christine Sekaggya-Wiltshire.;Anchalee Avihingsanon.;Rohit Sarin.;Padmasayee Papineni.;Andrew J Nunn.;Angela M Crook.; .
来源: N Engl J Med. 2023年388卷10期873-887页
Tuberculosis is usually treated with a 6-month rifampin-based regimen. Whether a strategy involving shorter initial treatment may lead to similar outcomes is unclear.
255. Rucaparib or Physician's Choice in Metastatic Prostate Cancer.
作者: Karim Fizazi.;Josep M Piulats.;M Neil Reaume.;Peter Ostler.;Ray McDermott.;Joel R Gingerich.;Elias Pintus.;Srikala S Sridhar.;Richard M Bambury.;Urban Emmenegger.;Henriette Lindberg.;David Morris.;Franco Nolè.;John Staffurth.;Charles Redfern.;María I Sáez.;Wassim Abida.;Gedske Daugaard.;Axel Heidenreich.;Laurence Krieger.;Brieuc Sautois.;Andrea Loehr.;Darrin Despain.;Catherine A Heyes.;Simon P Watkins.;Simon Chowdhury.;Charles J Ryan.;Alan H Bryce.; .
来源: N Engl J Med. 2023年388卷8期719-732页
In a phase 2 study, rucaparib, an inhibitor of poly(ADP-ribose) polymerase (PARP), showed a high level of activity in patients who had metastatic, castration-resistant prostate cancer associated with a deleterious BRCA alteration. Data are needed to confirm and expand on the findings of the phase 2 study.
256. Immunologic Effect of Bivalent mRNA Booster in Patients Undergoing Hemodialysis.
作者: Luca Huth.;Luise Schäfer.;Giovanni Almanzar.;Gaia Lupoli.;Marie Bischof.;Paul R Wratil.;Torsten Stövesand.;Christiane Drechsler.;Oliver T Keppler.;Martina Prelog.
来源: N Engl J Med. 2023年388卷10期950-952页 258. Evaluation of BNT162b2 Covid-19 Vaccine in Children Younger than 5 Years of Age.
作者: Flor M Muñoz.;Lawrence D Sher.;Charu Sabharwal.;Alejandra Gurtman.;Xia Xu.;Nicholas Kitchin.;Stephen Lockhart.;Robert Riesenberg.;Joanna M Sexter.;Hanna Czajka.;Grant C Paulsen.;Yvonne Maldonado.;Emmanuel B Walter.;Kawsar R Talaat.;Janet A Englund.;Uzma N Sarwar.;Caitlin Hansen.;Martha Iwamoto.;Chris Webber.;Luke Cunliffe.;Benita Ukkonen.;Silvina N Martínez.;Barbara A Pahud.;Iona Munjal.;Joseph B Domachowske.;Kena A Swanson.;Hua Ma.;Kenneth Koury.;Susan Mather.;Claire Lu.;Jing Zou.;Xuping Xie.;Pei-Yong Shi.;David Cooper.;Özlem Türeci.;Uğur Şahin.;Kathrin U Jansen.;William C Gruber.; .
来源: N Engl J Med. 2023年388卷7期621-634页
Safe and effective vaccines against coronavirus disease 2019 (Covid-19) are urgently needed in young children.
259. Early Treatment with Pegylated Interferon Lambda for Covid-19.
作者: Gilmar Reis.;Eduardo A S Moreira Silva.;Daniela C Medeiros Silva.;Lehana Thabane.;Vitoria H S Campos.;Thiago S Ferreira.;Castilho V Q Santos.;Ana M R Nogueira.;Ana P F G Almeida.;Leonardo C M Savassi.;Adhemar D Figueiredo-Neto.;Ana C F Dias.;Adelino M Freire Júnior.;Carina Bitarães.;Aline C Milagres.;Eduardo D Callegari.;Maria I C Simplicio.;Luciene B Ribeiro.;Rosemary Oliveira.;Ofir Harari.;Lindsay A Wilson.;Jamie I Forrest.;Hinda Ruton.;Sheila Sprague.;Paula McKay.;Christina M Guo.;Eve H Limbrick-Oldfield.;Steve Kanters.;Gordon H Guyatt.;Craig R Rayner.;Christopher Kandel.;Mia J Biondi.;Robert Kozak.;Bettina Hansen.;M Atif Zahoor.;Paul Arora.;Colin Hislop.;Ingrid Choong.;Jordan J Feld.;Edward J Mills.;Jeffrey S Glenn.; .
来源: N Engl J Med. 2023年388卷6期518-528页
The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear.
260. Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer.
作者: Nasser Altorki.;Xiaofei Wang.;David Kozono.;Colleen Watt.;Rodney Landrenau.;Dennis Wigle.;Jeffrey Port.;David R Jones.;Massimo Conti.;Ahmad S Ashrafi.;Moishe Liberman.;Kazuhiro Yasufuku.;Stephen Yang.;John D Mitchell.;Harvey Pass.;Robert Keenan.;Thomas Bauer.;Daniel Miller.;Leslie J Kohman.;Thomas E Stinchcombe.;Everett Vokes.
来源: N Engl J Med. 2023年388卷6期489-498页
The increased detection of small-sized peripheral non-small-cell lung cancer (NSCLC) has renewed interest in sublobar resection in lieu of lobectomy.
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