当前位置: 首页 >> 检索结果
201. Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis.
作者: Scott M Palmer.;Laurie Snyder.;Jamie L Todd.;Benjamin Soule.;Rose Christian.;Kevin Anstrom.;Yi Luo.;Robert Gagnon.;Glenn Rosen.
来源: Chest. 2018年154卷5期1061-1069页
Idiopathic pulmonary fibrosis (IPF) causes irreversible loss of lung function. The lysophosphatidic acid receptor 1 (LPA1) pathway is implicated in IPF etiology. Safety and efficacy of BMS-986020, a high-affinity LPA1 antagonist, was assessed vs placebo in a phase 2 study in patients with IPF.
202. Circulating Biomarkers From the Phase 1 Trial of Sirolimus and Autophagy Inhibition for Patients With Lymphangioleiomyomatosis.
作者: Anthony M Lamattina.;Angelo Taveira-Dasilva.;Hilary J Goldberg.;Shefali Bagwe.;Ye Cui.;Ivan O Rosas.;Joel Moss.;Elizabeth P Henske.;Souheil El-Chemaly.
来源: Chest. 2018年154卷5期1070-1082页
We have previously conducted the Sirolimus and Autophagy Inhibition in LAM (SAIL) trial, a phase 1 dose-escalation study of the combination of sirolimus and hydroxychloroquine in patients with lymphangioleiomyomatosis (LAM). The goal of the present study was to analyze sera from the SAIL trial to identify novel biomarkers that could shed light into disease pathogenesis and response to therapy.
203. Standard Bronchoscopy With Fluoroscopy vs Thin Bronchoscopy and Radial Endobronchial Ultrasound for Biopsy of Pulmonary Lesions: A Multicenter, Prospective, Randomized Trial.
作者: Nichole T Tanner.;Lonny Yarmus.;Alexander Chen.;Jessica Wang Memoli.;Hiren J Mehta.;Nicholas J Pastis.;Hans Lee.;Michael A Jantz.;Paul J Nietert.;Gerard A Silvestri.
来源: Chest. 2018年154卷5期1035-1043页
New technology has resulted in bronchoscopy being increasingly used for diagnosing pulmonary lesions. Reported yield from these procedures varies widely with few randomized clinical trials. This study compares the diagnostic yield of a thin bronchoscope and radial endobronchial ultrasound (R-EBUS) with standard bronchoscopy and fluoroscopy (SB-F) in lung lesions.
204. Surgical Disparities Among Patients With Stage I Lung Cancer in the National Lung Screening Trial.
Low-dose CT scan reduces lung cancer mortality in high-risk patients fit to undergo surgical resection. Racial disparities in resection of lung cancer in nonscreening populations are well described. We describe surgical resection patterns of patients with early stage non-small cell lung cancer (NSCLC) in the National Lung Screening Trial (NLST) and examine whether racial disparities exist among blacks.
205. Efficacy of Dexamethasone in Preventing Acute Mountain Sickness in COPD Patients: Randomized Trial.
作者: Michael Furian.;Mona Lichtblau.;Sayaka S Aeschbacher.;Bermet Estebesova.;Berik Emilov.;Ulan Sheraliev.;Nuriddin H Marazhapov.;Maamed Mademilov.;Batyr Osmonov.;Maya Bisang.;Stefanie Ulrich.;Tsogyal D Latshang.;Silvia Ulrich.;Talant M Sooronbaev.;Konrad E Bloch.
来源: Chest. 2018年154卷4期788-797页
Patients with COPD may experience acute mountain sickness (AMS) and other altitude-related adverse health effects (ARAHE) when traveling to high altitudes. This study evaluated whether dexamethasone, a drug used for the prevention of AMS in healthy individuals, would prevent AMS/ARAHE in patients with COPD.
206. Can Patients With COPD Assimilate Disease-Specific Information During an Acute Exacerbation?: Results of a Pilot Randomized Controlled Trial.
作者: Tania Janaudis-Ferreira.;Sylvia Jocelyn Carr.;Samantha L Harrison.;Andrea S Gershon.;Siobhan C Milner.;Sean Carr.;David Fishbein.;Roger Goldstein.
来源: Chest. 2018年154卷3期588-596页
The study aimed to determine the feasibility and effectiveness of an introductory disease-specific educational program delivered during an acute exacerbation of COPD (AECOPD) on objective measures of disease-specific knowledge.
207. Left Atrial Volume as a Biomarker of Target Organ Damage in Cardionephrology: A Study in a Wide Range of Renal Function.
作者: Zach Rozenbaum.;Orit Kliuk Ben-Bassat.;Yitzhak Hadad.;Moshe Iluz.;Yoav Granot.;Tomer Ziv-Baran.;Shlomo Berliner.;Galit Aviram.
来源: Chest. 2018年154卷4期893-903页
Cardiac chamber size was previously studied by echocardiography, among patients with progressive kidney disease only. We aimed to explore the relations between all heart chamber volumes as assessed by CT pulmonary angiography and renal function, throughout all ranges.
