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201. Efficacy of Dexamethasone in Preventing Acute Mountain Sickness in COPD Patients: Randomized Trial.
作者: Michael Furian.;Mona Lichtblau.;Sayaka S Aeschbacher.;Bermet Estebesova.;Berik Emilov.;Ulan Sheraliev.;Nuriddin H Marazhapov.;Maamed Mademilov.;Batyr Osmonov.;Maya Bisang.;Stefanie Ulrich.;Tsogyal D Latshang.;Silvia Ulrich.;Talant M Sooronbaev.;Konrad E Bloch.
来源: Chest. 2018年154卷4期788-797页
Patients with COPD may experience acute mountain sickness (AMS) and other altitude-related adverse health effects (ARAHE) when traveling to high altitudes. This study evaluated whether dexamethasone, a drug used for the prevention of AMS in healthy individuals, would prevent AMS/ARAHE in patients with COPD.
202. Can Patients With COPD Assimilate Disease-Specific Information During an Acute Exacerbation?: Results of a Pilot Randomized Controlled Trial.
作者: Tania Janaudis-Ferreira.;Sylvia Jocelyn Carr.;Samantha L Harrison.;Andrea S Gershon.;Siobhan C Milner.;Sean Carr.;David Fishbein.;Roger Goldstein.
来源: Chest. 2018年154卷3期588-596页
The study aimed to determine the feasibility and effectiveness of an introductory disease-specific educational program delivered during an acute exacerbation of COPD (AECOPD) on objective measures of disease-specific knowledge.
203. Left Atrial Volume as a Biomarker of Target Organ Damage in Cardionephrology: A Study in a Wide Range of Renal Function.
作者: Zach Rozenbaum.;Orit Kliuk Ben-Bassat.;Yitzhak Hadad.;Moshe Iluz.;Yoav Granot.;Tomer Ziv-Baran.;Shlomo Berliner.;Galit Aviram.
来源: Chest. 2018年154卷4期893-903页
Cardiac chamber size was previously studied by echocardiography, among patients with progressive kidney disease only. We aimed to explore the relations between all heart chamber volumes as assessed by CT pulmonary angiography and renal function, throughout all ranges.
204. Tobacco Dependence Predicts Higher Lung Cancer and Mortality Rates and Lower Rates of Smoking Cessation in the National Lung Screening Trial.
作者: Alana M Rojewski.;Nichole T Tanner.;Lin Dai.;James G Ravenel.;Mulugeta Gebregziabher.;Gerard A Silvestri.;Benjamin A Toll.
来源: Chest. 2018年154卷1期110-118页
Incorporating tobacco treatment within lung cancer screening programs has the potential to influence cessation in high-risk smokers. We aimed to better understand the characteristics of smokers within a screening cohort, correlate those variables with downstream outcomes, and identify predictors of continued smoking.
205. Persistence of Central Venous Oxygen Desaturation During Early Sepsis Is Associated With Higher Mortality: A Retrospective Analysis of the ALBIOS Trial.
作者: Alessandro Protti.;Serge Masson.;Roberto Latini.;Roberto Fumagalli.;Marilena Romero.;Carla Pessina.;Giovanni Pasetti.;Gianni Tognoni.;Antonio Pesenti.;Luciano Gattinoni.;Pietro Caironi.
来源: Chest. 2018年154卷6期1291-1300页
Relevance of low (< 70%) central venous oxygen saturation (Scvo2) during early sepsis has been recently questioned by three negative trials (Protocol-Based Care for Early Septic Shock, Australasian Resuscitation in Sepsis Evaluation, and Protocolized Management in Sepsis) on early goal-directed therapy; however, subjects included in those trials had Scvo2 at enrollment as high as 71 ± 13%, 73 ± 11%, and 70 ± 12%. Here we assess the association between Scvo2 < 70% at 6 h and 90-day mortality in subjects enrolled in the Albumin Italian Outcome Sepsis (ALBIOS) trial, focusing on those with initial Scvo2 < 70%.
206. Psychometric Validation of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) Questionnaire: Results of the SYMPHONY Trial.
作者: Kelly M Chin.;Mardi Gomberg-Maitland.;Richard N Channick.;Michael J Cuttica.;Aryeh Fischer.;Robert P Frantz.;Elke Hunsche.;Leah Kleinman.;John W McConnell.;Vallerie V McLaughlin.;Chad E Miller.;Roham T Zamanian.;Michael S Zastrow.;David B Badesch.
来源: Chest. 2018年154卷4期848-861页
Disease-specific patient-reported outcome (PRO) instruments are important in assessing the impact of disease and treatment. The Pulmonary Arterial Hypertension-Symptoms and Impact Questionnaire is the first instrument for quantifying pulmonary arterial hypertension (PAH) symptoms and impacts developed according to the 2009 US Food and Drug Administration PRO guidance; previous qualitative research in patients with PAH supported its initial content validity.
