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181. Geographic Variation in the Utilization of Cancer Care From Subspecialized Medical Oncologists in the United States, 2008 to 2020.
作者: René Karadakic.;Christopher Manz.;Arno Cai.;David C Chan.;Bruce E Landon.;Jukka-Pekka Onnela.;Nancy L Keating.;Michael L Barnett.
来源: Ann Intern Med. 2025年178卷10期1420-1428页
The growing complexity of cancer care may be driving an increase in subspecialized medical oncologists who focus on treating specific cancer types. However, little is known about trends in subspecialization among oncologists and differences in utilization of subspecialists.
182. How Would You Treat Tricuspid Valve Infective Endocarditis in a Patient Who Uses Injection Drugs? Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
作者: Zahir Kanjee.;Wendy Stead.;Arminder Jassar.;Eileen E Reynolds.
来源: Ann Intern Med. 2025年178卷8期1160-1171页
Infective endocarditis is a common and morbid condition involving prolonged hospital stays, significant disability, and a high mortality rate. The current crises of injection drug use and opioid use disorder have contributed to high rates of infective endocarditis in the United States. Endocarditis in patients who inject drugs involves additional management complexity for multiple reasons. Several infective endocarditis management guidelines exist, including from the American Heart Association and the European Society of Cardiology. In light of the unique challenges of caring for this particular population, in 2022 the American Heart Association published a scientific statement specifically focusing on infective endocarditis in people who inject drugs. In these rounds, 2 experts in their respective fields, an infectious diseases specialist and a cardiac surgeon, discuss medical management, interventional approaches, and the value of multidisciplinary care for tricuspid valve endocarditis in a person who uses injection drugs, both in general and in relation to Mr. Y, a 30-year-old man with a history of substance use disorder, methicillin-sensitive Staphylococcus aureus bacteremia, and right-sided endocarditis.
183. Irritable Bowel Syndrome.
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, with a prevalence of 4% to 10%. It is a chronic condition characterized by abdominal pain in conjunction with altered bowel habits, abdominal distention, or bloating. IBS can present with 3 different defecation patterns: IBS with constipation, IBS with diarrhea, or mixed IBS. Recent advances in IBS include a positive diagnosis based on symptom-based criteria and a treatment plan based on IBS subtype and bothersome symptoms. In addition to diet and lifestyle modifications, this article discusses the role of new pharmacologic and nonpharmacologic treatment options for the management of IBS.
184. The Effect of Weight Loss Before In Vitro Fertilization on Reproductive Outcomes in Women With Obesity : A Systematic Review and Meta-analysis.
作者: Moscho Michalopoulou.;Susan Ann Jebb.;Alice Hobson.;Shen Chuen Khaw.;Richard Stevens.;Pedro Melo.;Stella Jane Pierce Haffner.;Kathryn Sheridan Clay.;Sarah Mounsey.;Ingrid Granne.;Lee Lim.;Tim Child.;Nerys Marie Astbury.
来源: Ann Intern Med. 2025年178卷9期1298-1313页
It is unclear whether weight loss before in vitro fertilization (IVF) improves reproductive outcomes in women with obesity.
186. Treatment With Canagliflozin Versus Placebo in Children and Adolescents With Type 2 Diabetes : A Randomized Clinical Trial.
作者: Ulhas Nadgir.;Saberi Rana Ali.;Jagadish Gogate.;Wayne Shaw.;José Antunes.;Sergio Fonseca.
来源: Ann Intern Med. 2025年178卷9期1217-1226页
Treatment options for children and adolescents with type 2 diabetes mellitus (T2DM) are limited. Canagliflozin is a sodium-glucose cotransporter-2 inhibitor approved for the treatment of T2DM in adults.
187. In inpatients with an abdominal infection, CPOE prompts with personalized risk for MDRO reduced extended-spectrum antibiotic use.
GIM/FP/GP: [Formula: see text] Infectious Disease: [Formula: see text].
188. In urogenital gonorrhea, gepotidacin was noninferior to ceftriaxone + azithromycin for microbiological success.
GIM/FP/GP: [Formula: see text] Infectious Disease: [Formula: see text].
189. At 4.5 to 24 h after posterior circulation stroke onset, alteplase vs. standard medical care increased 90-d functional independence.
Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Neurology: [Formula: see text].
190. Efficacy of a Very-Low-Calorie Weight Loss Diet Plus Exercise Compared With Exercise Alone on Hip Osteoarthritis Pain : A Randomized Controlled Trial.
作者: Michelle Hall.;Rana S Hinman.;Gabrielle Knox.;Libby Spiers.;Fiona McManus.;Anurika P De Silva.;Priya Sumithran.;Anthony Harris.;Nicholas J Murphy.;Flavia Cicuttini.;David J Hunter.;Stephen P Messier.;Kim L Bennell.
来源: Ann Intern Med. 2025年178卷9期1227-1237页
Exercise is recommended to manage hip osteoarthritis, but weight loss recommendations are conflicting.
193. In PAH with high risk for death, sotatercept reduced a composite of death, lung transplantation, or PAH hospitalization >24 h at 9 mo.
GIM/FP/GP: [Formula: see text] Pulmonology: [Formula: see text].
194. In adults with active cancer and VTE, extended reduced-dose apixaban was noninferior to full-dose apixaban for VTE recurrence at 1 y.
