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182. The association between modified cardiometabolic index with non-alcoholic fatty liver disease and liver fibrosis: a cross-sectional study.
Cardiometabolic index (CMI) was proposed ten years ago as an indicator combining obesity and dyslipidemia. This study aimed to investigate the relationships between newly modified CMI (MCMI) with non-alcoholic fatty liver disease (NAFLD) and liver fibrosis.
183. Cost-effectiveness of NALIRIFOX versus Nab-paclitaxel and gemcitabine in previously untreated metastatic pancreatic ductal adenocarcinoma.
作者: Wenjie Liu.;Yuting Fang.;Chao Zhang.;Midan Xiang.;Lijuan Qi.;Aijiang Su.;Yongkun Sun.
来源: BMC Gastroenterol. 2025年25卷1期266页
The NAPOLI 3 trial demonstrated that compared to the nab-paclitaxel and gemcitabine (GemNab) regimen, the NALIRIFOX (5-fluorouracil, leucovorin, liposomal irinotecan, oxaliplatin) regimen can significantly improve patients' overall survival (OS) and progression-free survival (PFS), and the safety of this regimen is generally controllable. To ensure the appropriateness of the chosen treatment, economic evaluation is essential. Thus, from the perspective of American healthcare systems, we explored the cost-effectiveness comparison between NALIRIFOX or GemNab in treating patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) who had not previously received treatment.
184. MAFLD mediates the association between CHR and gallstones in the U.S. adults: evidence from NHANES 2021-2023.
作者: Xin Feng.;Xiangyu Song.;Xi'an Yang.;Fuxiang Luan.;Yufei Gu.;Fengyu Zheng.;Huahu Guo.;Shishi Qiao.
来源: BMC Gastroenterol. 2025年25卷1期268页
Gallstones, a global hepatobiliary disorder, are linked to systemic inflammation, lipid disturbances, and metabolic-associated fatty liver disease (MAFLD). This population-based study aims to investigate the association of the novel inflammation-lipid composite biomarker high-sensitivity C-reactive protein-to-HDL cholesterol ratio (CHR) with gallstones and evaluate whether MAFLD mediates this relationship.
185. A nomogram to predict pulmonary complications after gastrointestinal surgery: a retrospective study.
We aimed at developing a nomogram able to predict postoperative pulmonary complications (PPC) after gastrointestinal surgery.
186. Dynamic variations in peripheral blood indices and their association with efficacy and adverse reactions of pd- 1 inhibitor combined chemotherapy in patients with advanced gastric cancer.
作者: Rui Wang.;Huihui Zeng.;Mengting Shi.;Yue Wu.;Yang Liu.;Tiantian Zhang.
来源: BMC Gastroenterol. 2025年25卷1期264页
Gastric cancer (GC) continues to pose a significant global health challenge, particularly in advanced stages where treatment options are severely constrained. Immunotherapy represents a groundbreaking advancement in cancer treatment, exhibiting promising therapeutic effects in patients diagnosed with gastric cancer. However, the efficacy of immunotherapy is not universally applicable to all individuals. Revealing precise biomarkers for tumor immunotherapy as targets or indicators for detection and evaluation can facilitate the resolution of this predicament. This study aims to identify serum tumor markers and blood cell ratios as predictive biomarkers to aid in the selection of gastric cancer patients who may benefit from PD-1 inhibitors therapy.
187. Endo-loop or interrupted suture closure of gallbladder remnant during laparoscopic subtotal cholecystectomy- a retrospective analysis of our experience at a high-volume centre of Eastern Nepal.
作者: Abhijeet Kumar.;Bhawani Khanal Designation.;Bikash Kumar Sah.;Parbat Raj Regmi.;Rakesh Kumar Gupta.;Suresh Prasad Sah.
来源: BMC Gastroenterol. 2025年25卷1期262页
Subtotal laparoscopic cholecystectomy (LSC) is a rescue procedure in difficult case, retaining all advantages of minimally invasive surgery. The most reputed definition of subtotal cholecystectomy is the removal of 3/4th of gallbladder with closure of the infundibulum. The closure of the infundibulum can be with either intracorporeal interrupted suture or pre-knotted endo-loop. This study aims to share our experience with the stump closure techniques (either interrupted suture closure or endo-loop closure) during LSC so that the result of the study helps surgeons to choose an appropriate technique of the stump closure.
188. Comparative analysis of β-Estradiol and testosterone on lipid droplet accumulation, and regulatory protein expression in palmitate/oleate-induced fatty HepG2 cells.
