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181. Contemporary management of acute exacerbations of COPD: a systematic review and metaanalysis.
Systemic corticosteroids, antibiotics, and noninvasive positive pressure ventilation (NPPV) are recommended for patients with acute exacerbation of COPD. However, their clinical benefits in various settings are uncertain. We undertook a systematic review and metaanalysis to systematically evaluate the effectiveness of these therapies.
182. Is the mortality higher in the pulmonary vs the extrapulmonary ARDS? A meta analysis.
作者: Ritesh Agarwal.;Rajagopala Srinivas.;Alok Nath.;Surinder K Jindal.
来源: Chest. 2008年133卷6期1463-1473页
ARDS can occur from the following two pathogenetic pathways: a direct pulmonary injury (ARDSp); and an indirect injury (ARDSexp). The predisposing clinical factor can influence the pathogenesis and clinical outcome of ARDS. This metaanalysis was aimed at evaluating whether there is any difference in mortality between the two groups.
183. Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age.
作者: Martin Penagos.;Giovanni Passalacqua.;Enrico Compalati.;Carlos E Baena-Cagnani.;Socorro Orozco.;Alvaro Pedroza.;Giorgio Walter Canonica.
来源: Chest. 2008年133卷3期599-609页
Recent studies have documented the efficacy and safety of sublingual immunotherapy (SLIT) in patients with rhinitis, but the value of this treatment in those with asthma is still debated. We evaluated the efficacy of SLIT in the treatment of allergic asthma in children by a metaanalysis of randomized, double-blind, and placebo-controlled (DBPC) clinical trials.
184. Differences between low-molecular-weight and unfractionated heparin for venous thromboembolism prevention following ischemic stroke: a metaanalysis.
Venous thromboembolism (VTE) remains a major cause of morbidity following stroke. The optimal form of pharmacologic prophylaxis following stroke is unknown.
185. No difference in risk for thrombocytopenia during treatment of pulmonary embolism and deep venous thrombosis with either low-molecular-weight heparin or unfractionated heparin: a metaanalysis.
作者: Timothy A Morris.;Selene Castrejon.;Gehan Devendra.;Anthony C Gamst.
来源: Chest. 2007年132卷4期1131-9页
Low-molecular-weight heparin (LMWH) is a popular alternative to unfractionated heparin (UH) for the treatment of pulmonary embolism (PE) and deep vein thrombosis (DVT), in part based on the perception of a lower risk for heparin-induced thrombocytopenia (HIT). To investigate the evidence supporting this perception, we performed a metaanalysis to compare the incidence of thrombocytopenia between LMWH and UH during PE and/or DVT treatment.
186. Comparison of first-line with second-line antibiotics for acute exacerbations of chronic bronchitis: a metaanalysis of randomized controlled trials.
作者: George Dimopoulos.;Ilias I Siempos.;Ioanna P Korbila.;Katerina G Manta.;Matthew E Falagas.
来源: Chest. 2007年132卷2期447-55页
Although acute exacerbations of chronic bronchitis (AECBs) are common, there has been no metaanalysis that focused on the optimum regimen.
187. Analyzing the short-term effect of placebo therapy in pulmonary arterial hypertension: potential implications for the design of future clinical trials.
作者: Donald L Helman.;Alexander W Brown.;Jeffrey L Jackson.;Andrew F Shorr.
来源: Chest. 2007年132卷3期764-72页
Placebo is commonly used in short-term randomized trials for pulmonary arterial hypertension (PAH). Currently, outcome data regarding placebo are lacking. We conducted a systematic review and performed a metaanalysis to assess its effect.
188. Diagnostic value of interferon-gamma in tuberculous pleurisy: a metaanalysis.
作者: Jing Jiang.;Huan-Zhong Shi.;Qiu-Li Liang.;Shou-Ming Qin.;Xue-Jun Qin.
来源: Chest. 2007年131卷4期1133-41页
Conventional tests are not always helpful in making a diagnosis of tuberculous pleurisy. Many studies have investigated the usefulness of interferon (IFN)-gamma measurements in pleural fluid for the early diagnosis of tuberculous pleurisy. We conducted a metaanalysis to determine the accuracy of IFN-gamma measurements in the diagnosis of tuberculous pleurisy.
189. Endoscopic ultrasound-guided fine-needle aspiration for non-small cell lung cancer staging: A systematic review and metaanalysis.
作者: Carlos G Micames.;Douglas C McCrory.;Darren A Pavey.;Paul S Jowell.;Frank G Gress.
来源: Chest. 2007年131卷2期539-48页
Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is a minimally invasive alternative technique for mediastinal staging of non-small cell lung cancer. A metaanalysis was performed to estimate the diagnostic accuracy of EUS-FNA for staging mediastinal lymph nodes (N2/N3 disease) in patients with lung cancer.
190. Twice vs three times daily heparin dosing for thromboembolism prophylaxis in the general medical population: A metaanalysis.
作者: Christopher S King.;Aaron B Holley.;Jeffrey L Jackson.;Andrew F Shorr.;Lisa K Moores.
来源: Chest. 2007年131卷2期507-16页
Prophylaxis with unfractionated heparin (UFH) has been proven to reduce rates of venous thromboembolism (VTE) in hospitalized medical patients. While twice-daily (BID) and three-times-daily (TID) dosing regimens have been studied, the two have never been directly compared. We performed a metaanalysis to assess whether TID is superior to BID dosing in the prevention of VTE.
