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221. Methacholine Challenge Testing: A Novel Method for Measuring PD20.
作者: Beth E Davis.;Samuel K Simonson.;Christianne M Blais.;Donald W Cockcroft.
来源: Chest. 2017年152卷6期1251-1257页
New guidelines for methacholine challenge testing recommend reporting the test outcome as dose rather than concentration. Jet nebulizers have historically been used for methacholine challenge testing, but much of the weight loss, often (incorrectly) referred to as aerosol output, is actually evaporation. The Wright nebulizer is well characterized and still widely used, but its availability is unclear, and it is nondisposable. We developed a novel method using a vibrating mesh nebulizer (Solo). This method was compared with the standard 2-min tidal breathing method using the Wright nebulizer. Repeatability within and between nebulizers was also tested.
222. A Multicenter Randomized Trial of a Checklist for Endotracheal Intubation of Critically Ill Adults.
作者: David R Janz.;Matthew W Semler.;Aaron M Joffe.;Jonathan D Casey.;Robert J Lentz.;Bennett P deBoisblanc.;Yasin A Khan.;Jairo I Santanilla.;Itay Bentov.;Todd W Rice.; .; .
来源: Chest. 2018年153卷4期816-824页
Hypoxemia and hypotension are common complications during endotracheal intubation of critically ill adults. Verbal performance of a written, preintubation checklist may prevent these complications. We compared a written, verbally performed, preintubation checklist with usual care regarding lowest arterial oxygen saturation or lowest systolic BP experienced by critically ill adults undergoing endotracheal intubation.
223. Clinical Impact of Asymptomatic Presentation Status in Patients With Paroxysmal and Sustained Atrial Fibrillation: The Fushimi AF Registry.
作者: Masahiro Esato.;Yeong-Hwa Chun.;Yoshimori An.;Hisashi Ogawa.;Hiromichi Wada.;Koji Hasegawa.;Hikari Tsuji.;Mitsuru Abe.;Gregory Y H Lip.;Masaharu Akao.
来源: Chest. 2017年152卷6期1266-1275页
The clinical characteristics and outcomes of asymptomatic patients with paroxysmal or persistent/permanent atrial fibrillation (AF) are largely unknown.
224. Baseline Symptom Score Impact on Benefits of Glycopyrrolate/Formoterol Metered Dose Inhaler in COPD.
作者: Fernando J Martinez.;Leonardo M Fabbri.;Gary T Ferguson.;Chad Orevillo.;Patrick Darken.;Ubaldo J Martin.;Colin Reisner.
来源: Chest. 2017年152卷6期1169-1178页
The clinical severity of COPD is currently categorized by symptom burden and exacerbation risk. Previous 24-week phase III trials (NCT01854645 and NCT01854658) that demonstrated better improvement of lung function with glycopyrrolate/formoterol fumarate (GFF) metered dose inhaler (MDI) (an MDI fixed-dose of GFF 18/9.6 μg) over individual monocomponent MDIs included a cross-section of patients with moderate to very severe airflow limitation and a broad range of COPD symptoms.
225. Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations.
作者: Khalid Alansari.;Bruce L Davidson.;Khalid Ibrahim Yousef.;Abdel Nasser H Mohamed.;Imad Alattar.
来源: Chest. 2017年152卷3期527-536页
Whether vitamin D reduces clinically important exacerbations of childhood asthma remains uncertain. We compared rapid to maintenance vitamin D repletion analyzed by baseline vitamin D level.
226. Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker.
作者: Elliott D Crouser.;Joseph E Parrillo.;Christopher Seymour.;Derek C Angus.;Keri Bicking.;Liliana Tejidor.;Robert Magari.;Diana Careaga.;JoAnna Williams.;Douglas R Closser.;Michael Samoszuk.;Luke Herren.;Emily Robart.;Fernando Chaves.
来源: Chest. 2017年152卷3期518-526页
Sepsis most often presents to the ED, and delayed detection is harmful. WBC count is often used to detect sepsis, but changes in WBC count size also correspond to sepsis. We sought to determine if volume increases of circulating immune cells add value to the WBC count for early sepsis detection in the ED.
227. Totally Implantable IV Treprostinil Therapy in Pulmonary Hypertension Assessment of the Implantation Procedure.
作者: Aaron B Waxman.;Hugh T McElderry.;Mardi Gomberg-Maitland.;Martin C Burke.;Edgar L Ross.;Malcolm M Bersohn.;Sanjog S Pangarkar.;James H Tarver.;Diane L Zwicke.;Jeremy P Feldman.;Murali M Chakinala.;Robert P Frantz.;Geoffrey B Thompson.;Fernando Torres.;Richard L Rauck.;Kathy Clagg.;Louise Durst.;Pei Li.;Marty Morris.;Kara L Southall.;Leigh Peterson.;Robert C Bourge.
