226. Secondary Prevention after Ischemic Stroke.
The risk of recurrent ischemic stroke can be reduced by managing modifiable risk factors and instituting a regimen of mechanism-specific secondary stroke prevention. Strategies for secondary prevention should be instituted as early as possible. Poststroke monitoring of risk metrics, lifestyle behaviors, and medication recommendations is of key importance.
229. Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges.
作者: Aadia I Rana.;Lu Zheng.;Jose Castillo-Mancilla.;Yajing Bao.;Sara Sieczkarski.;Kristina M Brooks.;Jordan E Lake.;Carl Fichtenbaum.;Sonya L Heath.;Pablo F Belaunzaran-Zamudio.;Karin Klingman.;Lawrence Fox.;Tia Morton.;Michael Stirratt.;Jonathan Z Li.;Edward P Acosta.;Charles Venuto.;Omar Galáarraga.;Steven Shoptaw.;David Wohl.;Madison Green.;Ceora Beijer.;Kathie Ferbas.;Cheryl Jennings.;Katherine Shin.;Romina Collahua.;Michael Dorosh.;Paul Wannamaker.;Ronald D'Amico.;Kimberly Smith.;William Spreen.;Kati Vandermeulen.;Rodica Van Solingen-Ristea.;Chanelle Wimbish.;Karen T Tashima.;Raphael J Landovitz.; .
来源: N Engl J Med. 2026年394卷9期858-871页
Randomized trials of long-acting injectable antiretroviral therapy (ART) in persons with human immunodeficiency virus (HIV) who face challenges with adherence to oral medication are lacking.
230. Perioperative Enfortumab Vedotin and Pembrolizumab in Bladder Cancer.
作者: Christof Vulsteke.;Nabil Adra.;Pongwut Danchaivijitr.;Maksym Sabadash.;Alejo Rodriguez-Vida.;Zhentao Zhang.;Vagif Atduev.;Y Emre Göger.;Steffen Rausch.;Seok-Ho Kang.;Yohann Loriot.;Jens Bedke.;Matthew D Galsky.;Peter H O'Donnell.;Gunhild von Amsberg.;Nimira Alimohamed.;Grzegorz Sulimka.;Shilpa Gupta.;Viktor Paramonov.;Keita Nakane.;Michael Mihm.;Changting Meng.;Caizhi David Huang.;Chethan Ramamurthy.;Blanca Homet Moreno.;Anders Ullén.; .
来源: N Engl J Med. 2026年394卷13期1257-1269页
Patients with muscle-invasive bladder cancer who are ineligible for cisplatin-based chemotherapy proceed directly to radical cystectomy with pelvic lymph-node dissection. Perioperative therapy may improve outcomes in this population.
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