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2001. A 17-Year-Old Girl Diagnosed With STING-Associated Vasculopathy With Onset in Infancy (SAVI) After Lung Transplantation.
A 17-year-old girl received lung transplantation after chronic respiratory failure. She developed a fever (> 38 °C) once or twice weekly starting 2 months after surgery, and multiple papulopustules on the skin waxed and waned for 4 months. She then developed blood-tinged sputum. She had been treated with triple immunosuppressants, including prednisolone, tacrolimus, and mycophenolate mofetil after lung transplantation, and her symptoms appeared during prednisolone dose reduction.
2002. A Case of Thrombotic Microangiopathy and Acute Sarcoidosis.
作者: Anthony W Martinelli.;William Dunn.;Mark E McClure.;Ieuan Walker.;Andrew Stewart.;Sumit Karia.;Stephen D Preston.;Sathia Thiru.;Nicholas Torpey.;Sanjay Ojha.;Emily Symington.;James A Nathan.
来源: Chest. 2022年162卷5期e245-e248页
Although sarcoidosis is an established cause of multiorgan dysfunction, acute presentation with thrombotic microangiopathy resulting in severe renal and hematological sequelae has not been reported. We describe the case of a patient presenting with hypercalcemia, pancreatitis, and acute renal failure, followed by microangiopathic hemolytic anemia. Although there were no significant respiratory symptoms, thoracic radiology and mediastinal lymph node biopsy results were in keeping with sarcoidosis as the underlying cause of this multisystem presentation. Corticosteroids were commenced with clinical and biochemical improvement. This novel case highlights the need to consider sarcoidosis as part of the differential diagnosis for unusual multiorgan presentations and for early multidisciplinary involvement in such cases to permit optimal treatment.
2019. Prevalence and Predictors of Sleep-Disordered Breathing in Men Participating in the Multicenter AIDS Cohort Study.
作者: Naresh M Punjabi.;Todd T Brown.;R Nisha Aurora.;Sanjay R Patel.;Valentina Stosor.;Joshua Hyong-Jin Cho.;Gypsyamber D'Souza.;Joseph B Margolick.
来源: Chest. 2023年163卷3期687-696页
Data on the prevalence of sleep-disordered breathing (SDB) in people with HIV are limited. Moreover, whether the associations between SDB and age or BMI differ by HIV status is unknown.
2020. Clinical Implications of Low Absolute Blood Eosinophil Count in the SPIROMICS COPD Cohort.
作者: W Blake LeMaster.;P Miguel Quibrera.;David Couper.;Donald P Tashkin.;Eugene R Bleecker.;Claire M Doerschuk.;Victor E Ortega.;Christopher Cooper.;MeiLan K Han.;Prescott G Woodruff.;Wanda K O'Neal.;Wayne H Anderson.;Neil E Alexis.;Russell P Bowler.;R Graham Barr.;Robert J Kaner.;Mark T Dransfield.;Robert Paine.;Victor Kim.;Jeffrey L Curtis.;Fernando J Martinez.;Annette T Hastie.;Igor Barjaktarevic.
来源: Chest. 2023年163卷3期515-528页
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) considers blood eosinophil counts < 100 cells/μL (BEC≤100) in people with COPD to predict poor inhaled corticosteroid (ICS) responsiveness. However, the BEC≤100 phenotype is inadequately characterized, especially in advanced COPD.
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