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201. Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD: A Randomized Controlled Trial.
作者: Michael I Polkey.;Zhi-Hui Qiu.;Lian Zhou.;Meng-Duo Zhu.;Ying-Xin Wu.;Yong-Yi Chen.;Sheng-Peng Ye.;Yu-Shan He.;Mei Jiang.;Bai-Ting He.;Bhavin Mehta.;Nan-Shan Zhong.;Yuan-Ming Luo.
来源: Chest. 2018年153卷5期1116-1124页
In COPD, functional status is improved by pulmonary rehabilitation (PR) but requires specific facilities. Tai Chi, which combines psychological treatment and physical exercise and requires no special equipment, is widely practiced in China and is becoming increasingly popular in the rest of the world. We hypothesized that Tai Chi is equivalent (ie, difference less than ±4 St. George's Respiratory Questionnaire [SGRQ] points) to PR.
202. A Pilot Feasibility Study in Establishing the Role of Ultrasound-Guided Pleural Biopsies in Pleural Infection (The AUDIO Study).
作者: Ioannis Psallidas.;Nikolaos I Kanellakis.;Rahul Bhatnagar.;Rahul Ravindran.;Ahmed Yousuf.;Anthony J Edey.;Rachel M Mercer.;John P Corcoran.;Robert J Hallifax.;Rachelle Asciak.;Prashanth Shetty.;Tao Dong.;Hania E G Piotrowska.;Colin Clelland.;Nick A Maskell.;Najib M Rahman.
来源: Chest. 2018年154卷4期766-772页
Pleural infection is a common complication of pneumonia associated with high mortality and poor clinical outcome. Treatment of pleural infection relies on the use of broad-spectrum antibiotics because reliable pathogen identification occurs infrequently. We performed a feasibility interventional clinical study assessing the safety and significance of ultrasound (US)-guided pleural biopsy culture to increase microbiological yield. In an exploratory investigation, the 16S ribosomal RNA technique was applied to assess its utility on increasing speed and accuracy vs standard microbiological diagnosis.
203. Vitamin C Pharmacokinetics in Critically Ill Patients: A Randomized Trial of Four IV Regimens.
作者: Harm-Jan de Grooth.;Wai-Ping Manubulu-Choo.;Anthe S Zandvliet.;Angélique M E Spoelstra-de Man.;Armand R Girbes.;Eleonora L Swart.;Heleen M Oudemans-van Straaten.
来源: Chest. 2018年153卷6期1368-1377页
Early high-dose IV vitamin C is being investigated as adjuvant therapy in patients who are critically ill, but the optimal dose and infusion method are unclear. The primary aim of this study was to describe the dose-plasma concentration relationship and safety of four different dosing regimens.
204. Management of Low-Risk Pulmonary Embolism Patients Without Hospitalization: The Low-Risk Pulmonary Embolism Prospective Management Study.
作者: Joseph R Bledsoe.;Scott C Woller.;Scott M Stevens.;Valerie Aston.;Rich Patten.;Todd Allen.;Benjamin D Horne.;Lydia Dong.;James Lloyd.;Greg Snow.;Troy Madsen.;C Gregory Elliott.
来源: Chest. 2018年154卷2期249-256页
The efficacy and safety of managing patients with low-risk pulmonary embolism (PE) without hospitalization requires objective data from US medical centers. We sought to determine the 90-day composite rate of recurrent symptomatic VTE, major bleeding events, and all-cause mortality among consecutive patients diagnosed with acute low-risk PE managed without inpatient hospitalization; and to measure patient satisfaction.
205. β-Blockers in COPD: A Cohort Study From the TONADO Research Program.
作者: François Maltais.;Roland Buhl.;Andrea Koch.;Valeria C Amatto.;Jim Reid.;Lars Grönke.;Ulrich Bothner.;Florian Voß.;Lorcan McGarvey.;Gary T Ferguson.
来源: Chest. 2018年153卷6期1315-1325页
Cardiovascular disease is a frequent comorbidity in patients with COPD. Many physicians, particularly pulmonologists, are reluctant to use β-adrenoceptor blocking agents (β-blockers) in patients with COPD, despite their proven effectiveness in preventing cardiovascular events.
206. A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma.
作者: Ritesh Agarwal.;Sahajal Dhooria.;Inderpaul Singh Sehgal.;Ashutosh N Aggarwal.;Mandeep Garg.;Biman Saikia.;Digambar Behera.;Arunaloke Chakrabarti.
来源: Chest. 2018年153卷3期656-664页
Whether itraconazole monotherapy is effective in the acute stage of allergic bronchopulmonary aspergillosis (ABPA) remains unknown. The goal of this study was to compare the efficacy and safety of itraconazole and prednisolone monotherapy in ABPA.
