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241. High-Resolution and Noninvasive Fetal Exome Screening.
作者: Harrison Brand.;Christopher W Whelan.;Michael Duyzend.;John Lemanski.;Monica Salani.;Stephanie P Hao.;Isaac Wong.;Elise Valkanas.;Caroline Cusick.;Casie Genetti.;Lori Dobson.;Courtney Studwell.;Kathleen Gianforcaro.;Louise Wilkins-Haug.;Stephanie Guseh.;Benjamin Currall.;Kathryn Gray.;Michael E Talkowski.
来源: N Engl J Med. 2023年389卷21期2014-2016页 246. Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
作者: Randall J Bateman.;Janice Smith.;Michael C Donohue.;Paul Delmar.;Rachid Abbas.;Stephen Salloway.;Jakub Wojtowicz.;Kaj Blennow.;Tobias Bittner.;Sandra E Black.;Gregory Klein.;Mercè Boada.;Timo Grimmer.;Akira Tamaoka.;Richard J Perry.;R Scott Turner.;David Watson.;Michael Woodward.;Angeliki Thanasopoulou.;Christopher Lane.;Monika Baudler.;Nick C Fox.;Jeffrey L Cummings.;Paulo Fontoura.;Rachelle S Doody.; .
来源: N Engl J Med. 2023年389卷20期1862-1876页
Monoclonal antibodies that target amyloid-beta (Aβ) have the potential to slow cognitive and functional decline in persons with early Alzheimer's disease. Gantenerumab is a subcutaneously administered, fully human, anti-Aβ IgG1 monoclonal antibody with highest affinity for aggregated Aβ that has been tested for the treatment of Alzheimer's disease.
247. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia.
作者: Jeffrey L Carson.;Maria Mori Brooks.;Paul C Hébert.;Shaun G Goodman.;Marnie Bertolet.;Simone A Glynn.;Bernard R Chaitman.;Tabassome Simon.;Renato D Lopes.;Andrew M Goldsweig.;Andrew P DeFilippis.;J Dawn Abbott.;Brian J Potter.;Francois Martin Carrier.;Sunil V Rao.;Howard A Cooper.;Shahab Ghafghazi.;Dean A Fergusson.;William J Kostis.;Helaine Noveck.;Sarang Kim.;Meechai Tessalee.;Gregory Ducrocq.;Pedro Gabriel Melo de Barros E Silva.;Darrell J Triulzi.;Caroline Alsweiler.;Mark A Menegus.;John D Neary.;Lynn Uhl.;Jordan B Strom.;Christopher B Fordyce.;Emile Ferrari.;Johanne Silvain.;Frances O Wood.;Benoit Daneault.;Tamar S Polonsky.;Manohara Senaratne.;Etienne Puymirat.;Claire Bouleti.;Benoit Lattuca.;Harvey D White.;Sheryl F Kelsey.;P Gabriel Steg.;John H Alexander.; .
来源: N Engl J Med. 2023年389卷26期2446-2456页
A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from a higher hemoglobin level.
248. Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation.
作者: Jeff S Healey.;Renato D Lopes.;Christopher B Granger.;Marco Alings.;Lena Rivard.;William F McIntyre.;Dan Atar.;David H Birnie.;Giuseppe Boriani.;A John Camm.;David Conen.;Julia W Erath.;Michael R Gold.;Stefan H Hohnloser.;John Ip.;Josef Kautzner.;Valentina Kutyifa.;Cecilia Linde.;Philippe Mabo.;Georges Mairesse.;Juan Benezet Mazuecos.;Jens Cosedis Nielsen.;Francois Philippon.;Marco Proietti.;Christian Sticherling.;Jorge A Wong.;David J Wright.;Ignatius G Zarraga.;Shelagh B Coutts.;Andrew Kaplan.;Marta Pombo.;Felix Ayala-Paredes.;Lizhen Xu.;Kim Simek.;Sandra Nevills.;Rajibul Mian.;Stuart J Connolly.; .
来源: N Engl J Med. 2024年390卷2期107-117页
Subclinical atrial fibrillation is short-lasting and asymptomatic and can usually be detected only by long-term continuous monitoring with pacemakers or defibrillators. Subclinical atrial fibrillation is associated with an increased risk of stroke by a factor of 2.5; however, treatment with oral anticoagulation is of uncertain benefit.
249. Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection - 2-Year Outcomes.
作者: Brenna L Hughes.;Rebecca G Clifton.;Dwight J Rouse.;George R Saade.;Mara J Dinsmoor.;Uma M Reddy.;Robert Pass.;Donna Allard.;Gail Mallett.;Cora MacPherson.;Ronald Wapner.;Torri Metz.;William H Goodnight.;Alan T N Tita.;Maged M Costantine.;Geeta K Swamy.;Kent D Heyborne.;Edward K Chien.;Suneet P Chauhan.;Yasser Y El-Sayed.;Brian M Casey.;Samuel Parry.;Hyagriv N Simhan.;Peter G Napolitano.;George A Macones.; .
