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201. A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma.
作者: Ritesh Agarwal.;Sahajal Dhooria.;Inderpaul Singh Sehgal.;Ashutosh N Aggarwal.;Mandeep Garg.;Biman Saikia.;Digambar Behera.;Arunaloke Chakrabarti.
来源: Chest. 2018年153卷3期656-664页
Whether itraconazole monotherapy is effective in the acute stage of allergic bronchopulmonary aspergillosis (ABPA) remains unknown. The goal of this study was to compare the efficacy and safety of itraconazole and prednisolone monotherapy in ABPA.
202. The Impact of Listening to Music During a High-Intensity Exercise Endurance Test in People With COPD.
作者: Annemarie L Lee.;Thomas E Dolmage.;Matthew Rhim.;Roger S Goldstein.;Dina Brooks.
来源: Chest. 2018年153卷5期1134-1141页
In people with COPD, dyspnea is the primary symptom limiting exercise tolerance. One approach to reducing dyspnea during exercise is through music listening. A constant speed endurance test reflects a high-intensity aerobic exercise training session, but whether listening to music affects endurance time is unknown. This study aimed to determine the effects of listening to music during a constant speed endurance test in COPD.
203. Impact of a Non-small Cell Lung Cancer Educational Program for Interdisciplinary Teams.
作者: Septimiu Murgu.;Robb Rabito.;Greg Lasko.;Chad Jackson.;Mari Mino-Kenudson.;David S Ettinger.;Suresh S Ramalingam.;Eric S Edell.; .
来源: Chest. 2018年153卷4期876-887页
Successful implementation of non-small cell lung cancer (NSCLC) evidence-based guideline recommendations requires effective educational programs that target all clinicians from interdisciplinary teams. This study describes and evaluates the Engaging an Interdisciplinary Team for NSCLC (GAIN 3.0) experiential learning-based educational curriculum.
204. Efficacy of Acupuncture Is Noninferior to Nicotine Replacement Therapy for Tobacco Cessation: Results of a Prospective, Randomized, Active-Controlled Open-Label Trial.
作者: Ying-Ying Wang.;Zhao Liu.;Yuan Wu.;Li Yang.;Lang-Tao Guo.;Hao-Bin Zhang.;Jin-Sheng Yang.; .
来源: Chest. 2018年153卷3期680-688页
We designed and conducted this multicenter randomized active-controlled open-label trial to evaluate the efficacy of acupuncture, auricular point pressing, and nicotine replacement therapy (NRT) on tobacco cessation in the Chinese population.
205. A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis.
作者: Ivan O Rosas.;Hilary J Goldberg.;Harold R Collard.;Souheil El-Chemaly.;Kevin Flaherty.;Gary M Hunninghake.;Joseph A Lasky.;David J Lederer.;Roberto Machado.;Fernando J Martinez.;Rie Maurer.;Danielle Teller.;Imre Noth.;Elizabeth Peters.;Ganesh Raghu.;Joe G N Garcia.;Augustine M K Choi.
来源: Chest. 2018年153卷1期94-104页
Preclinical studies have demonstrated that low-dose carbon monoxide (CO) can abrogate experimental lung fibrosis. To test the therapeutic role of inhaled CO, we designed a clinical study in patients with idiopathic pulmonary fibrosis (IPF).
206. Methacholine Challenge Testing: A Novel Method for Measuring PD20.
作者: Beth E Davis.;Samuel K Simonson.;Christianne M Blais.;Donald W Cockcroft.
来源: Chest. 2017年152卷6期1251-1257页
New guidelines for methacholine challenge testing recommend reporting the test outcome as dose rather than concentration. Jet nebulizers have historically been used for methacholine challenge testing, but much of the weight loss, often (incorrectly) referred to as aerosol output, is actually evaporation. The Wright nebulizer is well characterized and still widely used, but its availability is unclear, and it is nondisposable. We developed a novel method using a vibrating mesh nebulizer (Solo). This method was compared with the standard 2-min tidal breathing method using the Wright nebulizer. Repeatability within and between nebulizers was also tested.
207. A Multicenter Randomized Trial of a Checklist for Endotracheal Intubation of Critically Ill Adults.
作者: David R Janz.;Matthew W Semler.;Aaron M Joffe.;Jonathan D Casey.;Robert J Lentz.;Bennett P deBoisblanc.;Yasin A Khan.;Jairo I Santanilla.;Itay Bentov.;Todd W Rice.; .; .
来源: Chest. 2018年153卷4期816-824页
Hypoxemia and hypotension are common complications during endotracheal intubation of critically ill adults. Verbal performance of a written, preintubation checklist may prevent these complications. We compared a written, verbally performed, preintubation checklist with usual care regarding lowest arterial oxygen saturation or lowest systolic BP experienced by critically ill adults undergoing endotracheal intubation.
