当前位置: 首页 >> 检索结果
181. Association of Angiotensin Modulators With the Course of Idiopathic Pulmonary Fibrosis.
作者: Michael Kreuter.;David J Lederer.;Maria Molina-Molina.;Imre Noth.;Claudia Valenzuela.;Lutz Frankenstein.;Derek Weycker.;Mark Atwood.;Klaus-Uwe Kirchgaessler.;Vincent Cottin.
来源: Chest. 2019年156卷4期706-714页
Angiotensin peptides have been implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis. Angiotensin modulators are used to treat arterial hypertension, a frequent comorbidity of IPF. This post hoc analysis evaluated associations of antihypertensive treatments with disease-related outcomes in IPF.
182. Nasal High-Frequency Oscillatory Ventilation in Preterm Infants With Respiratory Distress Syndrome and ARDS After Extubation: A Randomized Controlled Trial.
Nasal high-frequency oscillatory ventilation (NHFOV) has been described as supplying the combined advantages of nasal CPAP (NCPAP) and HFOV. However, its effect on preterm infants needs to be further elucidated. Our objective was to assess whether NHFOV could reduce intubation and Pco2 levels as compared with NCPAP during the postextubation phase in preterm infants.
183. Predictors of Response to Endobronchial Coil Therapy in Patients With Advanced Emphysema.
作者: Dirk-Jan Slebos.;Joseph Cicenia.;Frank C Sciurba.;Gerard J Criner.;Jorine E Hartman.;Justin Garner.;Gaëtan Deslée.;Antoine Delage.;Michael Jantz.;Charles-Hugo Marquette.;Charlie Strange.;Umur Hatipoglu.;Atul C Mehta.;Adam S LaPrad.;Gerald Schmid-Bindert.;Felix J F Herth.;Pallav L Shah.; .
来源: Chest. 2019年155卷5期928-937页
The Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) trial reported improvements in quality of life, pulmonary function, and exercise performance following endobronchial coil treatment.
184. Rapid Detection of Methicillin-Resistant Staphylococcus aureus in BAL: A Pilot Randomized Controlled Trial.
作者: Joseph R Paonessa.;Raj D Shah.;Chiagozie I Pickens.;Bryan D Lizza.;Helen K Donnelly.;Michael Malczynski.;Chao Qi.;Richard G Wunderink.
来源: Chest. 2019年155卷5期999-1007页
Guidelines recommend empirical vancomycin or linezolid for patients with suspected pneumonia at risk for methicillin-resistant Staphylococcus aureus (MRSA). Unneeded vancomycin or linezolid use may unnecessarily alter host flora and expose patients to toxicity. We therefore sought to determine if rapid testing for MRSA in BAL can safely decrease use of vancomycin or linezolid for suspected MRSA pneumonia.
185. Prospective Multicentered Safety and Feasibility Pilot for Endobronchial Intratumoral Chemotherapy.
作者: Lonny Yarmus.;Christopher Mallow.;Jason Akulian.;Cheng Ting Lin.;David Ettinger.;Russell Hales.;Kinh Ranh Voong.;Hans Lee.;David Feller-Kopman.;Roy Semaan.;Kirk Seward.;Momen M Wahidi.
来源: Chest. 2019年156卷3期562-570页
Malignant airway obstruction (MAO) occurs in 30% of patients with advanced-stage lung cancer, leading to debilitating dyspnea, cough, and hemoptysis. Other than recanalization of the airways, these patients lack long-lasting palliative therapy. The goal of this study was to determine the safety and feasibility of local injection of paclitaxel into the airway wall with a novel microinjection catheter.
186. Interaction of Glutathione S-Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure on Lung Function in Adolescents.
作者: Xin Dai.;Shyamali C Dharmage.;Gayan Bowatte.;Nilakshi T Waidyatillake.;Jennifer L Perret.;Jennie Hui.;Bircan Erbas.;Michael J Abramson.;Adrian J Lowe.;John A Burgess.;Cecilie Svanes.;Caroline J Lodge.
来源: Chest. 2019年155卷1期94-102页
Glutathione S-transferase (GST) genes are involved in the management of oxidative stress in the lungs. We aimed to determine whether they modify the associations between early life smoke exposure and adverse lung health outcomes.
187. Efficacy of Pirfenidone in the Context of Multiple Disease Progression Events in Patients With Idiopathic Pulmonary Fibrosis.
作者: Steven D Nathan.;Ulrich Costabel.;Ian Glaspole.;Marilyn K Glassberg.;Lisa H Lancaster.;David J Lederer.;Carlos A Pereira.;Benjamin Trzaskoma.;Elizabeth A Morgenthien.;Susan L Limb.;Athol U Wells.