GIM/FP/GP: [Formula: see text] Oncology: [Formula: see text] Hematology: [Formula: see text].
195. In insulin-treated T2D, automated insulin delivery reduced HbA1c without increasing hypoglycemic events vs. usual care at 13 wk.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].
196. After PCI with DES followed by DAPT, clopidogrel reduced MACCE vs. aspirin monotherapy at 2 y in patients with high risk for recurrence.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
197. Engineering Infection Controls to Reduce Indoor Transmission of Respiratory Infections : A Scoping Review.
作者: Amiran Baduashvili.;Lewis Radonovich.;Louis Leslie.;Stephanie Pease.;Claire Brickson.;Leela Chockalingam.;Natalie Banacos.;Beret Fitzgerald.;Jeffrey Wagner.;William P Bahnfleth.;Jean Cox-Ganser.;Kenneth R Mead.;Paula Olsiewski.;Cria O Gregory.;Erin Stone.;Joanna Taliano.;David N Weissman.;Lisa Bero.
来源: Ann Intern Med. 2025年178卷9期1314-1325页
Engineering infection controls include a wide range of interventions used indoors to reduce occupants' exposure to respiratory pathogens.
198. High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm.
作者: Trevor B Birmingham.;Codie A Primeau.;Rebecca F Moyer.;Dianne M Bryant.;Jinhui Ma.;Kristyn M Leitch.;Wolfgang Wirth.;Ryan Degen.;Alan M Getgood.;Robert B Litchfield.;Kevin R Willits.;Felix Eckstein.;J Robert Giffin.
来源: Ann Intern Med. 2025年178卷9期1238-1248页
Medial opening wedge high tibial osteotomy (HTO) is a limb realignment surgery that aims to preserve joint structure and improve clinical outcomes by redistributing ambulatory loads on the knee among patients with knee osteoarthritis and varus alignment.
199. Rituximab Versus Conventional Therapy for Remission Induction in Eosinophilic Granulomatosis With Polyangiitis : A Randomized Controlled Trial.
作者: Benjamin Terrier.;Grégory Pugnet.;Claire de Moreuil.;Bernard Bonnotte.;Ygal Benhamou.;Dominique Chauveau.;Marie-Charlotte Besse.;Pierre Duffau.;Nicolas Limal.;Antoine Néel.;Geoffrey Urbanski.;Noémie Jourde-Chiche.;Nicolas Martin-Silva.;Julien Campagne.;Arsène Mekinian.;Nicolas Schleinitz.;Felix Ackermann.;Anne-Laure Fauchais.;Antoine Froissart.;Thomas Le Gallou.;Yurdagul Uzunhan.;Jean-François Viallard.;Alice Bérezné.;Laurent Chiche.;Camille Taillé.;Guillaume Direz.;Cécile-Audrey Durel.;Pascal Godmer.;Salim Trad.;Marc Lambert.;Mathilde de Menthon.;Thomas Quéméneur.;Jacques Cadranel.;Pierre Charles.;Antoine Dossier.;Léa Jilet.;Loïc Guillevin.;Hendy Abdoul.;Xavier Puéchal.; .
来源: Ann Intern Med. 2025年178卷9期1249-1257页
Eosinophilic granulomatosis with polyangiitis (EGPA) is an eosinophilic antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Rituximab has emerged as the standard of care in other types of ANCA-associated vasculitis, but controlled studies on its use in EGPA are yet lacking.
200. Social Determinants of Health and Risk for Long COVID in the U.S. RECOVER-Adult Cohort.
作者: Candace H Feldman.;Leah Santacroce.;Ingrid V Bassett.;Tanayott Thaweethai.;Radica Alicic.;Rachel Atchley-Challenner.;Alicia Chung.;Mark P Goldberg.;Carol R Horowitz.;Karen B Jacobson.;J Daniel Kelly.;Stacey Knight.;Karen Lutrick.;Praveen Mudumbi.;Sairam Parthasarathy.;Heather Prendergast.;Yuri Quintana.;Nasser Sharareh.;Judd Shellito.;Zaki A Sherif.;Brittany D Taylor.;Emily Taylor.;Joel Tsevat.;Zanthia Wiley.;Natasha J Williams.;Lynn Yee.;Lisa Aponte-Soto.;Jhony Baissary.;Jasmine Berry.;Alexander W Charney.;Maged M Costantine.;Alexandria M Duven.;Nathaniel Erdmann.;Kacey C Ernst.;Elen M Feuerriegel.;Valerie J Flaherman.;Minjoung Go.;Kellie Hawkins.;Vanessa Jacoby.;Janice John.;Sara Kelly.;Elijah Kindred.;Adeyinka Laiyemo.;Emily B Levitan.;Bruce D Levy.;Jennifer K Logue.;Jai G Marathe.;Jeffrey N Martin.;Grace A McComsey.;Torri D Metz.;Tony Minor.;Aoyjai P Montgomery.;Janet M Mullington.;Igho Ofotokun.;Megumi J Okumura.;Michael J Peluso.;Kristen Pogreba-Brown.;Hengameh Raissy.;Johana M Rosas.;Upinder Singh.;Timothy VanWagoner.;Cheryl R Clark.;Elizabeth W Karlson.
来源: Ann Intern Med. 2025年178卷9期1287-1297页
Social determinants of health (SDoH) contribute to disparities in SARS-CoV-2 infection, but their associations with long COVID are unknown.
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