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221. Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention: A Randomized Trial.
作者: Lindsey R Baden.;Etienne Karita.;Gaudensia Mutua.;Linda-Gail Bekker.;Glenda Gray.;Liesl Page-Shipp.;Stephen R Walsh.;Julien Nyombayire.;Omu Anzala.;Surita Roux.;Fatima Laher.;Craig Innes.;Michael S Seaman.;Yehuda Z Cohen.;Lauren Peter.;Nicole Frahm.;M Juliana McElrath.;Peter Hayes.;Edith Swann.;Nicole Grunenberg.;Maria Grazia-Pau.;Mo Weijtens.;Jerry Sadoff.;Len Dally.;Angela Lombardo.;Jill Gilmour.;Josephine Cox.;Raphael Dolin.;Patricia Fast.;Dan H Barouch.;Dagna S Laufer.; .
来源: Ann Intern Med. 2016年164卷5期313-22页
A prophylactic HIV-1 vaccine is a global health priority.
222. Medical Assistant-Based Care Management for High-Risk Patients in Small Primary Care Practices: A Cluster Randomized Clinical Trial.
作者: Tobias Freund.;Frank Peters-Klimm.;Cynthia M Boyd.;Cornelia Mahler.;Jochen Gensichen.;Antje Erler.;Martin Beyer.;Matthias Gondan.;Justine Rochon.;Ferdinand M Gerlach.;Joachim Szecsenyi.
来源: Ann Intern Med. 2016年164卷5期323-30页
Patients with multiple chronic conditions are at high risk for potentially avoidable hospitalizations, which may be reduced by care coordination and self-management support. Medical assistants are an increasingly available resource for patient care in primary care practices.
223. Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial.
作者: Kurt D Christensen.;J Scott Roberts.;Peter J Whitehouse.;Charmaine D M Royal.;Thomas O Obisesan.;L Adrienne Cupples.;Jacqueline A Vernarelli.;Deepak L Bhatt.;Erin Linnenbringer.;Melissa B Butson.;Grace-Ann Fasaye.;Wendy R Uhlmann.;Susan Hiraki.;Na Wang.;Robert Cook-Deegan.;Robert C Green.; .
来源: Ann Intern Med. 2016年164卷3期155-63页
Increasing use of genetic testing raises questions about disclosing secondary findings, including pleiotropic information.
224. Acupuncture for Menopausal Hot Flashes: A Randomized Trial.
作者: Carolyn Ee.;Charlie Xue.;Patty Chondros.;Stephen P Myers.;Simon D French.;Helena Teede.;Marie Pirotta.
来源: Ann Intern Med. 2016年164卷3期146-54页
Hot flashes (HFs) affect up to 75% of menopausal women and pose a considerable health and financial burden. Evidence of acupuncture efficacy as an HF treatment is conflicting.
225. Laparoscopic Lavage for Perforated Diverticulitis With Purulent Peritonitis: A Randomized Trial.
作者: Anders Thornell.;Eva Angenete.;Thue Bisgaard.;David Bock.;Jakob Burcharth.;Jane Heath.;Hans-Christian Pommergaard.;Jacob Rosenberg.;Nikolaj Stilling.;Stefan Skullman.;Eva Haglind.
来源: Ann Intern Med. 2016年164卷3期137-45页
Perforated diverticulitis with purulent peritonitis has traditionally been treated with open colon resection and stoma formation with risk for reoperations, morbidity, and mortality. Laparoscopic lavage alone has been suggested as definitive treatment.
226. A Combined Patient and Provider Intervention for Management of Osteoarthritis in Veterans: A Randomized Clinical Trial.
作者: Kelli D Allen.;William S Yancy.;Hayden B Bosworth.;Cynthia J Coffman.;Amy S Jeffreys.;Santanu K Datta.;Jennifer McDuffie.;Jennifer L Strauss.;Eugene Z Oddone.
来源: Ann Intern Med. 2016年164卷2期73-83页
Management of osteoarthritis requires both medical and behavioral strategies, but some recommended therapies are underused.
227. HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial.
作者: Karen T Tashima.;Laura M Smeaton.;Carl J Fichtenbaum.;Adriana Andrade.;Joseph J Eron.;Rajesh T Gandhi.;Victoria A Johnson.;Karin L Klingman.;Justin Ritz.;Sally Hodder.;Jorge L Santana.;Timothy Wilkin.;Richard H Haubrich.; .