来源: Chest. 2017年152卷6期1128-1134页
Prostacyclins improve symptoms and survival in pulmonary arterial hypertension (PAH). In response to risks associated with external delivery systems, an implantable IV infusion system was developed. A multicenter, prospective, single-arm, clinical trial (DelIVery for PAH) was conducted to evaluate this system for treprostinil in PAH. This analysis describes the findings related to the implant procedure.
228. A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa: A Proof of Concept Study.
作者: Pallavi Bedi.;James D Chalmers.;Catriona Graham.;Andrea Clarke.;Samantha Donaldson.;Catherine Doherty.;John R W Govan.;Donald J Davidson.;Adriano G Rossi.;Adam T Hill.
来源: Chest. 2017年152卷2期368-378页
There are no randomized controlled trials of statin therapy in patients with severe bronchiectasis who are chronically infected with Pseudomonas aeruginosa.
229. Effects of Pulmonary Rehabilitation on Exacerbation Number and Severity in People With COPD: An Historical Cohort Study Using Electronic Health Records.
作者: Elizabeth Moore.;Roger Newson.;Miland Joshi.;Thomas Palmer.;Kieran J Rothnie.;Sally Singh.;Azeem Majeed.;Michael Soljak.;Jennifer K Quint.
来源: Chest. 2017年152卷6期1188-1202页
In previous systematic reviews (predominantly of randomized controlled trials), pulmonary rehabilitation (PR) has been shown to reduce hospital admissions for acute exacerbations of COPD (AECOPD). However, findings have been less consistent for cohort studies. The goal of this study was to compare rates of hospitalized and general practice (GP)-treated AECOPD prior to and following PR.
230. A Multicenter, Randomized Trial of Ramped Position vs Sniffing Position During Endotracheal Intubation of Critically Ill Adults.
作者: Matthew W Semler.;David R Janz.;Derek W Russell.;Jonathan D Casey.;Robert J Lentz.;Aline N Zouk.;Bennett P deBoisblanc.;Jairo I Santanilla.;Yasin A Khan.;Aaron M Joffe.;William S Stigler.;Todd W Rice.; .; .
来源: Chest. 2017年152卷4期712-722页
Hypoxemia is the most common complication during endotracheal intubation of critically ill adults. Intubation in the ramped position has been hypothesized to prevent hypoxemia by increasing functional residual capacity and decreasing the duration of intubation, but has never been studied outside of the operating room.
231. How Well Does CAPTURE Translate?: An Exploratory Analysis of a COPD Case-Finding Method for Spanish-Speaking Patients.
作者: Wilson A Quezada.;Beth A Whippo.;Patricia A Jellen.;Nancy K Leidy.;David M Mannino.;Katherine J Kim.;MeiLan K Han.;Julia F Houfek.;Barry Make.;Karen G Malley.;Catherine A Meldrum.;Stephen I Rennard.;Barbara P Yawn.;Fernando J Martinez.;Byron M Thomashow.; .
来源: Chest. 2017年152卷4期761-770页
This study tested the properties of a Spanish translation of CAPTURE (COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk) with selective use of peak expiratory flow (PEF).
232. Circulating Biologically Active Adrenomedullin (bio-ADM) Predicts Hemodynamic Support Requirement and Mortality During Sepsis.
作者: Pietro Caironi.;Roberto Latini.;Joachim Struck.;Oliver Hartmann.;Andreas Bergmann.;Giuseppe Maggio.;Marco Cavana.;Gianni Tognoni.;Antonio Pesenti.;Luciano Gattinoni.;Serge Masson.; .
来源: Chest. 2017年152卷2期312-320页
The biological role of adrenomedullin (ADM), a hormone involved in hemodynamic homeostasis, is controversial in sepsis because administration of either the peptide or an antibody against it may be beneficial.
233. IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial.
作者: Khalid Alansari.;Rafah Sayyed.;Bruce L Davidson.;Shahaza Al Jawala.;Mohamed Ghadier.
来源: Chest. 2017年152卷1期113-119页
The goal of this study was to determine if IV magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in patients with bronchiolitis when added to supportive care.
234. Sirolimus and Autophagy Inhibition in Lymphangioleiomyomatosis: Results of a Phase I Clinical Trial.
作者: Souheil El-Chemaly.;Angelo Taveira-Dasilva.;Hilary J Goldberg.;Elizabeth Peters.;Mary Haughey.;Don Bienfang.;Amanda M Jones.;Patricia Julien-Williams.;Ye Cui.;Julian A Villalba.;Shefali Bagwe.;Rie Maurer.;Ivan O Rosas.;Joel Moss.;Elizabeth P Henske.
