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241. Ambulatory Reflux Monitoring Guides Proton Pump Inhibitor Discontinuation in Patients With Gastroesophageal Reflux Symptoms: A Clinical Trial.
作者: Rena Yadlapati.;Melina Masihi.;C Prakash Gyawali.;Dustin A Carlson.;Peter J Kahrilas.;Billy Darren Nix.;Anand Jain.;Joseph R Triggs.;Michael F Vaezi.;Leila Kia.;Alexander Kaizer.;John E Pandolfino.
来源: Gastroenterology. 2021年160卷1期174-182.e1页
Proton pump inhibitor (PPI) therapy fails to provide adequate symptom control in up to 50% of patients with gastroesophageal reflux symptoms. Although a proportion do not require ongoing PPI therapy, a diagnostic approach to identify candidates appropriate for PPI cessation is not available. This study aimed to examine the clinical utility of prolonged wireless reflux monitoring to predict the ability to discontinue PPIs.
242. 99mTc-sodium phytate is a valid alternative to the gold-standard 99mTc-sulfur colloid in the measurement of gastric emptying among healthy multi-ethnic Asian population: results of a randomized cross-over trial.
作者: Norazlina Mat Nawi.;Nashrulhaq Tagiling.;Mohd Fazrin Mohd Rohani.;Wan Mohd Nazlee Wan Zainon.;Muhammad Saifuddin Zanial.;Mung Seong Wong.;Yeong Yeh Lee.
来源: BMC Gastroenterol. 2020年20卷1期293页
It is unclear if the 99mTc-sodium phytate (99mTc-SP) is as reliable as the gold-standard 99mTc-sulfur colloid (99mTc-SC) for gastric emptying scintigraphy (GES). This study is aimed to compare the emptying rates of both radiotracers in a prospective, randomized cross-over trial and to determine the normative data of a healthy multi-ethnic Asian population.
243. Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain.
作者: Ehud Rinott.;Ilan Youngster.;Anat Yaskolka Meir.;Gal Tsaban.;Hila Zelicha.;Alon Kaplan.;Dan Knights.;Kieran Tuohy.;Francesca Fava.;Matthias Uwe Scholz.;Oren Ziv.;Elad Rubin.;Amir Tirosh.;Assaf Rudich.;Matthias Blüher.;Michael Stumvoll.;Uta Ceglarek.;Karine Clement.;Omry Koren.;Dong D Wang.;Frank B Hu.;Meir J Stampfer.;Iris Shai.
来源: Gastroenterology. 2021年160卷1期158-173.e10页
We evaluated the efficacy and safety of diet-modulated autologous fecal microbiota transplantation (aFMT) for treatment of weight regain after the weight-loss phase.
244. Relationship Between Combined Histologic and Endoscopic Endpoints and Efficacy of Ustekinumab Treatment in Patients With Ulcerative Colitis.
作者: Katherine Li.;Colleen Marano.;Hongyan Zhang.;Feifei Yang.;William J Sandborn.;Bruce E Sands.;Brian G Feagan.;David T Rubin.;Laurent Peyrin-Biroulet.;Joshua R Friedman.;Gert De Hertogh.
来源: Gastroenterology. 2020年159卷6期2052-2064页
Ustekinumab induces and maintains histologic improvement in patients with ulcerative colitis (UC). The clinical relevance of this endpoint alone, and in combination with endoscopic improvement, is unknown.
245. Efficacy of a high-dose proton pump inhibitor in patients with gastroesophageal reflux disease: a single center, randomized, open-label trial.
作者: Jae Ho Cho.;Cheol Min Shin.;Hyuk Yoon.;Young Soo Park.;Nayoung Kim.;Dong Ho Lee.
来源: BMC Gastroenterol. 2020年20卷1期275页
The extraesophageal manifestations of gastroesophageal reflux disease (GERD) are more difficult to manage than the typical symptoms. The efficacy of high-dose and standard-dose proton pump inhibitors against these atypical symptoms is not yet established.
246. Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis.
