To study the immediate and long-term results of multivisceral surgeries with pancreaticoduodenectomy for gastric cancer.

To analyze short-term outcomes of the McKeown esophagectomy in 4 cancer centers of the Russian Federation.

DICER1 syndrome is a rare monogenic disease with autosomal dominant inheritance. DICER1 protein is involved in the regulation of gene expression by microRNAs. Changes in the expression of DICER1 can be associated with various cancers. A 13,8-year-old girl with a history of embryonal rhabdomyosarcoma (ERMS) of uterine cervix and vagina excised at 6 months of age is presented with a thyroid follicular nodular disease (TFND). Molecular genetic examination revealed a heterozygous pathogenic variant p.Arg1003Ter in the DICER1 gene (NM_030621.4). The presented case emphasizes the importance of molecular genetic diagnosis of DICER1 syndrome in a diagnostic algorithm in the management of patients with TFND and history of malignancy. Considering ERMS of genital tract as a probable component of DICER1 syndrome it is necessary to screen for other manifestations of the disease as well.

Medullary thyroid carcinoma is a rare aggressive tumor of thyroid gland. Due to its neuroendocrine origine medullary thyroid carcinoma can be the source of ectopic production of different peptides and hormones. We describe a unique case of severe ACTH-dependent Cushing's syndrome due to ectopic corticotropin production by medullary thyroid carcinoma in a male patient of 39 years old with calcitonin level more than 4000 pg/ml (<11,8), thyroid nodule, multiple neck jugular and central lymphnodes. The potassium level was 1,34 mmol/l (3,5-5,1), hypercortisolemia up to 1613,2 nmol/l (185-624) with elevated level of ACTH up to 24,7 pmol/l (1,03-10,74). After the correction of water and electrolytes disorders an operation was performed - thyroidectomy, central and lateral neck dissection. Postoperative calcitonin decreased to 126 pg/ml (<11,8), calcium and parathormone blood levels remained normal. The potassium level didn't decrease without any pharmacological treatment. There was a sharp fall in postoperative blood levels of cortisol and ACTH. The hormonal replacement treatment with hydrocortisone was induced. Morphological examination showed medullary carcinoma with ACTH production in tumor nodule, with metastatic neck lymph nodes. Thus this is a rare case and successful treatment of patient with severe hypercortisolism by thyroidectomy and neck lymphnodes dissection.

 Analysis and assessment of the role of convolutional neural networks in the cytological diagnosis of the thyroid pathology, exploring their potential for increasing the accuracy and automation of diagnostic processes.

Valuate the effectiveness of autologous fat transplantation into post-lymphadenectomy cavity for prevention of lymphorrhea after total mastectomy with three-level lymphadenectomy in patients with breast cancer.

To study the incidence and risk factors of regional lymph node metastases in patients with early primary operable prognostically unfavorable breast cancer.

Kimura technique is a common variant of spleen-preserving distal pancreatectomy and preferable for patients with benign pancreatic lesions. We performed spleen-preserving distal pancreatectomy with preservation of splenic vessels in a patient with serous pancreatic cystadenoma. Preoperative imaging revealed fusion of neoplasm with splenic artery and vein within a short segment. This prepared surgeons for potential laparoscopic vascular suture.

To evaluate the effectiveness of repeated breast reconstruction in cancer patients depending on complications after primary reconstruction.

To evaluate the immediate and long-term functional results of total gastrectomy (TGE) with restoration of duodenal passage through double tract reconstruction (DTR) in comparison with Roux-en-Y reconstruction.

To develop a nomogram and risk assessment calculator for prolonged pleural effusion after lobectomy for lung cancer.

To analyze the first thousand of anatomical resections at the Herzen Moscow Oncology Research Institute between 2009 and 2023.

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by autonomous secretion of parathyroid hormone by altered parathyroid glands. In most cases PHPT is a sporadic disease, 5-10% of observations are genetically determined syndromal and non-syndromal forms. Studies of families with hereditary forms of PHPT have led to the discovery of key oncosuppressor genes and proto-oncogenes whose somatic mutations underlie the development of many sporadic parathyroid tumors. Another interest in the pathogenesis of primary hyperparathyroidism is studying mechanisms of epigenetic regulation in tumor tissue. In the first part of this review, we will discuss the classification, morphology, and etiology of PHPT. In the second part, we will present a summary of the most important studies using genetic analysis, classified according to the method used.

To analyze the immediate results of thoracoscopic (video-assisted thoracoscopic thymectomy - VATS TE) and open combined thymectomy (OTE) for invasive thymomas.

To analyze the results of major right-sided hemihepatectomies in infants with various neoplasms.

The steady increase in the incidence of colorectal cancer and its early diagnosis contribute to the identification of resectable forms of this disease, which in turn increases the number of minimally invasive surgical interventions. Therefore, the question of studying the influence of risk factors for the development of hernias and the search for an "ideal" place on the abdominal wall, which would provide the most convenient access for safe removal of the macropreparation and subsequent extracorporeal surgical procedures, as well as a low incidence of wound complications and postoperative ventral hernias, is the most pressing issue in colon cancer surgery.

To study the factors of delayed gastric emptying after pancreaticoduodenectomy using artificial intelligence.

To improve preoperative examination of patients with follicular thyroid tumors using ultrasound-guided core-needle biopsy.

To evaluate the diagnostic capability of intraoperative fluorescence lymphography (FLG) in detecting of sentinel lymph nodes (SLN) and lymph outflow pathways in patients with biliary cancer (BC).

The combination of liver resection and chemotherapy is the most effective way to treat primary and secondary malignant liver tumors. One of the methods for increasing resectability is the use of two-stage liver resection (associated liver partition and portal vein ligation for staged hepatectomy - ALPPS).