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2141. Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis: A Randomized Controlled Trial.
作者: Andrew J Goldberg.;Kashfia Chowdhury.;Ekaterina Bordea.;Iva Hauptmannova.;James Blackstone.;Deirdre Brooking.;Elizabeth L Deane.;Stephen Bendall.;Andrew Bing.;Chris Blundell.;Sunil Dhar.;Andrew Molloy.;Steve Milner.;Mike Karski.;Steve Hepple.;Malik Siddique.;David T Loveday.;Viren Mishra.;Paul Cooke.;Paul Halliwell.;David Townshend.;Simon S Skene.;Caroline J Doré.; .;Rick Brown.;Michael Butler.;Carolyn Chadwick.;Tim Clough.;Nick Cullen.;Mark Davies.;Howard Davies.;Bill Harries.;Michael Khoo.;Nilesh Makwana.;An Murty.;Ali Najefi.;Paul O'Donnell.;Martin Raglan.;Rhys Thomas.;Paulo Torres.;Matthew Welck.;Ian Winson.;Razi Zaidi.
来源: Ann Intern Med. 2022年175卷12期1648-1657页
End-stage ankle osteoarthritis causes severe pain and disability. There are no randomized trials comparing the 2 main surgical treatments: total ankle replacement (TAR) and ankle fusion (AF).
2145. Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial.
作者: Michael Camilleri.;Thyagarajan Subramanian.;Fernando Pagan.;Stuart Isaacson.;Ramon Gil.;Robert A Hauser.;Mary Feldman.;Mark Goldstein.;Rajeev Kumar.;Daniel Truong.;Nisha Chhabria.;Benjamin L Walter.;Jonathan Eskenazi.;Robert Riesenberg.;Daniel Burdick.;Winona Tse.;Eric Molho.;Bradley Robottom.;Perminder Bhatia.;Srinath Kadimi.;Kevin Klos.;David Shprecher.;Otto Marquez-Mendoza.;Gonzalo Hidalgo.;Stephen Grill.;George Li.;Howard Mandell.;Mary Hughes.;Sharisse Stephenson.;Joel Vandersluis.;Michael Pfeffer.;Andrew Duker.;Vikram Shivkumar.;William Kinney.;James MacDougall.;Michael Zasloff.;Denise Barbut.
来源: Ann Intern Med. 2022年175卷12期1666-1674页
Parkinson disease (PD) is associated with α-synuclein (αS) aggregation within enteric neurons. ENT-01 inhibits the formation of αS aggregates and improved constipation in an open-label study in patients with PD.
2146. Contact Tracing and Exposure Investigation in Response to the First Case of Monkeypox Virus Infection in the United States During the 2022 Global Monkeypox Outbreak.
作者: Erica S Shenoy.;Sharon B Wright.;Deborah N Barbeau.;Lisa A Foster.;Aleah D King.;Patrick S Gordon.;Preeti Mehrotra.;Dana E Pepe.;Daniel A Caroff.;Lindsey R Kim.;Shannon E McGrath.;Amy Courtney.;Meredith Fahy.;David C Hooper.;Kaitlin Macdonald.;Eileen F Searle.;Jennifer A Shearer.;Kimon C Zachary.;Lindsay Bouton.;Melissa Cumming.;Brandi Hopkins.;Juliana Jacoboski.;Erin Mann.;Matthew Osborne.;Carley Perez.;Jordan Schultz.;Sarah Scotland.;Elizabeth Traphagen.;Lawrence C Madoff.;Catherine M Brown.
来源: Ann Intern Med. 2022年175卷12期1639-1647页
In May 2022, the first case of monkeypox virus (MPXV) infection in the United States in the current global outbreak was identified. As part of the public health and health care facility response, a contact tracing and exposure investigation was done.
2147. Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations : A Randomized, Multicenter Trial.
作者: Jeff S Healey.;Andrew D Krahn.;Jamil Bashir.;Guy Amit.;François Philippon.;William F McIntyre.;Bernice Tsang.;Jacqueline Joza.;Derek V Exner.;David H Birnie.;Mouhannad Sadek.;Darryl P Leong.;Markus Sikkel.;Victoria Korley.;John L Sapp.;Jean-Francois Roux.;Shun Fu Lee.;Gloria Wong.;Angie Djuric.;Danna Spears.;Sandra Carroll.;Eugene Crystal.;Tom Hruczkowski.;Stuart J Connolly.;Blandine Mondesert.; .
