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241. Endoscopic injection sclerotherapy versus N-Butyl-2 Cyanoacrylate injection in the management of actively bleeding esophageal varices: a randomized controlled trial.
作者: Mohamed A Elsebaey.;Mohamed A Tawfik.;Sherif Ezzat.;Amal Selim.;Heba Elashry.;Sherief Abd-Elsalam.
来源: BMC Gastroenterol. 2019年19卷1期23页
The management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may necessitate an alternative therapy for this group of patients. This study was conducted to assess the safety and efficacy of sclerotherapy versus cyanoacrylate injection for management of actively bleeding esophageal varices in cirrhotic patients.
242. High-intensity interval training and moderate-intensity continuous training in adults with Crohn's disease: a pilot randomised controlled trial.
作者: Garry A Tew.;Dean Leighton.;Roger Carpenter.;Simon Anderson.;Louise Langmead.;John Ramage.;James Faulkner.;Elizabeth Coleman.;Caroline Fairhurst.;Michael Seed.;Lindsay Bottoms.
来源: BMC Gastroenterol. 2019年19卷1期19页
This study assessed the feasibility and acceptability of two common types of exercise training-high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)-in adults with Crohn's disease (CD).
244. Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.
作者: Man Fung Yuen.;Edward J Gane.;Dong Joon Kim.;Frank Weilert.;Henry Lik Yuen Chan.;Jacob Lalezari.;Seong Gyu Hwang.;Tuan Nguyen.;Osvaldo Flores.;George Hartman.;Sandy Liaw.;Oliver Lenz.;Thomas N Kakuda.;Willem Talloen.;Christian Schwabe.;Klaus Klumpp.;Nathaniel Brown.
来源: Gastroenterology. 2019年156卷5期1392-1403.e7页
NVR 3-778 is a first-in-class hepatitis B virus (HBV) capsid assembly modulator that can inhibit HBV replication. We performed a proof-of-concept study to examine the safety, pharmacokinetics, and antiviral activity of NVR 3-778 in patients with chronic HBV infection.
245. Preventive effect of ecabet sodium on low-dose aspirin-induced small intestinal mucosal injury: a randomized, double-blind, pilot study.
作者: Kazuhiro Ota.;Toshihisa Takeuchi.;Yuichi Kojima.;Satoshi Harada.;Yuki Hirata.;Noriaki Sugawara.;Sadaharu Nouda.;Kazuki Kakimoto.;Takanori Kuramoto.;Kazuhide Higuchi.
来源: BMC Gastroenterol. 2019年19卷1期4页
We aimed to investigate how high-dose ecabet sodium affects low-dose aspirin-induced small intestinal mucosal injury in healthy volunteers.
246. Fecal Microbiota Transplantation Is Superior to Fidaxomicin for Treatment of Recurrent Clostridium difficile Infection.
作者: Christian Lodberg Hvas.;Simon Mark Dahl Jørgensen.;Søren Peter Jørgensen.;Merete Storgaard.;Lars Lemming.;Mette Mejlby Hansen.;Christian Erikstrup.;Jens Frederik Dahlerup.
来源: Gastroenterology. 2019年156卷5期1324-1332.e3页
Fecal microbiota transplantation (FMT) is recommended for treatment of recurrent Clostridium difficile infection (rCDI). We performed a single-center randomized trial to compare the effects of FMT with those of fidaxomicin and vancomycin.
247. An Interactive Web-Based Educational Tool Improves Detection and Delineation of Barrett's Esophagus-Related Neoplasia.
作者: Jacques J G H M Bergman.;A Jeroen de Groof.;O Pech.;K Ragunath.;D Armstrong.;N Mostafavi.;L Lundell.;J Dent.;M Vieth.;G N Tytgat.;P Sharma.; .
来源: Gastroenterology. 2019年156卷5期1299-1308.e3页
Endoscopic detection of early Barrett's esophagus-related neoplasia (BORN) is a challenge. We aimed to develop a web-based teaching tool for improving detection and delineation of BORN.
