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202. Sins of Omission: Model-Based Estimates of the Health Effects of Excluding Pregnant Participants From Randomized Controlled Trials.
More than 90 million women in the United States have given birth. Randomized controlled trials (RCTs) of medications almost always exclude pregnant participants.
203. Empowering Physicians Through Collective Action: A Position Paper From the American College of Physicians.
Physicians are increasingly frustrated with the nation's health care system. The erosion of the patient-physician relationship, diminished clinical independence, the mounting burden of administrative tasks, and the growing influence of nonclinicians in the health care system have left many physicians disempowered, demoralized, and burned out. As a result, physicians, most of whom are employed by hospitals, health systems, and other organizations, are exploring collective action to enhance their ability to deliver high-quality care to patients, regain control of their profession, and improve their well-being. In this position paper, the American College of Physicians offers recommendations on how physicians can become effective advocates for their patients and their profession through advocacy, the organized medical staff, responsible collective bargaining, and other means.
204. Impact of the COVID-19 Pandemic on Antibiotic Resistant Infection Burden in U.S. Hospitals : Retrospective Cohort Study of Trends and Risk Factors.
作者: Christina Yek.;Alex G Mancera.;Guoqing Diao.;Morgan Walker.;Maniraj Neupane.;Emad A Chishti.;Roxana Amirahmadi.;Mary E Richert.;Chanu Rhee.;Michael Klompas.;Bruce Swihart.;Sarah R Warner.;Sameer S Kadri.; .
来源: Ann Intern Med. 2025年178卷6期796-807页
In 2022, the U.S. Centers for Disease Control and Prevention reported increases in antimicrobial resistance (AMR) across U.S. hospitals during the COVID-19 pandemic. The key drivers and lasting effects of this phenomenon remain unexplored.
206. Sexual Trauma, Suicide, and Overdose in a National Cohort of Older Veterans.
作者: Anita S Hargrave.;Beth E Cohen.;Carolyn J Gibson.;Salomeh Keyhani.;Yixia Li.;W John Boscardin.;Amy L Byers.
来源: Ann Intern Med. 2025年178卷6期775-787页
Little is known about the association between military sexual trauma (MST) and risk for suicide-related outcomes later in life.
207. High Frequency of Chronic Urticaria Following an Investigational HIV-1 BG505 MD39.3 Trimer mRNA Vaccine in a Phase 1, Randomized, Open-Label Clinical Trial (HVTN 302).
作者: Sharon A Riddler.;Zoe Moodie.;Jesse Clark.;Catherine Yen.;Mary Allen.;Briana D Furch.;Huiyin Lu.;Shannon Grant.;Kajari Mondal.;Maija Anderson.;Janine Maenza.;Maria P Lemos.;Amanda S Woodward Davis.;Stephen R Walsh.;Magdalena E Sobieszczyk.;Ian Frank.;Paul Goepfert.;Kathryn E Stephenson.;Lindsey R Baden.;Hong-Van Tieu.;Michael C Keefer.;M Juliana McElrath.;James G Kublin.;Lawrence Corey.
来源: Ann Intern Med. 2025年178卷7期963-974页
The mRNA platform is under investigation for many vaccines, including HIV-1 vaccines.
211. Availability of Cardioprotective Medications for Type 2 Diabetes in the Medicaid Program.
作者: Anil N Makam.;Logan Bailey.;Nigel Anderson.;Kathy Bellitti.;Sasha Skinner.;Oanh Kieu Nguyen.
来源: Ann Intern Med. 2025年178卷6期808-818页
Sodium-glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are the only type 2 diabetes medications that reduce cardiovascular disease and death, yet their availability in Medicaid is unclear.
212. Prophylactic Weekly Efanesoctocog Alfa Versus Standard-Care Factor VIII in People Living With Severe Hemophilia A : A Cost-Effectiveness Analysis.
作者: Satoko Ito.;Kunal C Potnis.;Jessica Preston Harvey.;Manraj Sra.;Jan Phillipp Bewersdorf.;Robert D Bona.;Harlan M Krumholz.;Adam Cuker.;Ankur Pandya.;George Goshua.
来源: Ann Intern Med. 2025年178卷6期819-828页
Prophylaxis goals for patients with severe hemophilia A encompass advancement toward the hemophilia-free mind (freedom from bleeding, pain, arthropathy, and treatment burden). Efanesoctocog alfa, the first ultra-long half-life factor VIII agent that enables once-weekly prophylaxis, shows a 77% improvement in annualized bleeding rate compared with standard-care factor VIII prophylaxis.
218. Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023.
作者: Adam Rowh.;Marissa Zwald.;Steven Sumner.;Nisha George.;Michael Sheppard.;Kristin Holland.
来源: Ann Intern Med. 2025年178卷5期663-670页
Monitoring temporal trends in firearm injury-related emergency department (ED) visits is challenging because traditional surveillance systems lack detailed temporal information.
220. Trends in Utilization of Glucose- and Weight-Lowering Medications After Tirzepatide Approval in the United States : A Population-Based Cohort Study.
作者: John W Ostrominski.;Janinne Ortega-Montiel.;Helen Tesfaye.;Caroline Alix.;Elyse DiCesare.;Sara J Cromer.;Deborah J Wexler.;Julie M Paik.;Elisabetta Patorno.
来源: Ann Intern Med. 2025年178卷5期620-633页
Recent trends in use of tirzepatide, a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide receptor agonist (RA), versus other glucose-lowering medications (GLMs) and weight-lowering medications (WLMs) remain unexplored.
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