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1. Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk.
作者: Parag R Gajendragadkar.;Adam Von Ende.;Federico Murgia.;Alison Offer.;C Fielder Camm.;Rohan S Wijesurendra.;Barbara Casadei.;Jemma C Hopewell.
来源: Circ Genom Precis Med. 2025年18卷3期e004932页
Genome-wide association studies have clustered candidate genes associated with atrial fibrillation (AF) into biological pathways reflecting different pathophysiological mechanisms. We investigated whether these pathways associate with distinct intermediate phenotypes and confer differing risks of cardioembolic stroke.
4. Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: the PRINCE Randomized Clinical Trial.
作者: Massimiliano Greco.;Gaetano Lombardi.;Claudia Brusasco.;Marina Pieri.;Agostino Roasio.;Fabrizio Monaco.;Levan Berikashvili.;Alessandro Belletti.;Francesco Meroi.;Stefano Fresilli.;Aituar Kabibulatov.;Giuseppe Giardina.;Andrea Russo.;Federico Mattia Oliva.;Sergey Efremov.;Rosalba Lembo.;Lini Wang.;Simone Vietri.;Elena Momesso.;Filippo D'Amico.;Kristina Kadantseva.;Rosa Labanca.;Pavel Ryzhkov.;Marilena Marmiere.;Valery Subbotin.;Alessandro Pruna.;Nerlep Rana.;Francesca Livi.;Hugo Mantilla-Gutierrez.;Fabio Guarracino.;Lorenzo Schiavoni.;Ivan Šitum.;Marco Micali.;Stefano Bosso.;Anastasia Smirnova.;Giuseppe Fresta.;Andrey Cherednichenko.;Luigi Beretta.;Giacomo Monti.;Lian Kah Ti.;Pasquale Sansone.;Francesco Corradi.;Maurizio Cecconi.;Andrey Yavorovskiy.;Chong Lei.;Aidos Konkayev.;Tiziana Bove.;Valery Likhvantsev.;Alberto Zangrillo.;Giovanni Landoni.;Rinaldo Bellomo.;Remo Daniel Covello.;Stefano Turi.; .
来源: Circulation. 2025年
Major noncardiac surgery carries high rates of postoperative myocardial injury and other complications. Remote ischemic preconditioning (RIPC) was reported to decrease these complications. However, such supportive evidence lacks robustness.
5. How a Topological Mindset May Offer Extra Control During Mapping and Ablation of Left-Sided Reentrant Atrial Tachycardia.
作者: Mattias Duytschaever.;Maarten De Smet.;Jordi Martens.;Milad El Haddad.;Benjamin De Becker.;Clara Francois.;Rene Tavernier.;Robin Van den Abeele.;Sander Hendrickx.;Nele Vandersickel.;Jean-Benoit Le Polain de Waroux.;Sebastien Knecht.
来源: Circ Arrhythm Electrophysiol. 2025年e013780页
Reentry (macro or localized) is historically described as multiple pathways that are separated by barriers (either anatomic or functional) and involve active and passive loops (identified by electro-anatomic and entrainment mapping, EAM/ETM). Some reentrant atrial tachycardia (AT) cases are characterized by challenging activation patterns and unexpected ablation responses. A recent translational study, focusing on topology and the role of boundaries, suggests that thinking topology within EAM/ETM might offer extra control during mapping and ablation of reentrant AT. We aimed to propose and prospectively validate a workflow (EAM/ETM+TOP) in which we integrate topological thinking within an EAM/ETM workflow for mapping and ablation of left-sided (left atrium) AT.
6. Feasibility of Machine Learned Intracardiac Electrograms to Predict Postinfarction Ventricular Scar Topography.
作者: Kasun De Silva.;Timothy Campbell.;Richard G Bennett.;Samual Turnbull.;Ashwin Bhaskaran.;Robert D Anderson.;Chris Davey.;Alexandra K O'Donohue.;Aaron Schindeler.;Dinesh Selvakumar.;Yasuhito Kotake.;Chi-Jen Hsu.;James J H Chong.;Eddy Kizana.;Saurabh Kumar.
来源: Circ Arrhythm Electrophysiol. 2025年e013611页
Accurate delineation of scar patterns is valuable for guiding catheter ablation of ventricular tachycardia. We hypothesized that scar and its pattern of distribution can be determined from intracardiac electrograms using computational signal processing and that further improvements in classification can be achieved with a convolutional neural network.
7. Plasma Proteomics Reveals Dysregulated Pathways Across the Spectrum LMNA Cardiomyopathy.
作者: Usman A Tahir.;Daniel Reichart.;Anisha Purohit.;Jacob L Barber.;Gaurav Tiwari.;Laurie Farrell.;Julia Marine.;Darius Roy.;Joshen Patel.;Catherine Ireland.;Carolyn Y Ho.;Christine E Seidman.;Robert E Gerszten.;Neal K Lakdawala.
