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181. Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data.
作者: Mika Kivimäki.;Solja T Nyberg.;G David Batty.;Eleonor I Fransson.;Katriina Heikkilä.;Lars Alfredsson.;Jakob B Bjorner.;Marianne Borritz.;Hermann Burr.;Annalisa Casini.;Els Clays.;Dirk De Bacquer.;Nico Dragano.;Jane E Ferrie.;Goedele A Geuskens.;Marcel Goldberg.;Mark Hamer.;Wendela E Hooftman.;Irene L Houtman.;Matti Joensuu.;Markus Jokela.;France Kittel.;Anders Knutsson.;Markku Koskenvuo.;Aki Koskinen.;Anne Kouvonen.;Meena Kumari.;Ida E H Madsen.;Michael G Marmot.;Martin L Nielsen.;Maria Nordin.;Tuula Oksanen.;Jaana Pentti.;Reiner Rugulies.;Paula Salo.;Johannes Siegrist.;Archana Singh-Manoux.;Sakari B Suominen.;Ari Väänänen.;Jussi Vahtera.;Marianna Virtanen.;Peter J M Westerholm.;Hugo Westerlund.;Marie Zins.;Andrew Steptoe.;Töres Theorell.; .
来源: Lancet. 2012年380卷9852期1491-7页
Published work assessing psychosocial stress (job strain) as a risk factor for coronary heart disease is inconsistent and subject to publication bias and reverse causation bias. We analysed the relation between job strain and coronary heart disease with a meta-analysis of published and unpublished studies.
182. Effect of intermittent preventive treatment for malaria during infancy on serological responses to measles and other vaccines used in the Expanded Programme on Immunization: results from five randomised controlled trials.
作者: Jane Crawley.;Charalambos Sismanidis.;Tracey Goodman.;Paul Milligan.; .
来源: Lancet. 2012年380卷9846期1001-10页
Intermittent preventive treatment for malaria during infancy (IPTi) is the administration of a full therapeutic course of antimalarial drugs to infants living in settings where malaria is endemic, at the time of routine vaccination in the first year of life. We investigated whether IPTi with sulfadoxine-pyrimethamine or other antimalarial drug combinations adversely affected serological responses to vaccines used in the Expanded Programme on Immunization (EPI).
183. Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: a meta-analysis.
作者: Gregorio A Millett.;John L Peterson.;Stephen A Flores.;Trevor A Hart.;William L Jeffries.;Patrick A Wilson.;Sean B Rourke.;Charles M Heilig.;Jonathan Elford.;Kevin A Fenton.;Robert S Remis.
来源: Lancet. 2012年380卷9839期341-8页
We did a meta-analysis to assess factors associated with disparities in HIV infection in black men who have sex with men (MSM) in Canada, the UK, and the USA.
184. Prevalence and risk of violence against children with disabilities: a systematic review and meta-analysis of observational studies.
作者: Lisa Jones.;Mark A Bellis.;Sara Wood.;Karen Hughes.;Ellie McCoy.;Lindsay Eckley.;Geoff Bates.;Christopher Mikton.;Tom Shakespeare.;Alana Officer.
来源: Lancet. 2012年380卷9845期899-907页
Globally, at least 93 million children have moderate or severe disability. Children with disabilities are thought to have a substantially greater risk of being victims of violence than are their non-disabled peers. Establishment of reliable estimates of the scale of the problem is an essential first step in the development of effective prevention programmes. We therefore undertook a systematic review and meta-analysis to synthesise evidence for the prevalence and risk of violence against children with disabilities.
185. Effectiveness of quality improvement strategies on the management of diabetes: a systematic review and meta-analysis.
作者: Andrea C Tricco.;Noah M Ivers.;Jeremy M Grimshaw.;David Moher.;Lucy Turner.;James Galipeau.;Ilana Halperin.;Brigitte Vachon.;Tim Ramsay.;Braden Manns.;Marcello Tonelli.;Kaveh Shojania.
来源: Lancet. 2012年379卷9833期2252-61页
The effectiveness of quality improvement (QI) strategies on diabetes care remains unclear. We aimed to assess the effects of QI strategies on glycated haemoglobin (HbA(1c)), vascular risk management, microvascular complication monitoring, and smoking cessation in patients with diabetes.
186. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications.