来源: Ann Intern Med. 2015年163卷12期908-17页
Nucleoside reverse transcriptase inhibitors (NRTIs) are often included in antiretroviral regimens in treatment-experienced patients in the absence of data from randomized trials.
228. Sofosbuvir Plus Velpatasvir Combination Therapy for Treatment-Experienced Patients With Genotype 1 or 3 Hepatitis C Virus Infection: A Randomized Trial.
作者: Stephen Pianko.;Steven L Flamm.;Mitchell L Shiffman.;Sonal Kumar.;Simone I Strasser.;Gregory J Dore.;John McNally.;Diana M Brainard.;Lingling Han.;Brian Doehle.;Erik Mogalian.;John G McHutchison.;Mordechai Rabinovitz.;William J Towner.;Edward J Gane.;Catherine A M Stedman.;K Rajender Reddy.;Stuart K Roberts.
来源: Ann Intern Med. 2015年163卷11期809-17页
Effective treatment options are needed for patients with genotype 1 or 3 hepatitis C virus (HCV) infection in whom previous therapy has failed.
229. Sofosbuvir With Velpatasvir in Treatment-Naive Noncirrhotic Patients With Genotype 1 to 6 Hepatitis C Virus Infection: A Randomized Trial.
作者: Gregory T Everson.;William J Towner.;Mitchell N Davis.;David L Wyles.;Ronald G Nahass.;Paul J Thuluvath.;Kyle Etzkorn.;Federico Hinestrosa.;Myron Tong.;Mordechai Rabinovitz.;John McNally.;Diana M Brainard.;Lingling Han.;Brian Doehle.;John G McHutchison.;Timothy Morgan.;Raymond T Chung.;Tram T Tran.
来源: Ann Intern Med. 2015年163卷11期818-26页
Effective, pangenotypic treatments for hepatitis C virus (HCV) infection are needed.
230. Alexander Technique Lessons or Acupuncture Sessions for Persons With Chronic Neck Pain: A Randomized Trial.
作者: Hugh MacPherson.;Helen Tilbrook.;Stewart Richmond.;Julia Woodman.;Kathleen Ballard.;Karl Atkin.;Martin Bland.;Janet Eldred.;Holly Essex.;Catherine Hewitt.;Ann Hopton.;Ada Keding.;Harriet Lansdown.;Steve Parrott.;David Torgerson.;Aniela Wenham.;Ian Watt.
来源: Ann Intern Med. 2015年163卷9期653-62页
Management of chronic neck pain may benefit from additional active self-care-oriented approaches.
231. Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes: A 2-Year Randomized, Controlled Trial.
作者: Yftach Gepner.;Rachel Golan.;Ilana Harman-Boehm.;Yaakov Henkin.;Dan Schwarzfuchs.;Ilan Shelef.;Ronen Durst.;Julia Kovsan.;Arkady Bolotin.;Eran Leitersdorf.;Shoshana Shpitzen.;Shai Balag.;Elad Shemesh.;Shula Witkow.;Osnat Tangi-Rosental.;Yoash Chassidim.;Idit F Liberty.;Benjamin Sarusi.;Sivan Ben-Avraham.;Anders Helander.;Uta Ceglarek.;Michael Stumvoll.;Matthias Blüher.;Joachim Thiery.;Assaf Rudich.;Meir J Stampfer.;Iris Shai.
来源: Ann Intern Med. 2015年163卷8期569-79页
Recommendations for moderate alcohol consumption remain controversial, particularly in type 2 diabetes mellitus (T2DM). Long-term randomized, controlled trials (RCTs) are lacking.
232. Visit-to-Visit Variability of Blood Pressure and Coronary Heart Disease, Stroke, Heart Failure, and Mortality: A Cohort Study.
作者: Paul Muntner.;Jeff Whittle.;Amy I Lynch.;Lisandro D Colantonio.;Lara M Simpson.;Paula T Einhorn.;Emily B Levitan.;Paul K Whelton.;William C Cushman.;Gail T Louis.;Barry R Davis.;Suzanne Oparil.
来源: Ann Intern Med. 2015年163卷5期329-38页
Variability of blood pressure (BP) across outpatient visits is frequently dismissed as random fluctuation around a patient's underlying BP.
