"N Engl J Med"[journal] 检索结果

201. Zongertinib in Previously Treated HER2-Mutant Non-Small-Cell Lung Cancer.

作者: John V Heymach.;Gerrina Ruiter.;Myung-Ju Ahn.;Nicolas Girard.;Egbert F Smit.;David Planchard.;Yi-Long Wu.;Byoung Chul Cho.;Noboru Yamamoto.;Joshua K Sabari.;Yanqiu Zhao.;Hai-Yan Tu.;Kiyotaka Yoh.;Ernest Nadal.;Behbood Sadrolhefazi.;Maren Rohrbacher.;Ute von Wangenheim.;Sabina Eigenbrod-Giese.;Jon Zugazagoitia.; .
来源: N Engl J Med. 2025年392卷23期2321-2333页

Innovative oral targeted therapies are warranted for patients with human epidermal growth factor receptor 2 (HER2)-mutant non-small-cell lung cancer (NSCLC). Zongertinib is an oral, irreversible, HER2-selective tyrosine kinase inhibitor that has been shown to have efficacy in persons with advanced or metastatic solid tumors with HER2 alterations in a phase 1 study.

202. Nonoperative Management of Mismatch Repair-Deficient Tumors.

作者: Andrea Cercek.;Michael B Foote.;Benoit Rousseau.;J Joshua Smith.;Jinru Shia.;Jenna Sinopoli.;Jill Weiss.;Melissa Lumish.;Lindsay Temple.;Miteshkumar Patel.;Callahan Wilde.;Leonard B Saltz.;Guillem Argiles.;Zsofia Stadler.;Oliver Artz.;Steven Maron.;Geoffrey Ku.;Ping Gu.;Yelena Y Janjigian.;Daniela Molena.;Gopa Iyer.;Jonathan Coleman.;Wassim Abida.;Seth Cohen.;Kevin Soares.;Mark Schattner.;Vivian E Strong.;Rona Yaeger.;Philip Paty.;Marina Shcherba.;Ryan Sugarman.;Paul B Romesser.;Alice Zervoudakis.;Avni Desai.;Neil H Segal.;Imane El Dika.;Maria Widmar.;Iris Wei.;Emmanouil Pappou.;Gerard Fumo.;Santiago Aparo.;Mithat Gonen.;Marc Gollub.;Vetri S Jayaprakasam.;Tae-Hyung Kim.;Julio Garcia Aguilar.;Martin Weiser.;Luis A Diaz.
来源: N Engl J Med. 2025年392卷23期2297-2308页

Among patients with mismatch repair-deficient (dMMR), locally advanced rectal cancer, neoadjuvant checkpoint blockade eliminated the need for surgery in a high proportion of patients. Whether this approach can be extended to all early-stage dMMR solid tumors, regardless of tumor site, is unknown.

203. Death and Taxes - Is Alcohol the Solution?

作者: Arthur Robin Williams.
来源: N Engl J Med. 2025年392卷17期1665-1667页

204. Routine Surveillance for Cancer Metastases - Does It Help or Harm Patients?

作者: H Gilbert Welch.;Lesly A Dossett.
来源: N Engl J Med. 2025年392卷17期1667-1670页

205. A Good Innings - A Tale of Hope, Heartbreak, and Healing.

作者: Nihanthy D Sreenath.
来源: N Engl J Med. 2025年392卷17期1670-1671页

206. NEJM Outbreaks Update - H5N1 in Indiana.

作者: Eric J Rubin.;Lindsey R Baden.;Lindsay M Weaver.;Stephen Morrissey.
来源: N Engl J Med. 2025年392卷19期e47页

207. APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans. Reply.

作者: Rasheed A Gbadegesin.;Dwomoa Adu.;Akinlolu Ojo.
来源: N Engl J Med. 2025年392卷16期1664页

208. APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans.

作者: Maxime Ingwiller.
来源: N Engl J Med. 2025年392卷16期1663-1664页

209. APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans.

作者: Xu-Jie Zhou.
来源: N Engl J Med. 2025年392卷16期1663页

210. Oral Anticoagulation during TAVI. Reply.

作者: Dirk Jan van Ginkel.;Willem L Bor.;Jurriën M Ten Berg.
来源: N Engl J Med. 2025年392卷16期1662-1663页

211. Oral Anticoagulation during TAVI.

作者: Bartosz Hudzik.;Przemysław Skulik.;Mariusz Gąsior.
来源: N Engl J Med. 2025年392卷16期1662页

212. Tirzepatide for Heart Failure and Obesity. Reply.

作者: Milton Packer.;Christopher M Kramer.;Barry A Borlaug.
来源: N Engl J Med. 2025年392卷16期1661-1662页

213. Tirzepatide for Heart Failure and Obesity.

作者: M Kasim Ali.
来源: N Engl J Med. 2025年392卷16期1661页

214. Tirzepatide for Heart Failure and Obesity.

作者: Joseph E Marine.;John Mandrola.;Vinay Prasad.
来源: N Engl J Med. 2025年392卷16期1660页

215. Tirzepatide for Heart Failure and Obesity.

作者: Jesse C Krakauer.;Nir Y Krakauer.
来源: N Engl J Med. 2025年392卷16期1660页

216. Tirzepatide for Heart Failure and Obesity.

作者: Jeffrey Wagner.
来源: N Engl J Med. 2025年392卷16期1659-1660页

217. Performance of Dialysis Facilities after Health-Equity Scoring Incentive.

作者: Kalli G Koukounas.;Meehir N Dixit.;Rebecca Thorsness.;Rachel E Patzer.;Adam S Wilk.;Kelsey M Drewry.;Rajnish Mehrotra.;Maricruz Rivera-Hernandez.;David J Meyers.;Daeho Kim.;Ankur D Shah.;Christopher H Schmid.;Amal N Trivedi.
来源: N Engl J Med. 2025年392卷16期1657-1659页

218. Clonal Hematopoiesis as a Driver of Solid Tumors.

作者: Lachelle D Weeks.;Benjamin L Ebert.
来源: N Engl J Med. 2025年392卷16期1654-1656页

219. Baloxavir Treatment to Reduce Influenza Virus Transmission.

作者: Timothy M Uyeki.;Vivien G Dugan.;Demetre C Daskalakis.
来源: N Engl J Med. 2025年392卷16期1652-1654页

220. Defanging the Neutrophil to Treat Bronchiectasis.

作者: Adam T Hill.
来源: N Engl J Med. 2025年392卷16期1649-1652页

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