207. Acute Tetrahydrobiopterin Improves Endothelial Function in Patients With COPD.
作者: Paula Rodriguez-Miguelez.;Justin Gregg.;Nichole Seigler.;Leon Bass.;Jeffrey Thomas.;Jennifer S Pollock.;Jennifer C Sullivan.;Thomas A Dillard.;Ryan A Harris.
来源: Chest. 2018年154卷3期597-606页
Cardiovascular diseases represent a hallmark characteristic in COPD, and endothelial dysfunction has been observed in these patients. Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide (NO) synthesis and a regulator of endothelial function. The goal of this study was to test the hypothesis that a single dose of BH4 would improve endothelial function in patients with COPD via an increase in NO bioavailability.
208. Comparison of Two Lidocaine Administration Techniques on Perceived Pain From Bedside Procedures: A Randomized Clinical Trial.
作者: Bhakti K Patel.;Blair N Wendlandt.;Krysta S Wolfe.;Shruti B Patel.;Elizabeth R Doman.;Anne S Pohlman.;Jesse B Hall.;John P Kress.
来源: Chest. 2018年154卷4期773-780页
Lidocaine is used to alleviate procedural pain but paradoxically increases pain during injection. Pain perception can be modulated by non-noxious stimuli such as temperature or touch according to the gate control theory of pain. We postulated that lidocaine dripped onto the skin prior to injection would cool or add the sensation of touch at the skin surface to reduce pain perception from the procedure.
209. CPAP Adherence Predictors in a Randomized Trial of Moderate-to-Severe OSA Enriched With Women and Minorities.
作者: Anna M May.;Tarek Gharibeh.;Lu Wang.;Amanda Hurley.;Harneet Walia.;Kingman P Strohl.;Reena Mehra.
来源: Chest. 2018年154卷3期567-578页
Suboptimal CPAP adherence in OSA clinical trials involving predominantly white men limits interpretability and generalizability. We examined predictors of CPAP adherence in a clinical trial enriched with minorities.
210. Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD: A Randomized Controlled Trial.
作者: Michael I Polkey.;Zhi-Hui Qiu.;Lian Zhou.;Meng-Duo Zhu.;Ying-Xin Wu.;Yong-Yi Chen.;Sheng-Peng Ye.;Yu-Shan He.;Mei Jiang.;Bai-Ting He.;Bhavin Mehta.;Nan-Shan Zhong.;Yuan-Ming Luo.
来源: Chest. 2018年153卷5期1116-1124页
In COPD, functional status is improved by pulmonary rehabilitation (PR) but requires specific facilities. Tai Chi, which combines psychological treatment and physical exercise and requires no special equipment, is widely practiced in China and is becoming increasingly popular in the rest of the world. We hypothesized that Tai Chi is equivalent (ie, difference less than ±4 St. George's Respiratory Questionnaire [SGRQ] points) to PR.
211. A Pilot Feasibility Study in Establishing the Role of Ultrasound-Guided Pleural Biopsies in Pleural Infection (The AUDIO Study).
作者: Ioannis Psallidas.;Nikolaos I Kanellakis.;Rahul Bhatnagar.;Rahul Ravindran.;Ahmed Yousuf.;Anthony J Edey.;Rachel M Mercer.;John P Corcoran.;Robert J Hallifax.;Rachelle Asciak.;Prashanth Shetty.;Tao Dong.;Hania E G Piotrowska.;Colin Clelland.;Nick A Maskell.;Najib M Rahman.
来源: Chest. 2018年154卷4期766-772页
Pleural infection is a common complication of pneumonia associated with high mortality and poor clinical outcome. Treatment of pleural infection relies on the use of broad-spectrum antibiotics because reliable pathogen identification occurs infrequently. We performed a feasibility interventional clinical study assessing the safety and significance of ultrasound (US)-guided pleural biopsy culture to increase microbiological yield. In an exploratory investigation, the 16S ribosomal RNA technique was applied to assess its utility on increasing speed and accuracy vs standard microbiological diagnosis.
212. Vitamin C Pharmacokinetics in Critically Ill Patients: A Randomized Trial of Four IV Regimens.
作者: Harm-Jan de Grooth.;Wai-Ping Manubulu-Choo.;Anthe S Zandvliet.;Angélique M E Spoelstra-de Man.;Armand R Girbes.;Eleonora L Swart.;Heleen M Oudemans-van Straaten.
来源: Chest. 2018年153卷6期1368-1377页
Early high-dose IV vitamin C is being investigated as adjuvant therapy in patients who are critically ill, but the optimal dose and infusion method are unclear. The primary aim of this study was to describe the dose-plasma concentration relationship and safety of four different dosing regimens.
213. Management of Low-Risk Pulmonary Embolism Patients Without Hospitalization: The Low-Risk Pulmonary Embolism Prospective Management Study.
作者: Joseph R Bledsoe.;Scott C Woller.;Scott M Stevens.;Valerie Aston.;Rich Patten.;Todd Allen.;Benjamin D Horne.;Lydia Dong.;James Lloyd.;Greg Snow.;Troy Madsen.;C Gregory Elliott.