233. Vitamin D and Calcium Attenuate Bone Loss With Antiretroviral Therapy Initiation: A Randomized Trial.
作者: Edgar Turner Overton.;Ellen S Chan.;Todd T Brown.;Pablo Tebas.;Grace A McComsey.;Kathleen M Melbourne.;Andrew Napoli.;William Royce Hardin.;Heather J Ribaudo.;Michael T Yin.
来源: Ann Intern Med. 2015年162卷12期815-24页
Antiretroviral therapy initiation for HIV-1 infection is associated with 2% to 6% loss of bone mineral density (BMD).
234. Effect of Allowing Choice of Diet on Weight Loss: A Randomized Trial.
作者: William S Yancy.;Stephanie B Mayer.;Cynthia J Coffman.;Valerie A Smith.;Ronette L Kolotkin.;Paula J Geiselman.;Megan A McVay.;Eugene Z Oddone.;Corrine I Voils.
来源: Ann Intern Med. 2015年162卷12期805-14页
Choosing a diet rather than being prescribed one could improve weight loss.
235. Coronary Computed Tomography Angiography Versus Radionuclide Myocardial Perfusion Imaging in Patients With Chest Pain Admitted to Telemetry: A Randomized Trial.
作者: Jeffrey M Levsky.;Daniel M Spevack.;Mark I Travin.;Mark A Menegus.;Paul W Huang.;Elana T Clark.;Choo-Won Kim.;Esther Hirschhorn.;Katherine D Freeman.;Jonathan N Tobin.;Linda B Haramati.
来源: Ann Intern Med. 2015年163卷3期174-83页
The role of coronary computed tomography angiography (CCTA) in the management of symptomatic patients suspected of having coronary artery disease is expanding. However, prospective intermediate-term outcomes are lacking.
236. Low-molecular-weight heparin for women with unexplained recurrent pregnancy loss: a multicenter trial with a minimization randomization scheme.
作者: Ekkehard Schleussner.;Gabriele Kamin.;Gregor Seliger.;Nina Rogenhofer.;Susanne Ebner.;Bettina Toth.;Michael Schenk.;Melanie Henes.;Michael K Bohlmann.;Thorsten Fischer.;Oana Brosteanu.;Rupert Bauersachs.;David Petroff.; .
来源: Ann Intern Med. 2015年162卷9期601-9页
A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit is questionable.
237. Grazoprevir-Elbasvir Combination Therapy for Treatment-Naive Cirrhotic and Noncirrhotic Patients With Chronic Hepatitis C Virus Genotype 1, 4, or 6 Infection: A Randomized Trial.
作者: Stefan Zeuzem.;Reem Ghalib.;K Rajender Reddy.;Paul J Pockros.;Ziv Ben Ari.;Yue Zhao.;Deborah D Brown.;Shuyan Wan.;Mark J DiNubile.;Bach-Yen Nguyen.;Michael N Robertson.;Janice Wahl.;Eliav Barr.;Joan R Butterton.
来源: Ann Intern Med. 2015年163卷1期1-13页
Novel interferon- and ribavirin-free regimens are needed to treat hepatitis C virus (HCV) infection.
238. Surgery versus nonsurgical treatment of lumbar spinal stenosis: a randomized trial.
作者: Anthony Delitto.;Sara R Piva.;Charity G Moore.;Julie M Fritz.;Stephen R Wisniewski.;Deborah A Josbeno.;Mark Fye.;William C Welch.
来源: Ann Intern Med. 2015年162卷7期465-73页
Primary care management decisions for patients with symptomatic lumbar spinal stenosis (LSS) are challenging, and nonsurgical guidance is limited by lack of evidence.
239. Effects of exercise amount and intensity on abdominal obesity and glucose tolerance in obese adults: a randomized trial.
Exercise reduces obesity and related glucose tolerance, but whether increasing exercise intensity offers additional benefit at fixed exercise amounts is unknown.
240. Single-component versus multicomponent dietary goals for the metabolic syndrome: a randomized trial.
作者: Yunsheng Ma.;Barbara C Olendzki.;Jinsong Wang.;Gioia M Persuitte.;Wenjun Li.;Hua Fang.;Philip A Merriam.;Nicole M Wedick.;Ira S Ockene.;Annie L Culver.;Kristin L Schneider.;Gin-Fei Olendzki.;James Carmody.;Tingjian Ge.;Zhiying Zhang.;Sherry L Pagoto.
来源: Ann Intern Med. 2015年162卷4期248-57页
Few studies have compared diets to determine whether a program focused on 1 dietary change results in collateral effects on other untargeted healthy diet components.
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