Kimura technique is a common variant of spleen-preserving distal pancreatectomy and preferable for patients with benign pancreatic lesions. We performed spleen-preserving distal pancreatectomy with preservation of splenic vessels in a patient with serous pancreatic cystadenoma. Preoperative imaging revealed fusion of neoplasm with splenic artery and vein within a short segment. This prepared surgeons for potential laparoscopic vascular suture.

To evaluate the effectiveness of repeated breast reconstruction in cancer patients depending on complications after primary reconstruction.

To evaluate the immediate and long-term functional results of total gastrectomy (TGE) with restoration of duodenal passage through double tract reconstruction (DTR) in comparison with Roux-en-Y reconstruction.

To develop a nomogram and risk assessment calculator for prolonged pleural effusion after lobectomy for lung cancer.

To analyze the first thousand of anatomical resections at the Herzen Moscow Oncology Research Institute between 2009 and 2023.

The article presents an overview of the intermediate results of treatment for maxillary sinus melanoma in a 66-year-old patient. The importance of timely diagnosis and active surgical tactics for achieving the best survival results up to 5 years is noted. After further examination, the diagnosis was confirmed, the patient underwent genomic sequencing of the tumor tissue biopsy, which revealed a BRAF mutation. In this regard, adjuvant therapy was prescribed according to the dabrafenib+trametinib regimen. It was noted that this rare pathology requires careful study, monitoring of clinical outcomes and features of surgical tactics, considering the multifocal nature of the tumor and its high aggressiveness in comparison with the cutaneous form. In the future, the possibility of surgical intervention is discussed, extensive resection is considered, the expected volume, which can reach the removal of both soft tissue and bone structures up to resection of a part of the lower wall of the orbit.

The article presents a literature review and a clinical case of an adenomatoid odontogenic tumor in a 3-year-old child. After the surgical treatment, an morphological and immunohistochemical (with antibodies to Ki-67, CK7, CK 14 and CK 18) studies of the remote material were performed. The histological features of the neoplasm are shown, and its origin from the odontogenic epithelium is substantiated.

Based on eight clinical cases the article analyzes the main clinical and radiographic features of eight children aged 6-14 years with rare cystic lesions: juvenile inflammatory collateral cyst (ICC). ICCs were associated with incompletely erupted first (6 children) or second (2 children) permanent molars. Only in 5 cases did they manifest as pain in the area of the affected teeth, in the remaining cases they were radiographic findings during examination before orthodontic treatment. At the same time, the teeth in the projection of the cyst retained their vitality in all cases, which was confirmed by the cold test and continued root growth after cystectomy. On OPG, ICCs were manifested by a wide variety of localizations (in the bifurcation projection, below, distal or medial to the roots of the teeth), but CBCT made it possible to detect a common symptom - predominantly the vestibular location of the lesion. Cystectomy without endodontic treatment of teeth in the projection of the cyst turned out to be a successful treatment tactic, which is confirmed by observation for 6 -84 months without recurrence of ICCs and dental complications.

The probability of meningiomas metastasizing is 0.18%, and the causes are unclear. The most common localizations of extracranial metastases are lung (37.2%), bones (16.5%) and liver (9.2%). There are no effective treatment algorithms for metastatic meningiomas. Treatment tactics consists of symptomatic surgery and radiotherapy.

Sellar tumors are predominantly benign neoplasms accounting for approximately 14-18% of all brain tumors. For many decades, there have been a few clinical cases confirming possible simultaneous coexistence of two nosological groups in one area. We present 2 rare cases of sellar collision tumors (a 61-year-old male with pituitary adenoma and craniopharyngioma; a 68-year-old female with pituitary adenoma and meningioma of tubercle), clinical features, anamnesis, preoperative neuroimaging, intraoperative picture and postoperative outcomes. Combination of pituitary adenoma and craniopharyngioma/ meningioma as a type of collision tumors requires caution at all stages of treatment due to impossible preoperative analysis of tumor density and, accordingly, correct choice of surgical access. Transsphenoidal endoscopic access reduces mortality rate according to literature data. Preoperative MR elastometry needs to be studied in depth including patients with sellar collision tumors.

Combination of different intracranial tumors is an infrequent phenomenon. Combination of pituitary adenomas with craniopharyngiomas is extremely rare.

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by autonomous secretion of parathyroid hormone by altered parathyroid glands. In most cases PHPT is a sporadic disease, 5-10% of observations are genetically determined syndromal and non-syndromal forms. Studies of families with hereditary forms of PHPT have led to the discovery of key oncosuppressor genes and proto-oncogenes whose somatic mutations underlie the development of many sporadic parathyroid tumors. Another interest in the pathogenesis of primary hyperparathyroidism is studying mechanisms of epigenetic regulation in tumor tissue. In the first part of this review, we will discuss the classification, morphology, and etiology of PHPT. In the second part, we will present a summary of the most important studies using genetic analysis, classified according to the method used.

