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2162. In asymptomatic adults, a COVID-19 Ag-RDT with combined nasal and throat samples had 82% to 89% positive percent agreement.
Goodall BL, LeBlanc JJ, Hatchette TF, et al. Investigating the sensitivity of nasal or throat swabs: combination of both swabs increases the sensitivity of SARS-CoV-2 rapid antigen tests. Microbiol Spectr. 2022;10:e0021722 35762772.
2163. In hospitalized adults with fever, fever therapy does not reduce mortality or serious adverse events.
Holgersson J, Ceric A, Sethi N, et al. Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses. BMJ. 2022;378:e069620. 35820685.
2164. Challenged Urine Bicarbonate Excretion as a Measure of Cystic Fibrosis Transmembrane Conductance Regulator Function in Cystic Fibrosis.
作者: Peder Berg.;Mads V Sorensen.;Amalie Quist Rousing.;Hanne Vebert Olesen.;Søren Jensen-Fangel.;Majbritt Jeppesen.;Jens Leipziger.
来源: Ann Intern Med. 2022年175卷11期1543-1551页
In cystic fibrosis (CF), renal base excretion is impaired. Accordingly, challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function.
2165. In adults using oral anticoagulants, PPI use may be associated with lower risk for upper GI bleeding.
Kurlander JE, Barnes GD, Fisher A, et al. Association of antisecretory drugs with upper gastrointestinal bleeding in patients using oral anticoagulants: a systematic review and meta-analysis. Am J Med. 2022;135:1231-43.e8. 35679879.
2167. In degenerative meniscal tears, PT was noninferior to arthroscopic partial meniscectomy for knee function at 5 y.
Noorduyn JCA, van de Graaf VA, Willigenburg NW, et al. Effect of physical therapy vs arthroscopic partial meniscectomy in people with degenerative meniscal tears: five-year follow-up of the ESCAPE randomized clinical trial. JAMA Netw Open. 2022;5:e2220394. 35802374.
2169. Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study.
Low vitamin D status is associated with increased mortality, but randomized trials on severely deficient participants are lacking.
2171. Safety and Immunogenicity of Intradermal Fractional Dose Administration of the mRNA-1273 Vaccine: A Proof-of-Concept Study.
作者: Geert V T Roozen.;Margaretha L M Prins.;Rob van Binnendijk.;Gerco den Hartog.;Vincent P Kuiper.;Corine Prins.;Jacqueline J Janse.;Annelieke C Kruithof.;Mariet C W Feltkamp.;Marjan Kuijer.;Frits R Rosendaal.;Meta Roestenberg.;Leo G Visser.;Anna H E Roukens.
来源: Ann Intern Med. 2022年175卷12期1771-1774页 2173. Environmental Health: A Position Paper From the American College of Physicians.
Environmental health refers to the health effects associated with environmental factors, such as air pollution, water contamination, and climate change. Environmental hazards are associated with poor outcomes in common diseases, including diabetes and heart disease. In this position paper, the American College of Physicians (ACP) seeks to inform physicians about environmental health and offers policymakers recommendations to reduce the adverse health consequences of climate change, improve air and water quality, reduce exposure to toxic substances, and address environmental injustice. ACP affirms that all communities, including people of color, people with low income, and marginalized populations, deserve to live in a healthy environment.
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