来源: Circ Genom Precis Med. 2025年e004924页
Pathogenic variants in the lamin A/C (LMNA) gene cause an aggressive form of dilated cardiomyopathy (DCM), marked by higher rates of advanced conduction disease, malignant ventricular tachyarrhythmias, and advanced heart failure compared with other causes of nonischemic cardiomyopathy. However, the mechanisms that drive the development and progression of LMNA DCM are incompletely understood.
9. Considerations of Intraoperative Transesophageal Echocardiography During Adult Cardiac Surgery: A Scientific Statement From the American Heart Association.
作者: Lisa Q Rong.;Linda Shore-Lesserson.;Kiran Belani.;Abimbola Faloye.;Enrique Garcia-Sayan.;Jennifer Lawton.;Timothy Maus.;Wanda Miller-Hance.;Alina Nicoara.;Richard Sheu.; .
来源: Circulation. 2025年
Intraoperative transesophageal echocardiography is used with increasing frequency in cardiac surgery for monitoring and diagnostic purposes. Recent data have shown the impact of improved outcomes in patients undergoing cardiac surgery and the use of intraoperative transesophageal echocardiography in managing complex surgical decisions. However, specialty society recommendations have not been updated to reflect these trends. This scientific statement reviews the state-of-the-art practice of intraoperative echocardiography, summarizes the association of the use of intraoperative transesophageal echocardiography with enhanced outcomes, and provides specific perioperative and procedural transesophageal echocardiography considerations in the cardiac surgical population.
10. Prompt Identification of the Location of Gap Conduction in the Mitral Isthmus Following Vein of Marshall Ethanol Infusion and Endocardial Ablation.
作者: Qiaoyuan Li.;Yanguang Li.;Zhuo Liang.;Tao Zhang.;Xu Liu.;Dongping Fang.;Jin Bai.;Jian Li.;Fengxiang Zhang.;Yunlong Wang.
来源: Circ Arrhythm Electrophysiol. 2025年e013454页
Mitral isthmus (MI) gap conduction is common despite ethanol infusion into the vein of Marshall (EI-VOM) and endocardial ablation of the MI. This study aimed to investigate the characteristics of electrograms of the distal coronary sinus (CSd) to guide the identification of the gap location in the MI.
13. Impact of Echocardiographic Probability of Pulmonary Hypertension on Prognosis and Outcomes Among Patients With Myeloproliferative Neoplasms.
作者: Orly Leiva.;Steven Soo.;Nathaniel R Smilowitz.;Harmony Reynolds.;Binita Shah.;Samuel Bernard.;Joan How.;Michelle Hyunju Lee.;Gabriela Hobbs.
来源: Circ Cardiovasc Imaging. 2025年e017986页
Myeloproliferative neoplasms (MPN) are a group of chronic leukemias that are associated with pulmonary hypertension (PH), which has been associated with increased risk adverse outcomes. The echocardiographic characterization of PH in MPN has not been reported, and the prognostic significance of PH among patients with MPN remains unclear.
16. Loss of Methyltransferase and Hypomethylated m6A Sarcomere Transcripts Leading to Early-Onset Dilated Cardiomyopathy.
作者: Sophie Marie Hand.;Yi Zhao.;Donna Li.;Savanna Burke.;Hee-Woong Lim.;Jessie Yester.;Vidu Garg.;Federica Accornero.;Xiao Li.;Deqiang Li.;Jihyun Jang.
来源: Circulation. 2025年151卷23期1692-1695页 17. FMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1.
作者: Changchen Xiao.;Chao Wang.;Jingyi Wang.;Xianpeng Wu.;Changle Ke.;Jinliang Nan.;Hao Ding.;Yinghui Xu.;Yanna Shi.;Jing Zhao.;Cheng Ni.;Qingnian Liu.;Jiamin Li.;Shuyuan Sheng.;Hua Chen.;Jiayue Cai.;Tonghui Zhao.;Jinghai Chen.;Qiming Sun.;Bin Zhou.;Jian'an Wang.;Wei Zhu.;Xinyang Hu.
来源: Circulation. 2025年151卷23期1667-1685页
Cardiac hypertrophy, as an important pathological change, contributes to heart failure. Recent studies indicate that the mitochondria-associated endoplasmic reticulum membranes (MAMs) play key roles in this pathological process. However, the molecular mechanism remains unclear. This study aims to elucidate the effects and mechanisms of MAM-resident FMO2 (flavin-containing monooxygenase 2) in cardiac hypertrophy and heart failure.
18. Response by Campo and Pavasini to Letter Regarding Article, "Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis".19. Letter by Pan et al Regarding Article, "Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis". |