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221. Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization.
作者: Neal A Chatterjee.;Franco Giulianini.;Bastiaan Geelhoed.;Kathryn L Lunetta.;Jeffrey R Misialek.;Maartje N Niemeijer.;Michiel Rienstra.;Lynda M Rose.;Albert V Smith.;Dan E Arking.;Patrick T Ellinor.;Jan Heeringa.;Honghuang Lin.;Steven A Lubitz.;Elsayed Z Soliman.;Niek Verweij.;Alvaro Alonso.;Emelia J Benjamin.;Vilmundur Gudnason.;Bruno H C Stricker.;Pim Van Der Harst.;Daniel I Chasman.;Christine M Albert.
来源: Circulation. 2017年135卷8期741-754页
Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from observational studies, however, is subject to residual confounding, reverse causation, and bias. The primary objective of this study was to evaluate the causal association between BMI and AF by using genetic predictors of BMI.
222. Thrombus Aspiration in ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis: Thrombectomy Trialists Collaboration.
作者: Sanjit S Jolly.;Stefan James.;Vladimír Džavík.;John A Cairns.;Karim D Mahmoud.;Felix Zijlstra.;Salim Yusuf.;Goran K Olivecrona.;Henrik Renlund.;Peggy Gao.;Bo Lagerqvist.;Ashraf Alazzoni.;Sasko Kedev.;Goran Stankovic.;Brandi Meeks.;Ole Frøbert.
来源: Circulation. 2017年135卷2期143-152页
Thrombus aspiration during percutaneous coronary intervention (PCI) for the treatment of ST-segment-elevation myocardial infarction (STEMI) has been widely used; however, recent trials have questioned its value and safety. In this meta-analysis, we, the trial investigators, aimed to pool the individual patient data from these trials to determine the benefits and risks of thrombus aspiration during PCI in patients with ST-segment-elevation myocardial infarction.
223. Associations of Epicardial, Abdominal, and Overall Adiposity With Atrial Fibrillation.
作者: Christopher X Wong.;Michelle T Sun.;Ayodele Odutayo.;Connor A Emdin.;Rajiv Mahajan.;Dennis H Lau.;Rajeev K Pathak.;Dennis T Wong.;Joseph B Selvanayagam.;Prashanthan Sanders.;Robert Clarke.
来源: Circ Arrhythm Electrophysiol. 2016年9卷12期
Although adiposity is increasingly recognized as a risk factor for atrial fibrillation (AF), the importance of epicardial fat compared with other adipose tissue depots remains uncertain. We sought to characterize and compare the associations of AF with epicardial fat and measures of abdominal and overall adiposity.
224. Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials.
作者: Nitesh Nerlekar.;Francis J Ha.;Kunal P Verma.;Martin R Bennett.;James D Cameron.;Ian T Meredith.;Adam J Brown.
来源: Circ Cardiovasc Interv. 2016年9卷12期
Current guidelines suggest that coronary artery bypass grafting (CABG) should be the preferred revascularization method for unprotected left main coronary artery stenosis. In light of evidence from recent randomized trials, we assessed whether percutaneous coronary intervention (PCI) using drug-eluting stents is as safe and effective as CABG for the treatment of unprotected left main coronary artery disease.
225. Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities.
作者: Chisato Shimizu.;Hariklia Eleftherohorinou.;Victoria J Wright.;Jihoon Kim.;Martin P Alphonse.;James C Perry.;Rolando Cimaz.;David Burgner.;Nagib Dahdah.;Long T Hoang.;Chiea Chuen Khor.;Andrea Salgado.;Adriana H Tremoulet.;Sonia Davila.;Taco W Kuijpers.;Martin L Hibberd.;Todd A Johnson.;Atsushi Takahashi.;Tatsuhiko Tsunoda.;Michiaki Kubo.;Toshihiro Tanaka.;Yoshihiro Onouchi.;Rae S M Yeung.;Lachlan J M Coin.;Michael Levin.;Jane C Burns.; .
来源: Circ Cardiovasc Genet. 2016年9卷6期559-568页
Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies and linkage studies only partially explain the influence of genetics on KD susceptibility.
226. Heart Rate Turbulence Is a Powerful Predictor of Cardiac Death and Ventricular Arrhythmias in Postmyocardial Infarction and Heart Failure Patients: A Systematic Review and Meta-Analysis.
作者: Marcello Disertori.;Michela Masè.;Marta Rigoni.;Giandomenico Nollo.;Flavia Ravelli.
