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201. Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression.
作者: Anselm Mak.;Mike W-L Cheung.;Alicia Ai-cia Cheak.;Roger Chun-Man Ho.
来源: Rheumatology (Oxford). 2010年49卷2期281-8页
The combination of heparin and aspirin was regarded as the 'standard therapy' for patients with recurrent pregnancy loss (RPL) and positive aPL antibodies to enhance live births, but it largely stems from expert opinion. We performed a meta-analysis of randomized controlled trials (RCTs) to assess whether this combination works better than aspirin alone.
202. Efficacy of joint lavage in knee osteoarthritis: meta-analysis of randomized controlled studies.
作者: Jérome Avouac.;Eric Vicaut.;Thomas Bardin.;Pascal Richette.
来源: Rheumatology (Oxford). 2010年49卷2期334-40页
Regarding the efficacy of joint lavage in the treatment of knee OA, we evaluated reports of randomized controlled trials (RCTs) to assess the efficacy of joint lavage alone or joint lavage combined with IA steroid injection to alleviate pain and improve function in knee OA.
203. A systematic comparison of combination DMARD therapy and tumour necrosis inhibitor therapy with methotrexate in patients with early rheumatoid arthritis.
作者: Margaret H Y Ma.;Gabrielle H Kingsley.;David L Scott.
来源: Rheumatology (Oxford). 2010年49卷1期91-8页
We examined how combination DMARD therapies and TNF inhibitors therapies plus MTX (TNF/MTX) affect clinical and radiological outcomes compared with MTX monotherapy in early RA.
204. Response of elderly patients with rheumatoid arthritis to methotrexate or TNF inhibitors compared with younger patients.
作者: Marcus D Köller.;Daniel Aletaha.;Julia Funovits.;Aileen Pangan.;Daniel Baker.;Josef S Smolen.
来源: Rheumatology (Oxford). 2009年48卷12期1575-80页
To compare the efficacy of MTX and MTX+TNF inhibitors (TNFis) in elderly patients with RA with that in patients of younger age.
205. Lack of association of TNF-alpha promoter polymorphisms with ankylosing spondylitis: a meta-analysis.
Genetic factors, in addition to the HLA-B27, could play a role in the pathogenesis of AS. TNF-alpha promoter polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF-alpha promoter polymorphisms confer susceptibility to AS.
206. Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies.
作者: Christophe Meune.;Emmanuel Touzé.;Ludovic Trinquart.;Yannick Allanore.
来源: Rheumatology (Oxford). 2009年48卷10期1309-13页
RA is known to be associated with a high cardiovascular (CV) risk. Longitudinal data suggest that RA disease course may have become milder over the past decades. Thus, we set out to estimate the magnitude of the overall increase in CV mortality associated with RA and to determine whether it has decreased over the past 50 years.
207. Efficacy of hydrotherapy in fibromyalgia syndrome--a meta-analysis of randomized controlled clinical trials.
作者: Jost Langhorst.;Frauke Musial.;Petra Klose.;Winfried Häuser.
来源: Rheumatology (Oxford). 2009年48卷9期1155-9页
To systematically review the efficacy of hydrotherapy in FM syndrome (FMS).
208. Early response to COX-2 inhibitors as a predictor of overall response in osteoarthritis: pooled results from two identical trials comparing etoricoxib, celecoxib and placebo.
作者: Clifton O Bingham.;Steven S Smugar.;Hongwei Wang.;Andrew M Tershakovec.
来源: Rheumatology (Oxford). 2009年48卷9期1122-7页
We evaluated whether early response to NSAIDs predicted later response, and when this was established.
209. Mycophenolate mofetil is as efficacious as, but safer than, cyclophosphamide in the treatment of proliferative lupus nephritis: a meta-analysis and meta-regression.
作者: Anselm Mak.;Alicia A C Cheak.;Jason Y S Tan.;Hnin Cho Su.;Roger C M Ho.;Chak Sing Lau.
来源: Rheumatology (Oxford). 2009年48卷8期944-52页
Since mycophenolate mofetil (MMF) has emerged as an immunosuppressant for treating proliferative lupus nephritis, the role of cyclophosphamide (CYC)-containing regimens is being challenged. Efficacy data from randomized controlled trials (RCTs) and previous meta-analyses comparing these two agents for treating lupus nephritis have been inconsistent as they were heterogeneous in design and of small sample size. An updated meta-analysis is therefore required.
210. Methotrexate in combination with sulfasalazine is more effective in rheumatoid arthritis patients who failed sulfasalazine than in patients naive to both drugs.
作者: Lydia G Schipper.;Jaap Fransen.;Pilar Barrera.;Piet L C M Van Riel.
来源: Rheumatology (Oxford). 2009年48卷7期828-33页
For pharmacological reasons, the effect of the combination of MTX and SSZ may be different in RA patients who are naïve to these drugs compared to patients with an insufficient response to one of them. Therefore, we compared the results of randomized controlled trials (RCTs) on the combination of MTX and SSZ in naïve patients and in patients with an insufficient response to SSZ.