来源: Ann Intern Med. 2022年175卷12期1658-1665页
Implantable cardioverter defibrillators (ICDs) improve survival in patients at risk for cardiac arrest, but are associated with intravascular lead-related complications. The subcutaneous ICD (S-ICD), with no intravascular components, was developed to minimize lead-related complications.
2149. Preoperative Evaluation for Noncardiac Surgery.
The previous In the Clinic that addressed preoperative evaluation for noncardiac surgery was published in December 2016. This update reaffirms much of the information in the previous version and provides new information that has accumulated since then. The goal of preoperative assessment is to identify the risk for postoperative complications so health care teams can more fully understand how to implement strategies to mitigate risks before and after the operation.
2150. Characteristics of High-Need, High-Cost Patients : A "Best-Fit" Framework Synthesis.
作者: Nancy D Berkman.;Eva Chang.;Julie Seibert.;Rania Ali.
来源: Ann Intern Med. 2022年175卷12期1728-1741页
Accurately identifying high-need, high-cost (HNHC) patients to reduce their preventable or modifiable health care use for their chronic conditions is a priority and a challenge for U.S. policymakers, health care delivery systems, and payers.
2151. Recommendations for pharmacologic management of IBS with constipation.
Chang L, Sultan S, Lembo A, et al. AGA clinical practice guideline on the pharmacological management of irritable bowel syndrome with constipation. Gastroenterology. 2022;163:118-36. 35738724.
2153. In ASCVD, moderate-intensity statin + ezetimibe was noninferior to high-intensity statin alone at 3 y.
Kim BK, Hong SJ, Lee YJ, et al. Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial. Lancet. 202;400:380-90. 35863366.
2154. In acute ischemic stroke, thrombectomy was not noninferior to alteplase + thrombectomy for 90-d functional independence.
Fischer U, Kaesmacher J, Strbian D, et al. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial. Lancet. 2022;400:104-15. 35810756.
2155. Recommendations for pharmacologic management of IBS with diarrhea.
Lembo A, Sultan S, Chang L, et al. AGA clinical practice guideline on the pharmacological management of irritable bowel syndrome with diarrhea. Gastroenterology. 2022;163:137-51. 35738725.
2156. In acutely ill inpatients, benefits and harms of anticoagulants for VTE prophylaxis were assessed.
Eck RJ, Elling T, Sutton AJ, et al. Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital: systematic review and network meta-analysis. BMJ. 2022;378:e070022. 35788047.
2158. Comparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation : A Multinational Population-Based Cohort Study.
作者: Wallis C Y Lau.;Carmen Olga Torre.;Kenneth K C Man.;Henry Morgan Stewart.;Sarah Seager.;Mui Van Zandt.;Christian Reich.;Jing Li.;Jack Brewster.;Gregory Y H Lip.;Aroon D Hingorani.;Li Wei.;Ian C K Wong.
来源: Ann Intern Med. 2022年175卷11期1515-1524页
Current guidelines recommend using direct oral anticoagulants (DOACs) over warfarin in patients with atrial fibrillation (AF), but head-to-head trial data do not exist to guide the choice of DOAC.
2159. Ticagrelor-Aspirin Versus Clopidogrel-Aspirin Among CYP2C19 Loss-of-Function Carriers With Minor Stroke or Transient Ischemic Attack in Relation to Renal Function: A Post Hoc Analysis of the CHANCE-2 Trial.
作者: Anxin Wang.;Xuewei Xie.;Xue Tian.;S Claiborne Johnston.;Hao Li.;Philip M Bath.;Yingting Zuo.;Jing Jing.;Jinxi Lin.;Yilong Wang.;Xingquan Zhao.;Zixiao Li.;Yong Jiang.;Liping Liu.;Xia Meng.;Yongjun Wang.
来源: Ann Intern Med. 2022年175卷11期1534-1542页
Evidence on the risk-benefit ratio of dual antiplatelet therapies among patients with stroke and impaired renal function is limited and inconsistent.
2160. In acute ischemic stroke, early IV tenecteplase was noninferior to alteplase for excellent functional outcome.
Menon BK, Buck BH, Singh N, et al. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial. Lancet. 2022;400:161-9. 35779553.
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