来源: Circ Arrhythm Electrophysiol. 2016年9卷12期
Heart rate turbulence (HRT) has been proposed as a candidate marker of altered autonomic tone, and some studies showed its prognostic value for both cardiac death (CD) and sudden death. Nevertheless, HRT is not currently used in the clinical practice.
227. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.
作者: Pradeep Natarajan.;Joshua C Bis.;Lawrence F Bielak.;Amanda J Cox.;Marcus Dörr.;Mary F Feitosa.;Nora Franceschini.;Xiuqing Guo.;Shih-Jen Hwang.;Aaron Isaacs.;Min A Jhun.;Maryam Kavousi.;Ruifang Li-Gao.;Leo-Pekka Lyytikäinen.;Riccardo E Marioni.;Ulf Schminke.;Nathan O Stitziel.;Hayato Tada.;Jessica van Setten.;Albert V Smith.;Dina Vojinovic.;Lisa R Yanek.;Jie Yao.;Laura M Yerges-Armstrong.;Najaf Amin.;Usman Baber.;Ingrid B Borecki.;J Jeffrey Carr.;Yii-Der Ida Chen.;L Adrienne Cupples.;Pim A de Jong.;Harry de Koning.;Bob D de Vos.;Ayse Demirkan.;Valentin Fuster.;Oscar H Franco.;Mark O Goodarzi.;Tamara B Harris.;Susan R Heckbert.;Gerardo Heiss.;Udo Hoffmann.;Albert Hofman.;Ivana Išgum.;J Wouter Jukema.;Mika Kähönen.;Sharon L R Kardia.;Brian G Kral.;Lenore J Launer.;Joe Massaro.;Roxana Mehran.;Braxton D Mitchell.;Thomas H Mosley.;Renée de Mutsert.;Anne B Newman.;Khanh-Dung Nguyen.;Kari E North.;Jeffrey R O'Connell.;Matthijs Oudkerk.;James S Pankow.;Gina M Peloso.;Wendy Post.;Michael A Province.;Laura M Raffield.;Olli T Raitakari.;Dermot F Reilly.;Fernando Rivadeneira.;Frits Rosendaal.;Samantha Sartori.;Kent D Taylor.;Alexander Teumer.;Stella Trompet.;Stephen T Turner.;Andre G Uitterlinden.;Dhananjay Vaidya.;Aad van der Lugt.;Uwe Völker.;Joanna M Wardlaw.;Christina L Wassel.;Stefan Weiss.;Mary K Wojczynski.;Diane M Becker.;Lewis C Becker.;Eric Boerwinkle.;Donald W Bowden.;Ian J Deary.;Abbas Dehghan.;Stephan B Felix.;Vilmundur Gudnason.;Terho Lehtimäki.;Rasika Mathias.;Dennis O Mook-Kanamori.;Bruce M Psaty.;Daniel J Rader.;Jerome I Rotter.;James G Wilson.;Cornelia M van Duijn.;Henry Völzke.;Sekar Kathiresan.;Patricia A Peyser.;Christopher J O'Donnell.; .
来源: Circ Cardiovasc Genet. 2016年9卷6期511-520页
The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease. We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent coronary heart disease.
228. Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies.
作者: Bakhtawar K Mahmoodi.;Mary Cushman.;Inger Anne Næss.;Matthew A Allison.;Willem J Bos.;Sigrid K Brækkan.;Suzanne C Cannegieter.;Ron T Gansevoort.;Philimon N Gona.;Jens Hammerstrøm.;John-Bjarne Hansen.;Susan Heckbert.;Anders G Holst.;Susan G Lakoski.;Pamela L Lutsey.;JoAnn E Manson.;Lisa W Martin.;Kunihiro Matsushita.;Karina Meijer.;Kim Overvad.;Eva Prescott.;Marja Puurunen.;Jacques E Rossouw.;Yingying Sang.;Marianne T Severinsen.;Jur Ten Berg.;Aaron R Folsom.;Neil A Zakai.
来源: Circulation. 2017年135卷1期7-16页
Much controversy surrounds the association of traditional cardiovascular disease risk factors with venous thromboembolism (VTE).
229. Genetic Polymorphisms and Clopidogrel Efficacy for Acute Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis.
作者: Yuesong Pan.;Weiqi Chen.;Yun Xu.;Xingyang Yi.;Yan Han.;Qingwu Yang.;Xin Li.;Li'an Huang.;S Claiborne Johnston.;Xingquan Zhao.;Liping Liu.;Qi Zhang.;Guangyao Wang.;Yongjun Wang.;Yilong Wang.