191. Respiratory physiotherapy to prevent pulmonary complications after abdominal surgery: a systematic review.
作者: Patrick Pasquina.;Martin R Tramèr.;Jean-Max Granier.;Bernhard Walder.
来源: Chest. 2006年130卷6期1887-99页
To examine the efficacy of respiratory physiotherapy for prevention of pulmonary complications after abdominal surgery.
192. Is recurrent venous thromboembolism after therapy reduced by low-molecular-weight heparin compared with oral anticoagulants?
作者: Gianluigi Ferretti.;Emilio Bria.;Diana Giannarelli.;Paolo Carlini.;Alessandra Felici.;Mario Mandalà.;Paola Papaldo.;Alessandra Fabi.;Mariangela Ciccarese.;Federica Cuppone.;Fabiana Letizia Cecere.;Carmen Nuzzo.;Edmondo Terzoli.;Francesco Cognetti.
来源: Chest. 2006年130卷6期1808-16页
To evaluate whether the incidence of recurrent venous thromboembolism (VTE) events after therapy differs for patients treated with long-term low-molecular-weight heparin (LMWH) or oral anticoagulant therapy (OAT).
193. How frequently is venous thromboembolism in heparin-treated patients associated with heparin-induced thrombocytopenia?
Patients receiving heparin for thromboprophylaxis or treatment may have new or recurrent venous thromboembolism (VTE) if immune-mediated heparin-induced thrombocytopenia (HIT) occurs or for other reasons, eg, if anticoagulation fails. We estimated from the literature how frequently a patient presenting with VTE during or following heparin therapy has HIT-associated VTE.
194. Cardiovascular function following surgical repair of pectus excavatum: a metaanalysis.
作者: Moh H Malek.;Dale E Berger.;Terry J Housh.;William D Marelich.;Jared W Coburn.;Travis W Beck.
来源: Chest. 2006年130卷2期506-16页
Despite numerous published reports, there is no consensus in the literature as to whether the surgical repair of the pectus excavatum improves cardiovascular function. As a result, it has been suggested that correction should be considered a cosmetic procedure, and therefore, many health insurance companies have questioned whether the repair of the pectus excavatum improves cardiovascular function and thus are reluctant to authorize the procedure. The purpose of this study was to apply metaanalysis methodology to generate a quantitative synthesis of the effects of surgical repair on cardiovascular function and to test the hypothesis that surgical repair of the pectus excavatum results in significant improvements in cardiovascular function.
195. Intrapleural fibrinolytic agents for empyema and complicated parapneumonic effusions: a meta-analysis.
作者: Yasuharu Tokuda.;Dai Matsushima.;Gerald H Stein.;Seishirou Miyagi.
来源: Chest. 2006年129卷3期783-90页
Randomized controlled trials have shown conflicting findings about the role of intrapleural fibrinolytic therapy for the treatment of empyema and complicated parapneumonic effusions in adult patients.
196. Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis.
作者: Fawziah Marra.;Larry Lynd.;Megan Coombes.;Kathryn Richardson.;Michael Legal.;J Mark Fitzgerald.;Carlo A Marra.
来源: Chest. 2006年129卷3期610-8页
To determine the association between antibiotic exposure in the first year of life and the development of childhood asthma.
197. Resolution of thromboemboli in patients with acute pulmonary embolism: a systematic review.
作者: Mathilde Nijkeuter.;Marcel M C Hovens.;Bruce L Davidson.;Menno V Huisman.
来源: Chest. 2006年129卷1期192-7页
Much attention has been paid in recent years to optimizing the diagnosis of acute pulmonary embolism (PE). However, little is known about the changes in clot burden that occur at the level of the pulmonary arteries after documented PE. It is often problematic to distinguish between a new or residual defect on lung scintigraphy or helical CT. This may lead to falsely labeling patients with residual PE as having recurrent PE and consequent unnecessary treatment changes.
198. Enoxaparin in the treatment of deep vein thrombosis with or without pulmonary embolism: an individual patient data meta-analysis.
作者: Patrick Mismetti.;Sara Quenet.;Mark Levine.;Geno Merli.;Hervé Decousus.;Eric Derobert.;Silvy Laporte.
来源: Chest. 2005年128卷4期2203-10页
Low-molecular-weight heparins have been compared with unfractionated heparin (UFH) for treatment of deep vein thrombosis (DVT). However, a comparison of their efficacy in the presence or absence of pulmonary embolism (PE) has not been studied. We estimated the efficacy and safety of enoxaparin vs UFH in patients with proximal DVT with/without symptomatic PE using a meta-analysis of individual data from randomized controlled trials.
199. Interferon-gamma1b therapy in idiopathic pulmonary fibrosis: a metaanalysis.
作者: Ednan K Bajwa.;Najib T Ayas.;Michael Schulzer.;Edwin Mak.;Jay H Ryu.;Atul Malhotra.
来源: Chest. 2005年128卷1期203-6页
Despite the investigation of multiple therapeutic options, idiopathic pulmonary fibrosis (IPF) remains a devastating, progressively fatal disease. Much interest has focused on the use of interferon (IFN)-gamma1b therapy, but the efficacy of this treatment has not been proven.
200. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature.
Conditions that give rise to reduced lung function are frequently associated with low-grade systemic inflammation, which may lead to poor cardiovascular outcomes. We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking.
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