来源: Chest. 2018年154卷2期249-256页
The efficacy and safety of managing patients with low-risk pulmonary embolism (PE) without hospitalization requires objective data from US medical centers. We sought to determine the 90-day composite rate of recurrent symptomatic VTE, major bleeding events, and all-cause mortality among consecutive patients diagnosed with acute low-risk PE managed without inpatient hospitalization; and to measure patient satisfaction.
214. β-Blockers in COPD: A Cohort Study From the TONADO Research Program.
作者: François Maltais.;Roland Buhl.;Andrea Koch.;Valeria C Amatto.;Jim Reid.;Lars Grönke.;Ulrich Bothner.;Florian Voß.;Lorcan McGarvey.;Gary T Ferguson.
来源: Chest. 2018年153卷6期1315-1325页
Cardiovascular disease is a frequent comorbidity in patients with COPD. Many physicians, particularly pulmonologists, are reluctant to use β-adrenoceptor blocking agents (β-blockers) in patients with COPD, despite their proven effectiveness in preventing cardiovascular events.
215. A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma.
作者: Ritesh Agarwal.;Sahajal Dhooria.;Inderpaul Singh Sehgal.;Ashutosh N Aggarwal.;Mandeep Garg.;Biman Saikia.;Digambar Behera.;Arunaloke Chakrabarti.
来源: Chest. 2018年153卷3期656-664页
Whether itraconazole monotherapy is effective in the acute stage of allergic bronchopulmonary aspergillosis (ABPA) remains unknown. The goal of this study was to compare the efficacy and safety of itraconazole and prednisolone monotherapy in ABPA.
216. The Impact of Listening to Music During a High-Intensity Exercise Endurance Test in People With COPD.
作者: Annemarie L Lee.;Thomas E Dolmage.;Matthew Rhim.;Roger S Goldstein.;Dina Brooks.
来源: Chest. 2018年153卷5期1134-1141页
In people with COPD, dyspnea is the primary symptom limiting exercise tolerance. One approach to reducing dyspnea during exercise is through music listening. A constant speed endurance test reflects a high-intensity aerobic exercise training session, but whether listening to music affects endurance time is unknown. This study aimed to determine the effects of listening to music during a constant speed endurance test in COPD.
217. Impact of a Non-small Cell Lung Cancer Educational Program for Interdisciplinary Teams.
作者: Septimiu Murgu.;Robb Rabito.;Greg Lasko.;Chad Jackson.;Mari Mino-Kenudson.;David S Ettinger.;Suresh S Ramalingam.;Eric S Edell.; .
来源: Chest. 2018年153卷4期876-887页
Successful implementation of non-small cell lung cancer (NSCLC) evidence-based guideline recommendations requires effective educational programs that target all clinicians from interdisciplinary teams. This study describes and evaluates the Engaging an Interdisciplinary Team for NSCLC (GAIN 3.0) experiential learning-based educational curriculum.
218. Efficacy of Acupuncture Is Noninferior to Nicotine Replacement Therapy for Tobacco Cessation: Results of a Prospective, Randomized, Active-Controlled Open-Label Trial.
作者: Ying-Ying Wang.;Zhao Liu.;Yuan Wu.;Li Yang.;Lang-Tao Guo.;Hao-Bin Zhang.;Jin-Sheng Yang.; .
来源: Chest. 2018年153卷3期680-688页
We designed and conducted this multicenter randomized active-controlled open-label trial to evaluate the efficacy of acupuncture, auricular point pressing, and nicotine replacement therapy (NRT) on tobacco cessation in the Chinese population.
219. Patient Engagement Using New Technology to Improve Adherence to Positive Airway Pressure Therapy: A Retrospective Analysis.
作者: Atul Malhotra.;Maureen E Crocker.;Leslee Willes.;Colleen Kelly.;Sue Lynch.;Adam V Benjafield.
来源: Chest. 2018年153卷4期843-850页
Sleep apnea has major neurocognitive and cardiovascular and metabolic risks. Treatment of sleep apnea is suboptimal because of variable adherence to existing therapies.
220. A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis.
作者: Ivan O Rosas.;Hilary J Goldberg.;Harold R Collard.;Souheil El-Chemaly.;Kevin Flaherty.;Gary M Hunninghake.;Joseph A Lasky.;David J Lederer.;Roberto Machado.;Fernando J Martinez.;Rie Maurer.;Danielle Teller.;Imre Noth.;Elizabeth Peters.;Ganesh Raghu.;Joe G N Garcia.;Augustine M K Choi.
来源: Chest. 2018年153卷1期94-104页
Preclinical studies have demonstrated that low-dose carbon monoxide (CO) can abrogate experimental lung fibrosis. To test the therapeutic role of inhaled CO, we designed a clinical study in patients with idiopathic pulmonary fibrosis (IPF).
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