来源: Circulation. 2017年135卷1期21-33页
The association of genetic polymorphisms and clopidogrel efficacy in patients with ischemic stroke or transient ischemic attack (TIA) remains controversial. We performed a systematic review and meta-analysis to assess the association between genetic polymorphisms, especially CYP2C19 genotype, and clopidogrel efficacy for ischemic stroke or TIA.
230. Epigenetic Signatures of Cigarette Smoking.
作者: Roby Joehanes.;Allan C Just.;Riccardo E Marioni.;Luke C Pilling.;Lindsay M Reynolds.;Pooja R Mandaviya.;Weihua Guan.;Tao Xu.;Cathy E Elks.;Stella Aslibekyan.;Hortensia Moreno-Macias.;Jennifer A Smith.;Jennifer A Brody.;Radhika Dhingra.;Paul Yousefi.;James S Pankow.;Sonja Kunze.;Sonia H Shah.;Allan F McRae.;Kurt Lohman.;Jin Sha.;Devin M Absher.;Luigi Ferrucci.;Wei Zhao.;Ellen W Demerath.;Jan Bressler.;Megan L Grove.;Tianxiao Huan.;Chunyu Liu.;Michael M Mendelson.;Chen Yao.;Douglas P Kiel.;Annette Peters.;Rui Wang-Sattler.;Peter M Visscher.;Naomi R Wray.;John M Starr.;Jingzhong Ding.;Carlos J Rodriguez.;Nicholas J Wareham.;Marguerite R Irvin.;Degui Zhi.;Myrto Barrdahl.;Paolo Vineis.;Srikant Ambatipudi.;André G Uitterlinden.;Albert Hofman.;Joel Schwartz.;Elena Colicino.;Lifang Hou.;Pantel S Vokonas.;Dena G Hernandez.;Andrew B Singleton.;Stefania Bandinelli.;Stephen T Turner.;Erin B Ware.;Alicia K Smith.;Torsten Klengel.;Elisabeth B Binder.;Bruce M Psaty.;Kent D Taylor.;Sina A Gharib.;Brenton R Swenson.;Liming Liang.;Dawn L DeMeo.;George T O'Connor.;Zdenko Herceg.;Kerry J Ressler.;Karen N Conneely.;Nona Sotoodehnia.;Sharon L R Kardia.;David Melzer.;Andrea A Baccarelli.;Joyce B J van Meurs.;Isabelle Romieu.;Donna K Arnett.;Ken K Ong.;Yongmei Liu.;Melanie Waldenberger.;Ian J Deary.;Myriam Fornage.;Daniel Levy.;Stephanie J London.
来源: Circ Cardiovasc Genet. 2016年9卷5期436-447页
DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers, osteoporosis, lung, and cardiovascular disorders.
231. Impact of Statin Use After Heart Transplantation: A Meta-Analysis.
Although various studies revealed the beneficial effects of statins in post-cardiac transplant patients, these were relatively small and low-powered studies. We performed a meta-analysis of published studies to evaluate the role of statins in post-cardiac transplant patients, specifically examining the effects on hemodynamically significant/fatal graft rejection, coronary vasculopathy, terminal cancer, and overall survival.
232. Distribution of Estimated 10-Year Risk of Recurrent Vascular Events and Residual Risk in a Secondary Prevention Population.
作者: Lotte Kaasenbrood.;S Matthijs Boekholdt.;Yolanda van der Graaf.;Kausik K Ray.;Ron J G Peters.;John J P Kastelein.;Pierre Amarenco.;John C LaRosa.;Maarten J M Cramer.;Jan Westerink.;L Jaap Kappelle.;Gert J de Borst.;Frank L J Visseren.
来源: Circulation. 2016年134卷19期1419-1429页
Among patients with clinically manifest vascular disease, the risk of recurrent vascular events is likely to vary. We assessed the distribution of estimated 10-year risk of recurrent vascular events in a secondary prevention population. We also estimated the potential risk reduction and residual risk that can be achieved if patients reach guideline-recommended risk factor targets.
233. Presence of Late Gadolinium Enhancement by Cardiac Magnetic Resonance Among Patients With Suspected Cardiac Sarcoidosis Is Associated With Adverse Cardiovascular Prognosis: A Systematic Review and Meta-Analysis.
作者: Edward Hulten.;Vikram Agarwal.;Michael Cahill.;Geoff Cole.;Tomas Vita.;Scott Parrish.;Marcio Sommer Bittencourt.;Venkatesh L Murthy.;Raymond Kwong.;Marcelo F Di Carli.;Ron Blankstein.