作者: Stephen A Harrison.;Guy Neff.;Cynthia D Guy.;Mustafa R Bashir.;Angelo H Paredes.;Juan P Frias.;Ziad Younes.;James F Trotter.;Nadege T Gunn.;Sam E Moussa.;Anita Kohli.;Kristin Nelson.;Mildred Gottwald.;William C G Chang.;Andrew Z Yan.;Alex M DePaoli.;Lei Ling.;Hsiao D Lieu.
来源: Gastroenterology. 2021年160卷1期219-231.e1页
Aldafermin, an engineered analog of fibroblast growth factor 19, inhibits bile acid synthesis and regulates metabolic homeostasis. We report results from a 24-week, phase 2 study, with serial liver biopsies, of patients with nonalcoholic steatohepatitis (NASH).
247. A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis.
作者: Matthew R Henn.;Edward J O'Brien.;Liyang Diao.;Brian G Feagan.;William J Sandborn.;Curtis Huttenhower.;Jennifer R Wortman.;Barbara H McGovern.;Sherry Wang-Weigand.;David I Lichter.;Meghan Chafee.;Christopher B Ford.;Patricia Bernardo.;Peng Zhao.;Sheri Simmons.;Amelia D Tomlinson.;David N Cook.;Roger J Pomerantz.;Bharat K Misra.;John G Auninš.;Michele Trucksis.
来源: Gastroenterology. 2021年160卷1期115-127.e30页
Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of patients with ulcerative colitis (UC). In a phase 1b trial of patients with UC, we evaluated the safety and efficacy of SER-287, an oral formulation of Firmicutes spores, and the effects of vancomycin preconditioning on expansion (engraftment) of SER-287 species in the colon.
248. A randomized crossover trial to assess therapeutic efficacy and cost reduction of acid ursodeoxycholic manufactured by the university hospital for the treatment of primary biliary cholangitis.
作者: Larissa Akeme Nakano.;Eduardo Luiz Rachid Cançado.;Cleuber Esteves Chaves.;Maria Cristina Vaz Madeira.;Jéssica Toshie Katayose.;Mariana Akemi Nabeshima.;Victor Fossaluza.;Gabriela Guimarães Uhrigshardt.;Zheng Liting.;Vanusa Barbosa Pinto.;Flair José Carrilho.;Suzane Kioko Ono.
来源: BMC Gastroenterol. 2020年20卷1期253页
Health care costs are growing faster than the rest of the global economy, according to the World Health Organization (WHO). Countries' health expenditures include paying for general medicine, diagnostic procedures, hospitalizations and surgeries, as well as medications and prescribed treatment. Primary biliary cholangitis (PBC) is a rare autoimmune liver disease and the first line available treatment is ursodeoxycholic acid (UDCA), however, direct and indirect treatment costs are expensive. Main aim of this trial was to assess if the therapeutic efficacy of UDCA manufactured by the university hospital is equivalent to that of standard UDCA and treatment cost reduction in patients with PBC.
249. Outcomes of Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Diseases and Recurrent Clostridioides difficile Infection.
作者: Jessica R Allegretti.;Colleen R Kelly.;Ari Grinspan.;Benjamin H Mullish.;Zain Kassam.;Monika Fischer.
来源: Gastroenterology. 2020年159卷5期1982-1984页 250. Budesonide Orodispersible Tablets Maintain Remission in a Randomized, Placebo-Controlled Trial of Patients With Eosinophilic Esophagitis.
作者: Alex Straumann.;Alfredo J Lucendo.;Stephan Miehlke.;Michael Vieth.;Christoph Schlag.;Luc Biedermann.;Cecilio Santander Vaquero.;Constanza Ciriza de Los Rios.;Christoph Schmoecker.;Ahmed Madisch.;Petr Hruz.;Jamal Hayat.;Ulrike von Arnim.;Albert Jan Bredenoord.;Stefan Schubert.;Ralph Mueller.;Roland Greinwald.;Alain Schoepfer.;Stephen Attwood.; .
来源: Gastroenterology. 2020年159卷5期1672-1685.e5页
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder. Swallowed topical-acting corticosteroids are effective in bringing active EoE into remission. However, it is not clear whether these drugs are effective for long-term maintenance of remission.