来源: N Engl J Med. 2023年389卷19期1822-1824页 250. A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy.
作者: Mohit Mathur.;Jonathan Barratt.;Bobby Chacko.;Tak Mao Chan.;Laura Kooienga.;Kook-Hwan Oh.;Manisha Sahay.;Yusuke Suzuki.;Muh Geot Wong.;Jill Yarbrough.;Jing Xia.;Brian J G Pereira.; .
来源: N Engl J Med. 2024年390卷1期20-31页
A proliferation-inducing ligand (APRIL) is implicated in the pathogenesis of IgA nephropathy. Sibeprenlimab is a humanized IgG2 monoclonal antibody that binds to and neutralizes APRIL.
253. Convalescent Plasma for Covid-19-Induced ARDS in Mechanically Ventilated Patients.
作者: Benoît Misset.;Michael Piagnerelli.;Eric Hoste.;Nadia Dardenne.;David Grimaldi.;Isabelle Michaux.;Elisabeth De Waele.;Alexander Dumoulin.;Philippe G Jorens.;Emmanuel van der Hauwaert.;Frédéric Vallot.;Stoffel Lamote.;Walter Swinnen.;Nicolas De Schryver.;Vincent Fraipont.;Nathalie de Mey.;Nicolas Dauby.;Nathalie Layios.;Jean-Baptiste Mesland.;Geert Meyfroidt.;Michel Moutschen.;Veerle Compernolle.;André Gothot.;Daniel Desmecht.;Maria I Taveira da Silva Pereira.;Mutien Garigliany.;Tome Najdovski.;Axelle Bertrand.;Anne-Françoise Donneau.;Pierre-François Laterre.
来源: N Engl J Med. 2023年389卷17期1590-1600页
Passive immunization with plasma collected from convalescent patients has been regularly used to treat coronavirus disease 2019 (Covid-19). Minimal data are available regarding the use of convalescent plasma in patients with Covid-19-induced acute respiratory distress syndrome (ARDS).
254. Mucosal and Serum Antibodies 3 Weeks after Symptomatic BA.2.86 Infection.
作者: Oscar Bladh.;Nina Greilert-Norin.;Sebastian Havervall.;Ulrika Marking.;Katherina Aguilera.;Jessica J Alm.;Kim Blom.;Mikael Åberg.;Jonas Klingström.;Charlotte Thålin.
来源: N Engl J Med. 2023年389卷17期1626-1628页 255. Patisiran Treatment in Patients with Transthyretin Cardiac Amyloidosis.
作者: Mathew S Maurer.;Parag Kale.;Marianna Fontana.;John L Berk.;Martha Grogan.;Finn Gustafsson.;Rebecca R Hung.;Robert L Gottlieb.;Thibaud Damy.;Alejandra González-Duarte.;Nitasha Sarswat.;Yoshiki Sekijima.;Nobuhiro Tahara.;Mark S Taylor.;Milos Kubanek.;Erwan Donal.;Tomas Palecek.;Kenichi Tsujita.;W H Wilson Tang.;Wen-Chung Yu.;Laura Obici.;Marcus Simões.;Fábio Fernandes.;Steen Hvitfeldt Poulsen.;Igor Diemberger.;Federico Perfetto.;Scott D Solomon.;Marcelo Di Carli.;Prajakta Badri.;Matthew T White.;Jihong Chen.;Elena Yureneva.;Marianne T Sweetser.;Patrick Y Jay.;Pushkal P Garg.;John Vest.;Julian D Gillmore.; .
来源: N Engl J Med. 2023年389卷17期1553-1565页
Transthyretin amyloidosis, also called ATTR amyloidosis, is associated with accumulation of ATTR amyloid deposits in the heart and commonly manifests as progressive cardiomyopathy. Patisiran, an RNA interference therapeutic agent, inhibits the production of hepatic transthyretin.
