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221. Impact of a Non-small Cell Lung Cancer Educational Program for Interdisciplinary Teams.
作者: Septimiu Murgu.;Robb Rabito.;Greg Lasko.;Chad Jackson.;Mari Mino-Kenudson.;David S Ettinger.;Suresh S Ramalingam.;Eric S Edell.; .
来源: Chest. 2018年153卷4期876-887页
Successful implementation of non-small cell lung cancer (NSCLC) evidence-based guideline recommendations requires effective educational programs that target all clinicians from interdisciplinary teams. This study describes and evaluates the Engaging an Interdisciplinary Team for NSCLC (GAIN 3.0) experiential learning-based educational curriculum.
222. Efficacy of Acupuncture Is Noninferior to Nicotine Replacement Therapy for Tobacco Cessation: Results of a Prospective, Randomized, Active-Controlled Open-Label Trial.
作者: Ying-Ying Wang.;Zhao Liu.;Yuan Wu.;Li Yang.;Lang-Tao Guo.;Hao-Bin Zhang.;Jin-Sheng Yang.; .
来源: Chest. 2018年153卷3期680-688页
We designed and conducted this multicenter randomized active-controlled open-label trial to evaluate the efficacy of acupuncture, auricular point pressing, and nicotine replacement therapy (NRT) on tobacco cessation in the Chinese population.
223. Patient Engagement Using New Technology to Improve Adherence to Positive Airway Pressure Therapy: A Retrospective Analysis.
作者: Atul Malhotra.;Maureen E Crocker.;Leslee Willes.;Colleen Kelly.;Sue Lynch.;Adam V Benjafield.
来源: Chest. 2018年153卷4期843-850页
Sleep apnea has major neurocognitive and cardiovascular and metabolic risks. Treatment of sleep apnea is suboptimal because of variable adherence to existing therapies.
224. A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis.
作者: Ivan O Rosas.;Hilary J Goldberg.;Harold R Collard.;Souheil El-Chemaly.;Kevin Flaherty.;Gary M Hunninghake.;Joseph A Lasky.;David J Lederer.;Roberto Machado.;Fernando J Martinez.;Rie Maurer.;Danielle Teller.;Imre Noth.;Elizabeth Peters.;Ganesh Raghu.;Joe G N Garcia.;Augustine M K Choi.
来源: Chest. 2018年153卷1期94-104页
Preclinical studies have demonstrated that low-dose carbon monoxide (CO) can abrogate experimental lung fibrosis. To test the therapeutic role of inhaled CO, we designed a clinical study in patients with idiopathic pulmonary fibrosis (IPF).
225. Methacholine Challenge Testing: A Novel Method for Measuring PD20.
作者: Beth E Davis.;Samuel K Simonson.;Christianne M Blais.;Donald W Cockcroft.
来源: Chest. 2017年152卷6期1251-1257页
New guidelines for methacholine challenge testing recommend reporting the test outcome as dose rather than concentration. Jet nebulizers have historically been used for methacholine challenge testing, but much of the weight loss, often (incorrectly) referred to as aerosol output, is actually evaporation. The Wright nebulizer is well characterized and still widely used, but its availability is unclear, and it is nondisposable. We developed a novel method using a vibrating mesh nebulizer (Solo). This method was compared with the standard 2-min tidal breathing method using the Wright nebulizer. Repeatability within and between nebulizers was also tested.
226. A Multicenter Randomized Trial of a Checklist for Endotracheal Intubation of Critically Ill Adults.
作者: David R Janz.;Matthew W Semler.;Aaron M Joffe.;Jonathan D Casey.;Robert J Lentz.;Bennett P deBoisblanc.;Yasin A Khan.;Jairo I Santanilla.;Itay Bentov.;Todd W Rice.; .; .
来源: Chest. 2018年153卷4期816-824页
Hypoxemia and hypotension are common complications during endotracheal intubation of critically ill adults. Verbal performance of a written, preintubation checklist may prevent these complications. We compared a written, verbally performed, preintubation checklist with usual care regarding lowest arterial oxygen saturation or lowest systolic BP experienced by critically ill adults undergoing endotracheal intubation.
227. Clinical Impact of Asymptomatic Presentation Status in Patients With Paroxysmal and Sustained Atrial Fibrillation: The Fushimi AF Registry.
作者: Masahiro Esato.;Yeong-Hwa Chun.;Yoshimori An.;Hisashi Ogawa.;Hiromichi Wada.;Koji Hasegawa.;Hikari Tsuji.;Mitsuru Abe.;Gregory Y H Lip.;Masaharu Akao.