作者: Hannah Blencowe.;Simon Cousens.;Mikkel Z Oestergaard.;Doris Chou.;Ann-Beth Moller.;Rajesh Narwal.;Alma Adler.;Claudia Vera Garcia.;Sarah Rohde.;Lale Say.;Joy E Lawn.
来源: Lancet. 2012年379卷9832期2162-72页
Preterm birth is the second largest direct cause of child deaths in children younger than 5 years. Yet, data regarding preterm birth (<37 completed weeks of gestation) are not routinely collected by UN agencies, and no systematic country estimates nor time trend analyses have been done. We report worldwide, regional, and national estimates of preterm birth rates for 184 countries in 2010 with time trends for selected countries, and provide a quantitative assessment of the uncertainty surrounding these estimates.
187. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.
作者: Benjamin F Voight.;Gina M Peloso.;Marju Orho-Melander.;Ruth Frikke-Schmidt.;Maja Barbalic.;Majken K Jensen.;George Hindy.;Hilma Hólm.;Eric L Ding.;Toby Johnson.;Heribert Schunkert.;Nilesh J Samani.;Robert Clarke.;Jemma C Hopewell.;John F Thompson.;Mingyao Li.;Gudmar Thorleifsson.;Christopher Newton-Cheh.;Kiran Musunuru.;James P Pirruccello.;Danish Saleheen.;Li Chen.;Alexandre F R Stewart.;Arne Schillert.;Unnur Thorsteinsdottir.;Gudmundur Thorgeirsson.;Sonia Anand.;James C Engert.;Thomas Morgan.;John Spertus.;Monika Stoll.;Klaus Berger.;Nicola Martinelli.;Domenico Girelli.;Pascal P McKeown.;Christopher C Patterson.;Stephen E Epstein.;Joseph Devaney.;Mary-Susan Burnett.;Vincent Mooser.;Samuli Ripatti.;Ida Surakka.;Markku S Nieminen.;Juha Sinisalo.;Marja-Liisa Lokki.;Markus Perola.;Aki Havulinna.;Ulf de Faire.;Bruna Gigante.;Erik Ingelsson.;Tanja Zeller.;Philipp Wild.;Paul I W de Bakker.;Olaf H Klungel.;Anke-Hilse Maitland-van der Zee.;Bas J M Peters.;Anthonius de Boer.;Diederick E Grobbee.;Pieter W Kamphuisen.;Vera H M Deneer.;Clara C Elbers.;N Charlotte Onland-Moret.;Marten H Hofker.;Cisca Wijmenga.;W M Monique Verschuren.;Jolanda M A Boer.;Yvonne T van der Schouw.;Asif Rasheed.;Philippe Frossard.;Serkalem Demissie.;Cristen Willer.;Ron Do.;Jose M Ordovas.;Gonçalo R Abecasis.;Michael Boehnke.;Karen L Mohlke.;Mark J Daly.;Candace Guiducci.;Noël P Burtt.;Aarti Surti.;Elena Gonzalez.;Shaun Purcell.;Stacey Gabriel.;Jaume Marrugat.;John Peden.;Jeanette Erdmann.;Patrick Diemert.;Christina Willenborg.;Inke R König.;Marcus Fischer.;Christian Hengstenberg.;Andreas Ziegler.;Ian Buysschaert.;Diether Lambrechts.;Frans Van de Werf.;Keith A Fox.;Nour Eddine El Mokhtari.;Diana Rubin.;Jürgen Schrezenmeir.;Stefan Schreiber.;Arne Schäfer.;John Danesh.;Stefan Blankenberg.;Robert Roberts.;Ruth McPherson.;Hugh Watkins.;Alistair S Hall.;Kim Overvad.;Eric Rimm.;Eric Boerwinkle.;Anne Tybjaerg-Hansen.;L Adrienne Cupples.;Muredach P Reilly.;Olle Melander.;Pier M Mannucci.;Diego Ardissino.;David Siscovick.;Roberto Elosua.;Kari Stefansson.;Christopher J O'Donnell.;Veikko Salomaa.;Daniel J Rader.;Leena Peltonen.;Stephen M Schwartz.;David Altshuler.;Sekar Kathiresan.
来源: Lancet. 2012年380卷9841期572-80页
High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.
188. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials.