256. Simvastatin in Critically Ill Patients with Covid-19.
作者: .;Thomas E Hills.;Elizabeth Lorenzi.;Lindsay R Berry.;Murali Shyamsundar.;Farah Al-Beidh.;Djillali Annane.;Yaseen Arabi.;Diptesh Aryal.;Carly Au.;Abigail Beane.;Zahra Bhimani.;Marc Bonten.;Charlotte A Bradbury.;Frank M Brunkhorst.;Aidan Burrell.;Meredith Buxton.;Carolyn S Calfee.;Maurizio Cecconi.;Allen C Cheng.;Matthew E Cove.;Michelle A Detry.;Lise J Estcourt.;Mark Fitzgerald.;Ewan C Goligher.;Herman Goossens.;Cameron Green.;Rashan Haniffa.;David A Harrison.;Madiha Hashmi.;Alisa M Higgins.;Christopher Horvat.;David T Huang.;Nao Ichihara.;Deva Jayakumar.;Peter S Kruger.;François Lamontagne.;Lamprini Lampro.;Patrick R Lawler.;John C Marshall.;Alexina J Mason.;Anna McGlothlin.;Shay McGuinness.;Zoe K McQuilten.;Bryan J McVerry.;Paul R Mouncey.;Srinivas Murthy.;Matthew D Neal.;Alistair D Nichol.;Cecilia M O'Kane.;Rachael L Parke.;Jane C Parker.;Ebenezer Rabindrarajan.;Luis F Reyes.;Kathryn M Rowan.;Hiroki Saito.;Marlene Santos.;Christina T Saunders.;Christopher W Seymour.;Manu Shankar-Hari.;Pratik Sinha.;B Taylor Thompson.;Alexis F Turgeon.;Anne M Turner.;Frank van de Veerdonk.;Sebastian Weis.;Ian S Young.;Ryan Zarychanski.;Roger J Lewis.;Colin J McArthur.;Derek C Angus.;Scott M Berry.;Lennie P G Derde.;Steve A Webb.;Anthony C Gordon.;Daniel F McAuley.
来源: N Engl J Med. 2023年389卷25期2341-2354页
The efficacy of simvastatin in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.
257. First-Line Selpercatinib or Chemotherapy and Pembrolizumab in RET Fusion-Positive NSCLC.
作者: Caicun Zhou.;Benjamin Solomon.;Herbert H Loong.;Keunchil Park.;Maurice Pérol.;Edurne Arriola.;Silvia Novello.;Baohui Han.;Jianying Zhou.;Andrea Ardizzoni.;M Perez Mak.;Fernando C Santini.;Yasir Y Elamin.;Alexander Drilon.;Jürgen Wolf.;Nalin Payakachat.;Minji K Uh.;Deborah Rajakumar.;Hongmei Han.;Tarun Puri.;Victoria Soldatenkova.;A Bence Lin.;Boris K Lin.;Koichi Goto.; .
来源: N Engl J Med. 2023年389卷20期1839-1850页
Selpercatinib, a highly selective potent and brain-penetrant RET inhibitor, was shown to have efficacy in patients with advanced RET fusion-positive non-small-cell lung cancer (NSCLC) in a nonrandomized phase 1-2 study.
258. Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma.
作者: Jessica C Hassel.;Sophie Piperno-Neumann.;Piotr Rutkowski.;Jean-Francois Baurain.;Max Schlaak.;Marcus O Butler.;Ryan J Sullivan.;Reinhard Dummer.;John M Kirkwood.;Marlana Orloff.;Joseph J Sacco.;Sebastian Ochsenreither.;Anthony M Joshua.;Lauris Gastaud.;Brendan Curti.;Josep M Piulats.;April K S Salama.;Alexander N Shoushtari.;Lev Demidov.;Mohammed Milhem.;Bartosz Chmielowski.;Kevin B Kim.;Richard D Carvajal.;Omid Hamid.;Laura Collins.;Koustubh Ranade.;Chris Holland.;Constance Pfeiffer.;Paul Nathan.
来源: N Engl J Med. 2023年389卷24期2256-2266页
Tebentafusp, a T-cell receptor-bispecific molecule that targets glycoprotein 100 and CD3, is approved for adult patients who are positive for HLA-A*02:01 and have unresectable or metastatic uveal melanoma. The primary analysis in the present phase 3 trial supported a long-term survival benefit associated with the drug.
259. Nivolumab plus Gemcitabine-Cisplatin in Advanced Urothelial Carcinoma.
作者: Michiel S van der Heijden.;Guru Sonpavde.;Thomas Powles.;Andrea Necchi.;Mauricio Burotto.;Michael Schenker.;Juan Pablo Sade.;Aristotelis Bamias.;Philippe Beuzeboc.;Jens Bedke.;Jan Oldenburg.;Gurkamal Chatta.;Yüksel Ürün.;Dingwei Ye.;Zhisong He.;Begoña P Valderrama.;Ja Hyeon Ku.;Yoshihiko Tomita.;Jeiry Filian.;Lily Wang.;Daniela Purcea.;Miraj Y Patel.;Federico Nasroulah.;Matthew D Galsky.; .
来源: N Engl J Med. 2023年389卷19期1778-1789页
No new agent has improved overall survival in patients with unresectable or metastatic urothelial carcinoma when added to first-line cisplatin-based chemotherapy.
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