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221. A Multicenter, Randomized Trial of Ramped Position vs Sniffing Position During Endotracheal Intubation of Critically Ill Adults.
作者: Matthew W Semler.;David R Janz.;Derek W Russell.;Jonathan D Casey.;Robert J Lentz.;Aline N Zouk.;Bennett P deBoisblanc.;Jairo I Santanilla.;Yasin A Khan.;Aaron M Joffe.;William S Stigler.;Todd W Rice.; .; .
来源: Chest. 2017年152卷4期712-722页
Hypoxemia is the most common complication during endotracheal intubation of critically ill adults. Intubation in the ramped position has been hypothesized to prevent hypoxemia by increasing functional residual capacity and decreasing the duration of intubation, but has never been studied outside of the operating room.
222. How Well Does CAPTURE Translate?: An Exploratory Analysis of a COPD Case-Finding Method for Spanish-Speaking Patients.
作者: Wilson A Quezada.;Beth A Whippo.;Patricia A Jellen.;Nancy K Leidy.;David M Mannino.;Katherine J Kim.;MeiLan K Han.;Julia F Houfek.;Barry Make.;Karen G Malley.;Catherine A Meldrum.;Stephen I Rennard.;Barbara P Yawn.;Fernando J Martinez.;Byron M Thomashow.; .
来源: Chest. 2017年152卷4期761-770页
This study tested the properties of a Spanish translation of CAPTURE (COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk) with selective use of peak expiratory flow (PEF).
223. Circulating Biologically Active Adrenomedullin (bio-ADM) Predicts Hemodynamic Support Requirement and Mortality During Sepsis.
作者: Pietro Caironi.;Roberto Latini.;Joachim Struck.;Oliver Hartmann.;Andreas Bergmann.;Giuseppe Maggio.;Marco Cavana.;Gianni Tognoni.;Antonio Pesenti.;Luciano Gattinoni.;Serge Masson.; .
来源: Chest. 2017年152卷2期312-320页
The biological role of adrenomedullin (ADM), a hormone involved in hemodynamic homeostasis, is controversial in sepsis because administration of either the peptide or an antibody against it may be beneficial.
224. IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial.
作者: Khalid Alansari.;Rafah Sayyed.;Bruce L Davidson.;Shahaza Al Jawala.;Mohamed Ghadier.
来源: Chest. 2017年152卷1期113-119页
The goal of this study was to determine if IV magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in patients with bronchiolitis when added to supportive care.
225. Sirolimus and Autophagy Inhibition in Lymphangioleiomyomatosis: Results of a Phase I Clinical Trial.
作者: Souheil El-Chemaly.;Angelo Taveira-Dasilva.;Hilary J Goldberg.;Elizabeth Peters.;Mary Haughey.;Don Bienfang.;Amanda M Jones.;Patricia Julien-Williams.;Ye Cui.;Julian A Villalba.;Shefali Bagwe.;Rie Maurer.;Ivan O Rosas.;Joel Moss.;Elizabeth P Henske.
来源: Chest. 2017年151卷6期1302-1310页
Animal and cellular studies support the importance of autophagy inhibition in lymphangioleiomyomatosis (LAM). In a cohort of subjects with LAM, we tested the hypothesis that treatment with sirolimus and hydroxychloroquine (an autophagy inhibitor) at two different dose levels is safe and well tolerated. Secondary end points included changes in lung function.
226. A Randomized Clinical Trial Comparing the Effects of Antitussive Agents on Respiratory Center Output in Patients With Chronic Cough.
作者: Claudia Mannini.;Federico Lavorini.;Alessandro Zanasi.;Federico Saibene.;Luigi Lanata.;Giovanni Fontana.
来源: Chest. 2017年151卷6期1288-1294页
Cough is produced by the same neuronal pool implicated in respiratory rhythm generation, and antitussive drugs acting at the central level, such as opioids, may depress ventilation. Levodropropizine is classified as a nonopioid peripherally acting antitussive drug that acts at the level of airway sensory nerves. However, the lack of a central action by levodropropizine remains to be fully established. We set out to compare the effects of levodropropizine and the opioid antitussive agent dihydrocodeine on the respiratory responses to a conventional CO2 rebreathing test in patients with chronic cough of any origin.
227. Endothelial Permeability and Hemostasis in Septic Shock: Results From the ProCESS Trial.
作者: Peter C Hou.;Michael R Filbin.;Henry Wang.;Long Ngo.;David T Huang.;William C Aird.;Donald M Yealy.;Derek C Angus.;John A Kellum.;Nathan I Shapiro.; .
来源: Chest. 2017年152卷1期22-31页
We studied patients from the Protocolized Care in Early Septic Shock (ProCESS) trial to determine the effects of alternative resuscitation strategies on circulating markers of endothelial cell permeability and hemostasis and the association between biomarkers and mortality.
228. The Long-term Effect of Bacille Calmette-Guérin Vaccination on Tuberculin Skin Testing: A 55-Year Follow-Up Study.
作者: James D Mancuso.;Rupal M Mody.;Cara H Olsen.;Lee H Harrison.;Mathuram Santosham.;Naomi E Aronson.