208. Tobacco Dependence Predicts Higher Lung Cancer and Mortality Rates and Lower Rates of Smoking Cessation in the National Lung Screening Trial.
作者: Alana M Rojewski.;Nichole T Tanner.;Lin Dai.;James G Ravenel.;Mulugeta Gebregziabher.;Gerard A Silvestri.;Benjamin A Toll.
来源: Chest. 2018年154卷1期110-118页
Incorporating tobacco treatment within lung cancer screening programs has the potential to influence cessation in high-risk smokers. We aimed to better understand the characteristics of smokers within a screening cohort, correlate those variables with downstream outcomes, and identify predictors of continued smoking.
209. Persistence of Central Venous Oxygen Desaturation During Early Sepsis Is Associated With Higher Mortality: A Retrospective Analysis of the ALBIOS Trial.
作者: Alessandro Protti.;Serge Masson.;Roberto Latini.;Roberto Fumagalli.;Marilena Romero.;Carla Pessina.;Giovanni Pasetti.;Gianni Tognoni.;Antonio Pesenti.;Luciano Gattinoni.;Pietro Caironi.
来源: Chest. 2018年154卷6期1291-1300页
Relevance of low (< 70%) central venous oxygen saturation (Scvo2) during early sepsis has been recently questioned by three negative trials (Protocol-Based Care for Early Septic Shock, Australasian Resuscitation in Sepsis Evaluation, and Protocolized Management in Sepsis) on early goal-directed therapy; however, subjects included in those trials had Scvo2 at enrollment as high as 71 ± 13%, 73 ± 11%, and 70 ± 12%. Here we assess the association between Scvo2 < 70% at 6 h and 90-day mortality in subjects enrolled in the Albumin Italian Outcome Sepsis (ALBIOS) trial, focusing on those with initial Scvo2 < 70%.
210. Psychometric Validation of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) Questionnaire: Results of the SYMPHONY Trial.
作者: Kelly M Chin.;Mardi Gomberg-Maitland.;Richard N Channick.;Michael J Cuttica.;Aryeh Fischer.;Robert P Frantz.;Elke Hunsche.;Leah Kleinman.;John W McConnell.;Vallerie V McLaughlin.;Chad E Miller.;Roham T Zamanian.;Michael S Zastrow.;David B Badesch.
来源: Chest. 2018年154卷4期848-861页
Disease-specific patient-reported outcome (PRO) instruments are important in assessing the impact of disease and treatment. The Pulmonary Arterial Hypertension-Symptoms and Impact Questionnaire is the first instrument for quantifying pulmonary arterial hypertension (PAH) symptoms and impacts developed according to the 2009 US Food and Drug Administration PRO guidance; previous qualitative research in patients with PAH supported its initial content validity.
211. Acute Tetrahydrobiopterin Improves Endothelial Function in Patients With COPD.
作者: Paula Rodriguez-Miguelez.;Justin Gregg.;Nichole Seigler.;Leon Bass.;Jeffrey Thomas.;Jennifer S Pollock.;Jennifer C Sullivan.;Thomas A Dillard.;Ryan A Harris.
来源: Chest. 2018年154卷3期597-606页
Cardiovascular diseases represent a hallmark characteristic in COPD, and endothelial dysfunction has been observed in these patients. Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide (NO) synthesis and a regulator of endothelial function. The goal of this study was to test the hypothesis that a single dose of BH4 would improve endothelial function in patients with COPD via an increase in NO bioavailability.
212. Comparison of Two Lidocaine Administration Techniques on Perceived Pain From Bedside Procedures: A Randomized Clinical Trial.
作者: Bhakti K Patel.;Blair N Wendlandt.;Krysta S Wolfe.;Shruti B Patel.;Elizabeth R Doman.;Anne S Pohlman.;Jesse B Hall.;John P Kress.
来源: Chest. 2018年154卷4期773-780页
Lidocaine is used to alleviate procedural pain but paradoxically increases pain during injection. Pain perception can be modulated by non-noxious stimuli such as temperature or touch according to the gate control theory of pain. We postulated that lidocaine dripped onto the skin prior to injection would cool or add the sensation of touch at the skin surface to reduce pain perception from the procedure.
213. CPAP Adherence Predictors in a Randomized Trial of Moderate-to-Severe OSA Enriched With Women and Minorities.
作者: Anna M May.;Tarek Gharibeh.;Lu Wang.;Amanda Hurley.;Harneet Walia.;Kingman P Strohl.;Reena Mehra.
来源: Chest. 2018年154卷3期567-578页
Suboptimal CPAP adherence in OSA clinical trials involving predominantly white men limits interpretability and generalizability. We examined predictors of CPAP adherence in a clinical trial enriched with minorities.
214. Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD: A Randomized Controlled Trial.
作者: Michael I Polkey.;Zhi-Hui Qiu.;Lian Zhou.;Meng-Duo Zhu.;Ying-Xin Wu.;Yong-Yi Chen.;Sheng-Peng Ye.;Yu-Shan He.;Mei Jiang.;Bai-Ting He.;Bhavin Mehta.;Nan-Shan Zhong.;Yuan-Ming Luo.