248. Treatment of Active Crohn's Disease With an Ordinary Food-based Diet That Replicates Exclusive Enteral Nutrition.
作者: Vaios Svolos.;Richard Hansen.;Ben Nichols.;Christopher Quince.;Umer Z Ijaz.;Rodanthi T Papadopoulou.;Christine A Edwards.;David Watson.;Adel Alghamdi.;Asker Brejnrod.;Cecilia Ansalone.;Hazel Duncan.;Lisa Gervais.;Rachel Tayler.;Jonathan Salmond.;Daniele Bolognini.;Robert Klopfleisch.;Daniel R Gaya.;Simon Milling.;Richard K Russell.;Konstantinos Gerasimidis.
来源: Gastroenterology. 2019年156卷5期1354-1367.e6页
Exclusive enteral nutrition (EEN) is the only established dietary treatment for Crohn's disease (CD), but its acceptability is limited. There is a need for novel dietary treatments for CD.
249. Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis.
作者: Sudarshan Paramsothy.;Shaun Nielsen.;Michael A Kamm.;Nandan P Deshpande.;Jeremiah J Faith.;Jose C Clemente.;Ramesh Paramsothy.;Alissa J Walsh.;Johan van den Bogaerde.;Douglas Samuel.;Rupert W L Leong.;Susan Connor.;Watson Ng.;Enmoore Lin.;Thomas J Borody.;Marc R Wilkins.;Jean-Frederic Colombel.;Hazel M Mitchell.;Nadeem O Kaakoush.
来源: Gastroenterology. 2019年156卷5期1440-1454.e2页
Fecal microbiota transplantation (FMT) can induce remission in patients with ulcerative colitis (UC). In a randomized controlled trial of FMT in patients with active UC, we aimed to identify bacterial taxonomic and functional factors associated with response to therapy.
250. Risk of Postpolypectomy Bleeding With Uninterrupted Clopidogrel Therapy in an Industry-Independent, Double-Blind, Randomized Trial.
作者: Francis K L Chan.;Moe H Kyaw.;John C Hsiang.;Bing Yee Suen.;Ka Man Kee.;Yee Kit Tse.;Jessica Y L Ching.;Pui Kuan Cheong.;Daphne Ng.;Kelvin Lam.;Angeline Lo.;Vivian Lee.;Siew C Ng.
来源: Gastroenterology. 2019年156卷4期918-925.e1页
Guidelines recommend withholding clopidogrel 7 days before polypectomy to decrease bleeding risk, but these were written based on limited evidence. We investigated whether uninterrupted clopidogrel therapy increases the risk of delayed postpolypectomy bleeding in patients undergoing colonoscopy.
251. Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis.
作者: William J Sandborn.;Marcoli Cyrille.;Mark Berner Hansen.;Brian G Feagan.;Edward V Loftus.;Gerhard Rogler.;Severine Vermeire.;Martha L Cruz.;Jun Yang.;Michael J Boedigheimer.;Lubna Abuqayyas.;Christine M Evangelista.;Barbara A Sullivan.;Walter Reinisch.
来源: Gastroenterology. 2019年156卷4期946-957.e18页
The α4β7 integrin is a validated target in inflammatory bowel disease. This randomized, phase 2b, placebo-controlled, double-blind study evaluated the efficacy and safety of the anti-α4β7 antibody abrilumab in patients with moderate-to-severe ulcerative colitis despite treatment with conventional therapies.
252. Acceptance and Commitment Therapy Reduces Psychological Stress in Patients With Inflammatory Bowel Diseases.
作者: Brona Wynne.;Louise McHugh.;Wei Gao.;Denise Keegan.;Kathryn Byrne.;Catherine Rowan.;Karen Hartery.;Clemens Kirschbaum.;Glen Doherty.;Garret Cullen.;Barbara Dooley.;Hugh E Mulcahy.
来源: Gastroenterology. 2019年156卷4期935-945.e1页
Patients with Crohn's disease or ulcerative colitis have relatively high levels of stress and psychological dysfunction. Acceptance and commitment therapy (ACT) is a psychological intervention that comprises acceptance and mindfulness procedures, along with commitment and behavior change strategies, to increase psychological flexibility and reduce stress. We performed a randomized controlled trial to investigate the effect of ACT on stress in patients with inflammatory bowel diseases (IBD).