来源: Chest. 2017年152卷2期282-294页
Bacille Calmette-Guérin (BCG) vaccination is known to cause false-positive tuberculin skin test (TST) results from cross-reactions with mycobacterial antigens. However, the duration of BCG vaccination influence on the TST is poorly characterized. The objective of this study was to assess the long-term effect of BCG vaccination on TST reactivity.
229. Improved Cough and Cough-Specific Quality of Life in Patients Treated for Scleroderma-Related Interstitial Lung Disease: Results of Scleroderma Lung Study II.
作者: Donald P Tashkin.;Elizabeth R Volkmann.;Chi-Hong Tseng.;Michael D Roth.;Dinesh Khanna.;Daniel E Furst.;Philip J Clements.;Arthur Theodore.;Suzanne Kafaja.;Grace Hyun Kim.;Jonathan Goldin.;Edgar Ariolla.;Robert M Elashoff.
来源: Chest. 2017年151卷4期813-820页
Cough is a common symptom of scleroderma-related interstitial lung disease (SSc-ILD), but its relationship to other characteristics of SSc-ILD, impact on cough-specific quality of life (QoL), and response to therapy for SSc-ILD have not been well studied.
230. Postoperative Oxygen Therapy in Patients With OSA: A Randomized Controlled Trial.
作者: Pu Liao.;Jean Wong.;Mandeep Singh.;David T Wong.;Sazzadul Islam.;Maged Andrawes.;Colin M Shapiro.;David P White.;Frances Chung.
来源: Chest. 2017年151卷3期597-611页
Surgical patients with OSA are at increased risk for perioperative complications. Postoperative supplemental oxygen is commonly used, but it may contribute to respiratory depression in patients with OSA receiving opioids. The objective of the study is to investigate the effect of postoperative supplemental oxygen on arterial oxygen saturation (Sao2), sleep respiratory events, and CO2 level in patients with untreated OSA.
231. Short-term Effects of Supplemental Oxygen on 6-Min Walk Test Outcomes in Patients With COPD: A Randomized, Placebo-Controlled, Single-blind, Crossover Trial.
作者: Inga Jarosch.;Rainer Gloeckl.;Eva Damm.;Anna-Lena Schwedhelm.;David Buhrow.;Andreas Jerrentrup.;Martijn A Spruit.;Klaus Kenn.
来源: Chest. 2017年151卷4期795-803页
The acute effect of supplemental oxygen during exercise has been shown to differ largely among patients with COPD. It is unknown what factors influence oxygen response.
232. Efficacy and Safety of Glycopyrrolate/Formoterol Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Patients With COPD.
作者: Fernando J Martinez.;Klaus F Rabe.;Gary T Ferguson.;Leonardo M Fabbri.;Stephen Rennard.;Gregory J Feldman.;Sanjay Sethi.;Selwyn Spangenthal.;Gregory M Gottschlich.;Roberto Rodriguez-Roisin.;Samir Arora.;Thomas M Siler.;Shahid Siddiqui.;Patrick Darken.;Tracy Fischer.;Andrea Maes.;Michael Golden.;Chad Orevillo.;Colin Reisner.
来源: Chest. 2017年151卷2期340-357页
Long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) combinations are a treatment option for patients with COPD who continue to have symptoms despite treatment with a LAMA or a LABA alone. The Efficacy and Safety of PT003, PT005, and PT001 in Subjects with Moderate-to-Very Severe COPD (PINNACLE-1) (NCT01854645) and the Multi-Center Study to Assess the Efficacy and Safety of PT003, PT005, and PT001 in Subjects with Moderate-to-Very Severe COPD (PINNACLE-2) (NCT01854658) trials investigated the efficacy and safety of a novel glycopyrrolate [GP]/formoterol [FF] 18/9.6-μg (GFF) metered dose inhaler (MDI) formulated using the Co-Suspension Delivery Technology in patients with moderate-to-very severe COPD.
233. A Randomized Trial of the Amikacin Fosfomycin Inhalation System for the Adjunctive Therapy of Gram-Negative Ventilator-Associated Pneumonia: IASIS Trial.
作者: Marin H Kollef.;Jean-Damien Ricard.;Damien Roux.;Bruno Francois.;Eleni Ischaki.;Zsolt Rozgonyi.;Thierry Boulain.;Zsolt Ivanyi.;Gál János.;Denis Garot.;Firas Koura.;Epaminondas Zakynthinos.;George Dimopoulos.;Antonio Torres.;Wayne Danker.;A Bruce Montgomery.
来源: Chest. 2017年151卷6期1239-1246页
Clinical failures in ventilator-associated pneumonia (VAP) caused by gram-negative bacteria are common and associated with substantial morbidity, mortality, and resource utilization.
234. Allogeneic Human Mesenchymal Stem Cells in Patients With Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER): A Phase I Safety Clinical Trial.
作者: Marilyn K Glassberg.;Julia Minkiewicz.;Rebecca L Toonkel.;Emmanuelle S Simonet.;Gustavo A Rubio.;Darcy DiFede.;Shirin Shafazand.;Aisha Khan.;Marietsy V Pujol.;Vincent F LaRussa.;Lisa H Lancaster.;Glenn D Rosen.;Joel Fishman.;Yolanda N Mageto.;Adam Mendizabal.;Joshua M Hare.