来源: Chest. 2019年155卷4期712-719页
Declines in percent predicted FVC (% predicted FVC), declines in 6-min walk distance (6MWD), and respiratory hospitalizations are events associated with disease progression and mortality in idiopathic pulmonary fibrosis. The incidence of multiple events in the same patient over 12 months of pirfenidone treatment is unknown.
188. Multimodal Remote Monitoring of High Cardiovascular Risk Patients With OSA Initiating CPAP: A Randomized Trial.
作者: Jean-Louis Pépin.;Ingrid Jullian-Desayes.;Marc Sapène.;Erika Treptow.;Marie Joyeux-Faure.;Meriem Benmerad.;Sébastien Bailly.;Yves Grillet.;Bruno Stach.;Philippe Richard.;Patrick Lévy.;Jean-François Muir.;Renaud Tamisier.
来源: Chest. 2019年155卷4期730-739页
The management of patients with high cardiovascular risk and OSA must target not only improving adherence to CPAP, but should also include strategies aimed at reducing BP and increasing physical activity. The study aims to evaluate the effectiveness of an integrated intervention using remote patient telemonitoring in reducing BP in high cardiovascular risk patients with OSA.
189. Solriamfetol for the Treatment of Excessive Sleepiness in OSA: A Placebo-Controlled Randomized Withdrawal Study.
作者: Patrick J Strollo.;Jan Hedner.;Nancy Collop.;Daniel G Lorch.;Dan Chen.;Lawrence P Carter.;Yuan Lu.;Lawrence Lee.;Jed Black.;Jean-Louis Pépin.;Susan Redline.; .
来源: Chest. 2019年155卷2期364-374页
Excessive sleepiness (ES) is a common symptom of OSA, which often persists despite primary OSA therapy. This phase III randomized withdrawal trial evaluated solriamfetol (JZP-110) for the treatment of ES in adults with OSA.
190. Rapidly Improving ARDS in Therapeutic Randomized Controlled Trials.
作者: Edward J Schenck.;Clara Oromendia.;Lisa K Torres.;David A Berlin.;Augustine M K Choi.;Ilias I Siempos.
来源: Chest. 2019年155卷3期474-482页
Observational studies suggest that some patients meeting criteria for ARDS no longer fulfill the oxygenation criterion early in the course of their illness. This subphenotype of rapidly improving ARDS has not been well characterized. We attempted to assess the prevalence, characteristics, and outcomes of rapidly improving ARDS and to identify which variables are useful to predict it.
191. Inhaled Tranexamic Acid for Hemoptysis Treatment: A Randomized Controlled Trial.
作者: Ori Wand.;Elad Guber.;Alexander Guber.;Gali Epstein Shochet.;Lilach Israeli-Shani.;David Shitrit.
来源: Chest. 2018年154卷6期1379-1384页
Tranexamic acid (TA) is an antifibrinolytic drug currently used systemically to control bleeding. To date, there have been no prospective studies of the effectiveness of inhaled TA for the treatment of hemoptysis.
192. Safety and Efficacy of Remimazolam Compared With Placebo and Midazolam for Moderate Sedation During Bronchoscopy.
作者: Nicholas J Pastis.;Lonny B Yarmus.;Frank Schippers.;Randall Ostroff.;Alexander Chen.;Jason Akulian.;Momen Wahidi.;Samira Shojaee.;Nichole T Tanner.;Sean P Callahan.;Gregory Feldman.;Daniel G Lorch.;Ikeadi Ndukwu.;Michael A Pritchett.;Gerard A Silvestri.; .
来源: Chest. 2019年155卷1期137-146页
While the complexity of flexible bronchoscopy has increased, standard options for moderate sedation medications have not changed in three decades. There is a need to improve moderate sedation while maintaining safety. Remimazolam was developed to address shortcomings of current sedation strategies.
193. Chest CT Scan at Radiation Dose of a Posteroanterior and Lateral Chest Radiograph Series: A Proof of Principle in Lymphangioleiomyomatosis.
作者: Eileen Hu-Wang.;John L Schuzer.;Shirley Rollison.;Eric S Leifer.;Chloe Steveson.;Vissaagan Gopalakrishnan.;Jianhua Yao.;Tania Machado.;Amanda M Jones.;Patricia Julien-Williams.;Joel Moss.;Marcus Y Chen.
来源: Chest. 2019年155卷3期528-533页
Given the rising utilization of medical imaging and the risks of radiation, there is increased interest in reducing radiation exposure. The objective of this study was to evaluate, as a proof of principle, CT scans performed at radiation doses equivalent to that of a posteroanterior and lateral chest radiograph series in the cystic lung disease lymphangioleiomyomatosis (LAM).