来源: Chest. 2017年152卷6期1266-1275页
The clinical characteristics and outcomes of asymptomatic patients with paroxysmal or persistent/permanent atrial fibrillation (AF) are largely unknown.
228. Baseline Symptom Score Impact on Benefits of Glycopyrrolate/Formoterol Metered Dose Inhaler in COPD.
作者: Fernando J Martinez.;Leonardo M Fabbri.;Gary T Ferguson.;Chad Orevillo.;Patrick Darken.;Ubaldo J Martin.;Colin Reisner.
来源: Chest. 2017年152卷6期1169-1178页
The clinical severity of COPD is currently categorized by symptom burden and exacerbation risk. Previous 24-week phase III trials (NCT01854645 and NCT01854658) that demonstrated better improvement of lung function with glycopyrrolate/formoterol fumarate (GFF) metered dose inhaler (MDI) (an MDI fixed-dose of GFF 18/9.6 μg) over individual monocomponent MDIs included a cross-section of patients with moderate to very severe airflow limitation and a broad range of COPD symptoms.
229. Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations.
作者: Khalid Alansari.;Bruce L Davidson.;Khalid Ibrahim Yousef.;Abdel Nasser H Mohamed.;Imad Alattar.
来源: Chest. 2017年152卷3期527-536页
Whether vitamin D reduces clinically important exacerbations of childhood asthma remains uncertain. We compared rapid to maintenance vitamin D repletion analyzed by baseline vitamin D level.
230. Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker.
作者: Elliott D Crouser.;Joseph E Parrillo.;Christopher Seymour.;Derek C Angus.;Keri Bicking.;Liliana Tejidor.;Robert Magari.;Diana Careaga.;JoAnna Williams.;Douglas R Closser.;Michael Samoszuk.;Luke Herren.;Emily Robart.;Fernando Chaves.
来源: Chest. 2017年152卷3期518-526页
Sepsis most often presents to the ED, and delayed detection is harmful. WBC count is often used to detect sepsis, but changes in WBC count size also correspond to sepsis. We sought to determine if volume increases of circulating immune cells add value to the WBC count for early sepsis detection in the ED.
231. Totally Implantable IV Treprostinil Therapy in Pulmonary Hypertension Assessment of the Implantation Procedure.
作者: Aaron B Waxman.;Hugh T McElderry.;Mardi Gomberg-Maitland.;Martin C Burke.;Edgar L Ross.;Malcolm M Bersohn.;Sanjog S Pangarkar.;James H Tarver.;Diane L Zwicke.;Jeremy P Feldman.;Murali M Chakinala.;Robert P Frantz.;Geoffrey B Thompson.;Fernando Torres.;Richard L Rauck.;Kathy Clagg.;Louise Durst.;Pei Li.;Marty Morris.;Kara L Southall.;Leigh Peterson.;Robert C Bourge.
来源: Chest. 2017年152卷6期1128-1134页
Prostacyclins improve symptoms and survival in pulmonary arterial hypertension (PAH). In response to risks associated with external delivery systems, an implantable IV infusion system was developed. A multicenter, prospective, single-arm, clinical trial (DelIVery for PAH) was conducted to evaluate this system for treprostinil in PAH. This analysis describes the findings related to the implant procedure.
232. A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa: A Proof of Concept Study.
作者: Pallavi Bedi.;James D Chalmers.;Catriona Graham.;Andrea Clarke.;Samantha Donaldson.;Catherine Doherty.;John R W Govan.;Donald J Davidson.;Adriano G Rossi.;Adam T Hill.
来源: Chest. 2017年152卷2期368-378页
There are no randomized controlled trials of statin therapy in patients with severe bronchiectasis who are chronically infected with Pseudomonas aeruginosa.
233. Effects of Pulmonary Rehabilitation on Exacerbation Number and Severity in People With COPD: An Historical Cohort Study Using Electronic Health Records.
作者: Elizabeth Moore.;Roger Newson.;Miland Joshi.;Thomas Palmer.;Kieran J Rothnie.;Sally Singh.;Azeem Majeed.;Michael Soljak.;Jennifer K Quint.
来源: Chest. 2017年152卷6期1188-1202页
In previous systematic reviews (predominantly of randomized controlled trials), pulmonary rehabilitation (PR) has been shown to reduce hospital admissions for acute exacerbations of COPD (AECOPD). However, findings have been less consistent for cohort studies. The goal of this study was to compare rates of hospitalized and general practice (GP)-treated AECOPD prior to and following PR.
234. A Multicenter, Randomized Trial of Ramped Position vs Sniffing Position During Endotracheal Intubation of Critically Ill Adults.
