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221. Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLD.
作者: Yaqiong Wang.;Kuangyang Chen.;Jie Yu.;Yifan Tu.;Yuxin Zhao.;Yikai Zhang.;Yepeng Hu.;Hong Yang.;Han Yan.;Chao Zheng.
来源: BMC Gastroenterol. 2025年25卷1期448页
Inflammation plays a key role in the onset of MASLD, progression to MASH, and is associated with poor prognosis of MASLD. The aim of this study was to thoroughly investigate the association of different systemic inflammatory indicators with all-cause mortality and CVD mortality outcome in MASLD.
222. Abnormal anorectal manometric and sensory functions in patients with functional anorectal pain.
作者: Hongyan Zheng.;Yanlan Wu.;Sangsang Wu.;Fan Liu.;Jiande D Z Chen.;Dan Chai.;Min Ni.
来源: BMC Gastroenterol. 2025年25卷1期498页
High-resolution anorectal manometry (HARM) is widely used for diagnosis and assessment of constipation and fecal incontinence. However, limited information is available on HARM-identifiable characteristics in patients with functional anorectal pain (FARP). This study explored the pathogenesis of FARP by investigating their anorectal physiological and psychological characteristics using HARM.
223. Routine psychological problems screening in hospitalized inflammatory bowel diseases and its effect for progression-free survival from disease worsening.
To examine the progression-free survival from disease worsening after the implementation of routine screening for psychological problems in hospitalized patients with inflammatory bowel diseases (IBDs) during a long-term follow-up.
224. Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021.
Gallbladder and biliary tract cancer (GBTC) denotes a range of invasive tumors. Emerging evidence has revealed a rising trend in the incidence of early-onset GBTC (EOGBTC) patients, referring to individuals under the age of 50 years old. We conducted an epidemiological study to assess the disease burden of EOGBTC.
225. Neuroendocrine carcinoma of esophagus: systematic review and meta-analysis of case series.
作者: Seyed Morteza Pourfaraji.;Amirmohsen Jalaeefar.;Fatemeh Ojaghi Shirmard.;Dorsa Salabat.;Sara Mohammadi.;Narjes Mohammadzadeh.
来源: BMC Gastroenterol. 2025年25卷1期462页
Neuroendocrine carcinoma of the esophagus is a highly aggressive and rare type of cancer, making diagnosis and treatment challenging for clinicians. The current guidelines provide conflicting recommendations, and no standardized treatment protocol is available. We aim to deliver a systematic review of esophageal neuroendocrine carcinoma, including patient characteristics, treatment options, and prognostic factors.
226. Diagnostic performance of a new algorithm combining simple, non-invasive and inexpensive tests for predicting the presence of advanced liver fibrosis in patients with chronic hepatitis B.
作者: Jean Nana.;Jean Luc Bosson.;Kristina Skaare.;Céline Vermorel.;Vincent Leroy.;Tarik Asselah.;Michael Adler.;Jean-Pierre Zarski.
来源: BMC Gastroenterol. 2025年25卷1期447页
Non-invasive methods for scoring fibrosis have been developed to overcome the limitations of liver biopsy. These techniques have not been fully validated for assessing liver fibrosis in chronic hepatitis B (CHB). This study evaluated the utility of combining new, simple, non-invasive, and inexpensive tests to predict advanced liver fibrosis in CHB patients, assisting primary care physicians, especially in resource-limited settings.
227. Unveiling the diagnostic and pro-inflammatory role of crohn's disease: insights from 16 S-guided discovery and species-specific validation.
作者: Yao Xu.;Runxiang Xie.;Yuqing Weng.;Yewei Fang.;Huimin Chen.;Shuan Tao.;He Zhang.;Yawen Ye.;Xinyu Deng.;Axiang Han.;Qi Jiang.;Wei Liang.
来源: BMC Gastroenterol. 2025年25卷1期468页
The rising incidence of Crohn's disease (CD) in Asia underscores the need to explore its underlying mechanisms. The interaction between gut microbiota and the host is strongly linked to CD onset and progression, yet the precise mechanisms remain unclear. Previous studies have demonstrated that Ruminococcus gnavus (R. gnavus) is closely associated with the development and progression of CD. Therefore, this study focuses on the inflammatory role of R. gnavus in CD pathogenesis.
