Cholecystectomy is one of the most common surgical procedures for the treatment of diseases associated with gallstones, and the incidence of post-cholecystectomy diarrhea (PCD) has attracted attention in recent years. The aim of this study was to assess the prevalence of PCD in patients with gallstones and to analyze the factors influencing it.

Probiotic supplementation has been proposed as a preventive measure for necrotizing enterocolitis (NEC) in preterm infants. This umbrella meta-analysis assesses the effects of probiotics, including single-strain and multi-strain formulations, on NEC and related mortality.

Perianal abscess (PA) is a complication of infection in patients with hematologic malignancies. However, the simultaneous occurrence of neutropenia and increased susceptibility to bleeding pose significant challenges for surgical intervention in perianal abscesses. In this retrospective study, we sought to evaluate and compare the efficacy of pharmacological therapy and surgical intervention in the management of PA in patients with hematologic malignancies, bwtween 2015 and 2022 at the Fujian Medical University Union Hospital. In total, 53 patients were enrolled in this study, including 19 cases with surgical intervention, and 34 cases with conservative treatment. During the 60-day follow-up period, a significant improvement of symptoms or complete resolution was observed in 48 patients (90.5%). But the cure rates between the two groups showed no significant difference (p > 0.05). Additionally, the surgical group demonstrated a significantly lower recurrence rate compared to the conservative group, while there was no statistically significant disparity in recurrence rates (10.4% vs. 23.6%, p > 0.05). Patients with conservative treatment showed significantly shorter recovery time compared to patients with surgical treatment (p = 0.048). In conclusion, both conservative and surgical management approaches were safe and effective in relieving symptoms, but surgical intervention significantly decreased the recurrence rate. Therefore, consideration of surgical intervention is warranted for patients with recurrent perianal infections after conservative treatment.

Our research aims to explore the effects of different exercise on liver function and bile acid in patients with non-alcoholic fatty liver disease (NAFLD), to identify the most beneficial exercise modalities for patients with NAFLD.

The relationship between KRAS mutations and the risk of venous thromboembolism (VTE) recurrence in metastatic colorectal cancer (mCRC) patients with established cancer-associated thrombosis (CAT) remains uncertain. This study aims to (1) evaluate the predictive value of seven KRAS mutation subtypes for VTE recurrence and (2) assess the impact of incorporating these mutations into two existing VTE risk scores: the Khorana score and the Ottawa score.

Colon cancer is one of the most prevalent malignancies globally. Anthropometric data are widely accessible. However, numerous anthropometric indicators exist, and no study has identified the most reliable predictor for colon cancer. This study aims to identify the most effective anthropometric indicators for predicting colon cancer.

Metabolic score for visceral fat (METS-VF) as an effective marker of visceral obesity has been correlated with non-alcoholic fatty liver disease (NAFLD). This study aims to explore the correlation between METS-VF and both all-cause mortality and cardiovascular disease (CVD)-related mortality among individuals with NAFLD.

To evaluate the correlation and consistency between hepatic venous pressure gradient(F-HVPG) calculated as the wedged hepatic venous pressure (WHVP) minus free hepatic venous pressure (FHVP), I-HVPG calculated as WHVP minus inferior vena cava pressure (IVCP) in the hepatic segment, and portal pressure gradient (PPG).

Endoscopic retrograde cholangiopancreatography (ERCP) is important in the management of pancreatobiliary diseases and requires fluoroscopy resulting in radiation exposure to those involved. ERCP is performed in different hospital settings such as the endoscopy unit (EU), radiology suite (RS), and operating room (OR) depending on numerous factors. Our study examines the differences in duration of fluoroscopy time (FT) as a surrogate for radiation dosages between multiple unique settings.

Transcription-replication conflicts (TRCs) are a key source of replication stress in cancer, with pancreatic ductal adenocarcinoma (PDAC) showing uniquely high levels. This study investigated the mechanism, oncogene dependency, subtype specificity, and preclinical activity of the TRC-targeting molecule AOH1996 in PDAC models. Initial clinical evidence of AOH1996 activity in patients with PDAC is also provided.

