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243. Cost-Effectiveness of Extending Human Papillomavirus Vaccination to Population Subgroups Older Than 26 Years Who Are at Higher Risk for Human Papillomavirus Infection in the United States.250. Cost-Effectiveness of Extending Human Papillomavirus Vaccination to Population Subgroups Older Than 26 Years Who Are at Higher Risk for Human Papillomavirus Infection in the United States.
作者: Jean-François Laprise.;Harrell W Chesson.;Lauri E Markowitz.;Mélanie Drolet.;Marc Brisson.
来源: Ann Intern Med. 2025年178卷11期1674-1675页 251. Influenza Vaccines for 2025-2026 in Adults Who Are Not Pregnant or Immunocompromised: Rapid Practice Points From the American College of Physicians.
作者: Amir Qaseem.;Timothy J Wilt.;Curtis S Harrod.;Adam J Obley.;Kate Carroll.;Linda L Humphrey.; .;Ray Haeme.;Christopher D Jackson.;Devan Kansagara.;Alysa Krain.;Katherine Mackey.;Thejaswi Poonacha.;Sameer D Saini.;Chelsea Vigna.
来源: Ann Intern Med. 2026年179卷1期110-117页
The American College of Physicians (ACP) developed these rapid practice points addressing the comparative effectiveness and harms of trivalent (3 different influenza viruses or viral proteins) and quadrivalent (4 different influenza viruses or viral proteins) influenza vaccines in adults aged 18 years or older who are not pregnant or immunocompromised. These practice points do not address adults aged 18 years or older who are pregnant or immunocompromised.
252. Web Exclusive. Annals Video Summary - Efficacy of Individual-Level Interventions to Mitigate the Risk for Burnout Among Health Care Professionals: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
来源: Ann Intern Med. 2026年179卷1期e2504275VS页
254. Web Exclusive. Annals Video Summary - Comparative Effectiveness and Harm of Seasonal Influenza Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians.
来源: Ann Intern Med. 2026年179卷1期e2504658VS页
255. Comparative Effectiveness and Harm of Seasonal Influenza Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians.
作者: Andreea I Dobrescu.;Amin Sharifan.;Isolde Sommer.;Camilla I A Neubauer-Bruckner.;Arianna Gadinger.;Irma Klerings.;Claus Nowak.;Gerald Gartlehner.
来源: Ann Intern Med. 2026年179卷1期81-94页
Seasonal influenza is a contagious viral respiratory illness that causes yearly epidemics.
256. Efficacy of Individual-Level Interventions to Mitigate the Risk for Burnout Among Health Care Professionals : A Systematic Review and Meta-analysis of Randomized Controlled Trials.
作者: George Collett.;Jaya Gupta.;Abubaker Eltayeb.;Ania Korszun.;Linda Sharples.;Kenneth Rice.;Ajay K Gupta.
来源: Ann Intern Med. 2026年179卷1期51-66页
There is limited evidence of the strategies to mitigate burnout among all health care professionals (HCPs).
258. Patterns in Mental Health- and Substance Use-Related Visits From 2003 to 2022 Among Registered Ontario Physicians.
作者: Maya A Gibb.;Lyndsay Harrison.;Asnake Y Dumicho.;Manish M Sood.;Peter Tanuseputro.;Aliza Moledina.;Meltem Tuna.;Timite Halilou.;Claire E Kendall.;Ian Colman.;Shannon M Fernando.;Rhiannon L Roberts.;Courtney Maskerine.;Daniel T Myran.
来源: Ann Intern Med. 2026年179卷2期311-313页 260. Management of Sepsis in Hospitalized Patients.
Sepsis is the leading cause of death worldwide. Mortality has improved in the past few decades but remains high, and survivors frequently have long-term complications. Initial diagnostic evaluation focuses on risk stratification and source and pathogen identification. Treatment includes intravenous fluids, vasopressors, steroids if shock is present, antimicrobial therapy targeting the most likely source of infection, and source control. Patients with shock or high-risk organ failure syndromes should be admitted early to an intensive care unit. After initial antimicrobials and resuscitation, care should focus on antimicrobial deescalation, volume management, and high-quality supportive care. Shared decision making about goals of care and transitions is important to support survivors after discharge.
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