228. Correlation between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with prognosis in gastric cancer patients undergoing neoadjuvant chemotherapy: a meta-analysis.
作者: Shuang Yang.;Zhuoyang Li.;Tianhong Wang.;Congcong Zou.;Siman Wang.;Shuang Deng.;Yusi Hua.
来源: BMC Gastroenterol. 2025年25卷1期445页
Inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with poorer prognosis of gastric cancer (GC) patients and may guide treatment decisions. This meta-analysis aims to evaluate the impact of NLR and PLR on the prognosis of GC patients undergoing neoadjuvant chemotherapy (NAC).
229. Prevalence of advanced liver fibrosis in the general population of the Paris region according to FIB-4 score and liver risk score.
作者: Henri Tran.;Stefano Caruso.;Anne-Laure Mazialivoua.;Cecile Fargeat.;Odile Rousselet.;Adrien Ko.;Vincent Leroy.;Patrick Ingiliz.
来源: BMC Gastroenterol. 2025年25卷1期454页
The ideal non-invasive marker to identify patient at risk for liver fibrosis in the general population is unknown. Current guidelines (EASL) recommend using the FIB-4 score as a screening tool but the low specificity may result in a large number of potentially false-positive results. Recently, the liver risk score (LRS) has been suggested to more accurately identify patients at-risk. The aim of our study was to identify populations at-risk using the two scores.
230. Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal cancer surgery: A systematic review and meta-analysis of randomised controlled trials.
作者: Dedrick Kok Hong Chan.;Jerrald Lau.;Jarrod Kah-Hwee Tan.;Bryan Jun Liang Buan.;Kai-Yin Lee.;Norman Sihan Lin.;Ian Jse-Wei Tan.;Jing-Yu Ng.;Bettina Lieske.;Wai-Kit Cheong.;Ker-Kan Tan.
来源: BMC Gastroenterol. 2025年25卷1期491页
A defunctioning ileostomy is frequently created to avert the implications of a colo-rectal anastomotic dehiscence in rectal cancer surgery. The timing of closure of the ileostomy remains debatable as it is believed that early closure (EC) may be beneficial to most patients than the standard practice of late closure (LC). This meta-analysis was performed to compare surgical outcomes in patients who underwent EC versus LC.
231. Infliximab for patients with moderate to severely active ulcerative colitis: an updated meta-analysis of randomized controlled trials.
作者: Min Zhang.;Manman Li.;Yangzan Ou.;Qin Huang.;Mingmin Leng.;Xiangdong Yang.;Tao Yang.
来源: BMC Gastroenterol. 2025年25卷1期458页
Ulcerative colitis (UC) is a serious inflammatory bowel disease with significant morbidity and mortality. Infliximab (IFX), a TNF-alpha antagonist, is recommended by the American Gastroenterological Association, but its clinical effectiveness and safety are based on limited studies. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy and safety of IFX in moderate-to-severe active UC, providing evidence for its clinical application.
232. Prevalence and associated risk factors of Helicobacter pylori infection among medical students at Shendi university, Sudan.
作者: Nemat Khalid Abd Almajed Naser.;Mazin Babekir Musa Bashir.;Alhaj Saad Mohamed Ahmed Ali.
来源: BMC Gastroenterol. 2025年25卷1期466页
Helicobacter pylori is a significant pathogen of the gastrointestinal tract infection connected with gastritis, peptic ulcers, and gastric carcinoma. Its infection influences more than half of the world's inhabitants.
233. Genetic mechanism of β-alanine metabolic pathway affecting colorectal cancer prognosis.
作者: Tingyu Zhao.;Yali Jiang.;Qi Liang.;Sumeng Wang.;Xiao Zhang.;Siqi Ni.;Yi Jiao.;Lingxiang Liu.