194. The Effects of Long-term CPAP on Weight Change in Patients With Comorbid OSA and Cardiovascular Disease: Data From the SAVE Trial.
作者: Qiong Ou.;Baixin Chen.;Kelly A Loffler.;Yuanming Luo.;Xilong Zhang.;Rui Chen.;Qian Wang.;Luciano F Drager.;Geraldo Lorenzi-Filho.;Michael Hlavac.;Nigel McArdle.;Sutapa Mukherjee.;Olga Mediano.;Ferran Barbe.;Craig S Anderson.;R Doug McEvoy.;Richard J Woodman.; .
来源: Chest. 2019年155卷4期720-729页
Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established.
195. Impact of Vasoactive Medications on ICU-Acquired Weakness in Mechanically Ventilated Patients.
作者: Krysta S Wolfe.;Bhakti K Patel.;Erica L MacKenzie.;Shewit P Giovanni.;Anne S Pohlman.;Matthew M Churpek.;Jesse B Hall.;John P Kress.
来源: Chest. 2018年154卷4期781-787页
Vasoactive medications are commonly used in the treatment of critically ill patients, but their impact on the development of ICU-acquired weakness is not well described. The objective of this study is to evaluate the relationship between vasoactive medication use and the outcome of ICU-acquired weakness.
196. Effects of Exercise Training and CPAP in Patients With Heart Failure and OSA: A Preliminary Study.
作者: Denise Maria Servantes.;Shahrokh Javaheri.;Ana Claudia Pelissari Kravchychyn.;Luciana Julio Storti.;Dirceu Rodrigues Almeida.;Marco Túlio de Mello.;Fátima Dumas Cintra.;Sergio Tufik.;Lia Bittencourt.
来源: Chest. 2018年154卷4期808-817页
Exercise and CPAP improve OSA. This study examined the effects of exercise in patients with heart failure (HF) and OSA.
197. Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis.
作者: Scott M Palmer.;Laurie Snyder.;Jamie L Todd.;Benjamin Soule.;Rose Christian.;Kevin Anstrom.;Yi Luo.;Robert Gagnon.;Glenn Rosen.
来源: Chest. 2018年154卷5期1061-1069页
Idiopathic pulmonary fibrosis (IPF) causes irreversible loss of lung function. The lysophosphatidic acid receptor 1 (LPA1) pathway is implicated in IPF etiology. Safety and efficacy of BMS-986020, a high-affinity LPA1 antagonist, was assessed vs placebo in a phase 2 study in patients with IPF.
198. Circulating Biomarkers From the Phase 1 Trial of Sirolimus and Autophagy Inhibition for Patients With Lymphangioleiomyomatosis.
作者: Anthony M Lamattina.;Angelo Taveira-Dasilva.;Hilary J Goldberg.;Shefali Bagwe.;Ye Cui.;Ivan O Rosas.;Joel Moss.;Elizabeth P Henske.;Souheil El-Chemaly.
来源: Chest. 2018年154卷5期1070-1082页
We have previously conducted the Sirolimus and Autophagy Inhibition in LAM (SAIL) trial, a phase 1 dose-escalation study of the combination of sirolimus and hydroxychloroquine in patients with lymphangioleiomyomatosis (LAM). The goal of the present study was to analyze sera from the SAIL trial to identify novel biomarkers that could shed light into disease pathogenesis and response to therapy.
199. Standard Bronchoscopy With Fluoroscopy vs Thin Bronchoscopy and Radial Endobronchial Ultrasound for Biopsy of Pulmonary Lesions: A Multicenter, Prospective, Randomized Trial.
作者: Nichole T Tanner.;Lonny Yarmus.;Alexander Chen.;Jessica Wang Memoli.;Hiren J Mehta.;Nicholas J Pastis.;Hans Lee.;Michael A Jantz.;Paul J Nietert.;Gerard A Silvestri.
来源: Chest. 2018年154卷5期1035-1043页
New technology has resulted in bronchoscopy being increasingly used for diagnosing pulmonary lesions. Reported yield from these procedures varies widely with few randomized clinical trials. This study compares the diagnostic yield of a thin bronchoscope and radial endobronchial ultrasound (R-EBUS) with standard bronchoscopy and fluoroscopy (SB-F) in lung lesions.
200. Surgical Disparities Among Patients With Stage I Lung Cancer in the National Lung Screening Trial.
Low-dose CT scan reduces lung cancer mortality in high-risk patients fit to undergo surgical resection. Racial disparities in resection of lung cancer in nonscreening populations are well described. We describe surgical resection patterns of patients with early stage non-small cell lung cancer (NSCLC) in the National Lung Screening Trial (NLST) and examine whether racial disparities exist among blacks.
|