作者: Motahare-Sadat Hosseini.;Fereshteh Barjesteh.;Fereshteh Azedi.;Iraj Alipourfard.;Zahra Rezaei.;Elham Bahreini.
来源: BMC Gastroenterol. 2025年25卷1期263页
The higher prevalence of non-alcoholic fatty liver disease (NAFLD) in men than women before menopause and the reduced difference post-menopause suggest that sex hormones may influence liver lipid accumulation. This study compared the effects of sex hormones on lipid droplet (LD) accumulation in palmitate/ oleate-treated HepG2 cells.
189. Frequency of insulin resistance among non-diabetic patients with non-alcoholic fatty liver disease using HOMA-IR: an experience of a tertiary care hospital in Karachi, Pakistan.
Non-alcoholic fatty liver disease (NAFLD) is a global problem strongly interlinked with metabolic syndrome. Insulin resistance (IR) is a key factor both in pathogenesis and in the progression to liver fibrosis. This article highlights the frequency of IR in local population.
190. Analysis of the distribution characteristics of infecting microorganisms in the wound tissue of patients with perianal abscess combined with infection and the influencing factors of wound healing.
This study aimed to analyze the distribution characteristics of infecting microorganisms in the wound tissue of patients with perianal abscess and infection, as well as to identify factors affecting wound healing.
191. Development and verification of a radiomics model to forecast Ki67 index and prognosis in advanced gastric tubular adenocarcinoma.
作者: Jiatong Lu.;Yong Xiao.;Qiushuang Wang.;Fangfang Chen.;Zhi Zeng.;Junfeng Yan.;Qiang Li.;Qiang Tong.
来源: BMC Gastroenterol. 2025年25卷1期260页
The purpose of this research is to evaluate the predictive capabilities of a radiomics model for the Ki67 index and its correlation with prognosis in advanced gastric tubular adenocarcinoma patients.
192. Association of ultrasound signs of sarcopenia with serum ferritin levels and hepatic indices like NFS and FIB-4 in NAFLD patients.
作者: Bahar Arasteh.;Sina Hamzehzadeh.;Kia Seyed Toutounchi.;Zeinab Nikniaz.;Leila Amini.;Leila Alizadeh.
来源: BMC Gastroenterol. 2025年25卷1期261页
Non-alcoholic fatty liver disease is one of the most common chronic diseases all around the world, which significantly correlates with metabolic disorders and inflammatory cycles. Sarcopenia is a decrease in the mass of skeletal muscles interacting with factors such as inflammatory processes and chronic diseases. It can also lead to the aggravation of chronic diseases.
193. A nomogram for prognostic prediction and for therapeutic decision making of elderly HCC patients.
作者: Shuyu Liu.;Mengyue Zhou.;Peng Chen.;Xueting Deng.;Jiayi Gu.;Lin Miao.
来源: BMC Gastroenterol. 2025年25卷1期257页
Hepatocellular carcinoma (HCC) has a poor prognosis, especially in elderly HCC patients. A growing number of studies have confirmed that nomogram based on demographic information, pathologic information, and treatment modalities are effective in predicting the prognosis of cancer patients. We aimed to develop an individualized and clinically useful nomogram for elderly patients.We also aimed to investigate the prognostic significance of different treatment modalities.
194. Application effect of standardized nursing process of abdominal drainage tube in cholelithiasis: a single-center retrospective cohort study.
作者: Wenhui Shi.;Yan Huang.;Zipeng Xu.;Xinyi Huang.;Genxi Tong.;Jiamei Lin.;Yanan Zhou.;Qinyan Yang.;Chaobo Chen.
来源: BMC Gastroenterol. 2025年25卷1期253页
and aims: Although abdominal drainage tubes have been widely used to treat cholelithiasis, complications still affect patients' prognoses. There is no Standardized Nursing Process (SNP) for abdominal drainage tubes after Laparoscopic cholecystectomy (LC). This study aims to observe the clinical efficacy and explore the feasibility of SNP intervention for abdominal drainage tubes in cholelithiasis patients after LC.
195. Machine learning-based disease risk stratification and prediction of metabolic dysfunction-associated fatty liver disease using vibration-controlled transient elastography: Result from NHANES 2021-2023.
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common chronic liver disease and represents a significant public health issue. Nevertheless, current risk stratification methods remain inadequate. The study aimed to use machine learning in the identification of significant features and the development of a predictive model to determine its usefulness in discrimination of MAFLD's risk stratification (low, moderate, and high) in adults.
196. Comprehensive analysis of glycometabolism-related genes reveals PLOD2 as a prognostic biomarker and therapeutic target in gastric cancer.