来源: BMC Gastroenterol. 2025年25卷1期480页
Colorectal cancer (CRC) is a common cause of cancer-related mortality and is mainly influenced by metabolic dysfunction. The β-alanine metabolic pathway plays an important role in altering the aggressiveness and metabolic characteristics of the cancer cells. This study aimed to investigate the genetic role of the β-alanine metabolic pathway in CRC patient survival.
234. Prophylactic endotracheal intubation prior to emergency endoscopy for acute esophagogastric variceal hemorrhage: a retrospective single center study.
Prophylactic endotracheal intubation (PEI) is widely performed before emergency endoscopy in patients with acute esophagogastric variceal bleeding (AEVB). However, its safety and benefits remain controversial. This study aims to evaluate the efficacy of PEI in patients with AEVB and the appropriate extubation time.
235. Pan-immune-inflammation value and mortality in the US adult MASLD: a nonlinear NHANES analysis.
Systemic inflammatory markers derived from immune cell counts have been associated with mortality risk in metabolic dysfunction-associated steatotic liver disease (MASLD). However, the clinical relevance of the pan-immune-inflammation value (PIV), a composite index incorporating neutrophil, platelet, monocyte, and lymphocyte counts, in relation to mortality has not been fully elucidated. This study aimed to evaluate the association between PIV and both all-cause and cardiovascular mortality in individuals with MASLD.
236. Hospital-based prevalence and predictors of upper gastrointestinal bleeding in Northern Uganda: a retrospective cross-sectional study.
Upper gastrointestinal bleeding (UGIB) is a potentially life-threatening condition and a common reason for hospitalisation worldwide. However, the exact burden, as well as the associated factors and treatment outcomes of UGIB in this study setting, have not been determined to guide evidence-based interventions.
237. The nomograph predicting the recurrence of Solid Pseudopapillary Neoplasm of the Pancreas: a study of the SEER database and a Chinese cohort.
作者: Qidong Pei.;Junzong Chen.;Gang Deng.;Dong Li.;Yajun Tang.;Jiaming Lai.;Di Tang.
来源: BMC Gastroenterol. 2025年25卷1期482页
Solid pseudopapillary neoplasm of the pancreas (SPN) represents a rare form of low-grade malignant pancreatic cystic neoplasm. This study seeks to construct a predictive nomograph model for SPN recurrence.
238. Research and experiments of a new premedication for improving mucosal visibility during esophagogastroduodenoscopy.
作者: Li-Na Qu.;Tao Jiang.;Yao-Ping Zhang.;Jin-Yong Hao.;Xiao-Jun Huang.
来源: BMC Gastroenterol. 2025年25卷1期450页
Mucus and bubbles are important factors that can reduce endoscope visibility. This may result in missed diagnoses of minor or early lesions. Therefore, dimethicone, such as drugs used before esophagogastroduodenoscopy (EGD), is called premedication. There is no uniform premedication worldwide. Moreover, the clinical effects of existing preoperative medications cannot meet the needs of endoscopists.
239. TyG-BMI as a superior predictor of MAFLD and pre-MAFLD in Chinese adults: a cross-sectional study.
作者: Xinru Huang.;Yanyun Hu.;Lining Dong.;Liying Zhu.;Jie Li.;Ji Hu.;Wei Shao.;Yongde Peng.;Fang Liu.
来源: BMC Gastroenterol. 2025年25卷1期495页
Metabolic-associated fatty liver disease (MAFLD), a highly prevalent global liver disorder, requires early diagnosis and treatment to delay progression, yet lacks simple diagnostic tools. We aimed to evaluate the validity of the triglyceride-glucose index (TyG) and its related indexes in predicting MAFLD and pre-MAFLD among Chinese individuals.
240. Association between blood lead levels and constipation in adults: insights from NHANES data (2005-2010).
作者: Yue-Juan Li.;Hui Dong.;Wen-Xing Chen.;Deng-Chao Wang.;Miao Yu.
来源: BMC Gastroenterol. 2025年25卷1期455页
Constipation is a common health issue affecting quality of life. While environmental factors like lead exposure may influence gastrointestinal function, the link between blood lead levels and constipation is underexplored. This study, based on NHANES data, investigates the association between blood lead levels and constipation prevalence in adults.
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