来源: Chest. 2017年151卷6期1302-1310页
Animal and cellular studies support the importance of autophagy inhibition in lymphangioleiomyomatosis (LAM). In a cohort of subjects with LAM, we tested the hypothesis that treatment with sirolimus and hydroxychloroquine (an autophagy inhibitor) at two different dose levels is safe and well tolerated. Secondary end points included changes in lung function.
235. A Randomized Clinical Trial Comparing the Effects of Antitussive Agents on Respiratory Center Output in Patients With Chronic Cough.
作者: Claudia Mannini.;Federico Lavorini.;Alessandro Zanasi.;Federico Saibene.;Luigi Lanata.;Giovanni Fontana.
来源: Chest. 2017年151卷6期1288-1294页
Cough is produced by the same neuronal pool implicated in respiratory rhythm generation, and antitussive drugs acting at the central level, such as opioids, may depress ventilation. Levodropropizine is classified as a nonopioid peripherally acting antitussive drug that acts at the level of airway sensory nerves. However, the lack of a central action by levodropropizine remains to be fully established. We set out to compare the effects of levodropropizine and the opioid antitussive agent dihydrocodeine on the respiratory responses to a conventional CO2 rebreathing test in patients with chronic cough of any origin.
236. Endothelial Permeability and Hemostasis in Septic Shock: Results From the ProCESS Trial.
作者: Peter C Hou.;Michael R Filbin.;Henry Wang.;Long Ngo.;David T Huang.;William C Aird.;Donald M Yealy.;Derek C Angus.;John A Kellum.;Nathan I Shapiro.; .
来源: Chest. 2017年152卷1期22-31页
We studied patients from the Protocolized Care in Early Septic Shock (ProCESS) trial to determine the effects of alternative resuscitation strategies on circulating markers of endothelial cell permeability and hemostasis and the association between biomarkers and mortality.
237. The Long-term Effect of Bacille Calmette-Guérin Vaccination on Tuberculin Skin Testing: A 55-Year Follow-Up Study.
作者: James D Mancuso.;Rupal M Mody.;Cara H Olsen.;Lee H Harrison.;Mathuram Santosham.;Naomi E Aronson.
来源: Chest. 2017年152卷2期282-294页
Bacille Calmette-Guérin (BCG) vaccination is known to cause false-positive tuberculin skin test (TST) results from cross-reactions with mycobacterial antigens. However, the duration of BCG vaccination influence on the TST is poorly characterized. The objective of this study was to assess the long-term effect of BCG vaccination on TST reactivity.
238. Improved Cough and Cough-Specific Quality of Life in Patients Treated for Scleroderma-Related Interstitial Lung Disease: Results of Scleroderma Lung Study II.
作者: Donald P Tashkin.;Elizabeth R Volkmann.;Chi-Hong Tseng.;Michael D Roth.;Dinesh Khanna.;Daniel E Furst.;Philip J Clements.;Arthur Theodore.;Suzanne Kafaja.;Grace Hyun Kim.;Jonathan Goldin.;Edgar Ariolla.;Robert M Elashoff.
来源: Chest. 2017年151卷4期813-820页
Cough is a common symptom of scleroderma-related interstitial lung disease (SSc-ILD), but its relationship to other characteristics of SSc-ILD, impact on cough-specific quality of life (QoL), and response to therapy for SSc-ILD have not been well studied.
239. Postoperative Oxygen Therapy in Patients With OSA: A Randomized Controlled Trial.
作者: Pu Liao.;Jean Wong.;Mandeep Singh.;David T Wong.;Sazzadul Islam.;Maged Andrawes.;Colin M Shapiro.;David P White.;Frances Chung.
来源: Chest. 2017年151卷3期597-611页
Surgical patients with OSA are at increased risk for perioperative complications. Postoperative supplemental oxygen is commonly used, but it may contribute to respiratory depression in patients with OSA receiving opioids. The objective of the study is to investigate the effect of postoperative supplemental oxygen on arterial oxygen saturation (Sao2), sleep respiratory events, and CO2 level in patients with untreated OSA.
240. Short-term Effects of Supplemental Oxygen on 6-Min Walk Test Outcomes in Patients With COPD: A Randomized, Placebo-Controlled, Single-blind, Crossover Trial.
作者: Inga Jarosch.;Rainer Gloeckl.;Eva Damm.;Anna-Lena Schwedhelm.;David Buhrow.;Andreas Jerrentrup.;Martijn A Spruit.;Klaus Kenn.
来源: Chest. 2017年151卷4期795-803页
The acute effect of supplemental oxygen during exercise has been shown to differ largely among patients with COPD. It is unknown what factors influence oxygen response.
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