作者: Wanchun Ye.;Xiaolei Zhang.;Zhongjie Tang.;Yufeng Hu.;Yuanliang Zheng.;Yuping Yuan.
来源: BMC Gastroenterol. 2025年25卷1期256页
Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide, with limited therapeutic options and a poor prognosis, particularly in advanced stages. Glycometabolism, a hallmark of cancer, plays a critical role in tumor progression, immune evasion, and response to therapy. However, the specific roles of glycometabolism-related genes and their prognostic and therapeutic implications in GC remain inadequately understood.
197. "Evaluation of hepatobiliary disorders using magnetic resonance cholangiopancreatography in a low-resource setting in Kano, Nigeria: a retrospective study".
作者: Nuraddeen Mukhtar Rabiu.;Abbas Rabiu Muhammad.;Ahmad Bashir Umar.;Sambo-Donga Donzomga.;Ibrahim Umar Garzali.;Suwaid Mohammed Abba.;Anas Ismail.
来源: BMC Gastroenterol. 2025年25卷1期254页
Biliary disorders are a major health concern in Nigeria, where magnetic resonance cholangiopancreatography (MRCP), a non-invasive imaging tool offering effective duct visualization without radiation, is emerging as a key diagnostic modality. This retrospective study in Kano explored its role in diagnosing biliary and pancreatic disorders.
198. Global Consensus Recommendations for Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis.
作者: Zobair M Younossi.;Shira Zelber-Sagi.;Jeffrey V Lazarus.;Vincent Wai-Sun Wong.;Yusuf Yilmaz.;Ajay Duseja.;Yuichiro Eguchi.;Laurent Castera.;Mário Guimarães Pessoa.;Claudia Pinto Oliveira.;Mohamed El-Kassas.;Emmanuel Tsochatzis.;Jian-Gao Fan.;C Wendy Spearman.;Frank Tacke.;Marlen Ivon Castellanos Fernandez.;Naim Alkhouri.;Jörn M Schattenberg.;Manuel Romero-Gómez.;Mazen Noureddin.;Alina M Allen.;Janus P Ong.;Stuart K Roberts.;Jay H Shubrook.;Patrizia Burra.;Rohit Kohli.;Achim Kautz.;Adriaan G Holleboom.;Brian Lam.;Scott Isaacs.;Paula Macedo.;Amalia Gastaldelli.;Linda Henry.;Dana Ivancovsky-Wajcman.;Fatema Nader.;Leyla de Avila.;Jillian K Price.;Henry E Mark.;Marcela Villota-Rivas.;Aurora Barberá.;Markos Kalligeros.;Lynn H Gerber.;Saleh A Alqahtani.
来源: Gastroenterology. 2025年
Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are associated with adverse clinical outcomes, impaired health-related quality of life, and large economic burden. The growing burden of MASLD and MASH has led to the publication of a large number of MASLD/MASH guidelines by national and international societies. However, important differences among the recommendations have created confusion, contributing to a low rate of implementation and suboptimal management of MASLD and MASH. Creating a consensus recommendation has become more important since the approval of a partial agonist of thyroid hormone β receptor (resmetirom) for MASH treatment in the United States. We built a consensus among the most recently published recommendations for MASLD/MASH.
199. Global burden of gallbladder and biliary diseases (1990-2021) with healthcare workforce analysis and projections to 2035.
作者: Fangyi Dai.;Yuzhou Cai.;Shangjin Yang.;Jingyang Zhang.;Yong Dai.
来源: BMC Gastroenterol. 2025年25卷1期249页
Gallbladder and biliary tract diseases pose a significant global health burden, yet comprehensive analyses of their long-term epidemiological trends and future projections remain limited. This study aims to examine the temporal and spatial patterns of these diseases globally from 1990 to 2021, analyze healthcare workforce distribution relative to disease burden, and project the disease burden to 2035.
200. Unfavorable outcomes and their predictors in patients treated for perforated peptic ulcer disease in Ethiopia: systematic review and meta-analysis.
作者: Destaw Endeshaw.;Ousman Adal.;Abiyu Abadi Tareke.;Natnael Kebede.;Amare Mebrat Delie.;Eyob Ketema Bogale.;Tadele Fentabel Anagaw.;Misganaw Guadie Tiruneh.;Eneyew Talie Fenta.
来源: BMC Gastroenterol. 2025年25卷1期248页
Perforated peptic ulcer (PPU) is a surgical emergency condition associated with substantial mortality and morbidity. Despite scattered studies, there exists a gap in comprehensive evidence on management outcomes of this condition in Ethiopia. Hence, this review aimed to assess the pooled mortality and complication rates along with their predictors in patients treated for PPU.
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