来源: Chest. 2018年153卷5期1116-1124页
In COPD, functional status is improved by pulmonary rehabilitation (PR) but requires specific facilities. Tai Chi, which combines psychological treatment and physical exercise and requires no special equipment, is widely practiced in China and is becoming increasingly popular in the rest of the world. We hypothesized that Tai Chi is equivalent (ie, difference less than ±4 St. George's Respiratory Questionnaire [SGRQ] points) to PR.
215. A Pilot Feasibility Study in Establishing the Role of Ultrasound-Guided Pleural Biopsies in Pleural Infection (The AUDIO Study).
作者: Ioannis Psallidas.;Nikolaos I Kanellakis.;Rahul Bhatnagar.;Rahul Ravindran.;Ahmed Yousuf.;Anthony J Edey.;Rachel M Mercer.;John P Corcoran.;Robert J Hallifax.;Rachelle Asciak.;Prashanth Shetty.;Tao Dong.;Hania E G Piotrowska.;Colin Clelland.;Nick A Maskell.;Najib M Rahman.
来源: Chest. 2018年154卷4期766-772页
Pleural infection is a common complication of pneumonia associated with high mortality and poor clinical outcome. Treatment of pleural infection relies on the use of broad-spectrum antibiotics because reliable pathogen identification occurs infrequently. We performed a feasibility interventional clinical study assessing the safety and significance of ultrasound (US)-guided pleural biopsy culture to increase microbiological yield. In an exploratory investigation, the 16S ribosomal RNA technique was applied to assess its utility on increasing speed and accuracy vs standard microbiological diagnosis.
216. Vitamin C Pharmacokinetics in Critically Ill Patients: A Randomized Trial of Four IV Regimens.
作者: Harm-Jan de Grooth.;Wai-Ping Manubulu-Choo.;Anthe S Zandvliet.;Angélique M E Spoelstra-de Man.;Armand R Girbes.;Eleonora L Swart.;Heleen M Oudemans-van Straaten.
来源: Chest. 2018年153卷6期1368-1377页
Early high-dose IV vitamin C is being investigated as adjuvant therapy in patients who are critically ill, but the optimal dose and infusion method are unclear. The primary aim of this study was to describe the dose-plasma concentration relationship and safety of four different dosing regimens.
217. Management of Low-Risk Pulmonary Embolism Patients Without Hospitalization: The Low-Risk Pulmonary Embolism Prospective Management Study.
作者: Joseph R Bledsoe.;Scott C Woller.;Scott M Stevens.;Valerie Aston.;Rich Patten.;Todd Allen.;Benjamin D Horne.;Lydia Dong.;James Lloyd.;Greg Snow.;Troy Madsen.;C Gregory Elliott.
来源: Chest. 2018年154卷2期249-256页
The efficacy and safety of managing patients with low-risk pulmonary embolism (PE) without hospitalization requires objective data from US medical centers. We sought to determine the 90-day composite rate of recurrent symptomatic VTE, major bleeding events, and all-cause mortality among consecutive patients diagnosed with acute low-risk PE managed without inpatient hospitalization; and to measure patient satisfaction.
218. β-Blockers in COPD: A Cohort Study From the TONADO Research Program.
作者: François Maltais.;Roland Buhl.;Andrea Koch.;Valeria C Amatto.;Jim Reid.;Lars Grönke.;Ulrich Bothner.;Florian Voß.;Lorcan McGarvey.;Gary T Ferguson.
来源: Chest. 2018年153卷6期1315-1325页
Cardiovascular disease is a frequent comorbidity in patients with COPD. Many physicians, particularly pulmonologists, are reluctant to use β-adrenoceptor blocking agents (β-blockers) in patients with COPD, despite their proven effectiveness in preventing cardiovascular events.
219. A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma.
作者: Ritesh Agarwal.;Sahajal Dhooria.;Inderpaul Singh Sehgal.;Ashutosh N Aggarwal.;Mandeep Garg.;Biman Saikia.;Digambar Behera.;Arunaloke Chakrabarti.
来源: Chest. 2018年153卷3期656-664页
Whether itraconazole monotherapy is effective in the acute stage of allergic bronchopulmonary aspergillosis (ABPA) remains unknown. The goal of this study was to compare the efficacy and safety of itraconazole and prednisolone monotherapy in ABPA.
220. The Impact of Listening to Music During a High-Intensity Exercise Endurance Test in People With COPD.
作者: Annemarie L Lee.;Thomas E Dolmage.;Matthew Rhim.;Roger S Goldstein.;Dina Brooks.
来源: Chest. 2018年153卷5期1134-1141页
In people with COPD, dyspnea is the primary symptom limiting exercise tolerance. One approach to reducing dyspnea during exercise is through music listening. A constant speed endurance test reflects a high-intensity aerobic exercise training session, but whether listening to music affects endurance time is unknown. This study aimed to determine the effects of listening to music during a constant speed endurance test in COPD.
|