253. An Endoscopic Transluminal Approach, Compared With Minimally Invasive Surgery, Reduces Complications and Costs for Patients With Necrotizing Pancreatitis.
作者: Ji Young Bang.;Juan Pablo Arnoletti.;Bronte A Holt.;Bryce Sutton.;Muhammad K Hasan.;Udayakumar Navaneethan.;Nicholas Feranec.;C Mel Wilcox.;Benjamin Tharian.;Robert H Hawes.;Shyam Varadarajulu.
来源: Gastroenterology. 2019年156卷4期1027-1040.e3页
Infected necrotizing pancreatitis is a highly morbid disease with poor outcomes. Intervention strategies have progressed from open necrosectomy to minimally invasive approaches. We compared outcomes of minimally invasive surgery vs endoscopic approaches for patients with infected necrotizing pancreatitis.
254. Dexlansoprazole and Esomeprazole Do Not Affect Bone Homeostasis in Healthy Postmenopausal Women.
作者: Karen E Hansen.;Jeri W Nieves.;Sai Nudurupati.;David C Metz.;Maria Claudia Perez.
来源: Gastroenterology. 2019年156卷4期926-934.e6页
Epidemiological studies have associated proton pump inhibitor (PPI) therapy with osteoporotic fractures, but it is not clear if PPIs directly cause osteoporosis. We evaluated the effect of dexlansoprazole and esomeprazole on bone turnover, bone mineral density (BMD), true fractional calcium absorption (TFCA), serum and urine levels of minerals, and levels of parathyroid hormone (PTH) in healthy postmenopausal women.
255. RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis.
作者: Ikuo Hirano.;Margaret H Collins.;Yehudith Assouline-Dayan.;Larry Evans.;Sandeep Gupta.;Alain M Schoepfer.;Alex Straumann.;Ekaterina Safroneeva.;Michael Grimm.;Heather Smith.;Cindy-Ann Tompkins.;Amy Woo.;Robert Peach.;Paul Frohna.;Sheila Gujrathi.;Darryl N Penenberg.;Caiyan Li.;Gregory J Opiteck.;Allan Olson.;Richard Aranda.;Marc E Rothenberg.;Evan S Dellon.; .
来源: Gastroenterology. 2019年156卷3期592-603.e10页
Eosinophilic esophagitis (EoE) is a chronic, esophageal, type 2 inflammatory response associated with increased serum levels of interleukin 13 (IL13), which might contribute to its pathogenesis. RPC4046, a recombinant humanized monoclonal antibody against IL13, prevents its binding to the receptor subunits IL13RA1 and IL13RA2. We performed a phase 2 trial to evaluate the efficacy and safety of RPC4046 in patients with EoE.
256. Superiority of Step-up Approach vs Open Necrosectomy in Long-term Follow-up of Patients With Necrotizing Pancreatitis.
作者: Robbert A Hollemans.;Olaf J Bakker.;Marja A Boermeester.;Thomas L Bollen.;Koop Bosscha.;Marco J Bruno.;Erik Buskens.;Cornelis H Dejong.;Peter van Duijvendijk.;Casper H van Eijck.;Paul Fockens.;Harry van Goor.;Wilhelmina M van Grevenstein.;Erwin van der Harst.;Joos Heisterkamp.;Eric J Hesselink.;Sijbrand Hofker.;Alexander P Houdijk.;Tom Karsten.;Philip M Kruyt.;Cornelis J van Laarhoven.;Johan S Laméris.;Maarten S van Leeuwen.;Eric R Manusama.;I Quintus Molenaar.;Vincent B Nieuwenhuijs.;Bert van Ramshorst.;Daphne Roos.;Camiel Rosman.;Alexander F Schaapherder.;George P van der Schelling.;Robin Timmer.;Robert C Verdonk.;Ralph J de Wit.;Hein G Gooszen.;Marc G Besselink.;Hjalmar C van Santvoort.; .