来源: Chest. 2017年151卷5期971-981页
Despite Food and Drug Administration approval of 2 new drugs for idiopathic pulmonary fibrosis (IPF), curative therapies remain elusive and mortality remains high. Preclinical and clinical data support the safety of human mesenchymal stem cells as a potential novel therapy for this fatal condition. The Allogeneic Human Cells (hMSC) in patients with Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER) trial was the first study designed to evaluate the safety of a single infusion of bone marrow-derived mesenchymal stem cells in patients with idiopathic pulmonary fibrosis.
235. Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers.
作者: Lucy Yang.;Joseph Cheriyan.;David D Gutterman.;Ruth J Mayer.;Zsuzsanna Ament.;Jules L Griffin.;Aili L Lazaar.;David E Newby.;Ruth Tal-Singer.;Ian B Wilkinson.
来源: Chest. 2017年151卷3期555-563页
Smoking and COPD are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium-derived epoxyeicosatrienoic acid (EET)-mediated endothelial function is impaired in patients with COPD and that a novel soluble epoxide hydrolase inhibitor, GSK2256294, attenuates EET-mediated endothelial dysfunction in human resistance vessels both in vitro and in vivo.
236. Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: An Open-label Randomized, Controlled, Phase IIb/III Trial.
作者: Ivan F N Hung.;Kelvin K W To.;Jasper F W Chan.;Vincent C C Cheng.;Kevin S H Liu.;Anthony Tam.;Tuen-Ching Chan.;Anna Jinxia Zhang.;Patrick Li.;Tin-Lun Wong.;Ricky Zhang.;Michael K S Cheung.;William Leung.;Johnson Y N Lau.;Manson Fok.;Honglin Chen.;Kwok-Hung Chan.;Kwok-Yung Yuen.
来源: Chest. 2017年151卷5期1069-1080页
Influenza causes excessive hospitalizations and deaths. The study assessed the efficacy and safety of a clarithromycin-naproxen-oseltamivir combination for treatment of serious influenza.
237. Stylet Use Does Not Improve Diagnostic Outcomes in Endobronchial Ultrasonographic Transbronchial Needle Aspiration: A Randomized Clinical Trial.
作者: Eric L Scholten.;Roy Semaan.;Peter Illei.;Christopher Mallow.;Sixto Arias.;David Feller-Kopman.;Karen Oakjones-Burgess.;Bernice Frimpong.;Ricardo O Amador.;Hans Lee.;Lonny Yarmus.
来源: Chest. 2017年151卷3期636-642页
Endobronchial ultrasonographically guided transbronchial needle aspiration (EBUS-TBNA) of thoracic structures is a commonly performed tissue sampling technique. The use of an inner-stylet in the EBUS needle has never been rigorously evaluated and may be unnecessary.
238. Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III.
作者: Faith S Luyster.;Patrick J Strollo.;Fernando Holguin.;Mario Castro.;Eleanor M Dunican.;John Fahy.;Benjamin Gaston.;Elliot Israel.;Nizar N Jarjour.;David T Mauger.;Wendy C Moore.;Sally E Wenzel.
来源: Chest. 2016年150卷6期1242-1250页
Sleep difficulties are commonly reported by patients with asthma; however, the prevalence of insomnia and its association with disease burden and well-being is unknown. We aimed to determine the prevalence of insomnia, defined as combined sleep-specific complaints with associated daytime symptoms, among a large sample of adults with asthma, and to compare well-being, asthma control, and asthma-related health care utilization in individuals with asthma and insomnia and those without insomnia.
239. Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial.
作者: Sanjay Mehta.;Bhagavatula Kutumba Srinivasa Sastry.;Rogério Souza.;Adam Torbicki.;Hossein-Ardeschir Ghofrani.;Richard N Channick.;Marion Delcroix.;Tomás Pulido.;Gérald Simonneau.;John Wlodarczyk.;Lewis J Rubin.;Pavel Jansa.;Elke Hunsche.;Nazzareno Galiè.;Loïc Perchenet.;Olivier Sitbon.
来源: Chest. 2017年151卷1期106-118页
Pulmonary arterial hypertension (PAH) leads to reduced health-related quality of life (HRQoL). The objectives of this analysis were to evaluate the effect of macitentan on HRQoL in patients with PAH in the Study with an Endothelin Receptor Antagonist in Pulmonary Arterial Hypertension to Improve Clinical Outcome (SERAPHIN) study. The association between baseline HRQoL and long-term outcomes was also investigated.
240. Cardiac Sarcoidosis: The Impact of Age and Implanted Devices on Survival.
作者: Ying Zhou.;Elyse E Lower.;Hui-Ping Li.;Alexandru Costea.;Mehran Attari.;Robert P Baughman.
来源: Chest. 2017年151卷1期139-148页
To assess the clinical characteristics, diagnosis, and outcome of cardiac sarcoidosis in a single institution sarcoidosis clinic.
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