Helicobacter pylori (H pylori) infection is a major risk factor for gastric cancer (GC); however, whether H pylori eradication (HPE) benefits the older population remains unclear. We compared GC incidence and mortality between H pylori-treated individuals and the general population, stratified by age.

Constipation-predominant irritable bowel syndrome (IBS-C) and functional constipation (FC) are prevalent disorders with overlapping and fluctuating symptoms, which pose challenges for accurate diagnosis. This study aimed to assess the consistency of diagnostic criteria for IBS-C and FC in adults across clinical practice guidelines (CPGs).

Gastric stromal tumors (GSTs) and gastric leiomyomas (GLs) represent the primary subtypes of gastric submucosal tumors (SMTs) characterized by distinct biological characteristics and treatment modalities. The accurate differentiation between GSTs and GLs poses a significant clinical challenge. Recent advancements in artificial intelligence (AI) leveraging endoscopic ultrasonography (EUS) have demonstrated promising results in the categorization of larger-diameter SMTs (> 2.0 cm). However, the diagnostic capacity of AI models for micro-diameter SMTs (< 1.0 cm) remains uncertain due to limited imaging features. This study seeks to develop a specialized diagnostic model utilizing EUS images to differentiate small and micro GSTs from GLs effectively.

Previous research has indicated that the fasting plasma glucose to high-density lipoprotein cholesterol ratio (FHR) is a novel biomarker for assessing cardiovascular disease prognosis. The objective of this study is to investigate the potential relationship of FHR with non-alcoholic fatty liver disease (NAFLD).

Extrahepatic cholangiocarcinoma (eCCA) is a rare but refractory cancer with dense desmoplasia. Prognosis-associated stromal cells in eCCA remain poorly characterized. Here, we profiled the tumor cellular composition and identified prognosis-related stromal signatures by single-cell RNA sequencing (scRNA-seq) in eCCA. ECCA patients were further stratified into different categories based on identified stromal signatures.

Given the need for effective interventions in metabolic dysfunction-associated steatohepatitis (MASH), understanding the role of adipose tissue macrophage (ATM)-derived small extracellular vesicles (sEVs) is important. We aimed to evaluate the contribution of MASH-ATM-sEVs to the development of liver fibrosis in obese male mice.

Death receptor 3 (DR3) and its ligand, tumor necrosis factor-like ligand 1A (TL1A), regulate the balance between effector and regulatory T cells in inflammatory bowel disease (IBD). Although interleukin 9 (IL9)-secreting T helper 9 (Th9) cells are linked to ulcerative colitis, their role in Crohn's disease (CD) is unclear. We investigated the role of DR3 signaling in Th9 cell differentiation in mouse models of CD-like ileitis and colitis.

The adult pancreas protects against cancer by actively expelling genetically mutated cells. Pancreatic cancer starts with cells carrying KRAS mutations; however, it is not clear how some KRAS mutant cells override cell elimination mechanisms to survive in tissues.

Primary biliary cholangitis (PBC) is a chronic, progressive autoimmune liver disease. Some patients with PBC do not adequately respond to Ursodeoxycholic acid (UDCA) as a first-line treatment, putting them at an increased risk of disease progression. Peroxisome Proliferator-Activated Receptor (PPAR) agonists are emerging as promising therapeutic options for PBC. We aim to investigate the efficacy and safety of PPAR agonists in treating PBC patients.

Whether include high-sensitivity C-reactive protein (Hs-CRP) in diagnostic flow remains debatable during the updated definition to metabolic dysfunction-associated steatotic liver disease (MASLD) despite systemic inflammation contributes to the disease development and progression. We aimed to identify values of hs-CRP compared to other inflammatory markers derived from routine blood tests in MASLD.