208. Baseline Symptom Score Impact on Benefits of Glycopyrrolate/Formoterol Metered Dose Inhaler in COPD.
作者: Fernando J Martinez.;Leonardo M Fabbri.;Gary T Ferguson.;Chad Orevillo.;Patrick Darken.;Ubaldo J Martin.;Colin Reisner.
来源: Chest. 2017年152卷6期1169-1178页
The clinical severity of COPD is currently categorized by symptom burden and exacerbation risk. Previous 24-week phase III trials (NCT01854645 and NCT01854658) that demonstrated better improvement of lung function with glycopyrrolate/formoterol fumarate (GFF) metered dose inhaler (MDI) (an MDI fixed-dose of GFF 18/9.6 μg) over individual monocomponent MDIs included a cross-section of patients with moderate to very severe airflow limitation and a broad range of COPD symptoms.
209. Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations.
作者: Khalid Alansari.;Bruce L Davidson.;Khalid Ibrahim Yousef.;Abdel Nasser H Mohamed.;Imad Alattar.
来源: Chest. 2017年152卷3期527-536页
Whether vitamin D reduces clinically important exacerbations of childhood asthma remains uncertain. We compared rapid to maintenance vitamin D repletion analyzed by baseline vitamin D level.
210. A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa: A Proof of Concept Study.
作者: Pallavi Bedi.;James D Chalmers.;Catriona Graham.;Andrea Clarke.;Samantha Donaldson.;Catherine Doherty.;John R W Govan.;Donald J Davidson.;Adriano G Rossi.;Adam T Hill.
来源: Chest. 2017年152卷2期368-378页
There are no randomized controlled trials of statin therapy in patients with severe bronchiectasis who are chronically infected with Pseudomonas aeruginosa.
211. Effects of Pulmonary Rehabilitation on Exacerbation Number and Severity in People With COPD: An Historical Cohort Study Using Electronic Health Records.
作者: Elizabeth Moore.;Roger Newson.;Miland Joshi.;Thomas Palmer.;Kieran J Rothnie.;Sally Singh.;Azeem Majeed.;Michael Soljak.;Jennifer K Quint.
来源: Chest. 2017年152卷6期1188-1202页
In previous systematic reviews (predominantly of randomized controlled trials), pulmonary rehabilitation (PR) has been shown to reduce hospital admissions for acute exacerbations of COPD (AECOPD). However, findings have been less consistent for cohort studies. The goal of this study was to compare rates of hospitalized and general practice (GP)-treated AECOPD prior to and following PR.
212. A Multicenter, Randomized Trial of Ramped Position vs Sniffing Position During Endotracheal Intubation of Critically Ill Adults.
作者: Matthew W Semler.;David R Janz.;Derek W Russell.;Jonathan D Casey.;Robert J Lentz.;Aline N Zouk.;Bennett P deBoisblanc.;Jairo I Santanilla.;Yasin A Khan.;Aaron M Joffe.;William S Stigler.;Todd W Rice.; .; .
来源: Chest. 2017年152卷4期712-722页
Hypoxemia is the most common complication during endotracheal intubation of critically ill adults. Intubation in the ramped position has been hypothesized to prevent hypoxemia by increasing functional residual capacity and decreasing the duration of intubation, but has never been studied outside of the operating room.
213. IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial.
作者: Khalid Alansari.;Rafah Sayyed.;Bruce L Davidson.;Shahaza Al Jawala.;Mohamed Ghadier.
来源: Chest. 2017年152卷1期113-119页
The goal of this study was to determine if IV magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in patients with bronchiolitis when added to supportive care.
214. A Randomized Clinical Trial Comparing the Effects of Antitussive Agents on Respiratory Center Output in Patients With Chronic Cough.
作者: Claudia Mannini.;Federico Lavorini.;Alessandro Zanasi.;Federico Saibene.;Luigi Lanata.;Giovanni Fontana.
来源: Chest. 2017年151卷6期1288-1294页
Cough is produced by the same neuronal pool implicated in respiratory rhythm generation, and antitussive drugs acting at the central level, such as opioids, may depress ventilation. Levodropropizine is classified as a nonopioid peripherally acting antitussive drug that acts at the level of airway sensory nerves. However, the lack of a central action by levodropropizine remains to be fully established. We set out to compare the effects of levodropropizine and the opioid antitussive agent dihydrocodeine on the respiratory responses to a conventional CO2 rebreathing test in patients with chronic cough of any origin.