251. Efficacy and Safety of Tradipitant in Patients With Diabetic and Idiopathic Gastroparesis in a Randomized, Placebo-Controlled Trial.
作者: Jesse L Carlin.;V Rose Lieberman.;Arya Dahal.;Madison S Keefe.;Changfu Xiao.;Gunther Birznieks.;Thomas L Abell.;Anthony Lembo.;Henry P Parkman.;Mihael H Polymeropoulos.
来源: Gastroenterology. 2021年160卷1期76-87.e4页
Treatments are needed for gastroparesis; antagonists of tachykinin receptor 1 (TACR1, also called NK1R) can reduce symptoms of nausea and vomiting. We investigated the safety and efficacy of tradipitant, an antagonist of NK1R, in patients with idiopathic or diabetic gastroparesis.
252. Fecal Microbiota Transplantation Reduces Symptoms in Some Patients With Irritable Bowel Syndrome With Predominant Abdominal Bloating: Short- and Long-term Results From a Placebo-Controlled Randomized Trial.
作者: Tom Holvoet.;Marie Joossens.;Jorge F Vázquez-Castellanos.;Evelien Christiaens.;Lander Heyerick.;Jerina Boelens.;Bruno Verhasselt.;Hans van Vlierberghe.;Martine De Vos.;Jeroen Raes.;Danny De Looze.
来源: Gastroenterology. 2021年160卷1期145-157.e8页
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with intestinal dysbiosis. Given the reported promising results of open-label fecal microbiota transplantation (FMT) therapy in patients with predominant abdominal bloating, we studied efficacy of this treatment in a randomized, placebo-controlled trial.
253. Non-inferiority comparative clinical trial between early oral REFEEDING and usual oral REFEEDING in predicted mild acute biliary pancreatitis.
作者: Edgard Efrén Lozada-Hernández.;Omar Barrón-González.;Santa Vázquez-Romero.;Martin Cano-Rosas.;Evelia Apolinar-Jimenez.
来源: BMC Gastroenterol. 2020年20卷1期228页
The aim of the study was to compare the onset of oral feeding in the first 24 h after hospital admission with usual oral refeeding and determine whether the timing of the onset of oral feeding influences the recurrence of pain or alters the blood levels of pancreatic enzymes in patients with predicted mild acute biliary pancreatitis.
254. Effect of bowel preparation volume in inpatient colonoscopy. Results of a prospective, randomized, comparative pilot study.
作者: Patricia V Hernandez.;Jennifer L Horsley-Silva.;Diana L Snyder.;Noemi Baffy.;Mary Atia.;Laura Koepke.;Matthew R Buras.;Elisabeth S Lim.;Kevin Ruff.;Sarah B Umar.;Sameer Islam.;Francisco C Ramirez.
来源: BMC Gastroenterol. 2020年20卷1期227页
Inpatient status has been shown to be a predictor of poor bowel preparation for colonoscopy; however, the optimal bowel preparation regimen for hospitalized patients is unknown. Our aim was to compare the efficacy of bowel preparation volume size in hospitalized patients undergoing inpatient colonoscopy.
255. Evaluation of breath, plasma, and urinary markers of lactose malabsorption to diagnose lactase non-persistence following lactose or milk ingestion.
作者: Aahana Shrestha.;Matthew P G Barnett.;Jo K Perry.;David Cameron-Smith.;Amber M Milan.
来源: BMC Gastroenterol. 2020年20卷1期204页
Adult lactase non-persistence (LNP) is due to low lactase expression, resulting in lactose malabsorption (LM). LNP is a genetic trait, but is typically determined by LM markers including breath H2, blood glucose, and urinary galactose after a lactose tolerance test. Known validity of these markers using milk is limited, despite being common practice. Compositional variation, such as β-casein variants, in milk may impact diagnostic efficacy. This study aimed to evaluate the diagnostic accuracy to detect LNP using these commonly measured LM markers after both lactose and milk challenges.