207. The Impact of Listening to Music During a High-Intensity Exercise Endurance Test in People With COPD.
作者: Annemarie L Lee.;Thomas E Dolmage.;Matthew Rhim.;Roger S Goldstein.;Dina Brooks.
来源: Chest. 2018年153卷5期1134-1141页
In people with COPD, dyspnea is the primary symptom limiting exercise tolerance. One approach to reducing dyspnea during exercise is through music listening. A constant speed endurance test reflects a high-intensity aerobic exercise training session, but whether listening to music affects endurance time is unknown. This study aimed to determine the effects of listening to music during a constant speed endurance test in COPD.
208. Impact of a Non-small Cell Lung Cancer Educational Program for Interdisciplinary Teams.
作者: Septimiu Murgu.;Robb Rabito.;Greg Lasko.;Chad Jackson.;Mari Mino-Kenudson.;David S Ettinger.;Suresh S Ramalingam.;Eric S Edell.; .
来源: Chest. 2018年153卷4期876-887页
Successful implementation of non-small cell lung cancer (NSCLC) evidence-based guideline recommendations requires effective educational programs that target all clinicians from interdisciplinary teams. This study describes and evaluates the Engaging an Interdisciplinary Team for NSCLC (GAIN 3.0) experiential learning-based educational curriculum.
209. Efficacy of Acupuncture Is Noninferior to Nicotine Replacement Therapy for Tobacco Cessation: Results of a Prospective, Randomized, Active-Controlled Open-Label Trial.
作者: Ying-Ying Wang.;Zhao Liu.;Yuan Wu.;Li Yang.;Lang-Tao Guo.;Hao-Bin Zhang.;Jin-Sheng Yang.; .
来源: Chest. 2018年153卷3期680-688页
We designed and conducted this multicenter randomized active-controlled open-label trial to evaluate the efficacy of acupuncture, auricular point pressing, and nicotine replacement therapy (NRT) on tobacco cessation in the Chinese population.
210. Patient Engagement Using New Technology to Improve Adherence to Positive Airway Pressure Therapy: A Retrospective Analysis.
作者: Atul Malhotra.;Maureen E Crocker.;Leslee Willes.;Colleen Kelly.;Sue Lynch.;Adam V Benjafield.
来源: Chest. 2018年153卷4期843-850页
Sleep apnea has major neurocognitive and cardiovascular and metabolic risks. Treatment of sleep apnea is suboptimal because of variable adherence to existing therapies.
211. A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis.
作者: Ivan O Rosas.;Hilary J Goldberg.;Harold R Collard.;Souheil El-Chemaly.;Kevin Flaherty.;Gary M Hunninghake.;Joseph A Lasky.;David J Lederer.;Roberto Machado.;Fernando J Martinez.;Rie Maurer.;Danielle Teller.;Imre Noth.;Elizabeth Peters.;Ganesh Raghu.;Joe G N Garcia.;Augustine M K Choi.
来源: Chest. 2018年153卷1期94-104页
Preclinical studies have demonstrated that low-dose carbon monoxide (CO) can abrogate experimental lung fibrosis. To test the therapeutic role of inhaled CO, we designed a clinical study in patients with idiopathic pulmonary fibrosis (IPF).
212. Methacholine Challenge Testing: A Novel Method for Measuring PD20.
作者: Beth E Davis.;Samuel K Simonson.;Christianne M Blais.;Donald W Cockcroft.
来源: Chest. 2017年152卷6期1251-1257页
New guidelines for methacholine challenge testing recommend reporting the test outcome as dose rather than concentration. Jet nebulizers have historically been used for methacholine challenge testing, but much of the weight loss, often (incorrectly) referred to as aerosol output, is actually evaporation. The Wright nebulizer is well characterized and still widely used, but its availability is unclear, and it is nondisposable. We developed a novel method using a vibrating mesh nebulizer (Solo). This method was compared with the standard 2-min tidal breathing method using the Wright nebulizer. Repeatability within and between nebulizers was also tested.
213. A Multicenter Randomized Trial of a Checklist for Endotracheal Intubation of Critically Ill Adults.
作者: David R Janz.;Matthew W Semler.;Aaron M Joffe.;Jonathan D Casey.;Robert J Lentz.;Bennett P deBoisblanc.;Yasin A Khan.;Jairo I Santanilla.;Itay Bentov.;Todd W Rice.; .; .
来源: Chest. 2018年153卷4期816-824页
Hypoxemia and hypotension are common complications during endotracheal intubation of critically ill adults. Verbal performance of a written, preintubation checklist may prevent these complications. We compared a written, verbally performed, preintubation checklist with usual care regarding lowest arterial oxygen saturation or lowest systolic BP experienced by critically ill adults undergoing endotracheal intubation.
214. Clinical Impact of Asymptomatic Presentation Status in Patients With Paroxysmal and Sustained Atrial Fibrillation: The Fushimi AF Registry.
