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2464. Allogeneic blood and bone-marrow stem-cell transplantation in haematological malignant diseases: a randomised trial.
作者: R Powles.;J Mehta.;S Kulkarni.;J Treleaven.;B Millar.;J Marsden.;V Shepherd.;A Rowland.;B Sirohi.;D Tait.;C Horton.;S Long.;S Singhal.
来源: Lancet. 2000年355卷9211期1231-7页
Autologous transplantation with peripheral blood stem cells (PBSC) results in faster haematopoietic-cell repopulation than with bone marrow. We prospectively compared bone marrow and PBSC for allogeneic transplantation.
2465. Low molecular-weight heparin versus aspirin in patients with acute ischaemic stroke and atrial fibrillation: a double-blind randomised study. HAEST Study Group. Heparin in Acute Embolic Stroke Trial.
Patients with acute ischaemic stroke and atrial fibrillation have an increased risk of early stroke recurrence, and anticoagulant treatment with heparins has been widely advocated, despite missing data on the balance of risk and benefit.
2466. Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: a randomised controlled trial.
作者: M Eddleston.;S Rajapakse.; Rajakanthan.;S Jayalath.;L Sjöström.;W Santharaj.;P N Thenabadu.;M H Sheriff.;D A Warrell.
来源: Lancet. 2000年355卷9208期967-72页
Severe cardiac glycoside cardiotoxicity after ingestion of yellow oleander seeds is an important problem in rural areas of Sri Lanka. Currently, patients must be transferred to the capital for temporary cardiac pacing. We did a randomised controlled trial to investigate whether anti-digoxin Fab could reverse serious oleander-induced arrhythmias.
2467. Photodynamic therapy with 5-aminolaevulinic acid or placebo for recalcitrant foot and hand warts: randomised double-blind trial.
Photodynamic therapy (PDT) with topical 5-aminolaevulinic acid (ALA) followed by irradiation with incoherent light (ALA-PDT) for recalcitrant warts have had beneficial results. Therefore, we undertook a randomised, parallel, double-blind clinical trial of ALA-PDT versus placeboPDT for recalcitrant foot and hand warts.
2469. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia.
作者: R E Hoffman.;N N Boutros.;S Hu.;R M Berman.;J H Krystal.;D S Charney.
来源: Lancet. 2000年355卷9209期1073-5页
12 patients with schizophrenia and auditory hallucinations received 1 Hz transcranial magnetic stimulation of left temporoparietial cortex. In a double-blind crossover trial, active stimulation significantly reduced hallucinations relative to sham stimulation.
2470. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial.
作者: J Y Douillard.;D Cunningham.;A D Roth.;M Navarro.;R D James.;P Karasek.;P Jandik.;T Iveson.;J Carmichael.;M Alakl.;G Gruia.;L Awad.;P Rougier.
来源: Lancet. 2000年355卷9209期1041-7页
Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We investigated the efficacy of these two agents combined for first-line treatment of metastatic colorectal cancer.
2471. Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial.
作者: M Camilleri.;A R Northcutt.;S Kong.;G E Dukes.;D McSorley.;A W Mangel.
来源: Lancet. 2000年355卷9209期1035-40页
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with symptoms of abdominal pain, discomfort, and altered bowel function. Antagonists of the type 3 serotonin receptor (5-HT3) have shown promising results in the relief of IBS-associated symptoms. We aimed to confirm these findings by doing a randomised, placebo-controlled trial.
2474. Response to different measles vaccine strains given by aerosol and subcutaneous routes to schoolchildren: a randomised trial.
作者: A Dilraj.;F T Cutts.;J F de Castro.;J G Wheeler.;D Brown.;C Roth.;H M Coovadia.;J V Bennett.
来源: Lancet. 2000年355卷9206期798-803页
More than one dose of measles vaccine is necessary for the sustained control of measles. The aerosol route is thought to be more immunogenic for booster doses than traditional subcutaneous injections, so we did a randomised comparative trial of aerosol and subcutaneous measles vaccines in South African schoolchildren.
2475. Effect of decreasing afferent vagal activity with ondansetron on symptoms of bulimia nervosa: a randomised, double-blind trial.
作者: P L Faris.;S W Kim.;W H Meller.;R L Goodale.;S A Oakman.;R D Hofbauer.;A M Marshall.;R S Daughters.;D Banerjee-Stevens.;E D Eckert.;B K Hartman.
来源: Lancet. 2000年355卷9206期792-7页
Several lines of evidence have led us to postulate that afferent vagal hyperactivity could be an important factor in the pathophysiology of the eating disorder bulimia nervosa. Ondansetron is a peripherally active antagonist of the serotonin receptor 5-HT3, and is marketed for prevention of vagally-mediated emesis caused by cancer chemotherapeutic agents. We investigated the effects of ondansetron on bulimic behaviours in patients with severe and chronic bulimia nervosa in a randomised, double-blind, placebo-controlled study.
2476. Stapling procedure for haemorrhoids versus Milligan-Morgan haemorrhoidectomy: randomised controlled trial.
Surgical haemorrhoidectomy has a reputation for being a painful procedure for a fairly benign disorder. The circular transanal stapled technique for the treatment of haemorrhoids has the potential to offer a less painful rectal procedure in place of ablative perianal surgery. We compared the short-term outcome of the circular stapled procedure for haemorrhoids with current standard surgery in a randomised controlled trial.
2477. Circumferential mucosectomy (stapled haemorrhoidectomy) versus conventional haemorrhoidectomy: randomised controlled trial.
Haemorrhoidectomy is commonly an inpatient procedure because it is frequently associated with postoperative pain. Day case haemorrhoidectomy is a similar operation to that used on inpatients but with different strategies for managing postoperative pain. Circumferential mucosectomy (stapled haemorrhoidectomy) may be associated with less postoperative pain than conventional haemorrhoidectomy. We compared stapled haemorrhoidectomy with conventional haemorrhoidectomy in patients with third degree haemorrhoids.
2478. Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study.
作者: J Crawley.;C Waruiru.;S Mithwani.;I Mwangi.;W Watkins.;D Ouma.;P Winstanley.;T Peto.;K Marsh.
来源: Lancet. 2000年355卷9205期701-6页
Seizures commonly complicate cerebral malaria and are associated with an increased risk of death and neurological sequelae. We undertook a randomised study to assess the efficacy of intramuscular phenobarbital in preventing seizures in childhood cerebral malaria.
2479. Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behçet's disease: a randomised trial.
Sight-threatening eye involvement is a serious complication of Behçet's disease. Extraocular complications such as arthritis, vascular occlusive disorders, mucocutaneous lesions, and central-nervous-system disease may lead to morbidity and even death. We designed a prospective study in newly diagnosed patients without previous eye disease to assess whether prevention of eye involvement and extraocular manifestations, and preservation of visual acuity are possible with combination treatments with and without interferon alfa-2b.
2480. Effects of replicating primary-reflex movements on specific reading difficulties in children: a randomised, double-blind, controlled trial.
Children with specific reading difficulties have problems that extend beyond the range of underlying language-related deficits (eg, they have difficulties with balance and motor control). We investigated the role of persistent primary reflexes (which are closely linked in the earliest months of life to the balance system) in disrupting the development of reading skills.
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