256. Lower Adenoma Miss Rate of Computer-Aided Detection-Assisted Colonoscopy vs Routine White-Light Colonoscopy in a Prospective Tandem Study.
作者: Pu Wang.;Peixi Liu.;Jeremy R Glissen Brown.;Tyler M Berzin.;Guanyu Zhou.;Shan Lei.;Xiaogang Liu.;Liangping Li.;Xun Xiao.
来源: Gastroenterology. 2020年159卷4期1252-1261.e5页
Up to 30% of adenomas might be missed during screening colonoscopy-these could be polyps that appear on-screen but are not recognized by endoscopists or polyps that are in locations that do not appear on the screen at all. Computer-aided detection (CADe) systems, based on deep learning, might reduce rates of missed adenomas by displaying visual alerts that identify precancerous polyps on the endoscopy monitor in real time. We compared adenoma miss rates of CADe colonoscopy vs routine white-light colonoscopy.
257. Short-course Rifaximin therapy efficacy and lactulose hydrogen breath test in Chinese patients with diarrhea-predominant irritable bowel syndrome.
Gut microbiota alterations including small intestinal bacterial overgrowth (SIBO) might play a role in pathogenesis of irritable bowel syndrome (IBS). Rifaximin could effectively and safely improve IBS symptoms. The aim of this study was to investigate the effect of rifaximin on Gastrointestinal (GI) symptoms, quality of life (QOL) and SIBO eradication in Chinese IBS-D patients.
258. Probiotics use for antibiotic-associated diarrhea: a pragmatic participatory evaluation in nursing homes.
作者: Herman A van Wietmarschen.;Martine Busch.;Annemiek van Oostveen.;Gerda Pot.;Miek C Jong.
来源: BMC Gastroenterol. 2020年20卷1期151页
Antibiotic-associated diarrhea (AAD) occurs in 2-25% of nursing home residents, which may lead to dehydration, malnutrition, severe complications and hospitalizations. Research shows that probiotics can be effective and safe in reducing AAD. However, probiotics are not routinely used in Dutch nursing homes. The objectives of this evaluation were to develop a procedure for the implementation of probiotics to prevent AAD in nursing homes, to evaluate effects on AAD occurrence, and to evaluate the implementation process of probiotics in daily care.
259. Effectiveness of concomitant use of green tea and polyethylene glycol in bowel preparation for colonoscopy: a randomized controlled study.
作者: Zong Hao.;Lifeng Gong.;Qiang Shen.;Huipeng Wang.;Shaowen Feng.;Xin Wang.;Yuankun Cai.;Jun Chen.
来源: BMC Gastroenterol. 2020年20卷1期150页
Polyethylene glycol solution (PEG) is widely used for bowel preparation prior to colonoscopies. However, patients often exhibited adverse events as nausea, vomit and distention due to its uncomfortable tastes and potential side affects. This study aimed to evaluate the effectiveness and safety of concomitant use of green tea (GT) with PEG in bowel preparation prior to colonoscopy.
260. Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial.
作者: Alessandro Repici.;Matteo Badalamenti.;Roberta Maselli.;Loredana Correale.;Franco Radaelli.;Emanuele Rondonotti.;Elisa Ferrara.;Marco Spadaccini.;Asma Alkandari.;Alessandro Fugazza.;Andrea Anderloni.;Piera Alessia Galtieri.;Gaia Pellegatta.;Silvia Carrara.;Milena Di Leo.;Vincenzo Craviotto.;Laura Lamonaca.;Roberto Lorenzetti.;Alida Andrealli.;Giulio Antonelli.;Michael Wallace.;Prateek Sharma.;Thomas Rosch.;Cesare Hassan.
来源: Gastroenterology. 2020年159卷2期512-520.e7页
One-fourth of colorectal neoplasias are missed during screening colonoscopies; these can develop into colorectal cancer (CRC). Deep learning systems allow for real-time computer-aided detection (CADe) of polyps with high accuracy. We performed a multicenter, randomized trial to assess the safety and efficacy of a CADe system in detection of colorectal neoplasias during real-time colonoscopy.
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