作者: .;B Mihaylova.;J Emberson.;L Blackwell.;A Keech.;J Simes.;E H Barnes.;M Voysey.;A Gray.;R Collins.;C Baigent.
来源: Lancet. 2012年380卷9841期581-90页
Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain.
189. Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis.
作者: Stefan Leucht.;Magdolna Tardy.;Katja Komossa.;Stephan Heres.;Werner Kissling.;Georgia Salanti.;John M Davis.
来源: Lancet. 2012年379卷9831期2063-71页
Relapse prevention with antipsychotic drugs compared with placebo in patients with schizophrenia has not been sufficiently addressed by previous systematic reviews. We aimed to assess the association between such drugs and various outcomes in patients with schizophrenia to resolve controversial issues.
190. Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis.
作者: Shakila Thangaratinam.;Kiritrea Brown.;Javier Zamora.;Khalid S Khan.;Andrew K Ewer.
来源: Lancet. 2012年379卷9835期2459-2464页
Screening for critical congenital heart defects in newborn babies can aid in early recognition, with the prospect of improved outcome. We assessed the performance of pulse oximetry as a screening method for the detection of critical congenital heart defects in asymptomatic newborn babies.
191. Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data.
作者: Matthias W Lorenz.;Joseph F Polak.;Maryam Kavousi.;Ellisiv B Mathiesen.;Henry Völzke.;Tomi-Pekka Tuomainen.;Dirk Sander.;Matthieu Plichart.;Alberico L Catapano.;Christine M Robertson.;Stefan Kiechl.;Tatjana Rundek.;Moïse Desvarieux.;Lars Lind.;Caroline Schmid.;Pronabesh DasMahapatra.;Lu Gao.;Kathrin Ziegelbauer.;Michiel L Bots.;Simon G Thompson.; .
来源: Lancet. 2012年379卷9831期2053-62页
Carotid intima-media thickness (cIMT) is related to the risk of cardiovascular events in the general population. An association between changes in cIMT and cardiovascular risk is frequently assumed but has rarely been reported. Our aim was to test this association.
192. Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis.
作者: Tullio Palmerini.;Giuseppe Biondi-Zoccai.;Diego Della Riva.;Christoph Stettler.;Diego Sangiorgi.;Fabrizio D'Ascenzo.;Takeshi Kimura.;Carlo Briguori.;Manel Sabatè.;Hyo-Soo Kim.;Antoinette De Waha.;Elvin Kedhi.;Pieter C Smits.;Christoph Kaiser.;Gennaro Sardella.;Antonino Marullo.;Ajay J Kirtane.;Martin B Leon.;Gregg W Stone.
来源: Lancet. 2012年379卷9824期1393-402页
The relative safety of drug-eluting stents and bare-metal stents, especially with respect to stent thrombosis, continues to be debated. In view of the overall low frequency of stent thrombosis, large sample sizes are needed to accurately estimate treatment differences between stents. We compared the risk of thrombosis between bare-metal and drug-eluting stents.
193. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials.
作者: Peter M Rothwell.;Michelle Wilson.;Jacqueline F Price.;Jill F F Belch.;Tom W Meade.;Ziyah Mehta.
来源: Lancet. 2012年379卷9826期1591-601页
Daily aspirin reduces the long-term incidence of some adenocarcinomas, but effects on mortality due to some cancers appear after only a few years, suggesting that it might also reduce growth or metastasis. We established the frequency of distant metastasis in patients who developed cancer during trials of daily aspirin versus control.
194. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials.
作者: Peter M Rothwell.;Jacqueline F Price.;F Gerald R Fowkes.;Alberto Zanchetti.;Maria Carla Roncaglioni.;Gianni Tognoni.;Robert Lee.;Jill F F Belch.;Michelle Wilson.;Ziyah Mehta.;Tom W Meade.
来源: Lancet. 2012年379卷9826期1602-12页
Daily aspirin reduces the long-term risk of death due to cancer. However, the short-term effect is less certain, especially in women, effects on cancer incidence are largely unknown, and the time course of risk and benefit in primary prevention is unclear. We studied cancer deaths in all trials of daily aspirin versus control and the time course of effects of low-dose aspirin on cancer incidence and other outcomes in trials in primary prevention.
195. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
作者: .;Daniel I Swerdlow.;Michael V Holmes.;Karoline B Kuchenbaecker.;Jorgen E L Engmann.;Tina Shah.;Reecha Sofat.;Yiran Guo.;Christina Chung.;Anne Peasey.;Roman Pfister.;Simon P Mooijaart.;Helen A Ireland.;Maarten Leusink.;Claudia Langenberg.;Ka Wah Li.;Jutta Palmen.;Philip Howard.;Jackie A Cooper.;Fotios Drenos.;John Hardy.;Michael A Nalls.;Yun Rose Li.;Gordon Lowe.;Marlene Stewart.;Suzette J Bielinski.;Julian Peto.;Nicholas J Timpson.;John Gallacher.;Malcolm Dunlop.;Richard Houlston.;Ian Tomlinson.;Ioanna Tzoulaki.;Jian'an Luan.;Jolanda M A Boer.;Nita G Forouhi.;N Charlotte Onland-Moret.;Yvonne T van der Schouw.;Renate B Schnabel.;Jaroslav A Hubacek.;Ruzena Kubinova.;Migle Baceviciene.;Abdonas Tamosiunas.;Andrzej Pajak.;Roman Topor-Madry.;Sofia Malyutina.;Damiano Baldassarre.;Bengt Sennblad.;Elena Tremoli.;Ulf de Faire.;Luigi Ferrucci.;Stefania Bandenelli.;Toshiko Tanaka.;James F Meschia.;Andrew Singleton.;Gerjan Navis.;Irene Mateo Leach.;Stephan J L Bakker.;Ron T Gansevoort.;Ian Ford.;Stephen E Epstein.;Mary Susan Burnett.;Joe M Devaney.;J Wouter Jukema.;Rudi G J Westendorp.;Gert Jan de Borst.;Yolanda van der Graaf.;Pim A de Jong.;Anke-Hilse Mailand-van der Zee.;Olaf H Klungel.;Anthonius de Boer.;Pieter A Doevendans.;Jeffrey W Stephens.;Charles B Eaton.;Jennifer G Robinson.;JoAnn E Manson.;F Gerry Fowkes.;Timonthy M Frayling.;Jackie F Price.;Peter H Whincup.;Richard W Morris.;Debbie A Lawlor.;George Davey Smith.;Yoav Ben-Shlomo.;Susan Redline.;Leslie A Lange.;Meena Kumari.;Nick J Wareham.;W M Monique Verschuren.;Emelia J Benjamin.;John C Whittaker.;Anders Hamsten.;Frank Dudbridge.;J A Chris Delaney.;Andrew Wong.;Diana Kuh.;Rebecca Hardy.;Berta Almoguera Castillo.;John J Connolly.;Pim van der Harst.;Eric J Brunner.;Michael G Marmot.;Christina L Wassel.;Steve E Humphries.;Philippa J Talmud.;Mika Kivimaki.;Folkert W Asselbergs.;Mikhail Voevoda.;Martin Bobak.;Hynek Pikhart.;James G Wilson.;Hakon Hakonarson.;Alex P Reiner.;Brendan J Keating.;Naveed Sattar.;Aroon D Hingorani.;Juan Pablo Casas.
来源: Lancet. 2012年379卷9822期1214-24页
A high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed for treatment of rheumatoid arthritis reduces systemic and articular inflammation. However, whether IL6R blockade also reduces risk of coronary heart disease is unknown.
196. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
作者: .;Nadeem Sarwar.;Adam S Butterworth.;Daniel F Freitag.;John Gregson.;Peter Willeit.;Donal N Gorman.;Pei Gao.;Danish Saleheen.;Augusto Rendon.;Christopher P Nelson.;Peter S Braund.;Alistair S Hall.;Daniel I Chasman.;Anne Tybjærg-Hansen.;John C Chambers.;Emelia J Benjamin.;Paul W Franks.;Robert Clarke.;Arthur A M Wilde.;Mieke D Trip.;Maristella Steri.;Jacqueline C M Witteman.;Lu Qi.;C Ellen van der Schoot.;Ulf de Faire.;Jeanette Erdmann.;Heather M Stringham.;Wolfgang Koenig.;Daniel J Rader.;David Melzer.;David Reich.;Bruce M Psaty.;Marcus E Kleber.;Demosthenes B Panagiotakos.;Johann Willeit.;Patrik Wennberg.;Mark Woodward.;Svetlana Adamovic.;Eric B Rimm.;Tom W Meade.;Richard F Gillum.;Jonathan A Shaffer.;Albert Hofman.;Altan Onat.;Johan Sundström.;Sylvia Wassertheil-Smoller.;Dan Mellström.;John Gallacher.;Mary Cushman.;Russell P Tracy.;Jussi Kauhanen.;Magnus Karlsson.;Jukka T Salonen.;Lars Wilhelmsen.;Philippe Amouyel.;Bernard Cantin.;Lyle G Best.;Yoav Ben-Shlomo.;JoAnn E Manson.;George Davey-Smith.;Paul I W de Bakker.;Christopher J O'Donnell.;James F Wilson.;Anthony G Wilson.;Themistocles L Assimes.;John-Olov Jansson.;Claes Ohlsson.;Åsa Tivesten.;Östen Ljunggren.;Muredach P Reilly.;Anders Hamsten.;Erik Ingelsson.;Francois Cambien.;Joseph Hung.;G Neil Thomas.;Michael Boehnke.;Heribert Schunkert.;Folkert W Asselbergs.;John J P Kastelein.;Vilmundur Gudnason.;Veikko Salomaa.;Tamara B Harris.;Jaspal S Kooner.;Kristine H Allin.;Børge G Nordestgaard.;Jemma C Hopewell.;Alison H Goodall.;Paul M Ridker.;Hilma Hólm.;Hugh Watkins.;Willem H Ouwehand.;Nilesh J Samani.;Stephen Kaptoge.;Emanuele Di Angelantonio.;Olivier Harari.;John Danesh.
来源: Lancet. 2012年379卷9822期1205-13页
Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.
197. Prevalence and risk of violence against adults with disabilities: a systematic review and meta-analysis of observational studies.
作者: Karen Hughes.;Mark A Bellis.;Lisa Jones.;Sara Wood.;Geoff Bates.;Lindsay Eckley.;Ellie McCoy.;Christopher Mikton.;Tom Shakespeare.;Alana Officer.
来源: Lancet. 2012年379卷9826期1621-9页
About 15% of adults worldwide have a disability. These individuals are frequently reported to be at increased risk of violence, yet quantitative syntheses of studies of this issue are scarce. We aimed to quantify violence against adults with disabilities.
198. Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial.
作者: Holger Thiele.;Jochen Wöhrle.;Rainer Hambrecht.;Harald Rittger.;Ralf Birkemeyer.;Bernward Lauer.;Petra Neuhaus.;Oana Brosteanu.;Peter Sick.;Marcus Wiemer.;Sebastian Kerber.;Klaus Kleinertz.;Ingo Eitel.;Steffen Desch.;Gerhard Schuler.
来源: Lancet. 2012年379卷9819期923-931页
Intracoronary administration of an abciximab bolus during a primary percutaneous coronary intervention results in a high local drug concentration, improved perfusion, and reduction of infarct size compared with intravenous bolus application. However, the safety and efficacy of intracoronary versus standard intravenous bolus application in patients with ST-elevation myocardial infarction (STEMI) undergoing this intervention has not been tested in a large-scale clinical trial.
199. Association of a difference in systolic blood pressure between arms with vascular disease and mortality: a systematic review and meta-analysis.
作者: Christopher E Clark.;Rod S Taylor.;Angela C Shore.;Obioha C Ukoumunne.;John L Campbell.
来源: Lancet. 2012年379卷9819期905-914页
Differences in systolic blood pressure (SBP) of 10 mm Hg or more or 15 mm Hg or more between arms have been associated with peripheral vascular disease and attributed to subclavian stenosis. We investigated whether an association exists between this difference and central or peripheral vascular disease, and mortality.
200. Lithium toxicity profile: a systematic review and meta-analysis.
作者: Rebecca F McKnight.;Marc Adida.;Katie Budge.;Sarah Stockton.;Guy M Goodwin.;John R Geddes.
来源: Lancet. 2012年379卷9817期721-8页
Lithium is a widely used and effective treatment for mood disorders. There has been concern about its safety but no adequate synthesis of the evidence for adverse effects. We aimed to undertake a clinically informative, systematic toxicity profile of lithium.
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