来源: Gastroenterology. 2019年156卷4期1016-1026页
In a 2010 randomized trial (the PANTER trial), a surgical step-up approach for infected necrotizing pancreatitis was found to reduce the composite endpoint of death or major complications compared with open necrosectomy; 35% of patients were successfully treated with simple catheter drainage only. There is concern, however, that minimally invasive treatment increases the need for reinterventions for residual peripancreatic necrotic collections and other complications during the long term. We therefore performed a long-term follow-up study.
257. Thermal Ablation of Mucosal Defect Margins Reduces Adenoma Recurrence After Colonic Endoscopic Mucosal Resection.
作者: Amir Klein.;David J Tate.;Vanoo Jayasekeran.;Luke Hourigan.;Rajvinder Singh.;Gregor Brown.;Farzan F Bahin.;Nicholas Burgess.;Stephen J Williams.;Eric Lee.;Mayenaaz Sidhu.;Karen Byth.;Michael J Bourke.
来源: Gastroenterology. 2019年156卷3期604-613.e3页
Colorectal cancer (CRC) can be prevented by colonoscopy and polypectomy. Endoscopic mucosal resection (EMR) is performed to remove large laterally spreading colonic lesions that have a high risk of progression to CRC. Endoscopically invisible micro-adenomas at the margins of the EMR site might contribute to adenoma recurrence, which occurs in 15% to 30% of patients who undergo surveillance. We aimed to determine the efficacy of adjuvant thermal ablation of the EMR mucosal defect margin in reducing polyp recurrence.
258. Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis.
作者: Rohit Loomba.;Arun J Sanyal.;Kris V Kowdley.;Norah Terrault.;Naga P Chalasani.;Manal F Abdelmalek.;Arthur J McCullough.;Reshma Shringarpure.;Beatrice Ferguson.;Lois Lee.;Jianfen Chen.;Alexander Liberman.;David Shapiro.;Brent A Neuschwander-Tetri.
来源: Gastroenterology. 2019年156卷1期88-95.e5页
Nonalcoholic steatohepatitis (NASH) is a leading cause of liver transplantation, and many trials are underway to evaluate potential therapies. The farnesoid X receptor ligand obeticholic acid in the NASH treatment trial evaluated the effects of obeticholic acid vs placebo on histologic response (defined as decrease in nonalcoholic fatty liver disease activity score [NAS] by ≥2, with no worsening of fibrosis); 45% of patients had a histologic response to obeticholic acid (25 mg), and 21% had a response to placebo (P < .01). We performed a secondary analysis of data from this trial to identify clinical parameters associated with a histologic response.
259. Efficacy and Safety of Budesonide, vs Mesalazine or Placebo, as Induction Therapy for Lymphocytic Colitis.
作者: Stephan Miehlke.;Daniela Aust.;Emese Mihaly.;Peter Armerding.;Günther Böhm.;Ole Bonderup.;Fernando Fernández-Bañares.;Juozas Kupcinskas.;Lars Kristian Munck.;Kai-Uwe Rehbehn.;Tanju Nacak.;Roland Greinwald.;Andreas Münch.; .
来源: Gastroenterology. 2018年155卷6期1795-1804.e3页
Lymphocytic colitis is a common cause of chronic, nonbloody diarrhea. However, the effects of treatment are unclear and randomized placebo-controlled trials were requested in a Cochrane review. We performed a randomized, placebo-controlled, multicenter study to evaluate budesonide and mesalazine as induction therapy for lymphocytic colitis.
260. Tolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia.
作者: Shuzhen Wang.;Xin Zhang.;Tao Han.;Wen Xie.;Yonggang Li.;Hong Ma.;Roman Liebe.;Honglei Weng.;Hui-Guo Ding.
来源: BMC Gastroenterol. 2018年18卷1期137页
Although tolvaptan treatment improves hyponatremia, only few studies have investigated whether tolvaptan actually benefits the survival of cirrhotic patients. This study evaluated the impact of tolvaptan on six-month survival of decompensated cirrhotic patients with and without hyponatremia.
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