215. Endothelial Permeability and Hemostasis in Septic Shock: Results From the ProCESS Trial.
作者: Peter C Hou.;Michael R Filbin.;Henry Wang.;Long Ngo.;David T Huang.;William C Aird.;Donald M Yealy.;Derek C Angus.;John A Kellum.;Nathan I Shapiro.; .
来源: Chest. 2017年152卷1期22-31页
We studied patients from the Protocolized Care in Early Septic Shock (ProCESS) trial to determine the effects of alternative resuscitation strategies on circulating markers of endothelial cell permeability and hemostasis and the association between biomarkers and mortality.
216. The Long-term Effect of Bacille Calmette-Guérin Vaccination on Tuberculin Skin Testing: A 55-Year Follow-Up Study.
作者: James D Mancuso.;Rupal M Mody.;Cara H Olsen.;Lee H Harrison.;Mathuram Santosham.;Naomi E Aronson.
来源: Chest. 2017年152卷2期282-294页
Bacille Calmette-Guérin (BCG) vaccination is known to cause false-positive tuberculin skin test (TST) results from cross-reactions with mycobacterial antigens. However, the duration of BCG vaccination influence on the TST is poorly characterized. The objective of this study was to assess the long-term effect of BCG vaccination on TST reactivity.
217. Improved Cough and Cough-Specific Quality of Life in Patients Treated for Scleroderma-Related Interstitial Lung Disease: Results of Scleroderma Lung Study II.
作者: Donald P Tashkin.;Elizabeth R Volkmann.;Chi-Hong Tseng.;Michael D Roth.;Dinesh Khanna.;Daniel E Furst.;Philip J Clements.;Arthur Theodore.;Suzanne Kafaja.;Grace Hyun Kim.;Jonathan Goldin.;Edgar Ariolla.;Robert M Elashoff.
来源: Chest. 2017年151卷4期813-820页
Cough is a common symptom of scleroderma-related interstitial lung disease (SSc-ILD), but its relationship to other characteristics of SSc-ILD, impact on cough-specific quality of life (QoL), and response to therapy for SSc-ILD have not been well studied.
218. Postoperative Oxygen Therapy in Patients With OSA: A Randomized Controlled Trial.
作者: Pu Liao.;Jean Wong.;Mandeep Singh.;David T Wong.;Sazzadul Islam.;Maged Andrawes.;Colin M Shapiro.;David P White.;Frances Chung.
来源: Chest. 2017年151卷3期597-611页
Surgical patients with OSA are at increased risk for perioperative complications. Postoperative supplemental oxygen is commonly used, but it may contribute to respiratory depression in patients with OSA receiving opioids. The objective of the study is to investigate the effect of postoperative supplemental oxygen on arterial oxygen saturation (Sao2), sleep respiratory events, and CO2 level in patients with untreated OSA.
219. Short-term Effects of Supplemental Oxygen on 6-Min Walk Test Outcomes in Patients With COPD: A Randomized, Placebo-Controlled, Single-blind, Crossover Trial.
作者: Inga Jarosch.;Rainer Gloeckl.;Eva Damm.;Anna-Lena Schwedhelm.;David Buhrow.;Andreas Jerrentrup.;Martijn A Spruit.;Klaus Kenn.
来源: Chest. 2017年151卷4期795-803页
The acute effect of supplemental oxygen during exercise has been shown to differ largely among patients with COPD. It is unknown what factors influence oxygen response.
220. Efficacy and Safety of Glycopyrrolate/Formoterol Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Patients With COPD.
作者: Fernando J Martinez.;Klaus F Rabe.;Gary T Ferguson.;Leonardo M Fabbri.;Stephen Rennard.;Gregory J Feldman.;Sanjay Sethi.;Selwyn Spangenthal.;Gregory M Gottschlich.;Roberto Rodriguez-Roisin.;Samir Arora.;Thomas M Siler.;Shahid Siddiqui.;Patrick Darken.;Tracy Fischer.;Andrea Maes.;Michael Golden.;Chad Orevillo.;Colin Reisner.
来源: Chest. 2017年151卷2期340-357页
Long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) combinations are a treatment option for patients with COPD who continue to have symptoms despite treatment with a LAMA or a LABA alone. The Efficacy and Safety of PT003, PT005, and PT001 in Subjects with Moderate-to-Very Severe COPD (PINNACLE-1) (NCT01854645) and the Multi-Center Study to Assess the Efficacy and Safety of PT003, PT005, and PT001 in Subjects with Moderate-to-Very Severe COPD (PINNACLE-2) (NCT01854658) trials investigated the efficacy and safety of a novel glycopyrrolate [GP]/formoterol [FF] 18/9.6-μg (GFF) metered dose inhaler (MDI) formulated using the Co-Suspension Delivery Technology in patients with moderate-to-very severe COPD.
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