来源: Circ Cardiovasc Imaging. 2016年9卷9期e005001页
Individuals with cardiac sarcoidosis have an increased risk of ventricular arrhythmia and death. Several small cohort studies have evaluated the ability of late gadolinium enhancement (LGE) by cardiac magnetic resonance imaging (MRI) to predict adverse cardiovascular events. However, studies have yielded inconsistent results, and some analyses were underpowered. Therefore, we sought to systematically review and perform meta-analysis of the prognostic value of cardiac MRI for patients with known or suspected cardiac sarcoidosis.
234. Glycemic Control for Patients With Type 2 Diabetes Mellitus: Our Evolving Faith in the Face of Evidence.
We sought to determine the concordance between the accumulating evidence about the impact of tight versus less tight glycemic control in patients with type 2 diabetes mellitus since the publication of UKPDS (UK Prospective Diabetes Study) in 1998 until 2015 with the views about that evidence published in journal articles and practice guidelines.
235. Echocardiographic Predictors of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study and Cardiovascular Health Study.
作者: Suma H Konety.;Ryan J Koene.;Faye L Norby.;Tony Wilsdon.;Alvaro Alonso.;David Siscovick.;Nona Sotoodehnia.;John Gottdiener.;Ervin R Fox.;Lin Y Chen.;Selcuk Adabag.;Aaron R Folsom.
来源: Circ Cardiovasc Imaging. 2016年9卷8期
This study assessed the echocardiographic predictors of sudden cardiac death (SCD) within 2 population-based cohorts.
236. Mendelian Randomization Studies Do Not Support a Role for Vitamin D in Coronary Artery Disease.
作者: Despoina Manousaki.;Lauren E Mokry.;Stephanie Ross.;David Goltzman.;J Brent Richards.
来源: Circ Cardiovasc Genet. 2016年9卷4期349-56页
Observational studies support a possible association between decreased vitamin D levels and risk of coronary artery disease (CAD); however, it remains unclear whether this relationship is causal. We aimed to evaluate whether genetically lowered vitamin D levels influence the risk of CAD using a Mendelian randomization approach.
237. Whole Grain Intake and Mortality From All Causes, Cardiovascular Disease, and Cancer: A Meta-Analysis of Prospective Cohort Studies.
Current findings on associations between whole grain (WG) intake and mortality are inconsistent and have not been summarized by meta-analysis.
238. Balloon Dilatation and Stenting for Aortic Coarctation: A Systematic Review and Meta-Analysis.
作者: Maximilian Salcher.;Huseyin Naci.;Tyler J Law.;Titus Kuehne.;Stephan Schubert.;Marcus Kelm.; .
来源: Circ Cardiovasc Interv. 2016年9卷6期
There is no systematic assessment of available evidence on effectiveness and comparative effectiveness of balloon dilatation and stenting for aortic coarctation.
239. Stent Polymers: Do They Make a Difference?
The necessity of polymers on drug-eluting stent (DES) platforms is dictated by the need of an adequate amount and optimal release kinetic of the antiproliferative drugs for achieving ideal DES performance. However, the chronic vessel wall inflammation related to permanent polymer persistence after the drug has been eluted might trigger late restenosis and stent thrombosis. Biodegradable polymers have the potential to avoid these adverse events. A variety of biodegradable polymer DES platforms have been clinically tested, showing equal outcomes with the standard-bearer permanent polymer DES within the first year of implantation. At longer-term follow-up, promising lower rates of stent thrombosis have been observed with the early generation biodegradable polymer DES platforms compared to first-generation DES. Whether this safety benefit still persists with newer biodegradable polymer DES generations against second-generation permanent polymer DES needs to be explored.
240. Impact of New-Onset Left Bundle Branch Block and Periprocedural Permanent Pacemaker Implantation on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.
作者: Ander Regueiro.;Omar Abdul-Jawad Altisent.;María Del Trigo.;Francisco Campelo-Parada.;Rishi Puri.;Marina Urena.;François Philippon.;Josep Rodés-Cabau.
来源: Circ Cardiovasc Interv. 2016年9卷5期e003635页
Available data on the clinical impact of new-onset left bundle branch block (LBBB) and permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR) remains controversial. We aimed to evaluate the impact of (1) periprocedural new-onset LBBB or PPI post-TAVR on cardiac mortality and all-cause 1-year mortality and (2) new-onset LBBB on the need for PPI at 1-year follow-up.
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