作者: Matthew W Semler.;David R Janz.;Derek W Russell.;Jonathan D Casey.;Robert J Lentz.;Aline N Zouk.;Bennett P deBoisblanc.;Jairo I Santanilla.;Yasin A Khan.;Aaron M Joffe.;William S Stigler.;Todd W Rice.; .; .
来源: Chest. 2017年152卷4期712-722页
Hypoxemia is the most common complication during endotracheal intubation of critically ill adults. Intubation in the ramped position has been hypothesized to prevent hypoxemia by increasing functional residual capacity and decreasing the duration of intubation, but has never been studied outside of the operating room.
235. How Well Does CAPTURE Translate?: An Exploratory Analysis of a COPD Case-Finding Method for Spanish-Speaking Patients.
作者: Wilson A Quezada.;Beth A Whippo.;Patricia A Jellen.;Nancy K Leidy.;David M Mannino.;Katherine J Kim.;MeiLan K Han.;Julia F Houfek.;Barry Make.;Karen G Malley.;Catherine A Meldrum.;Stephen I Rennard.;Barbara P Yawn.;Fernando J Martinez.;Byron M Thomashow.; .
来源: Chest. 2017年152卷4期761-770页
This study tested the properties of a Spanish translation of CAPTURE (COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk) with selective use of peak expiratory flow (PEF).
236. Circulating Biologically Active Adrenomedullin (bio-ADM) Predicts Hemodynamic Support Requirement and Mortality During Sepsis.
作者: Pietro Caironi.;Roberto Latini.;Joachim Struck.;Oliver Hartmann.;Andreas Bergmann.;Giuseppe Maggio.;Marco Cavana.;Gianni Tognoni.;Antonio Pesenti.;Luciano Gattinoni.;Serge Masson.; .
来源: Chest. 2017年152卷2期312-320页
The biological role of adrenomedullin (ADM), a hormone involved in hemodynamic homeostasis, is controversial in sepsis because administration of either the peptide or an antibody against it may be beneficial.
237. IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial.
作者: Khalid Alansari.;Rafah Sayyed.;Bruce L Davidson.;Shahaza Al Jawala.;Mohamed Ghadier.
来源: Chest. 2017年152卷1期113-119页
The goal of this study was to determine if IV magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in patients with bronchiolitis when added to supportive care.
238. Sirolimus and Autophagy Inhibition in Lymphangioleiomyomatosis: Results of a Phase I Clinical Trial.
作者: Souheil El-Chemaly.;Angelo Taveira-Dasilva.;Hilary J Goldberg.;Elizabeth Peters.;Mary Haughey.;Don Bienfang.;Amanda M Jones.;Patricia Julien-Williams.;Ye Cui.;Julian A Villalba.;Shefali Bagwe.;Rie Maurer.;Ivan O Rosas.;Joel Moss.;Elizabeth P Henske.
来源: Chest. 2017年151卷6期1302-1310页
Animal and cellular studies support the importance of autophagy inhibition in lymphangioleiomyomatosis (LAM). In a cohort of subjects with LAM, we tested the hypothesis that treatment with sirolimus and hydroxychloroquine (an autophagy inhibitor) at two different dose levels is safe and well tolerated. Secondary end points included changes in lung function.
239. A Randomized Clinical Trial Comparing the Effects of Antitussive Agents on Respiratory Center Output in Patients With Chronic Cough.
作者: Claudia Mannini.;Federico Lavorini.;Alessandro Zanasi.;Federico Saibene.;Luigi Lanata.;Giovanni Fontana.
来源: Chest. 2017年151卷6期1288-1294页
Cough is produced by the same neuronal pool implicated in respiratory rhythm generation, and antitussive drugs acting at the central level, such as opioids, may depress ventilation. Levodropropizine is classified as a nonopioid peripherally acting antitussive drug that acts at the level of airway sensory nerves. However, the lack of a central action by levodropropizine remains to be fully established. We set out to compare the effects of levodropropizine and the opioid antitussive agent dihydrocodeine on the respiratory responses to a conventional CO2 rebreathing test in patients with chronic cough of any origin.
240. Endothelial Permeability and Hemostasis in Septic Shock: Results From the ProCESS Trial.
作者: Peter C Hou.;Michael R Filbin.;Henry Wang.;Long Ngo.;David T Huang.;William C Aird.;Donald M Yealy.;Derek C Angus.;John A Kellum.;Nathan I Shapiro.; .
来源: Chest. 2017年152卷1期22-31页
We studied patients from the Protocolized Care in Early Septic Shock (ProCESS) trial to determine the effects of alternative resuscitation strategies on circulating markers of endothelial cell permeability and hemostasis and the association between biomarkers and mortality.
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