Transurethral resection of the bladder tumor (TURBT) is not only the main method for staging of bladder cancer, but also the standard of surgical treatment for patients with non-muscle-invasive tumosr. Previously, the generally accepted technique for performing TURBT was electroresection using loop, but the active introduction of laser technologies has made the resection of the entire tumor in a single block (en bloc) widely available. According to some authors, en bloc resection of the bladder tumor allows to overcome some limitations of standard TURBT, including insufficient quality of the specimen containing the muscle layer and implantation of floating tumor cells in the bladder. However, the en bloc resection also has limitations. When using the en bloc resection for tumors larger than 3 cm, successful evacuation of the entire lesion becomes unlikely, therefore, it is usually recommended to use it for smaller tumors. Publications devoted to the successful en bloc resection for large bladder tumors are included in the literature review. According to most authors, all the advantages of en bloc resection are preserved regardless of the tumor size, such as potentially better local control, lower recurrence rates outside the resection area, and higher quality of specimens for pathological study. A significant limitation of the technique is the inability to evacuate the tumor through the endoscope channel, which requires additional interventions (morcellation, dissection, ablation) or equipment (endoscopic baskets, forceps, etc.). Taking into account the conclusions of the Delphi consensus held in 2020, tumor size should not limit the use of the en bloc resection of the bladder tumor in the routine practice. However, an effective method for evacuating large bladder tumors that suits all specialists has not yet been proposed.

Fat necrosis is a benign inflammation of adipose tissue, which is associated with sterile saponification, due to impaired blood supply. At the same time, differential diagnostics with malignant neoplasms and tumor relapses is extremely difficult due to the similar features according to imaging studies (ultrasound, CT, MRI, PET/CT). We present a clinical case of fat necrosis, confirmed by the immunohistochemical study, simulating recurrent kidney cancer. The patient underwent partial nephrectomy for renal cell carcinoma. After 6 months, radiological signs of tumor recurrence were detected in the resection area, due to which patient underwent laparoscopic nephrectomy. Immunohistochemical study indicated fat necrosis.

To estimate frequency and type of renal injury in patients with metastatic renal cell carcinoma (RCC) receiving ipilimumab and nivolumab after nephrectomy.

Prostate cancer (PCa) is the second most common cancer worldwide. Current methods of definitive treatment of PCa provide good recurrence-free survival in patients with low and intermediate risk of progression, and yet about a third of men will face the local recurrence in the next 10 years of life. Today, there is a great need to find optimal technologies for treating local relapses of PCa.

To discuss the feasibility, safety, and efficiency of conventional laparoscopic partial nephrectomy (LPN) for patients with renal hilar tumors.

Progression of metastatic prostate cancer after castration resistance is one of the main challenges in prostate cancer therapy. 177Lu-PSMA-617 has been recently investigated in castration resistant metastatic prostate cancer.

Schwannoma is a benign tumor arising from the peripheral nerve sheaths and consisting of highly differentiated Schwann cells, which under physiological conditions produce the essential component of nerve fibers myelin. Frequent localization of neoplasms are areas with developed and abundant nerve supply - the head, neck, limbs, less often its occur in the chest, mediastinum, retroperitoneum, adrenal glands, organs of the gastrointestinal tract, cases of schwannoma of the penis and vulva are also described. In clinical practice, extratesticular schwannoma of the scrotum is extremely rare, when analyzing literary sources, descriptions of only isolated observations were found. Scrotal schwannoma is often associated with systemic pathology - neurofibromatosis type 2 or schwannomatosis, isolated development of the tumor is rather considered an exceptional event. In this article, we present a description of a clinical case of multiple large scrotal schwannoma in a 45-year-old man who underwent surgical treatment with excision of the tumor in 2011. During the period 2011-2024, the patient had no relapse of the disease, the quality of life was high and the prognosis was favorable.

Oncological diseases of the anogenital zone in men have become increasingly relevant in recent years. It is associated with the increasing incidence, subtle clinical manifestations, and difficulties in establishing a diagnosis, requiring, in most cases, histological examination, since the diagnostic capabilities of non-invasive methods, unfortunately, are limited. Precancerous conditions, both associated with the human papillomavirus (HPV) and HPV-negative, occupy a special place among penile oncological disorders, timely diagnosis of which is extremely important.