作者: Masahiro Esato.;Yeong-Hwa Chun.;Yoshimori An.;Hisashi Ogawa.;Hiromichi Wada.;Koji Hasegawa.;Hikari Tsuji.;Mitsuru Abe.;Gregory Y H Lip.;Masaharu Akao.
来源: Chest. 2017年152卷6期1266-1275页
The clinical characteristics and outcomes of asymptomatic patients with paroxysmal or persistent/permanent atrial fibrillation (AF) are largely unknown.
215. Baseline Symptom Score Impact on Benefits of Glycopyrrolate/Formoterol Metered Dose Inhaler in COPD.
作者: Fernando J Martinez.;Leonardo M Fabbri.;Gary T Ferguson.;Chad Orevillo.;Patrick Darken.;Ubaldo J Martin.;Colin Reisner.
来源: Chest. 2017年152卷6期1169-1178页
The clinical severity of COPD is currently categorized by symptom burden and exacerbation risk. Previous 24-week phase III trials (NCT01854645 and NCT01854658) that demonstrated better improvement of lung function with glycopyrrolate/formoterol fumarate (GFF) metered dose inhaler (MDI) (an MDI fixed-dose of GFF 18/9.6 μg) over individual monocomponent MDIs included a cross-section of patients with moderate to very severe airflow limitation and a broad range of COPD symptoms.
216. Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations.
作者: Khalid Alansari.;Bruce L Davidson.;Khalid Ibrahim Yousef.;Abdel Nasser H Mohamed.;Imad Alattar.
来源: Chest. 2017年152卷3期527-536页
Whether vitamin D reduces clinically important exacerbations of childhood asthma remains uncertain. We compared rapid to maintenance vitamin D repletion analyzed by baseline vitamin D level.
217. Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker.
作者: Elliott D Crouser.;Joseph E Parrillo.;Christopher Seymour.;Derek C Angus.;Keri Bicking.;Liliana Tejidor.;Robert Magari.;Diana Careaga.;JoAnna Williams.;Douglas R Closser.;Michael Samoszuk.;Luke Herren.;Emily Robart.;Fernando Chaves.
来源: Chest. 2017年152卷3期518-526页
Sepsis most often presents to the ED, and delayed detection is harmful. WBC count is often used to detect sepsis, but changes in WBC count size also correspond to sepsis. We sought to determine if volume increases of circulating immune cells add value to the WBC count for early sepsis detection in the ED.
218. Totally Implantable IV Treprostinil Therapy in Pulmonary Hypertension Assessment of the Implantation Procedure.
作者: Aaron B Waxman.;Hugh T McElderry.;Mardi Gomberg-Maitland.;Martin C Burke.;Edgar L Ross.;Malcolm M Bersohn.;Sanjog S Pangarkar.;James H Tarver.;Diane L Zwicke.;Jeremy P Feldman.;Murali M Chakinala.;Robert P Frantz.;Geoffrey B Thompson.;Fernando Torres.;Richard L Rauck.;Kathy Clagg.;Louise Durst.;Pei Li.;Marty Morris.;Kara L Southall.;Leigh Peterson.;Robert C Bourge.
来源: Chest. 2017年152卷6期1128-1134页
Prostacyclins improve symptoms and survival in pulmonary arterial hypertension (PAH). In response to risks associated with external delivery systems, an implantable IV infusion system was developed. A multicenter, prospective, single-arm, clinical trial (DelIVery for PAH) was conducted to evaluate this system for treprostinil in PAH. This analysis describes the findings related to the implant procedure.
219. A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa: A Proof of Concept Study.
作者: Pallavi Bedi.;James D Chalmers.;Catriona Graham.;Andrea Clarke.;Samantha Donaldson.;Catherine Doherty.;John R W Govan.;Donald J Davidson.;Adriano G Rossi.;Adam T Hill.
来源: Chest. 2017年152卷2期368-378页
There are no randomized controlled trials of statin therapy in patients with severe bronchiectasis who are chronically infected with Pseudomonas aeruginosa.
220. Effects of Pulmonary Rehabilitation on Exacerbation Number and Severity in People With COPD: An Historical Cohort Study Using Electronic Health Records.
作者: Elizabeth Moore.;Roger Newson.;Miland Joshi.;Thomas Palmer.;Kieran J Rothnie.;Sally Singh.;Azeem Majeed.;Michael Soljak.;Jennifer K Quint.
来源: Chest. 2017年152卷6期1188-1202页
In previous systematic reviews (predominantly of randomized controlled trials), pulmonary rehabilitation (PR) has been shown to reduce hospital admissions for acute exacerbations of COPD (AECOPD). However, findings have been less consistent for cohort studies. The goal of this study was to compare rates of hospitalized and general practice (GP)-treated AECOPD prior to and following PR.
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