211. Safety of medium- to long-term glucocorticoid therapy in rheumatoid arthritis: a meta-analysis.
Several randomized controlled trials (RCTs) and meta-analyses have confirmed clinical efficacy of glucocorticoids in RA. Concerns regarding safety associated with medium- to long-term use in RA have limited their use in clinical practice. In this meta-analysis, we assessed the toxicity related to medium- to long-term (defined as 1 year or longer) glucocorticoid therapy in RA.
212. The efficacy of complementary and alternative medicine in the treatment of Raynaud's phenomenon: a literature review and meta-analysis.
Conventional treatment for RP is limited due to side effects, and complementary and alternative medicines (CAM) are widely used by the population. Our objective was to find an effective and well-tolerated CAM for the treatment of RP.
213. Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series.
作者: Tugce Karaderi.;David Harvey.;Claire Farrar.;Louise H Appleton.;Millicent A Stone.;Roger D Sturrock.;Matthew A Brown.;Paul Wordsworth.;Jennifer J Pointon.
来源: Rheumatology (Oxford). 2009年48卷4期386-9页
It has been shown previously that IL-23R variants are associated with AS. We conducted an extended analysis in the UK population and a meta-analysis with the previously published studies, in order to refine these IL-23R associations with AS.
214. Analgesic effects of treatments for non-specific low back pain: a meta-analysis of placebo-controlled randomized trials.
作者: L A C Machado.;S J Kamper.;R D Herbert.;C G Maher.;J H McAuley.
来源: Rheumatology (Oxford). 2009年48卷5期520-7页
Estimates of treatment effects reported in placebo-controlled randomized trials are less subject to bias than those estimates provided by other study designs. The objective of this meta-analysis was to estimate the analgesic effects of treatments for non-specific low back pain reported in placebo-controlled randomized trials.
215. Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis.
作者: P Harrison.;J J Pointon.;K Chapman.;A Roddam.;B P Wordsworth.
来源: Rheumatology (Oxford). 2008年47卷12期1768-70页
IL-1 has a central role mediating inflammation and joint destruction in RA. Single nucleotide polymorphisms (SNPs) and haplotype structure in the promoter region can modulate IL-1 function. This study examined the effects of four common promoter SNPs in the IL-1 region on susceptibility and clinical characteristics of RA in British Caucasian patients and assessed the risk of RA by meta-analysis of published studies.
216. The cost-effectiveness of etanercept and infliximab for the treatment of patients with psoriatic arthritis.
作者: Y Bravo Vergel.;N S Hawkins.;K Claxton.;C Asseburg.;S Palmer.;N Woolacott.;I N Bruce.;M J Sculpher.
来源: Rheumatology (Oxford). 2007年46卷11期1729-35页
Tumour necrosis factor (TNF) antagonists have been shown to improve the outcomes in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA). We assess the cost-effectiveness of two TNF antagonists and so-called 'palliative care' for the treatment of active PsA from the perspective of the UK National Health Service (NHS).
217. Conservative treatments for tennis elbow do subgroups of patients respond differently?
作者: L Bisset.;N Smidt.;D A Van der Windt.;L M Bouter.;G Jull.;P Brooks.;B Vicenzino.
来源: Rheumatology (Oxford). 2007年46卷10期1601-5页
To determine if subgroups of patients with tennis elbow respond differently in treatment.
218. Cost effectiveness of adalimumab for the treatment of ankylosing spondylitis in the United Kingdom.
作者: M F Botteman.;J W Hay.;M P Luo.;A S Curry.;R L Wong.;B A van Hout.
来源: Rheumatology (Oxford). 2007年46卷8期1320-8页
This study evaluated the cost effectiveness of adalimumab vs conventional therapy in patients with active ankylosing spondylitis (AS).
219. The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: a meta-analysis and adjusted indirect comparisons.
New treatments that inhibit the cytokines tumour necrosis factor alpha (TNFalpha) and interleukin 1 (IL-1) in the treatment of rheumatoid arthritis have proven clinical effect against placebo and methotrexate (MTX) in several clinical trials in early and late-stage disease and different severity groups. Since there are no head-to-head randomized controlled trials directly comparing the currently available treatments, etanercept, adalimumab, infliximab or anakinra, we perform a meta-analysis that adjusts for differences between study characteristics, and allows indirect comparisons between treatments.
220. Combined analysis of three whole genome linkage scans for Ankylosing Spondylitis.
作者: K W Carter.;A Pluzhnikov.;A E Timms.;C Miceli-Richard.;C Bourgain.;B P Wordsworth.;H Jean-Pierre.;N J Cox.;L J Palmer.;M Breban.;J D Reveille.;M A Brown.
来源: Rheumatology (Oxford). 2007年46卷5期763-71页
Ankylosing spondylitis (AS) is a debilitating chronic inflammatory condition with a high degree of familiality (lambda(s) = 82) and heritability (>90%) that primarily affects spinal and sacroiliac joints. Whole genome scans for linkage to AS phenotypes have been conducted, although results have been inconsistent between studies and all have had modest sample sizes. One potential solution to these issues is to combine data from multiple studies in a retrospective meta-analysis.
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